KR100545431B1 - 축합된 이종방향족 글루코키나제 활성화제 - Google Patents

축합된 이종방향족 글루코키나제 활성화제 Download PDF

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Publication number
KR100545431B1
KR100545431B1 KR1020037007517A KR20037007517A KR100545431B1 KR 100545431 B1 KR100545431 B1 KR 100545431B1 KR 1020037007517 A KR1020037007517 A KR 1020037007517A KR 20037007517 A KR20037007517 A KR 20037007517A KR 100545431 B1 KR100545431 B1 KR 100545431B1
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KR
South Korea
Prior art keywords
cyclopentyl
phenyl
propionamide
methanesulfonyl
mmol
Prior art date
Application number
KR1020037007517A
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English (en)
Korean (ko)
Other versions
KR20030068555A (ko
Inventor
코벳웬디리
그림시조셉사무엘
하이네스낸시-엘렌
케스터로버트프랜시스
마하네이페이지에린
사라부라마칸트
Original Assignee
에프. 호프만-라 로슈 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of KR20030068555A publication Critical patent/KR20030068555A/ko
Application granted granted Critical
Publication of KR100545431B1 publication Critical patent/KR100545431B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
KR1020037007517A 2000-12-06 2001-11-28 축합된 이종방향족 글루코키나제 활성화제 KR100545431B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25163700P 2000-12-06 2000-12-06
US60/251,637 2000-12-06
PCT/EP2001/013870 WO2002046173A1 (en) 2000-12-06 2001-11-28 Fused heteroaromatic glucokinase activators

Publications (2)

Publication Number Publication Date
KR20030068555A KR20030068555A (ko) 2003-08-21
KR100545431B1 true KR100545431B1 (ko) 2006-01-24

Family

ID=22952803

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020037007517A KR100545431B1 (ko) 2000-12-06 2001-11-28 축합된 이종방향족 글루코키나제 활성화제

Country Status (21)

Country Link
US (3) US6448399B1 (US06448399-20020910-C00018.png)
EP (1) EP1341774B1 (US06448399-20020910-C00018.png)
JP (1) JP4109111B2 (US06448399-20020910-C00018.png)
KR (1) KR100545431B1 (US06448399-20020910-C00018.png)
CN (1) CN1226294C (US06448399-20020910-C00018.png)
AR (1) AR031627A1 (US06448399-20020910-C00018.png)
AT (1) ATE316965T1 (US06448399-20020910-C00018.png)
AU (2) AU2190202A (US06448399-20020910-C00018.png)
BR (1) BR0115999A (US06448399-20020910-C00018.png)
CA (1) CA2429642C (US06448399-20020910-C00018.png)
DE (1) DE60117059T2 (US06448399-20020910-C00018.png)
DK (1) DK1341774T3 (US06448399-20020910-C00018.png)
ES (1) ES2256340T3 (US06448399-20020910-C00018.png)
GT (1) GT200100243A (US06448399-20020910-C00018.png)
MX (1) MXPA03005119A (US06448399-20020910-C00018.png)
PA (1) PA8534301A1 (US06448399-20020910-C00018.png)
PE (1) PE20020753A1 (US06448399-20020910-C00018.png)
PT (1) PT1341774E (US06448399-20020910-C00018.png)
UY (1) UY27055A1 (US06448399-20020910-C00018.png)
WO (1) WO2002046173A1 (US06448399-20020910-C00018.png)
ZA (1) ZA200303748B (US06448399-20020910-C00018.png)

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JP4109111B2 (ja) 2008-07-02
AU2190202A (en) 2002-06-18
DE60117059D1 (de) 2006-04-13
PA8534301A1 (es) 2002-08-26
ZA200303748B (en) 2004-08-16
US20020107396A1 (en) 2002-08-08
DE60117059T2 (de) 2006-10-26
UY27055A1 (es) 2002-07-31
GT200100243A (es) 2002-06-04
ES2256340T3 (es) 2006-07-16
AR031627A1 (es) 2003-09-24
AU2002221902B2 (en) 2006-11-23
MXPA03005119A (es) 2004-10-15
JP2004517087A (ja) 2004-06-10
CN1226294C (zh) 2005-11-09
PT1341774E (pt) 2006-05-31
CN1476438A (zh) 2004-02-18
PE20020753A1 (es) 2002-08-27
CA2429642A1 (en) 2002-06-13
US6441184B1 (en) 2002-08-27
CA2429642C (en) 2007-11-20
ATE316965T1 (de) 2006-02-15
US6545155B2 (en) 2003-04-08
DK1341774T3 (da) 2006-06-12
US6448399B1 (en) 2002-09-10
BR0115999A (pt) 2003-09-30
EP1341774B1 (en) 2006-02-01
EP1341774A1 (en) 2003-09-10
US20020103241A1 (en) 2002-08-01
WO2002046173A1 (en) 2002-06-13
US20020103199A1 (en) 2002-08-01
KR20030068555A (ko) 2003-08-21

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