KR100577101B1 - 2-(3,5-비스-트리플루오로메틸-페닐)-Ｎ-[6-(1,1-디옥소-1λ6-티오모르폴린-4-일)-4-(2-메틸 또는 4-플루오로-2-메틸치환된)페닐-피리딘-3-일]-Ｎ-메틸-이소부티르아미드 - Google Patents
2-(3,5-비스-트리플루오로메틸-페닐)-Ｎ-[6-(1,1-디옥소-1λ6-티오모르폴린-4-일)-4-(2-메틸 또는 4-플루오로-2-메틸치환된)페닐-피리딘-3-일]-Ｎ-메틸-이소부티르아미드 Download PDFInfo
- Publication number
- KR100577101B1 KR100577101B1 KR1020047001322A KR20047001322A KR100577101B1 KR 100577101 B1 KR100577101 B1 KR 100577101B1 KR 1020047001322 A KR1020047001322 A KR 1020047001322A KR 20047001322 A KR20047001322 A KR 20047001322A KR 100577101 B1 KR100577101 B1 KR 100577101B1
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- phenyl
- disease
- thiomorpholin
- bis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC(C)(C(N(C)c(cnc(N(CC1)CCS1(=O)=O)c1)c1-c1c(C)cc(*)cc1)=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 Chemical compound CC(C)(C(N(C)c(cnc(N(CC1)CCS1(=O)=O)c1)c1-c1c(C)cc(*)cc1)=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 0.000 description 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P13/00—Drugs for disorders of the urinary system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Otolaryngology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Addiction (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01118412.4 | 2001-07-31 | ||
| EP01118412 | 2001-07-31 | ||
| PCT/EP2002/008311 WO2003011860A2 (en) | 2001-07-31 | 2002-07-26 | 2-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-N-[6-(1,1-DIOXO-1λ6-THIOMORPHOLIN-4-YL)-4-(2-METHYL OR 4-FLUORO-2-METHYL SUBSTITUTED)PHENYL-PYRIDIN-3-YL]-N-METHYL-ISOBUTYRAMIDE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20040029386A KR20040029386A (ko) | 2004-04-06 |
| KR100577101B1 true KR100577101B1 (ko) | 2006-05-10 |
Family
ID=8178193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020047001322A Expired - Fee Related KR100577101B1 (ko) | 2001-07-31 | 2002-07-26 | 2-(3,5-비스-트리플루오로메틸-페닐)-Ｎ-[6-(1,1-디옥소-1λ6-티오모르폴린-4-일)-4-(2-메틸 또는 4-플루오로-2-메틸치환된)페닐-피리딘-3-일]-Ｎ-메틸-이소부티르아미드 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6849624B2 (enExample) |
| EP (1) | EP1414525B1 (enExample) |
| JP (1) | JP4700908B2 (enExample) |
| KR (1) | KR100577101B1 (enExample) |
| CN (1) | CN1289497C (enExample) |
| AR (1) | AR034921A1 (enExample) |
| AT (1) | ATE430600T1 (enExample) |
| BR (1) | BR0211523A (enExample) |
| CA (1) | CA2452502C (enExample) |
| DE (1) | DE60232246D1 (enExample) |
| EA (1) | EA006238B1 (enExample) |
| EC (1) | ECSP044963A (enExample) |
| ES (1) | ES2324209T3 (enExample) |
| GT (1) | GT200200159A (enExample) |
| HR (1) | HRP20040039A2 (enExample) |
| HU (1) | HUP0400398A3 (enExample) |
| MA (1) | MA27055A1 (enExample) |
| MX (1) | MXPA04000917A (enExample) |
| MY (1) | MY128464A (enExample) |
| NO (1) | NO20040404L (enExample) |
| NZ (1) | NZ530579A (enExample) |
| PA (1) | PA8551601A1 (enExample) |
| PE (1) | PE20030276A1 (enExample) |
| PL (1) | PL366986A1 (enExample) |
| UA (1) | UA77685C2 (enExample) |
| UY (1) | UY27403A1 (enExample) |
| WO (1) | WO2003011860A2 (enExample) |
| YU (1) | YU2704A (enExample) |
| ZA (1) | ZA200400652B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100599134B1 (ko) * | 2001-04-23 | 2006-07-12 | 에프. 호프만-라 로슈 아게 | 양성 전립선 비대증에 대한 ｎｋ-1 수용체 길항물질의 용도 |
| SE521512C2 (sv) * | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
| ATE359075T1 (de) | 2002-12-20 | 2007-05-15 | Niconovum Ab | Chemisch und physikalisch stabiles teilchenförmiges material enthaltend nikotin und microcrystalline cellulose |
| CN100562320C (zh) * | 2003-01-31 | 2009-11-25 | 弗·哈夫曼-拉罗切有限公司 | 2-(3,5-二-三氟甲基-苯基)-N-[6-(1,1-二氧代-1λ6-硫代吗啉-4-基)-4-(4-氟-2-甲基-苯基)-吡啶-3-基]-N-甲基-异丁酰胺的新晶体变体 |
| ATE500224T1 (de) | 2004-07-06 | 2011-03-15 | Hoffmann La Roche | Herstellungsverfahren für carboxamid-pyridin- derivate als zwischenprodukte bei der synthese von nk-1-rezeptor-antagonisten |
| BRPI0606843A2 (pt) * | 2005-02-22 | 2009-07-21 | Hoffmann La Roche | antagonistas de nk 1 |
| UA90708C2 (ru) | 2005-02-25 | 2010-05-25 | Ф. Хоффманн-Ля Рош Аг | Таблетки с улучшенной дисперсностью лекарственного вещества |
| CA2646942C (en) | 2006-03-16 | 2014-07-29 | Niconovum Ab | Improved snuff composition |
| GB0808747D0 (en) | 2008-05-14 | 2008-06-18 | Glaxo Wellcome Mfg Pte Ltd | Novel compounds |
| US10383894B2 (en) * | 2010-03-17 | 2019-08-20 | Lutran Industries, Inc. | Human medicinal treatment using salt of peroxymonosulfuric acid |
| JP5806420B1 (ja) | 2013-11-08 | 2015-11-10 | キッセイ薬品工業株式会社 | カルボキシメチルピペリジン誘導体 |
| TWI649307B (zh) | 2014-05-07 | 2019-02-01 | 日商橘生藥品工業股份有限公司 | Cyclohexylpyridine derivative |
| KR20170122777A (ko) | 2015-03-04 | 2017-11-06 | 반다 파마슈티칼즈, 인코퍼레이티드. | 트라디피턴트에 의한 치료 방법 |
| US20210228555A1 (en) * | 2018-06-08 | 2021-07-29 | Vanda Pharmaceuticals Inc. | Method of treatment with tradipitant |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6435115A (en) * | 1987-07-31 | 1989-02-06 | Nippon Seiko Kk | Bearing device |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL111960A (en) | 1993-12-17 | 1999-12-22 | Merck & Co Inc | Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them |
| ES2164758T3 (es) | 1993-12-29 | 2002-03-01 | Merck Sharp & Dohme | Derivados de morfolina sustituidos y su uso como agentes terapeuticos. |
| TW385308B (en) | 1994-03-04 | 2000-03-21 | Merck & Co Inc | Prodrugs of morpholine tachykinin receptor antagonists |
| US5972938A (en) | 1997-12-01 | 1999-10-26 | Merck & Co., Inc. | Method for treating or preventing psychoimmunological disorders |
| DE60014216T2 (de) | 1999-02-24 | 2006-03-02 | F. Hoffmann-La Roche Ag | 4-Phenylpyridinderivate und deren Verwendung als NK-1 Rezeptorantagonisten |
| KR100599134B1 (ko) * | 2001-04-23 | 2006-07-12 | 에프. 호프만-라 로슈 아게 | 양성 전립선 비대증에 대한 ｎｋ-1 수용체 길항물질의 용도 |
-
2002
- 2002-07-17 US US10/196,795 patent/US6849624B2/en not_active Expired - Fee Related
- 2002-07-25 PE PE2002000667A patent/PE20030276A1/es not_active Application Discontinuation
- 2002-07-26 EA EA200400109A patent/EA006238B1/ru not_active IP Right Cessation
- 2002-07-26 EP EP02791471A patent/EP1414525B1/en not_active Expired - Lifetime
- 2002-07-26 HR HR20040039A patent/HRP20040039A2/hr not_active Application Discontinuation
- 2002-07-26 AT AT02791471T patent/ATE430600T1/de active
- 2002-07-26 YU YU2704A patent/YU2704A/sh unknown
- 2002-07-26 UA UA2004021462A patent/UA77685C2/uk unknown
- 2002-07-26 ES ES02791471T patent/ES2324209T3/es not_active Expired - Lifetime
- 2002-07-26 NZ NZ530579A patent/NZ530579A/en unknown
- 2002-07-26 HU HU0400398A patent/HUP0400398A3/hu unknown
- 2002-07-26 MX MXPA04000917A patent/MXPA04000917A/es active IP Right Grant
- 2002-07-26 CN CNB028151100A patent/CN1289497C/zh not_active Expired - Fee Related
- 2002-07-26 PA PA20028551601A patent/PA8551601A1/es unknown
- 2002-07-26 CA CA2452502A patent/CA2452502C/en not_active Expired - Fee Related
- 2002-07-26 KR KR1020047001322A patent/KR100577101B1/ko not_active Expired - Fee Related
- 2002-07-26 DE DE60232246T patent/DE60232246D1/de not_active Expired - Lifetime
- 2002-07-26 JP JP2003517052A patent/JP4700908B2/ja not_active Expired - Fee Related
- 2002-07-26 BR BR0211523-9A patent/BR0211523A/pt not_active Application Discontinuation
- 2002-07-26 WO PCT/EP2002/008311 patent/WO2003011860A2/en not_active Ceased
- 2002-07-26 PL PL02366986A patent/PL366986A1/xx not_active Application Discontinuation
- 2002-07-29 MY MYPI20022848A patent/MY128464A/en unknown
- 2002-07-29 AR ARP020102847A patent/AR034921A1/es not_active Application Discontinuation
- 2002-07-30 UY UY27403A patent/UY27403A1/es not_active Application Discontinuation
- 2002-07-31 GT GT200200159A patent/GT200200159A/es unknown
-
2004
- 2004-01-27 ZA ZA200400652A patent/ZA200400652B/xx unknown
- 2004-01-29 NO NO20040404A patent/NO20040404L/no unknown
- 2004-01-29 EC EC2004004963A patent/ECSP044963A/es unknown
- 2004-01-30 MA MA27507A patent/MA27055A1/fr unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6435115A (en) * | 1987-07-31 | 1989-02-06 | Nippon Seiko Kk | Bearing device |
Non-Patent Citations (1)
| Title |
|---|
| 유럽 제1035115호 |
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