KR100700907B1 - 벤조사이클로헵타피리딘 화합물 및 항신생물제를 포함하는 약제학적 조성물 - Google Patents

벤조사이클로헵타피리딘 화합물 및 항신생물제를 포함하는 약제학적 조성물 Download PDF

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KR100700907B1
KR100700907B1 KR1020007006938A KR20007006938A KR100700907B1 KR 100700907 B1 KR100700907 B1 KR 100700907B1 KR 1020007006938 A KR1020007006938 A KR 1020007006938A KR 20007006938 A KR20007006938 A KR 20007006938A KR 100700907 B1 KR100700907 B1 KR 100700907B1
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alkyl
substituted
aryl
pharmaceutical composition
compound
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KR1020007006938A
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Korean (ko)
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KR20010033452A (ko
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비숍월터알
카티노조셉제이
돌로날드제이
강글리아쉬트
기리쟈발라반비요르
키르슈마이어폴
리우밍
닐슨로레타엘
쿠틀러데이비드엘
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쉐링 코포레이션
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020007006938A 1997-12-22 1998-12-21 벤조사이클로헵타피리딘 화합물 및 항신생물제를 포함하는 약제학적 조성물 Expired - Fee Related KR100700907B1 (ko)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US99602797A 1997-12-22 1997-12-22
US8/996,027 1997-12-22
US08/996,027 1997-12-22
US14352998A 1998-08-28 1998-08-28
US09/143,529 1998-08-28
US9/143,529 1998-08-28
US18196998A 1998-10-29 1998-10-29
US09/181,969 1998-10-29
US9/181,969 1998-10-29
PCT/US1998/026224 WO1999032114A1 (en) 1997-12-22 1998-12-21 Combination of benzocycloheptapyridine compounds and antineoplastic drugs for treating proliferative diseases

Publications (2)

Publication Number Publication Date
KR20010033452A KR20010033452A (ko) 2001-04-25
KR100700907B1 true KR100700907B1 (ko) 2007-03-29

Family

ID=27385940

Family Applications (1)

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KR1020007006938A Expired - Fee Related KR100700907B1 (ko) 1997-12-22 1998-12-21 벤조사이클로헵타피리딘 화합물 및 항신생물제를 포함하는 약제학적 조성물

Country Status (25)

Country Link
EP (1) EP1041985B1 (https=)
JP (1) JP4502503B2 (https=)
KR (1) KR100700907B1 (https=)
CN (1) CN1129431C (https=)
AR (1) AR017440A1 (https=)
AT (1) ATE317697T1 (https=)
AU (1) AU756762B2 (https=)
BR (1) BR9814419A (https=)
CA (1) CA2315693C (https=)
CL (1) CL2007001889A1 (https=)
CO (1) CO5080764A1 (https=)
CZ (1) CZ298511B6 (https=)
DE (1) DE69833509T2 (https=)
DK (1) DK1041985T3 (https=)
ES (1) ES2255196T3 (https=)
HU (1) HUP0102473A3 (https=)
IL (1) IL136462A0 (https=)
MY (1) MY137303A (https=)
NO (1) NO326832B1 (https=)
NZ (1) NZ504928A (https=)
PE (1) PE20000042A1 (https=)
PT (1) PT1041985E (https=)
SK (1) SK285584B6 (https=)
TW (1) TW581763B (https=)
WO (1) WO1999032114A1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2787327B1 (fr) * 1998-12-21 2003-01-17 Aventis Pharma Sa Compositions contenant des inhibiteurs de farnesyle transferase
EP1233787B8 (fr) * 1999-11-09 2005-05-18 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Produit comprenant un inhibiteur de la transduction des signaux des proteines g heterotrimeriques en association avec un autre agent anti-cancereux pour une utilisation therapeutique dans le traitement du cancer
AU2292801A (en) * 1999-12-22 2001-07-03 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Compositions and methods for treatment of breast cancer
WO2001064196A2 (en) * 2000-02-29 2001-09-07 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitor combinations with vinca alkaloids
JP2003525244A (ja) * 2000-02-29 2003-08-26 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗腫瘍性アルキル化剤とのファルネシルタンパク質トランスフェラーゼ阻害剤組み合わせ剤
JP2003525238A (ja) * 2000-02-29 2003-08-26 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗腫瘍性ポドフィロトキシン誘導体とのファルネシルタンパク質トランスフェラーゼ阻害剤組み合わせ剤
CA2397690A1 (en) * 2000-02-29 2001-09-07 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitor combinations with anti-tumor nucleoside derivatives
AU2001244167A1 (en) * 2000-02-29 2001-09-12 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitor combinations with anti-tumor anthracycline derivatives
US20030027808A1 (en) * 2000-02-29 2003-02-06 Palmer Peter Albert Farnesyl protein transferase inhibitor combinations with platinum compounds
TWI310684B (en) 2000-03-27 2009-06-11 Bristol Myers Squibb Co Synergistic pharmaceutical kits for treating cancer
AU2002236813A1 (en) * 2001-01-22 2002-07-30 Schering Corporation Treatment of malaria with farnesyl protein transferase inhibitors
DE60230017D1 (de) * 2001-02-15 2009-01-08 Janssen Pharmaceutica Nv Farnesyl-protein-transferase hemmer in kombination mit antiöstrogenen
WO2003047697A2 (en) * 2001-11-30 2003-06-12 Schering Corporation Use of an farsenyl protein tranferase inhibitor in combination with other antineoplastic agents for the manufacture of a medicament against cancer
AU2002346644A1 (en) * 2001-12-03 2003-06-17 Schering Corporation Use of fpt inhibitors and at least two antineoplastic agents in the treatment of cancer
WO2008022535A1 (fr) * 2006-08-09 2008-02-28 Tian Jin Tasly Group Co., Ltd. Composition pharmaceutique pour traiter le gliome du cerveau, son procédé et sa préparation pharmaceutique
CN105198758A (zh) * 2015-09-22 2015-12-30 湖南大学 一种高纯度(z)-他莫昔酚的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992011034A1 (en) * 1990-12-18 1992-07-09 The Wellcome Foundation Limited Agents for potentiating the effects of antitumor agents and combating multiple drug resistance
WO1997038664A2 (en) * 1996-04-18 1997-10-23 Merck & Co., Inc. A method of treating cancer

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US5047246A (en) * 1988-09-09 1991-09-10 Bristol-Myers Company Direct compression cyclophosphamide tablet
JP2767176B2 (ja) * 1992-12-15 1998-06-18 大塚製薬株式会社 抗癌剤
US5637688A (en) * 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
WO1997005902A1 (fr) * 1995-08-09 1997-02-20 Banyu Pharmaceutical Co., Ltd. Composition medicinale
SK86198A3 (en) * 1995-12-22 1999-02-11 Schering Corp Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases
DE69735057T2 (de) * 1996-03-12 2006-08-31 PG-TXL Co., L.P., Houston Wasserlösliche paclitaxel-prodrogen
JP2000507584A (ja) * 1996-04-03 2000-06-20 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質転移酵素の阻害剤
CA2251716A1 (en) * 1996-04-15 1997-10-23 W. Gillies Mckenna Sensitization of cells to radiation and chemotherapy
JP2000508335A (ja) * 1996-05-30 2000-07-04 メルク エンド カンパニー インコーポレーテッド 癌の治療方法
JP2001508326A (ja) * 1997-01-29 2001-06-26 ピッカー メディカル システムズ リミテッド 予測的ボーラス追跡
CZ298488B6 (cs) * 1997-02-18 2007-10-17 Canji, Inc. Farmaceutický prostredek s obsahem tumor-supresorové nukleové kyseliny

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992011034A1 (en) * 1990-12-18 1992-07-09 The Wellcome Foundation Limited Agents for potentiating the effects of antitumor agents and combating multiple drug resistance
WO1997038664A2 (en) * 1996-04-18 1997-10-23 Merck & Co., Inc. A method of treating cancer

Also Published As

Publication number Publication date
CN1284875A (zh) 2001-02-21
MY137303A (en) 2009-01-30
CN1129431C (zh) 2003-12-03
EP1041985A1 (en) 2000-10-11
DE69833509T2 (de) 2006-10-26
CZ298511B6 (cs) 2007-10-24
SK8982000A3 (en) 2001-04-09
JP4502503B2 (ja) 2010-07-14
CZ20002236A3 (cs) 2001-04-11
TW581763B (en) 2004-04-01
NO326832B1 (no) 2009-02-23
NO20003229L (no) 2000-08-22
KR20010033452A (ko) 2001-04-25
CO5080764A1 (es) 2001-09-25
AU1907299A (en) 1999-07-12
NO20003229D0 (no) 2000-06-21
HUP0102473A3 (en) 2003-07-28
AR017440A1 (es) 2001-09-05
ATE317697T1 (de) 2006-03-15
PT1041985E (pt) 2006-07-31
CL2007001889A1 (es) 2008-01-11
JP2001526224A (ja) 2001-12-18
DE69833509D1 (de) 2006-04-20
AU756762B2 (en) 2003-01-23
NZ504928A (en) 2004-12-24
PE20000042A1 (es) 2000-02-17
ES2255196T3 (es) 2006-06-16
DK1041985T3 (da) 2006-06-19
HUP0102473A2 (hu) 2002-01-28
SK285584B6 (sk) 2007-04-05
EP1041985B1 (en) 2006-02-15
WO1999032114A1 (en) 1999-07-01
BR9814419A (pt) 2000-10-10
CA2315693A1 (en) 1999-07-01
IL136462A0 (en) 2001-06-14
CA2315693C (en) 2010-11-30

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