KR100634089B1 - 항박테리아제로서의 히드록삼산 유도체 - Google Patents

항박테리아제로서의 히드록삼산 유도체 Download PDF

Info

Publication number
KR100634089B1
KR100634089B1 KR1020007012819A KR20007012819A KR100634089B1 KR 100634089 B1 KR100634089 B1 KR 100634089B1 KR 1020007012819 A KR1020007012819 A KR 1020007012819A KR 20007012819 A KR20007012819 A KR 20007012819A KR 100634089 B1 KR100634089 B1 KR 100634089B1
Authority
KR
South Korea
Prior art keywords
alkyl
butyl
nhr
substituted
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020007012819A
Other languages
English (en)
Korean (ko)
Other versions
KR20010034861A (ko
Inventor
헌터미켈죠지
벡케트레이몬드포올
클리멘츠존마틴
화이타커마크
스파볼드조이마리에
Original Assignee
브리티쉬 바이오테크 파마슈티칼스 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 브리티쉬 바이오테크 파마슈티칼스 리미티드 filed Critical 브리티쉬 바이오테크 파마슈티칼스 리미티드
Publication of KR20010034861A publication Critical patent/KR20010034861A/ko
Application granted granted Critical
Publication of KR100634089B1 publication Critical patent/KR100634089B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
KR1020007012819A 1998-05-16 1999-05-14 항박테리아제로서의 히드록삼산 유도체 Expired - Fee Related KR100634089B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9810464.9A GB9810464D0 (en) 1998-05-16 1998-05-16 Hydroxamic acid derivatives
GB9810464.9 1998-05-16

Publications (2)

Publication Number Publication Date
KR20010034861A KR20010034861A (ko) 2001-04-25
KR100634089B1 true KR100634089B1 (ko) 2006-10-17

Family

ID=10832125

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007012819A Expired - Fee Related KR100634089B1 (ko) 1998-05-16 1999-05-14 항박테리아제로서의 히드록삼산 유도체

Country Status (23)

Country Link
US (3) US6441042B1 (enExample)
EP (2) EP1079819B1 (enExample)
JP (1) JP2002515427A (enExample)
KR (1) KR100634089B1 (enExample)
CN (1) CN1300210A (enExample)
AT (1) ATE347356T1 (enExample)
AU (1) AU754063B2 (enExample)
BR (1) BR9910488A (enExample)
CA (1) CA2332713C (enExample)
CY (1) CY1106452T1 (enExample)
DE (1) DE69934309T2 (enExample)
DK (1) DK1079819T3 (enExample)
ES (1) ES2278444T3 (enExample)
GB (2) GB9810464D0 (enExample)
HU (1) HUP0102290A3 (enExample)
IL (2) IL139059A0 (enExample)
NO (1) NO20005782L (enExample)
NZ (1) NZ507560A (enExample)
PL (1) PL344438A1 (enExample)
PT (1) PT1079819E (enExample)
TR (1) TR200003376T2 (enExample)
WO (1) WO1999059568A1 (enExample)
ZA (1) ZA200006131B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL137312A (en) * 1998-02-07 2005-12-18 Vernalis Oxford Ltd Pharmaceutical anti-bacterial compositions comprising n-formyl hydroxylamine derivatives and severalsuch derivatives
GB9810464D0 (en) * 1998-05-16 1998-07-15 British Biotech Pharm Hydroxamic acid derivatives
ATE293600T1 (de) * 1999-08-10 2005-05-15 Vernalis Oxford Ltd Antibakterielle mittel
WO2001040198A2 (fr) * 1999-11-30 2001-06-07 Aventis Pharma S.A. Derives macrocycliques de l'acide hydroxamique et leur utilisation en tant qu'antimicrobiens
FR2801591B1 (fr) * 1999-11-30 2002-03-01 Aventis Pharma Sa Derives macrocycliques de l'acide hydroxamique, leur preparation et les compositions qui les contiennent
JP2003534239A (ja) * 1999-12-17 2003-11-18 ヴァージコア・インコーポレーテッド 新規なスクシナート化合物、組成物、並びに使用及び調製方法
GB9929979D0 (en) * 1999-12-17 2000-02-09 Darwin Discovery Ltd Hydroxamic acid derivatives
WO2002028829A2 (en) * 2000-09-25 2002-04-11 Questcor Pharmaceuticals, Inc. Peptide deformylase inhibitors
WO2002041886A1 (en) * 2000-11-23 2002-05-30 British Biotech Pharmaceuticals Ltd Ydroxamic acid or n-formyl hydroxylamine derivatives as inhibitors of bakterial polypeptide deformylase for treating microbial infections
US6660741B2 (en) * 2001-03-19 2003-12-09 Sloan-Kettering Institute For Cancer Research Asymmetric synthesis of (S,S,R)-(-)-actinonin and its analogs and uses therefor
WO2002081426A1 (en) * 2001-04-05 2002-10-17 Smithkline Beecham Corporation Peptide deformylase inhibitors
GB0128943D0 (en) 2001-12-04 2002-01-23 Novo Pharmaceuticals De Ltd Bacterial enzyme inhibitors
JP4190862B2 (ja) * 2001-12-18 2008-12-03 シャープ株式会社 表示装置およびその駆動方法
GB0208579D0 (en) * 2002-04-13 2002-05-22 British Biotech Pharm Antibacterial agents
DE10320453A1 (de) * 2003-05-08 2004-11-25 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Bioisostere von Actinonin
ES2582555T3 (es) * 2007-11-29 2016-09-13 Inolex Investment Corporation Conservantes para composiciones cosméticas, de tocador y farmacéuticas
DE102011088962A1 (de) * 2011-12-19 2013-06-20 Beiersdorf Ag Wirkstoffkombinationen aus einer oder mehreren Carbonsäuren, insbesondereHydroxycarbonsäuren, und einer oder mehreren physiologisch unbedenklichen Hydroxamsäure sowie kosmetische oder dermatologische Zubereitungen, solcheWirkstoffkombinationen enthaltend
US10829440B2 (en) 2015-06-12 2020-11-10 Brown University Antibacterial compounds and methods of making and using same
CN111787800B (zh) * 2017-06-29 2022-11-25 金伯利-克拉克环球有限公司 包含二异羟肟酸的抗微生物组合物及用其抑制微生物生长的方法
CN108672095A (zh) * 2018-05-04 2018-10-19 广东省资源综合利用研究所 γ-羟基烷基羟肟酸及其制备方法与应用
US11555010B2 (en) 2019-07-25 2023-01-17 Brown University Diamide antimicrobial agents

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1028921A (en) * 1962-01-23 1966-05-11 Ranjeet Bhagwan Singh New antibiotic
US4303662A (en) * 1980-11-24 1981-12-01 E. R. Squibb & Sons, Inc. Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds
JPH0670019B2 (ja) * 1989-07-21 1994-09-07 明治製菓株式会社 新抗生物質ｓｆ２１９７ｃ物質およびその製造法
GB8919251D0 (en) * 1989-08-24 1989-10-04 British Bio Technology Compounds
JPH03157372A (ja) * 1989-11-13 1991-07-05 Yamanouchi Pharmaceut Co Ltd Ｙｌ―０１８６９ｐ物質及びその製造法
WO1992022523A2 (en) * 1991-06-14 1992-12-23 Research Corporation Technologies, Inc. Peptide derivatives of collagenase inhibitor
GB9223904D0 (en) 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
NZ271893A (en) * 1993-08-23 1997-11-24 Immunex Corp Inhibitors of tnf-alpha secretion
JP3157372B2 (ja) 1993-11-29 2001-04-16 三洋電機株式会社 フィルタ
DK0766664T3 (da) * 1994-06-22 2000-07-31 British Biotech Pharm Metalloproteinaseinhibitorer
US5532265A (en) * 1994-11-30 1996-07-02 The Board Of Trustees Of The Leland Stanford Junior University Treatment of central nervous system inflammatory disease with matrix metalloprotease inhibitors
GB9507799D0 (en) * 1995-04-18 1995-05-31 British Biotech Pharm Metalloproteinase inhibitors
US6281245B1 (en) * 1996-10-28 2001-08-28 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
EP0942746B1 (en) * 1996-12-06 2005-03-16 Fonden Til Fremme Af Eksperimentel Cancerforskning Inhibition of invasive remodelling
ZA9711121B (en) * 1996-12-13 1998-06-23 Handelman Joseph H Reduction of hair growth.
IL137312A (en) * 1998-02-07 2005-12-18 Vernalis Oxford Ltd Pharmaceutical anti-bacterial compositions comprising n-formyl hydroxylamine derivatives and severalsuch derivatives
GB9810464D0 (en) * 1998-05-16 1998-07-15 British Biotech Pharm Hydroxamic acid derivatives

Also Published As

Publication number Publication date
AU3942199A (en) 1999-12-06
HUP0102290A3 (en) 2001-12-28
DE69934309D1 (de) 2007-01-18
AU754063B2 (en) 2002-10-31
NO20005782D0 (no) 2000-11-15
ATE347356T1 (de) 2006-12-15
PL344438A1 (en) 2001-11-05
PT1079819E (pt) 2007-03-30
GB0024789D0 (en) 2000-11-22
CY1106452T1 (el) 2011-10-12
EP1079819B1 (en) 2006-12-06
ES2278444T3 (es) 2007-08-01
US20060211732A1 (en) 2006-09-21
NZ507560A (en) 2003-06-30
CA2332713C (en) 2008-04-01
HUP0102290A2 (hu) 2001-11-28
GB9810464D0 (en) 1998-07-15
IL139059A (en) 2006-12-31
EP1754477A2 (en) 2007-02-21
US7323563B2 (en) 2008-01-29
EP1754477A3 (en) 2007-03-14
US6992190B2 (en) 2006-01-31
DE69934309T2 (de) 2007-07-05
DK1079819T3 (da) 2007-04-10
ZA200006131B (en) 2002-01-30
WO1999059568A1 (en) 1999-11-25
GB2353708A (en) 2001-03-07
US20020198241A1 (en) 2002-12-26
KR20010034861A (ko) 2001-04-25
US6441042B1 (en) 2002-08-27
IL139059A0 (en) 2001-11-25
NO20005782L (no) 2001-01-15
TR200003376T2 (tr) 2001-03-21
EP1079819A1 (en) 2001-03-07
JP2002515427A (ja) 2002-05-28
CN1300210A (zh) 2001-06-20
CA2332713A1 (en) 1999-11-25
BR9910488A (pt) 2001-01-09

Similar Documents

Publication Publication Date Title
KR100634089B1 (ko) 항박테리아제로서의 히드록삼산 유도체
KR100600518B1 (ko) 항균제
US20110086877A1 (en) Small Molecule Inhibitors of Botulinum Neurotoxins
US9845323B2 (en) 2-(1,3,4-oxadiazol-2-yl)-7-oxo-1,6-diazabicyclo[3.2.1 ]octane derivatives and their use as antibacterial agents
US6716878B1 (en) Antimicrobial agents
CN105473578A (zh) 用于治疗抗药性和持续性结核病的化合物
KR20150016414A (ko) 프롤릴 히드록실라아제 저해제
US20230330065A1 (en) RelA Inhibitors for Biofilm Disruption
EP1146867B1 (en) Antibacterial hydroxamic acid derivatives
JP2002540197A (ja) 抗菌剤
US20060089363A1 (en) Antibacterial agents
CZ20004294A3 (cs) Deriváty kyseliny hydroxamové jako antibakteriální činidla
US7173053B2 (en) N-formyl hydroxylamine derivatives as inhibitors of bacterial polypeptide formylase for treating microbial infections
US20210346364A1 (en) Oxazolidinones as taro inhibitors
ZA200201093B (en) Antibacterial agents.
US20110319398A1 (en) Inhibition of yops translocation

Legal Events

Date Code Title Description
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20091010

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20091010