KR100730440B1 - 주사가능한 부프레노르핀 미세 입자 조성물 및 이의 용도 - Google Patents

주사가능한 부프레노르핀 미세 입자 조성물 및 이의 용도 Download PDF

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Publication number
KR100730440B1
KR100730440B1 KR1020027002567A KR20027002567A KR100730440B1 KR 100730440 B1 KR100730440 B1 KR 100730440B1 KR 1020027002567 A KR1020027002567 A KR 1020027002567A KR 20027002567 A KR20027002567 A KR 20027002567A KR 100730440 B1 KR100730440 B1 KR 100730440B1
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South Korea
Prior art keywords
microparticles
buprenorphine
microparticle composition
weight
ethyl acetate
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Expired - Fee Related
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KR1020027002567A
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English (en)
Korean (ko)
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KR20020053057A (ko
Inventor
토마스 알. 타이스
제이 케이. 스타스
테레사 엠. 페렐
피터 마크랜드
Original Assignee
브룩우드 파마슈티컬스, 인코포레이티드
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Publication of KR20020053057A publication Critical patent/KR20020053057A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020027002567A 1999-08-27 2000-08-25 주사가능한 부프레노르핀 미세 입자 조성물 및 이의 용도 Expired - Fee Related KR100730440B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15111299P 1999-08-27 1999-08-27
US60/151,112 1999-08-27

Publications (2)

Publication Number Publication Date
KR20020053057A KR20020053057A (ko) 2002-07-04
KR100730440B1 true KR100730440B1 (ko) 2007-06-19

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KR1020027002567A Expired - Fee Related KR100730440B1 (ko) 1999-08-27 2000-08-25 주사가능한 부프레노르핀 미세 입자 조성물 및 이의 용도

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US (2) US6495155B1 (enExample)
EP (1) EP1212061B1 (enExample)
JP (1) JP4913298B2 (enExample)
KR (1) KR100730440B1 (enExample)
CN (2) CN1248689C (enExample)
AT (1) ATE280579T1 (enExample)
AU (1) AU765496C (enExample)
BR (1) BR0013650A (enExample)
CA (1) CA2382577C (enExample)
CY (1) CY1106043T1 (enExample)
CZ (1) CZ2002728A3 (enExample)
DE (1) DE60015370T2 (enExample)
EA (1) EA009080B1 (enExample)
ES (1) ES2230154T3 (enExample)
HK (1) HK1046858B (enExample)
HU (1) HUP0203613A3 (enExample)
IL (2) IL148343A0 (enExample)
MX (1) MXPA02002105A (enExample)
NO (2) NO322650B1 (enExample)
NZ (1) NZ517997A (enExample)
PL (1) PL198334B1 (enExample)
PT (1) PT1212061E (enExample)
RO (1) RO121631B1 (enExample)
WO (1) WO2001015699A1 (enExample)

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CN1551770A (zh) 2001-07-06 2004-12-01 ������ҩ�����޹�˾ 羟吗啡酮控释制剂
US8329216B2 (en) 2001-07-06 2012-12-11 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
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US7842377B2 (en) * 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
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Publication number Publication date
NZ517997A (en) 2002-11-26
NO20020924D0 (no) 2002-02-26
AU7075100A (en) 2001-03-26
US20030152638A1 (en) 2003-08-14
HK1046858A1 (en) 2003-01-30
IL148343A0 (en) 2002-09-12
JP4913298B2 (ja) 2012-04-11
KR20020053057A (ko) 2002-07-04
EP1212061B1 (en) 2004-10-27
EA009080B1 (ru) 2007-10-26
DE60015370D1 (de) 2004-12-02
EP1212061A1 (en) 2002-06-12
CN1248689C (zh) 2006-04-05
US7473431B2 (en) 2009-01-06
CN100387228C (zh) 2008-05-14
AU765496B2 (en) 2003-09-18
HK1046858B (en) 2005-03-24
HUP0203613A2 (hu) 2003-02-28
PT1212061E (pt) 2005-01-31
US6495155B1 (en) 2002-12-17
PL198334B1 (pl) 2008-06-30
NO20063239L (no) 2002-04-03
NO322650B1 (no) 2006-11-13
IL148343A (en) 2008-03-20
NO20020924L (no) 2002-04-03
CN1382051A (zh) 2002-11-27
PL354977A1 (en) 2004-03-22
ATE280579T1 (de) 2004-11-15
EA200200295A1 (ru) 2002-08-29
CN1788721A (zh) 2006-06-21
HUP0203613A3 (en) 2005-01-28
CA2382577A1 (en) 2001-03-08
AU765496C (en) 2005-08-25
CY1106043T1 (el) 2011-04-06
BR0013650A (pt) 2002-05-07
WO2001015699A1 (en) 2001-03-08
RO121631B1 (ro) 2008-01-30
CZ2002728A3 (cs) 2002-08-14
ES2230154T3 (es) 2005-05-01
DE60015370T2 (de) 2006-03-09
CA2382577C (en) 2008-01-22
JP2003508439A (ja) 2003-03-04
MXPA02002105A (es) 2003-12-11

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