KR100815042B1 - 이형접합성 가족성 고콜레스테롤혈증 치료에 있어서로수바스타틴(ｚｄ－４５２２)의 용도 - Google Patents

이형접합성 가족성 고콜레스테롤혈증 치료에 있어서로수바스타틴(ｚｄ－４５２２)의 용도 Download PDF

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Publication number
KR100815042B1
KR100815042B1 KR1020037006791A KR20037006791A KR100815042B1 KR 100815042 B1 KR100815042 B1 KR 100815042B1 KR 1020037006791 A KR1020037006791 A KR 1020037006791A KR 20037006791 A KR20037006791 A KR 20037006791A KR 100815042 B1 KR100815042 B1 KR 100815042B1
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ldl
pharmaceutical composition
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dihydroxyhept
methylsulfonyl
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KR1020037006791A
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KR20030048479A (ko
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라자알리
허친슨하워드제라드
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아스트라제네카 아베
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Application filed by 아스트라제네카 아베 filed Critical 아스트라제네카 아베
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020037006791A 2000-11-22 2001-11-16 이형접합성 가족성 고콜레스테롤혈증 치료에 있어서로수바스타틴(ｚｄ－４５２２)의 용도 Ceased KR100815042B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0028429.9A GB0028429D0 (en) 2000-11-22 2000-11-22 Therapy
GB0028429.9 2000-11-22
PCT/GB2001/005041 WO2002041895A1 (en) 2000-11-22 2001-11-16 Use of rosuvastatin (zd-4522) in the treatment of heterozygous familial hypercholesterolemia

Publications (2)

Publication Number Publication Date
KR20030048479A KR20030048479A (ko) 2003-06-19
KR100815042B1 true KR100815042B1 (ko) 2008-03-18

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KR1020037006791A Ceased KR100815042B1 (ko) 2000-11-22 2001-11-16 이형접합성 가족성 고콜레스테롤혈증 치료에 있어서로수바스타틴(ｚｄ－４５２２)의 용도

Country Status (34)

Country Link
US (1) US6858618B2 (https=)
EP (1) EP1339409B1 (https=)
JP (2) JP5062940B2 (https=)
KR (1) KR100815042B1 (https=)
CN (1) CN1268339C (https=)
AR (1) AR031766A1 (https=)
AT (1) ATE394103T1 (https=)
AU (2) AU2002214165B9 (https=)
BG (1) BG66009B1 (https=)
BR (1) BR0115511A (https=)
CA (1) CA2429263C (https=)
CY (1) CY1110428T1 (https=)
CZ (1) CZ301583B6 (https=)
DE (1) DE60133921D1 (https=)
DK (1) DK1339409T3 (https=)
EE (1) EE05507B1 (https=)
ES (1) ES2305118T3 (https=)
GB (1) GB0028429D0 (https=)
HU (1) HUP0301380A3 (https=)
IL (2) IL155919A0 (https=)
IS (1) IS6819A (https=)
MX (1) MXPA03004336A (https=)
MY (1) MY134902A (https=)
NO (1) NO326245B1 (https=)
NZ (1) NZ525754A (https=)
PL (1) PL365386A1 (https=)
PT (1) PT1339409E (https=)
RU (1) RU2294744C2 (https=)
SI (1) SI1339409T1 (https=)
SK (1) SK6212003A3 (https=)
TW (1) TWI238720B (https=)
UA (1) UA75614C2 (https=)
WO (1) WO2002041895A1 (https=)
ZA (1) ZA200303636B (https=)

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GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
EA014685B1 (ru) 2003-04-25 2010-12-30 Джилид Сайэнс, Инк. Фосфонатсодержащие антивирусные соединения (варианты) и фармацевтическая композиция на их основе
US7452901B2 (en) * 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
KR20060022647A (ko) * 2003-04-25 2006-03-10 길리애드 사이언시즈, 인코포레이티드 키나아제 억제 포스포네이트 유사체
US7407965B2 (en) * 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
US20050261237A1 (en) * 2003-04-25 2005-11-24 Boojamra Constantine G Nucleoside phosphonate analogs
US7470724B2 (en) * 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
US20090247488A1 (en) * 2003-04-25 2009-10-01 Carina Cannizzaro Anti-inflammatory phosphonate compounds
CA2537271A1 (en) * 2003-08-28 2005-03-17 Teva Pharmaceutical Industries, Ltd. Process for preparation of rosuvastatin calcium
GB0322552D0 (en) 2003-09-26 2003-10-29 Astrazeneca Uk Ltd Therapeutic treatment
WO2005044308A1 (en) * 2003-10-24 2005-05-19 Gilead Sciences, Inc. Phosphonate analogs of antimetabolites
CA2546701C (en) 2003-11-24 2010-07-27 Teva Pharmaceutical Industries Ltd. Crystalline ammonium salts of rosuvastatin
CN1894221B (zh) * 2003-12-02 2012-08-08 特瓦制药工业有限公司 用于表征罗苏伐他汀的参照标准品
US7851624B2 (en) * 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
US20070179166A1 (en) * 2003-12-24 2007-08-02 Valerie Niddam-Hildesheim Process for preparation of statins with high syn to anti ratio
CA2567963A1 (en) * 2004-05-26 2005-12-08 Kgk Synergize Inc. Functional foods comprising flavonoids and tocotrienols and methods thereof
JP2007508379A (ja) * 2004-07-13 2007-04-05 テバ ファーマシューティカル インダストリーズ リミティド Ｔｅｍｐｏ媒介型酸化段階を包含するロスバスタチンの調製方法
AU2005330489B2 (en) 2004-07-27 2011-08-25 Gilead Sciences, Inc. Nucleoside phosphonate conjugates as anti HIV agents
US20070167625A1 (en) * 2005-02-22 2007-07-19 Anna Balanov Preparation of rosuvastatin
US7612203B2 (en) * 2005-02-22 2009-11-03 Teva Pharmaceutical Industries Ltd. Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof
US20070037979A1 (en) * 2005-02-22 2007-02-15 Valerie Niddam-Hildesheim Preparation of rosuvastatin
KR20070062996A (ko) * 2005-08-16 2007-06-18 테바 파마슈티컬 인더스트리즈 리미티드 결정성 로수바스타틴 중간체
US8383614B2 (en) * 2008-01-31 2013-02-26 The Trustees Of The University Of Pennsylvania Hypercholestrolemia and tendinous injuries
US9427437B2 (en) 2008-01-31 2016-08-30 The Trustees Of The University Of Pennsylvania Hypercholesterolemia and tendinous injuries
EP2298745B1 (en) 2008-05-27 2014-09-03 Changzhou Pharmaceutical Factory Preparation method of rosuvastatin calcium and its intermediates
US8658617B2 (en) 2008-07-08 2014-02-25 Gilead Sciences, Inc. Salts of HIV inhibitor compounds
AR092872A1 (es) 2012-09-17 2015-05-06 Madrigal Pharmaceuticals Inc Metodo para sintetizar analogos de la hormona tiroidea y polimorfos de los mismos
US9132117B2 (en) 2013-06-17 2015-09-15 Kgk Synergize, Inc Compositions and methods for glycemic control of subjects with impaired fasting glucose
US10600502B2 (en) 2016-12-20 2020-03-24 Astrazeneca Uk Ltd. Systems and methods for dispensing a statin medication over the counter
SI3661937T1 (sl) 2017-08-01 2021-11-30 Gilead Sciences, Inc. Kristalinične oblike etil((S)-((((2R,5R)-5-(6-amino-9H-purin-9-IL)-4- fluoro-2,5-dihidrofuran-2-IL)oksi)metil)(fenoksi)fosforil)-L-alaninata (GS-9131) za zdravljenje virusnih okužb
WO2020243134A1 (en) 2019-05-27 2020-12-03 Immatics US, Inc. Viral vectors and their use in adoptive cellular therapy
DE102020111571A1 (de) 2020-03-11 2021-09-16 Immatics US, Inc. Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren
US20220008519A1 (en) 2020-07-09 2022-01-13 Costa Rican Social Security Fund / Caja Costarricense de Seguro Social (CCSS) Treatment of severe acute respiratory syndrome-related coronavirus infection with klotho
US20220056411A1 (en) 2020-08-21 2022-02-24 Immatics US, Inc. Methods for isolating cd8+ selected t cells
KR20230142523A (ko) * 2021-02-01 2023-10-11 마드리갈 파마슈티칼스, 인크. 간 장애 또는 지질 장애의 치료를 위한 로수바스타틴 및 레스메티롬의 치료용 조합
US12377104B1 (en) 2024-02-06 2025-08-05 Madrigal Pharmaceuticals, Inc. Methods for treating a fatty liver disease

Citations (1)

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EP0521471A1 (en) * 1991-07-01 1993-01-07 Shionogi Seiyaku Kabushiki Kaisha Pyrimidine derivatives as HMG-CoA reductase inhibitors

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RU2051907C1 (ru) * 1989-05-22 1996-01-10 Сандос АГ Способ получения 7-замещенной гептен-6-овой кислоты
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US6369103B1 (en) * 1994-01-18 2002-04-09 Bristol-Myers Squibb Company Method for preventing or reducing risk of onset of cardiovascular events employing an HMG CoA reductase inhibitor
GB0001621D0 (en) * 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
ATE367802T1 (de) * 2000-09-20 2007-08-15 Jagotec Ag Verfahren zur sprühtrocknung von zusammensetzungen enthaltend fenofibrat

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EP0521471A1 (en) * 1991-07-01 1993-01-07 Shionogi Seiyaku Kabushiki Kaisha Pyrimidine derivatives as HMG-CoA reductase inhibitors

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Publication number Publication date
CZ20031406A3 (cs) 2003-09-17
MXPA03004336A (es) 2003-08-19
NO20032292L (no) 2003-07-17
PL365386A1 (en) 2005-01-10
UA75614C2 (uk) 2006-05-15
JP5062940B2 (ja) 2012-10-31
GB0028429D0 (en) 2001-01-10
US20040072852A1 (en) 2004-04-15
US6858618B2 (en) 2005-02-22
IL155919A0 (en) 2003-12-23
EP1339409A1 (en) 2003-09-03
CN1268339C (zh) 2006-08-09
BG66009B1 (bg) 2010-10-29
PT1339409E (pt) 2008-07-07
IL155919A (en) 2009-09-01
CA2429263A1 (en) 2002-05-30
RU2294744C2 (ru) 2007-03-10
AU2002214165B9 (en) 2013-07-04
WO2002041895A1 (en) 2002-05-30
CZ301583B6 (cs) 2010-04-21
AR031766A1 (es) 2003-10-01
AU2002214165B2 (en) 2006-12-14
HUP0301380A3 (en) 2007-03-28
JP2004522714A (ja) 2004-07-29
MY134902A (en) 2007-12-31
DE60133921D1 (de) 2008-06-19
NO326245B1 (no) 2008-10-27
CN1630520A (zh) 2005-06-22
AU1416502A (en) 2002-06-03
HUP0301380A2 (hu) 2003-10-28
ES2305118T3 (es) 2008-11-01
CY1110428T1 (el) 2015-04-29
EE05507B1 (et) 2012-02-15
NZ525754A (en) 2004-10-29
SK6212003A3 (en) 2003-11-04
HK1056691A1 (en) 2004-02-27
BR0115511A (pt) 2003-12-30
IS6819A (is) 2003-05-19
KR20030048479A (ko) 2003-06-19
CA2429263C (en) 2009-03-17
TWI238720B (en) 2005-09-01
NO20032292D0 (no) 2003-05-21
BG107811A (bg) 2004-03-31
SI1339409T1 (sl) 2008-08-31
JP2010031047A (ja) 2010-02-12
DK1339409T3 (da) 2008-09-08
ZA200303636B (en) 2004-08-12
EP1339409B1 (en) 2008-05-07
ATE394103T1 (de) 2008-05-15
EE200300239A (et) 2003-08-15

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