ATE323695T1 - Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer - Google Patents
Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmerInfo
- Publication number
- ATE323695T1 ATE323695T1 AT03765694T AT03765694T ATE323695T1 AT E323695 T1 ATE323695 T1 AT E323695T1 AT 03765694 T AT03765694 T AT 03765694T AT 03765694 T AT03765694 T AT 03765694T AT E323695 T1 ATE323695 T1 AT E323695T1
- Authority
- AT
- Austria
- Prior art keywords
- proton pump
- pump inhibitor
- benzimidazole derivatives
- inhibitor prodrugs
- prodrugs
- Prior art date
Links
- 229940002612 prodrug Drugs 0.000 title abstract 2
- 239000000651 prodrug Substances 0.000 title abstract 2
- 229940126409 proton pump inhibitor Drugs 0.000 title abstract 2
- 239000000612 proton pump inhibitor Substances 0.000 title abstract 2
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39745902P | 2002-07-19 | 2002-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE323695T1 true ATE323695T1 (de) | 2006-05-15 |
Family
ID=30771064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03765694T ATE323695T1 (de) | 2002-07-19 | 2003-07-15 | Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US6897227B2 (https=) |
| EP (1) | EP1556371B1 (https=) |
| JP (1) | JP4463103B2 (https=) |
| KR (2) | KR100788778B1 (https=) |
| AT (1) | ATE323695T1 (https=) |
| AU (1) | AU2003259154B2 (https=) |
| BR (1) | BR0312802A (https=) |
| CA (1) | CA2492718C (https=) |
| CO (1) | CO5690576A2 (https=) |
| DE (1) | DE60304726T2 (https=) |
| DK (1) | DK1556371T3 (https=) |
| ES (1) | ES2263028T3 (https=) |
| IL (1) | IL166371A0 (https=) |
| MX (1) | MXPA05000657A (https=) |
| NO (1) | NO20050801L (https=) |
| NZ (1) | NZ538221A (https=) |
| PL (1) | PL375255A1 (https=) |
| PT (1) | PT1556371E (https=) |
| RU (1) | RU2292342C2 (https=) |
| TW (1) | TW200502231A (https=) |
| WO (1) | WO2004009583A2 (https=) |
| ZA (1) | ZA200501116B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6852739B1 (en) * | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
| EP1534278A4 (en) * | 2002-08-01 | 2006-09-06 | Nitromed Inc | NITROSED PROTONATE PUMP INHIBITORS, COMPOSITIONS AND USE METHOD |
| AU2004264401A1 (en) * | 2003-07-15 | 2005-02-24 | Allergan, Inc. | Process for preparing isomerically pure prodrugs of proton pump inhibitors |
| US20050075371A1 (en) * | 2003-10-03 | 2005-04-07 | Allergan, Inc. | Methods and compositions for the oral administration of prodrugs of proton pump inhibitors |
| WO2005039640A1 (en) * | 2003-10-03 | 2005-05-06 | Allergan Inc. | Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump inhibitor prodrugs |
| AU2005216863A1 (en) * | 2004-02-18 | 2005-09-09 | Allergan, Inc. | Methods and compositions for the intravenous administration of compounds related to proton pump inhibitors |
| JP2007523163A (ja) * | 2004-02-18 | 2007-08-16 | アラーガン、インコーポレイテッド | プロトンポンプインヒビターのプロドラッグの投与のための方法および組成物 |
| BRPI0507796A (pt) * | 2004-03-11 | 2007-07-17 | Allergan Inc | métodos e composições para o tratamento de condições relacionadas com a secreção de ácido gástrico |
| EP1740571B1 (en) | 2004-04-28 | 2009-07-29 | Hetero Drugs Limited | A process for preparing pyridinylmethyl-1h- benzimidazole compounds in enantiomerically enriched form or as single enantiomers |
| WO2007073301A1 (en) * | 2005-12-23 | 2007-06-28 | Astrazeneca Ab | Benzoimidazole derivatives as prodrugs of proton pump inhibitors |
| WO2007081871A1 (en) * | 2006-01-10 | 2007-07-19 | Allergan, Inc. | Therapeutic salt compositions of sulfonyl ester prodrugs of proton pump inhibitors and methods for their preparation |
| BRPI0711048A2 (pt) * | 2006-05-09 | 2011-08-23 | Astrazeneca Ab | formulações parenteral esterilizada e sólida estáveis, solução para administração parenteral, processos para a preparação de uma formulação e para a fabricação de um produto, método para prevenir ou tratar doenças gastrintestinais, uso de uma formulação sólida estável |
| US20070293543A1 (en) * | 2006-06-19 | 2007-12-20 | Edward Lee | THRESHOLD BLOOD OMEPRAZOLE CONCENTRATION IS 50 NG/ML FOR THE MAINTENANCE OF INTRAGASTRIC pH OF AT LEAST 4.0 AFTER ORAL DOSING WITH CMA-OMEPRAZOLE, AGN 201904-Z |
| WO2008036201A1 (en) * | 2006-09-19 | 2008-03-27 | Alevium Pharmaceuticals, Inc. | Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety |
| WO2008036211A1 (en) * | 2006-09-19 | 2008-03-27 | Alevium Pharmaceuticals, Inc. | Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety |
| US20100265240A1 (en) * | 2007-10-05 | 2010-10-21 | Lg Electronics Inc. | Plasma display device |
| KR20090035195A (ko) * | 2007-10-05 | 2009-04-09 | 엘지전자 주식회사 | 플라즈마 디스플레이 장치 |
| KR100895333B1 (ko) * | 2007-11-01 | 2009-05-07 | 엘지전자 주식회사 | 플라즈마 디스플레이 패널의 구동 방법 및 그를 이용한플라즈마 디스플레이 장치 |
| EP2627178B1 (en) | 2010-10-11 | 2018-05-02 | Merck Sharp & Dohme Corp. | Quinazolinone-type compounds as crth2 antagonists |
| US9290453B2 (en) | 2010-12-23 | 2016-03-22 | Merck Sharp & Dohme Corp. | Quinolines and aza-quinolines as CRTH2 receptor modulators |
| US9469615B2 (en) | 2010-12-23 | 2016-10-18 | Merck Sharp & Dohme Corp. | Quinoxalines and AZA-quinoxalines as CRTH2 receptor modulators |
| US20180021319A1 (en) * | 2015-01-09 | 2018-01-25 | The Regents Of The University Of California | Compositions and methods for treating gastrointestinal infections |
| CN108997177A (zh) * | 2018-09-04 | 2018-12-14 | 邵阳学院 | 一种微波促进n-苯磺酰基硝基苯胺类化合物合成的方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US430042A (en) * | 1890-06-10 | Valve | ||
| SE416649B (sv) | 1974-05-16 | 1981-01-26 | Haessle Ab | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
| SE7804231L (sv) | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| JPS6150978A (ja) | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
| IL76839A (en) | 1984-10-31 | 1988-08-31 | Byk Gulden Lomberg Chem Fab | Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
| SE8505112D0 (sv) | 1985-10-29 | 1985-10-29 | Haessle Ab | Novel pharmacological compounds |
| NZ234564A (en) * | 1986-11-21 | 1991-04-26 | Haessle Ab | 1-substituted benzimidazoles and pharmaceutical compositions |
| US4758597A (en) | 1987-05-15 | 1988-07-19 | University Patents, Inc. | Carenadiol and derivatives |
| US4965269A (en) | 1989-12-20 | 1990-10-23 | Ab Hassle | Therapeutically active chloro substituted benzimidazoles |
| US5045522A (en) | 1990-03-27 | 1991-09-03 | Phillips Petroleum Company | Absorption composition comprising zinc titanate for removal of hydrogen sulfide from fluid streams |
| WO1991019712A1 (en) | 1990-06-20 | 1991-12-26 | Aktiebolaget Astra | Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use |
| SE9301830D0 (sv) | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
| FI964909L (fi) * | 1994-06-10 | 1996-12-09 | Byk Gulden Lomberg Chem Fab | Substituoidut aryylialkyylitioalkyylipyridiinit Helicobacter-bakteerien torjumiseksi |
| US5708017A (en) | 1995-04-04 | 1998-01-13 | Merck & Co., Inc. | Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors |
| US6093734A (en) | 1998-08-10 | 2000-07-25 | Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin | Prodrugs of proton pump inhibitors |
| TR200100431T2 (tr) * | 1998-08-10 | 2001-06-21 | Partnership Of Michael E. Garst, George Sachs & Jai Moo | Proton pompalama önleyici ilaçlar |
| ATE292631T1 (de) * | 1998-08-12 | 2005-04-15 | Gilead Sciences Inc | Verfahren zu herstellung von 1,3-oxathiolane nukleosiden |
| SE0002476D0 (sv) | 2000-06-30 | 2000-06-30 | Astrazeneca Ab | New compounds |
| US6599167B2 (en) | 2000-09-27 | 2003-07-29 | Glenn Waltz | Game call holder and amplifying device |
| CA2425363A1 (en) * | 2000-10-12 | 2003-04-10 | Fumihiko Sato | Benzimidazole compounds, process for producing the same and use thereof |
-
2003
- 2003-07-15 DE DE60304726T patent/DE60304726T2/de not_active Expired - Lifetime
- 2003-07-15 EP EP03765694A patent/EP1556371B1/en not_active Expired - Lifetime
- 2003-07-15 BR BR0312802-4A patent/BR0312802A/pt not_active IP Right Cessation
- 2003-07-15 NZ NZ538221A patent/NZ538221A/en unknown
- 2003-07-15 JP JP2004523537A patent/JP4463103B2/ja not_active Expired - Fee Related
- 2003-07-15 KR KR1020057000899A patent/KR100788778B1/ko not_active Expired - Fee Related
- 2003-07-15 WO PCT/US2003/022419 patent/WO2004009583A2/en not_active Ceased
- 2003-07-15 US US10/620,252 patent/US6897227B2/en not_active Expired - Lifetime
- 2003-07-15 CA CA2492718A patent/CA2492718C/en not_active Expired - Lifetime
- 2003-07-15 PT PT03765694T patent/PT1556371E/pt unknown
- 2003-07-15 MX MXPA05000657A patent/MXPA05000657A/es active IP Right Grant
- 2003-07-15 ES ES03765694T patent/ES2263028T3/es not_active Expired - Lifetime
- 2003-07-15 AT AT03765694T patent/ATE323695T1/de not_active IP Right Cessation
- 2003-07-15 RU RU2005105564/04A patent/RU2292342C2/ru not_active IP Right Cessation
- 2003-07-15 DK DK03765694T patent/DK1556371T3/da active
- 2003-07-15 PL PL03375255A patent/PL375255A1/xx not_active Application Discontinuation
- 2003-07-15 KR KR1020067026729A patent/KR100822981B1/ko not_active Expired - Fee Related
- 2003-07-15 AU AU2003259154A patent/AU2003259154B2/en not_active Ceased
- 2003-11-07 TW TW092131253A patent/TW200502231A/zh unknown
-
2005
- 2005-01-18 IL IL16637105A patent/IL166371A0/xx unknown
- 2005-01-20 US US11/039,631 patent/US20050143423A1/en not_active Abandoned
- 2005-01-20 US US11/039,630 patent/US20050182101A1/en not_active Abandoned
- 2005-02-08 ZA ZA200501116A patent/ZA200501116B/xx unknown
- 2005-02-15 CO CO05013468A patent/CO5690576A2/es not_active Application Discontinuation
- 2005-02-15 NO NO20050801A patent/NO20050801L/no not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE323695T1 (de) | Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer | |
| ATE465146T1 (de) | 1h-indolderivate als hochselektive cyclooxygenase-2-inhibitoren | |
| IS7721A (is) | Píperidín-pýrídasón og þalasón sem PDE4 hemlar | |
| ATE478044T1 (de) | Biphenylderivate und ihre verwendung bei der behandlung von hepatitis c | |
| EA200501928A1 (ru) | Пирролодигидроизохинолины как ингибиторы pde10 | |
| NO20025590D0 (no) | Fenylglycin-derivater | |
| MXPA05010000A (es) | Derivados de p-diaminobenceno substituidos. | |
| ATE355265T1 (de) | Biphenylcarboxamidderivate und ihre verwendung als p38 kinase inhibitoren | |
| ATE303384T1 (de) | 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren | |
| ATE374190T1 (de) | Tetrahydrochinazolinderivate als cfr-antagonisten | |
| DE60313350D1 (de) | Pyrimidin-2,4-dion-derivate als matrix-metalloproteinase-hemmer | |
| EA200600607A1 (ru) | Производные имидазопиридина в качестве ингибиторов индуцируемой no-синтазы | |
| NO20015892L (no) | Inhibitorer av metallproteinaser | |
| NO20062699L (no) | Smelteblandingsdispergeringer | |
| EA200301101A1 (ru) | Производные пиперазина и их применение в качестве ингибиторов pde4 | |
| EA200600601A1 (ru) | Производные аминопиридина в качестве ингибиторов индуцируемой no-синтазы | |
| ATE348800T1 (de) | 4'-methansulfonylbiphenylderivate als hochselektive cyclooxygenase-2-inhibitoren | |
| ATE373637T1 (de) | N-(2-phenylethyl)sulfamid-derivate als integrin- alpha4-antagonisten | |
| EA200600609A1 (ru) | Производные имидазопиридина в качестве ингибиторов индуцируемой no-синтазы | |
| ATE256124T1 (de) | Substituierte benzimidazole, ihre herstellung und ihre verwendung als mittel gegen parasitäre protozoen | |
| ATE277591T1 (de) | Verwendung von n,n'- dibenzylethylendiamindiessigsäurederivaten zum schutz gegen verschmutzung | |
| ATE374751T1 (de) | 3,4-dihydro-1h-chinolin-2-onderivate als norepinephrin-wiederaufnahme-hemmern | |
| DE50001742D1 (de) | Arylsulfonamid-substituierte benzimidazolderivate und ihre verwendung als tryptase-inhibitoren | |
| IS8034A (is) | Imídasó[4,5-B]kínólínafleiður og notkun þeirra sem NO-myndunarhemla | |
| ATE247092T1 (de) | Arylsulfonamid-substituierte benzimidazolderivate ihre verwendung als tryptase-inhibitoren |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1556371 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |