KR100501612B1 - 염증성장질환을치료하기위한캅파-아편제작용물질 - Google Patents

염증성장질환을치료하기위한캅파-아편제작용물질 Download PDF

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Publication number
KR100501612B1
KR100501612B1 KR1019960024568A KR19960024568A KR100501612B1 KR 100501612 B1 KR100501612 B1 KR 100501612B1 KR 1019960024568 A KR1019960024568 A KR 1019960024568A KR 19960024568 A KR19960024568 A KR 19960024568A KR 100501612 B1 KR100501612 B1 KR 100501612B1
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KR
South Korea
Prior art keywords
halogen
formula
compounds
nhcoa
nha
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Expired - Fee Related
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KR1019960024568A
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English (en)
Korean (ko)
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KR970000230A (ko
Inventor
바버 앤드류
세이프리트 크리스토프
바르토스칙 게르트
고트쉴리히 루돌프
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메르크 파텐트 게엠베하
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Publication of KR970000230A publication Critical patent/KR970000230A/ko
Application granted granted Critical
Publication of KR100501612B1 publication Critical patent/KR100501612B1/ko
Assigned to 티오가 파마슈티칼스, 인코포레이티드 reassignment 티오가 파마슈티칼스, 인코포레이티드 권리의 전부이전등록 Assignors: 메르크 파텐트 게엠베하
Anticipated expiration legal-status Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
KR1019960024568A 1995-06-28 1996-06-27 염증성장질환을치료하기위한캅파-아편제작용물질 Expired - Fee Related KR100501612B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19523502.9 1995-06-28
DE19523502A DE19523502A1 (de) 1995-06-28 1995-06-28 Kappa-Opiatagonisten für entzündliche Darmerkrankungen

Publications (2)

Publication Number Publication Date
KR970000230A KR970000230A (ko) 1997-01-21
KR100501612B1 true KR100501612B1 (ko) 2005-10-12

Family

ID=7765475

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960024568A Expired - Fee Related KR100501612B1 (ko) 1995-06-28 1996-06-27 염증성장질환을치료하기위한캅파-아편제작용물질

Country Status (26)

Country Link
US (2) US5776972A (https=)
EP (1) EP0752246B1 (https=)
JP (2) JP4415075B2 (https=)
KR (1) KR100501612B1 (https=)
CN (1) CN1119147C (https=)
AR (1) AR004671A1 (https=)
AT (1) ATE214275T1 (https=)
AU (1) AU708699B2 (https=)
BR (1) BR9602915A (https=)
CA (1) CA2179955C (https=)
CO (1) CO4700454A1 (https=)
CZ (1) CZ289805B6 (https=)
DE (2) DE19523502A1 (https=)
DK (1) DK0752246T3 (https=)
ES (1) ES2171577T3 (https=)
HU (1) HU226976B1 (https=)
NO (1) NO309674B1 (https=)
PL (1) PL185537B1 (https=)
PT (1) PT752246E (https=)
RU (1) RU2190401C2 (https=)
SI (1) SI0752246T1 (https=)
SK (1) SK283497B6 (https=)
TR (1) TR199600497A2 (https=)
TW (1) TW430557B (https=)
UA (1) UA51615C2 (https=)
ZA (1) ZA965480B (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6303611B1 (en) * 1996-03-08 2001-10-16 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
ATE235903T1 (de) * 1996-12-02 2003-04-15 Kyorin Seiyaku Kk Neue derivate von n-substituierten pyrrolidin derivaten und deren herstellungsverfahren
US6133307A (en) * 1997-04-30 2000-10-17 Warner-Lambert Company Certain benzofuranyl-N-[pyrrolidin-1-YL]-N-methyl-acetamide derivatives useful as opioid agonists
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
MXPA99011298A (es) * 1997-07-14 2004-10-28 Adolor Corp Formulaciones farmaceuticas antiprurito de agonista kappa y metodo para tratar prurito con las mismas.
DE19827633A1 (de) * 1998-04-20 1999-10-21 Merck Patent Gmbh Verfahren zur Herstellung von enantiomerenreinem N-Methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamid
DE10116978A1 (de) * 2001-04-05 2002-10-10 Merck Patent Gmbh Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase
US20050176746A1 (en) * 2002-05-17 2005-08-11 Frank Weber Use of compounds that are effective as selective opiate receptor modulators
WO2004039785A1 (en) * 2002-11-01 2004-05-13 Pfizer Products Inc. Process for the preparation of pyrrolidinyl ethylamine compounds via a copper-mediated aryl amination
DE10259245A1 (de) * 2002-12-17 2004-07-01 Merck Patent Gmbh Derivate des Asimadolins mit kovalent gebundenen Säuren
WO2005002622A1 (ja) * 2003-07-04 2005-01-13 Santen Pharmaceutical Co., Ltd. 疼痛閾値低下抑制剤
US7642274B2 (en) 2003-07-04 2010-01-05 Santen Pharmaceutical Co., Ltd. Inhibitor of pain threshold decrease
US20080090859A1 (en) * 2003-10-30 2008-04-17 Tioga Pharmaceuticals, Inc. Use of Selective Opiate Receptor Modulators In the Treatment Of Neuropathy
US7160902B2 (en) * 2003-11-14 2007-01-09 Adolor Corporation Amide derivatives and methods of their use
CN101677997B (zh) * 2007-03-30 2012-05-09 泰奥加制药公司 用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂
US9487510B2 (en) 2012-03-05 2016-11-08 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic acetamides as kappa opioid receptor (KOR) agonists
EA201691489A1 (ru) * 2014-01-24 2016-12-30 Кадила Хелзкэр Лимитед Новые гетероциклические соединения в качестве агонистов каппа-опиодиов
EP3558300B1 (en) 2016-12-21 2021-11-24 Tioga Pharmaceuticals, Inc. Solid pharmaceutical formulations of asimadoline
WO2019122361A1 (en) 2017-12-22 2019-06-27 Dr. August Wolff Gmbh & Co. Kg Arzneimittel Asimadoline for use in treating pulmonary diseases, vascular diseases, and sepsis
EP3932390A1 (en) 2020-07-02 2022-01-05 Dr. August Wolff GmbH & Co. KG Arzneimittel Topical gel formulation containing asimadoline

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0569802A1 (de) * 1992-05-09 1993-11-18 MERCK PATENT GmbH Arylacetamide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663343A (en) * 1985-07-19 1987-05-05 Warner-Lambert Company Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compounds
US5232978A (en) * 1988-12-23 1993-08-03 Merck Patent Gesellschaft Mit Beschrankter Haftung 1-(2-arylethyl)-pyrrolidines
DE4034785A1 (de) * 1990-11-02 1992-05-07 Merck Patent Gmbh 1-(2-arylethyl)-pyrrolidine
US5232266A (en) * 1989-07-24 1993-08-03 Mork William J Upholstered article of furniture with interchangeable seating module

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0569802A1 (de) * 1992-05-09 1993-11-18 MERCK PATENT GmbH Arylacetamide

Also Published As

Publication number Publication date
JP4415075B2 (ja) 2010-02-17
HUP9601798A1 (hu) 1998-03-30
PL185537B1 (pl) 2003-05-30
JP5308056B2 (ja) 2013-10-09
CZ289805B6 (cs) 2002-04-17
TW430557B (en) 2001-04-21
NO962720D0 (no) 1996-06-27
RU2190401C2 (ru) 2002-10-10
PT752246E (pt) 2002-09-30
ATE214275T1 (de) 2002-03-15
AR004671A1 (es) 1999-03-10
NO309674B1 (no) 2001-03-12
UA51615C2 (uk) 2002-12-16
PL314996A1 (en) 1997-01-06
EP0752246B1 (de) 2002-03-13
CN1145781A (zh) 1997-03-26
CZ186696A3 (en) 1997-01-15
CA2179955A1 (en) 1996-12-29
CN1119147C (zh) 2003-08-27
EP0752246A3 (de) 1997-02-26
ES2171577T3 (es) 2002-09-16
JP2008201794A (ja) 2008-09-04
ZA965480B (en) 1997-01-27
AU708699B2 (en) 1999-08-12
SI0752246T1 (en) 2002-10-31
CA2179955C (en) 2008-10-07
US5776972A (en) 1998-07-07
AU5616296A (en) 1997-01-09
SK283497B6 (sk) 2003-08-05
DE59608861D1 (de) 2002-04-18
US5977161A (en) 1999-11-02
BR9602915A (pt) 1998-04-22
HU226976B1 (en) 2010-04-28
CO4700454A1 (es) 1998-12-29
NO962720L (no) 1996-12-30
DK0752246T3 (da) 2002-05-13
TR199600497A2 (tr) 1997-01-21
JPH0920659A (ja) 1997-01-21
EP0752246A2 (de) 1997-01-08
DE19523502A1 (de) 1997-01-02
SK84396A3 (en) 1997-04-09
KR970000230A (ko) 1997-01-21

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