BR0113356A - Derivados de quinazolina como inibidores de quinase - Google Patents

Derivados de quinazolina como inibidores de quinase

Info

Publication number
BR0113356A
BR0113356A BR0113356-0A BR0113356A BR0113356A BR 0113356 A BR0113356 A BR 0113356A BR 0113356 A BR0113356 A BR 0113356A BR 0113356 A BR0113356 A BR 0113356A
Authority
BR
Brazil
Prior art keywords
kinases
phosphorylation
kinase inhibitors
quinazoline derivatives
pharmaceutically acceptable
Prior art date
Application number
BR0113356-0A
Other languages
English (en)
Inventor
Anjali Pandey
Robert M Scarborough
Kenji Matsuno
Michio Ichimura
Yuji Nomoto
Shigeki Fujiwara
Shinichi Ide
Eiji Tsukuda
Junko Irie
Shoki Oda
Original Assignee
Millennium Pharm Inc
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc, Kyowa Hakko Kogyo Kk filed Critical Millennium Pharm Inc
Publication of BR0113356A publication Critical patent/BR0113356A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

"DERIVADOS DE QUINAZOLINA COMO INIBIDORES DE QUINASE". A presente invenção está relacionada a compostos heterocíclicos contendo nitrogênio e sais farmaceuticamente aceitáveis desses que possuem atividade inibidora sobre a fosforilação de quinases, que inibe a atividade de tais quinases. A invenção também está relacionada a um método de inibição de quinases e a tratamento de estados de doença em um mamífero por inibição da fosforilação de quinases. Em um aspecto particular a presente invenção fornece compostos heterocíclicos contendo nitrogênio e sais farmaceuticamente aceitáveis desses inibem a fosforilação de um receptor PDGF para impedir crescimento celular anormal e desvio celular, e um método para prevenção e tratamento de doenças de proliferação celular tais como arteriosclerose, obstrução vascular, câncer e glomeruloesclerose.
BR0113356-0A 2000-08-18 2001-08-17 Derivados de quinazolina como inibidores de quinase BR0113356A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22612200P 2000-08-18 2000-08-18
PCT/US2001/041752 WO2002016351A1 (en) 2000-08-18 2001-08-17 Quinazoline derivatives as kinase inhibitors

Publications (1)

Publication Number Publication Date
BR0113356A true BR0113356A (pt) 2004-04-20

Family

ID=22847639

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0113356-0A BR0113356A (pt) 2000-08-18 2001-08-17 Derivados de quinazolina como inibidores de quinase

Country Status (25)

Country Link
US (5) US6982266B2 (pt)
EP (3) EP2277877A1 (pt)
JP (1) JP5073147B2 (pt)
KR (1) KR100831116B1 (pt)
CN (1) CN100358890C (pt)
AT (1) ATE402169T1 (pt)
AU (1) AU8544901A (pt)
BR (1) BR0113356A (pt)
CA (1) CA2426440C (pt)
CY (1) CY1110460T1 (pt)
CZ (1) CZ304061B6 (pt)
DE (1) DE60134990D1 (pt)
DK (1) DK1315715T3 (pt)
EA (1) EA005809B1 (pt)
ES (1) ES2311023T3 (pt)
HK (1) HK1057206A1 (pt)
HU (1) HU228668B1 (pt)
IL (2) IL154514A0 (pt)
MX (1) MXPA03001359A (pt)
NO (1) NO323782B1 (pt)
NZ (1) NZ524461A (pt)
PT (1) PT1315715E (pt)
SI (1) SI1315715T1 (pt)
WO (1) WO2002016351A1 (pt)
ZA (1) ZA200301510B (pt)

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Also Published As

Publication number Publication date
EA005809B1 (ru) 2005-06-30
CN1633431A (zh) 2005-06-29
SI1315715T1 (sl) 2008-12-31
CY1110460T1 (el) 2015-04-29
CA2426440C (en) 2011-03-15
US20150133439A1 (en) 2015-05-14
DE60134990D1 (de) 2008-09-04
US20050288297A1 (en) 2005-12-29
HU228668B1 (hu) 2013-05-28
IL154514A (en) 2011-03-31
JP2005501796A (ja) 2005-01-20
EP1964839A3 (en) 2008-11-05
ES2311023T3 (es) 2009-02-01
EP2277877A1 (en) 2011-01-26
US8324205B2 (en) 2012-12-04
NO20030747L (no) 2003-04-14
CZ2003765A3 (cs) 2004-08-18
NO20030747D0 (no) 2003-02-17
AU2001285449B2 (en) 2007-04-05
CN100358890C (zh) 2008-01-02
DK1315715T3 (da) 2008-11-17
EA200300265A1 (ru) 2003-12-25
HUP0302615A3 (en) 2008-03-28
US6982266B2 (en) 2006-01-03
ZA200301510B (en) 2004-06-22
CA2426440A1 (en) 2002-02-28
NZ524461A (en) 2004-12-24
US20050101609A1 (en) 2005-05-12
US20100113468A1 (en) 2010-05-06
IL154514A0 (en) 2003-09-17
PT1315715E (pt) 2008-10-30
KR100831116B1 (ko) 2008-05-20
AU8544901A (en) 2002-03-04
EP1315715A1 (en) 2003-06-04
MXPA03001359A (es) 2004-12-13
ATE402169T1 (de) 2008-08-15
EP1315715B1 (en) 2008-07-23
NO323782B1 (no) 2007-07-02
EP1964839A2 (en) 2008-09-03
CZ304061B6 (cs) 2013-09-11
KR20030082537A (ko) 2003-10-22
US20130274252A1 (en) 2013-10-17
WO2002016351A1 (en) 2002-02-28
JP5073147B2 (ja) 2012-11-14
HUP0302615A2 (hu) 2003-12-29
HK1057206A1 (en) 2004-03-19
US7560461B2 (en) 2009-07-14

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