KR100788778B1 - 벤즈이미다졸 유도체 및 이들의 프로톤 펌프 억제제의프로드럭으로서의 이용 - Google Patents

벤즈이미다졸 유도체 및 이들의 프로톤 펌프 억제제의프로드럭으로서의 이용 Download PDF

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KR100788778B1
KR100788778B1 KR1020057000899A KR20057000899A KR100788778B1 KR 100788778 B1 KR100788778 B1 KR 100788778B1 KR 1020057000899 A KR1020057000899 A KR 1020057000899A KR 20057000899 A KR20057000899 A KR 20057000899A KR 100788778 B1 KR100788778 B1 KR 100788778B1
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compound
formula
sulfonyl
methoxy
mixture
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KR20050047078A (ko
Inventor
마이클 이 가스트
죠지 사크
재무 신
Original Assignee
윈스턴 파마슈티컬즈, 엘엘씨
더 리전트 오브 더 유니버시티 오브 캘리포니아
유.에스. 거번먼트(레프리젠티드 바이 더 디파트먼트 오브 베테랑스 어페어즈)
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Application filed by 윈스턴 파마슈티컬즈, 엘엘씨, 더 리전트 오브 더 유니버시티 오브 캘리포니아, 유.에스. 거번먼트(레프리젠티드 바이 더 디파트먼트 오브 베테랑스 어페어즈) filed Critical 윈스턴 파마슈티컬즈, 엘엘씨
Publication of KR20050047078A publication Critical patent/KR20050047078A/ko
Application granted granted Critical
Publication of KR100788778B1 publication Critical patent/KR100788778B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
KR1020057000899A 2002-07-19 2003-07-15 벤즈이미다졸 유도체 및 이들의 프로톤 펌프 억제제의프로드럭으로서의 이용 Expired - Fee Related KR100788778B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39745902P 2002-07-19 2002-07-19
US60/397,459 2002-07-19

Related Child Applications (1)

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KR1020067026729A Division KR100822981B1 (ko) 2002-07-19 2003-07-15 벤즈이미다졸 유도체 및 이들의 프로톤 펌프 억제제의프로드럭으로서의 이용

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KR20050047078A KR20050047078A (ko) 2005-05-19
KR100788778B1 true KR100788778B1 (ko) 2007-12-27

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Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020057000899A Expired - Fee Related KR100788778B1 (ko) 2002-07-19 2003-07-15 벤즈이미다졸 유도체 및 이들의 프로톤 펌프 억제제의프로드럭으로서의 이용
KR1020067026729A Expired - Fee Related KR100822981B1 (ko) 2002-07-19 2003-07-15 벤즈이미다졸 유도체 및 이들의 프로톤 펌프 억제제의프로드럭으로서의 이용

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US (3) US6897227B2 (https=)
EP (1) EP1556371B1 (https=)
JP (1) JP4463103B2 (https=)
KR (2) KR100788778B1 (https=)
AT (1) ATE323695T1 (https=)
AU (1) AU2003259154B2 (https=)
BR (1) BR0312802A (https=)
CA (1) CA2492718C (https=)
CO (1) CO5690576A2 (https=)
DE (1) DE60304726T2 (https=)
DK (1) DK1556371T3 (https=)
ES (1) ES2263028T3 (https=)
IL (1) IL166371A0 (https=)
MX (1) MXPA05000657A (https=)
NO (1) NO20050801L (https=)
NZ (1) NZ538221A (https=)
PL (1) PL375255A1 (https=)
PT (1) PT1556371E (https=)
RU (1) RU2292342C2 (https=)
TW (1) TW200502231A (https=)
WO (1) WO2004009583A2 (https=)
ZA (1) ZA200501116B (https=)

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US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
EP1534278A4 (en) * 2002-08-01 2006-09-06 Nitromed Inc NITROSED PROTONATE PUMP INHIBITORS, COMPOSITIONS AND USE METHOD
AU2004264401A1 (en) * 2003-07-15 2005-02-24 Allergan, Inc. Process for preparing isomerically pure prodrugs of proton pump inhibitors
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
WO2005039640A1 (en) * 2003-10-03 2005-05-06 Allergan Inc. Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump inhibitor prodrugs
AU2005216863A1 (en) * 2004-02-18 2005-09-09 Allergan, Inc. Methods and compositions for the intravenous administration of compounds related to proton pump inhibitors
JP2007523163A (ja) * 2004-02-18 2007-08-16 アラーガン、インコーポレイテッド プロトンポンプインヒビターのプロドラッグの投与のための方法および組成物
BRPI0507796A (pt) * 2004-03-11 2007-07-17 Allergan Inc métodos e composições para o tratamento de condições relacionadas com a secreção de ácido gástrico
EP1740571B1 (en) 2004-04-28 2009-07-29 Hetero Drugs Limited A process for preparing pyridinylmethyl-1h- benzimidazole compounds in enantiomerically enriched form or as single enantiomers
WO2007073301A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Benzoimidazole derivatives as prodrugs of proton pump inhibitors
WO2007081871A1 (en) * 2006-01-10 2007-07-19 Allergan, Inc. Therapeutic salt compositions of sulfonyl ester prodrugs of proton pump inhibitors and methods for their preparation
BRPI0711048A2 (pt) * 2006-05-09 2011-08-23 Astrazeneca Ab formulações parenteral esterilizada e sólida estáveis, solução para administração parenteral, processos para a preparação de uma formulação e para a fabricação de um produto, método para prevenir ou tratar doenças gastrintestinais, uso de uma formulação sólida estável
US20070293543A1 (en) * 2006-06-19 2007-12-20 Edward Lee THRESHOLD BLOOD OMEPRAZOLE CONCENTRATION IS 50 NG/ML FOR THE MAINTENANCE OF INTRAGASTRIC pH OF AT LEAST 4.0 AFTER ORAL DOSING WITH CMA-OMEPRAZOLE, AGN 201904-Z
WO2008036201A1 (en) * 2006-09-19 2008-03-27 Alevium Pharmaceuticals, Inc. Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
WO2008036211A1 (en) * 2006-09-19 2008-03-27 Alevium Pharmaceuticals, Inc. Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety
US20100265240A1 (en) * 2007-10-05 2010-10-21 Lg Electronics Inc. Plasma display device
KR20090035195A (ko) * 2007-10-05 2009-04-09 엘지전자 주식회사 플라즈마 디스플레이 장치
KR100895333B1 (ko) * 2007-11-01 2009-05-07 엘지전자 주식회사 플라즈마 디스플레이 패널의 구동 방법 및 그를 이용한플라즈마 디스플레이 장치
EP2627178B1 (en) 2010-10-11 2018-05-02 Merck Sharp & Dohme Corp. Quinazolinone-type compounds as crth2 antagonists
US9290453B2 (en) 2010-12-23 2016-03-22 Merck Sharp & Dohme Corp. Quinolines and aza-quinolines as CRTH2 receptor modulators
US9469615B2 (en) 2010-12-23 2016-10-18 Merck Sharp & Dohme Corp. Quinoxalines and AZA-quinoxalines as CRTH2 receptor modulators
US20180021319A1 (en) * 2015-01-09 2018-01-25 The Regents Of The University Of California Compositions and methods for treating gastrointestinal infections
CN108997177A (zh) * 2018-09-04 2018-12-14 邵阳学院 一种微波促进n-苯磺酰基硝基苯胺类化合物合成的方法

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WO2000009498A1 (en) * 1998-08-10 2000-02-24 Partnership Of Michael E. Garst, George Sachs And Jai Moo Shin Prodrugs of proton pump inhibitors
WO2002030920A1 (en) * 2000-10-12 2002-04-18 Takeda Chemical Industries, Ltd. Benzimidazole compounds, process for producing the same and use thereof

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SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS6150978A (ja) 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
IL76839A (en) 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
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US4965269A (en) 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
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WO2000009498A1 (en) * 1998-08-10 2000-02-24 Partnership Of Michael E. Garst, George Sachs And Jai Moo Shin Prodrugs of proton pump inhibitors
WO2002030920A1 (en) * 2000-10-12 2002-04-18 Takeda Chemical Industries, Ltd. Benzimidazole compounds, process for producing the same and use thereof

Also Published As

Publication number Publication date
RU2292342C2 (ru) 2007-01-27
CO5690576A2 (es) 2006-10-31
US20050182101A1 (en) 2005-08-18
WO2004009583A2 (en) 2004-01-29
RU2005105564A (ru) 2005-10-10
JP4463103B2 (ja) 2010-05-12
MXPA05000657A (es) 2005-08-19
ZA200501116B (en) 2006-11-29
CA2492718A1 (en) 2004-01-29
HK1079207A1 (en) 2006-03-31
US6897227B2 (en) 2005-05-24
KR20050047078A (ko) 2005-05-19
ES2263028T3 (es) 2006-12-01
CA2492718C (en) 2010-12-21
EP1556371A2 (en) 2005-07-27
TW200502231A (en) 2005-01-16
NZ538221A (en) 2006-11-30
US20050143423A1 (en) 2005-06-30
BR0312802A (pt) 2005-04-19
AU2003259154A1 (en) 2004-02-09
ATE323695T1 (de) 2006-05-15
EP1556371B1 (en) 2006-04-19
KR20070005029A (ko) 2007-01-09
DK1556371T3 (da) 2006-08-21
IL166371A0 (en) 2006-01-16
AU2003259154C1 (en) 2004-02-09
JP2005536519A (ja) 2005-12-02
US20040102484A1 (en) 2004-05-27
DE60304726T2 (de) 2007-08-09
KR100822981B1 (ko) 2008-04-16
DE60304726D1 (de) 2006-05-24
AU2003259154B2 (en) 2006-12-07
NO20050801L (no) 2005-02-15
PT1556371E (pt) 2006-09-29
WO2004009583A3 (en) 2004-03-18
PL375255A1 (en) 2005-11-28

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