KR100579748B1 - 돌라스타틴 15 유도체 - Google Patents

돌라스타틴 15 유도체 Download PDF

Info

Publication number
KR100579748B1
KR100579748B1 KR1020007000565A KR20007000565A KR100579748B1 KR 100579748 B1 KR100579748 B1 KR 100579748B1 KR 1020007000565 A KR1020007000565 A KR 1020007000565A KR 20007000565 A KR20007000565 A KR 20007000565A KR 100579748 B1 KR100579748 B1 KR 100579748B1
Authority
KR
South Korea
Prior art keywords
methyl
carbonyl
formula
dimethyl
delete delete
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020007000565A
Other languages
English (en)
Korean (ko)
Other versions
KR20010021998A (ko
Inventor
베른트 얀센
테레사 바를로짜리
안드레아스 하웁트
토마스 치르케
안드레아스 클링
Original Assignee
애보트 게엠베하 운트 콤파니 카게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 애보트 게엠베하 운트 콤파니 카게 filed Critical 애보트 게엠베하 운트 콤파니 카게
Publication of KR20010021998A publication Critical patent/KR20010021998A/ko
Application granted granted Critical
Publication of KR100579748B1 publication Critical patent/KR100579748B1/ko
Assigned to 아비에 도이치란트 게엠베하 운트 콤파니 카게 reassignment 아비에 도이치란트 게엠베하 운트 콤파니 카게 권리의 전부이전등록 Assignors: 애보트 게엠베하 운트 콤파니 카게
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020007000565A 1997-07-18 1998-07-07 돌라스타틴 15 유도체 Expired - Fee Related KR100579748B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/896,394 US6143721A (en) 1997-07-18 1997-07-18 Dolastatin 15 derivatives
US8/896,394 1997-07-18
US08/896,394 1997-07-18
PCT/US1998/013901 WO1999003879A1 (en) 1997-07-18 1998-07-07 Dolastatin 15 derivatives

Publications (2)

Publication Number Publication Date
KR20010021998A KR20010021998A (ko) 2001-03-15
KR100579748B1 true KR100579748B1 (ko) 2006-05-15

Family

ID=25406130

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007000565A Expired - Fee Related KR100579748B1 (ko) 1997-07-18 1998-07-07 돌라스타틴 15 유도체

Country Status (32)

Country Link
US (6) US6143721A (https=)
EP (1) EP0991658B1 (https=)
JP (4) JP4508413B2 (https=)
KR (1) KR100579748B1 (https=)
CN (1) CN1268636C (https=)
AR (1) AR018501A1 (https=)
AT (1) ATE314387T1 (https=)
AU (1) AU750120B2 (https=)
BG (1) BG65212B1 (https=)
BR (1) BR9810911A (https=)
CA (1) CA2296036C (https=)
CO (1) CO4990967A1 (https=)
CY (1) CY1107047T1 (https=)
CZ (1) CZ303045B6 (https=)
DE (1) DE69832982T2 (https=)
DK (1) DK0991658T3 (https=)
ES (1) ES2258819T3 (https=)
HR (1) HRP980397A2 (https=)
HU (1) HU228996B1 (https=)
ID (1) ID24669A (https=)
IL (1) IL133784A (https=)
MY (1) MY135057A (https=)
NO (1) NO326827B1 (https=)
NZ (1) NZ502296A (https=)
PL (1) PL197884B1 (https=)
PT (1) PT991658E (https=)
RU (1) RU2195462C2 (https=)
SK (1) SK286581B6 (https=)
TR (2) TR200000132T2 (https=)
TW (1) TW533217B (https=)
WO (1) WO1999003879A1 (https=)
ZA (1) ZA986358B (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010009901A1 (en) * 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
AU2001227375A1 (en) * 2000-02-08 2001-08-20 Herbert T. Nagasawa N-terminal d(-)-penicillamine peptides as aldehyde sequestration agents
US6884869B2 (en) * 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US7256257B2 (en) * 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
AU2003228354B8 (en) 2002-03-22 2010-03-04 Eisai R&D Management Co., Ltd. Hemiasterlin derivatives and uses thereof in the treatment of cancer
US7064211B2 (en) * 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
SI1545613T1 (sl) * 2002-07-31 2011-11-30 Seattle Genetics Inc Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni
US7498298B2 (en) 2003-11-06 2009-03-03 Seattle Genetics, Inc. Monomethylvaline compounds capable of conjugation to ligands
US20060148014A1 (en) * 2004-12-09 2006-07-06 Sergei Agoulnik Tubulin isotype screening in cancer therapy using hemiasterlin analogs
US7772177B2 (en) 2005-05-18 2010-08-10 Aegera Therapeutics, Inc. BIR domain binding compounds
AU2007250443B2 (en) 2006-05-16 2013-06-13 Pharmascience Inc. IAP BIR domain binding compounds
DK2474557T3 (da) 2007-07-16 2014-11-10 Genentech Inc Anti-CD79b-antistoffer og immunkonjugater og fremgangsmåder til anvendelse
NZ583318A (en) 2007-07-16 2012-07-27 Genentech Inc Humanized anti-cd79b antibodies and immunoconjugates and methods of use
DE102007039706A1 (de) 2007-08-22 2009-02-26 Erhard Prof. Dr.-Ing. Kohn Chemischer Sensor auf Diamantschichten
SG187517A1 (en) 2008-01-31 2013-02-28 Genentech Inc Anti-cd79b antibodies and immunoconjugates and methods of use
KR20120118008A (ko) * 2009-12-18 2012-10-25 아이데닉스 파마슈티칼스, 인코포레이티드 5,5-융합 아릴렌 또는 헤테로아릴렌 간염 ｃ 바이러스 억제제
TW201129384A (en) 2010-02-10 2011-09-01 Immunogen Inc CD20 antibodies and uses thereof
WO2011098904A1 (en) 2010-02-12 2011-08-18 Aegera Therapeutics, Inc. Iap bir domain binding compounds
US10131682B2 (en) 2012-11-24 2018-11-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
CA2938919C (en) 2014-02-28 2020-12-29 Hangzhou Dac Biotech Co., Ltd Charged linkers and their uses for conjugation
PT3262071T (pt) 2014-09-23 2020-06-16 H Hoffnabb La Roche Ag Métodos de utilização de imunoconjugados anti-cd79b
CN112125929A (zh) 2015-06-15 2020-12-25 杭州多禧生物科技有限公司 用于偶联的亲水链接体
FI3319936T3 (fi) 2015-07-12 2026-03-12 Hangzhou Dac Biotech Co Ltd Silloituslinkkereitä soluun sitoutuvien molekyylien konjugoimiseksi
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
CA3042442C (en) 2016-11-14 2024-01-02 Hangzhou Dac Biotech Co., Ltd Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses of such conjugates with the linkers
MX2024002571A (es) 2021-09-03 2024-03-20 Toray Industries Composicion farmaceutica para tratamiento y/o prevencion de cancer.
CN117980327A (zh) 2021-11-03 2024-05-03 杭州多禧生物科技有限公司 抗体的特异性偶联

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
DE69232552T2 (de) * 1991-08-09 2002-10-31 Teikoku Hormone Mfg. Co., Ltd. Tetrapeptide Derivat
US5448045A (en) 1992-02-26 1995-09-05 Clark; Paul C. System for protecting computers via intelligent tokens or smart cards
US5533097A (en) * 1992-02-26 1996-07-02 Motorola, Inc. Portable communication system comprising a local and wide area communication units which can store a communication when the wide area communication system is not available
US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
RU2116312C1 (ru) * 1992-05-20 1998-07-27 Басф Акциенгезельшафт Производные пептида или их соли, фармацевтическая композиция
DE69329425T2 (de) * 1992-12-16 2001-01-18 Basf Ag Dolastatin analog
US5554993A (en) 1994-01-04 1996-09-10 Panasonic Technologies, Inc. Global position determining system and method
US5530097A (en) * 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5504191A (en) * 1994-08-01 1996-04-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide methyl esters
US5554725A (en) * 1994-09-14 1996-09-10 Arizona Board Of Regents Acting On Behalf Of Arizona State University Synthesis of dolastatin 15
US5663149A (en) * 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US5618232A (en) 1995-03-23 1997-04-08 Martin; John R. Dual mode gaming device methods and systems
US5970143A (en) 1995-11-22 1999-10-19 Walker Asset Management Lp Remote-auditing of computer generated outcomes, authenticated billing and access control, and software metering system using cryptographic and other protocols
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
TW474946B (en) * 1995-12-15 2002-02-01 Basf Ag Novel compounds, the preparation and use thereof
US6104815A (en) 1997-01-10 2000-08-15 Silicon Gaming, Inc. Method and apparatus using geographical position and universal time determination means to provide authenticated, secure, on-line communication between remote gaming locations
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6554705B1 (en) 1997-08-22 2003-04-29 Blake Cumbers Passive biometric customer identification and tracking system
US6629591B1 (en) 2001-01-12 2003-10-07 Igt Smart token
US6438382B1 (en) 2001-02-14 2002-08-20 Telefonaktiebolaget Lm Ericsson (Publ.) Expedited location determination in analog service areas

Also Published As

Publication number Publication date
CA2296036A1 (en) 1999-01-28
CZ2000176A3 (en) 2001-06-13
WO1999003879A1 (en) 1999-01-28
HU228996B1 (hu) 2013-07-29
ES2258819T3 (es) 2006-09-01
HRP980397A2 (en) 1999-04-30
EP0991658A1 (en) 2000-04-12
DE69832982D1 (de) 2006-02-02
TR200103545T2 (tr) 2002-06-21
JP5122429B2 (ja) 2013-01-16
CY1107047T1 (el) 2012-09-26
AU8475898A (en) 1999-02-10
KR20010021998A (ko) 2001-03-15
AR018501A1 (es) 2001-11-28
JP5047935B2 (ja) 2012-10-10
HK1029125A1 (en) 2001-03-23
JP2001515010A (ja) 2001-09-18
CZ303045B6 (cs) 2012-03-07
US7662786B2 (en) 2010-02-16
BR9810911A (pt) 2000-08-01
IL133784A0 (en) 2001-04-30
CN1264388A (zh) 2000-08-23
EP0991658B1 (en) 2005-12-28
JP2009137967A (ja) 2009-06-25
TW533217B (en) 2003-05-21
SK286581B6 (sk) 2009-01-07
US20060270606A1 (en) 2006-11-30
BG104089A (en) 2000-12-29
DK0991658T3 (da) 2006-05-15
BG65212B1 (bg) 2007-07-31
PT991658E (pt) 2006-05-31
ID24669A (id) 2000-07-27
CA2296036C (en) 2007-05-01
JP4508413B2 (ja) 2010-07-21
US20030153505A1 (en) 2003-08-14
US20100099843A1 (en) 2010-04-22
NO20000231D0 (no) 2000-01-17
JP2012211164A (ja) 2012-11-01
MY135057A (en) 2008-01-31
AU750120B2 (en) 2002-07-11
JP2009137968A (ja) 2009-06-25
DE69832982T2 (de) 2006-08-24
PL197884B1 (pl) 2008-05-30
HUP0004234A2 (hu) 2001-05-28
US20130046077A1 (en) 2013-02-21
HUP0004234A3 (en) 2001-08-28
TR200000132T2 (tr) 2000-05-22
ZA986358B (en) 2000-01-17
SK187999A3 (en) 2000-09-12
NO326827B1 (no) 2009-02-23
US6143721A (en) 2000-11-07
PL338144A1 (en) 2000-09-25
RU2195462C2 (ru) 2002-12-27
ATE314387T1 (de) 2006-01-15
NZ502296A (en) 2002-02-01
CN1268636C (zh) 2006-08-09
CO4990967A1 (es) 2000-12-26
US7084110B2 (en) 2006-08-01
US6458765B1 (en) 2002-10-01
IL133784A (en) 2005-09-25
NO20000231L (no) 2000-01-17
US8163698B2 (en) 2012-04-24

Similar Documents

Publication Publication Date Title
KR100579748B1 (ko) 돌라스타틴 15 유도체
AU725164B2 (en) Novel dolastatin derivatives, their preparation and use
US5502032A (en) Peptides, the preparation and use thereof
KR20010053428A (ko) 돌라스타틴 15 유도체
US5741892A (en) Pentapeptides as antitumor agents
MXPA00000019A (en) Dolastatin 15 derivatives

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
AMND Amendment
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

AMND Amendment
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E601 Decision to refuse application
PE0601 Decision on rejection of patent

St.27 status event code: N-2-6-B10-B15-exm-PE0601

J201 Request for trial against refusal decision
PJ0201 Trial against decision of rejection

St.27 status event code: A-3-3-V10-V11-apl-PJ0201

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R11-asn-PN2301

R19-X000 Request for party data change rejected

St.27 status event code: A-3-3-R10-R19-oth-X000

AMND Amendment
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PB0901 Examination by re-examination before a trial

St.27 status event code: A-6-3-E10-E12-rex-PB0901

B701 Decision to grant
PB0701 Decision of registration after re-examination before a trial

St.27 status event code: A-3-4-F10-F13-rex-PB0701

N231 Notification of change of applicant
PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

R17-X000 Change to representative recorded

St.27 status event code: A-5-5-R10-R17-oth-X000

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

FPAY Annual fee payment

Payment date: 20130429

Year of fee payment: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R11-asn-PN2301

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R14-asn-PN2301

FPAY Annual fee payment

Payment date: 20140430

Year of fee payment: 9

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20150509

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20150509

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301