KR100831116B1 - 키나아제 억제제로서의 퀴나졸린 유도체 - Google Patents

키나아제 억제제로서의 퀴나졸린 유도체 Download PDF

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Publication number
KR100831116B1
KR100831116B1 KR1020037002381A KR20037002381A KR100831116B1 KR 100831116 B1 KR100831116 B1 KR 100831116B1 KR 1020037002381 A KR1020037002381 A KR 1020037002381A KR 20037002381 A KR20037002381 A KR 20037002381A KR 100831116 B1 KR100831116 B1 KR 100831116B1
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South Korea
Prior art keywords
methoxy
piperazinyl
carboxamide
quinazolin
phenyl
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Expired - Fee Related
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KR1020037002381A
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English (en)
Korean (ko)
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KR20030082537A (ko
Inventor
안잴리 팬디
로버트 엠. 스카보로우
켄지 마츠노
미치오 이치무라
유지 노모토
시니치 이데
에이지 츠쿠다
준코 이리에
쇼지 오다
Original Assignee
밀레니엄 파머슈티컬스 인코퍼레이티드
교와 학꼬 고교 가부시키가이샤
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Publication of KR20030082537A publication Critical patent/KR20030082537A/ko
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Publication of KR100831116B1 publication Critical patent/KR100831116B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020037002381A 2000-08-18 2001-08-17 키나아제 억제제로서의 퀴나졸린 유도체 Expired - Fee Related KR100831116B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22612200P 2000-08-18 2000-08-18
US60/226,122 2000-08-18
PCT/US2001/041752 WO2002016351A1 (en) 2000-08-18 2001-08-17 Quinazoline derivatives as kinase inhibitors

Publications (2)

Publication Number Publication Date
KR20030082537A KR20030082537A (ko) 2003-10-22
KR100831116B1 true KR100831116B1 (ko) 2008-05-20

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KR1020037002381A Expired - Fee Related KR100831116B1 (ko) 2000-08-18 2001-08-17 키나아제 억제제로서의 퀴나졸린 유도체

Country Status (24)

Country Link
US (5) US6982266B2 (https=)
EP (3) EP2277877A1 (https=)
JP (1) JP5073147B2 (https=)
KR (1) KR100831116B1 (https=)
CN (1) CN100358890C (https=)
AT (1) ATE402169T1 (https=)
AU (1) AU8544901A (https=)
BR (1) BR0113356A (https=)
CA (1) CA2426440C (https=)
CY (1) CY1110460T1 (https=)
CZ (1) CZ304061B6 (https=)
DE (1) DE60134990D1 (https=)
DK (1) DK1315715T3 (https=)
EA (1) EA005809B1 (https=)
ES (1) ES2311023T3 (https=)
HU (1) HU228668B1 (https=)
IL (2) IL154514A0 (https=)
MX (1) MXPA03001359A (https=)
NO (1) NO323782B1 (https=)
NZ (1) NZ524461A (https=)
PT (1) PT1315715E (https=)
SI (1) SI1315715T1 (https=)
WO (1) WO2002016351A1 (https=)
ZA (1) ZA200301510B (https=)

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WO2002016351A1 (en) 2002-02-28
US20050101609A1 (en) 2005-05-12
CZ2003765A3 (cs) 2004-08-18
EP1964839A3 (en) 2008-11-05
US7560461B2 (en) 2009-07-14
MXPA03001359A (es) 2004-12-13
US20130274252A1 (en) 2013-10-17
US20100113468A1 (en) 2010-05-06
DK1315715T3 (da) 2008-11-17
NO323782B1 (no) 2007-07-02
CZ304061B6 (cs) 2013-09-11
US20050288297A1 (en) 2005-12-29
HU228668B1 (hu) 2013-05-28
ZA200301510B (en) 2004-06-22
CN100358890C (zh) 2008-01-02
EA005809B1 (ru) 2005-06-30
AU8544901A (en) 2002-03-04
HK1057206A1 (en) 2004-03-19
US6982266B2 (en) 2006-01-03
IL154514A (en) 2011-03-31
HUP0302615A3 (en) 2008-03-28
US20150133439A1 (en) 2015-05-14
ES2311023T3 (es) 2009-02-01
DE60134990D1 (de) 2008-09-04
SI1315715T1 (sl) 2008-12-31
NO20030747L (no) 2003-04-14
AU2001285449B2 (en) 2007-04-05
IL154514A0 (en) 2003-09-17
CA2426440C (en) 2011-03-15
EA200300265A1 (ru) 2003-12-25
JP2005501796A (ja) 2005-01-20
EP1315715A1 (en) 2003-06-04
KR20030082537A (ko) 2003-10-22
JP5073147B2 (ja) 2012-11-14
BR0113356A (pt) 2004-04-20
EP2277877A1 (en) 2011-01-26
NO20030747D0 (no) 2003-02-17
EP1315715B1 (en) 2008-07-23
EP1964839A2 (en) 2008-09-03
NZ524461A (en) 2004-12-24
CN1633431A (zh) 2005-06-29
US8324205B2 (en) 2012-12-04
CA2426440A1 (en) 2002-02-28
HUP0302615A2 (hu) 2003-12-29
PT1315715E (pt) 2008-10-30
CY1110460T1 (el) 2015-04-29
ATE402169T1 (de) 2008-08-15

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