KR100483300B1 - 선택적 환형 펩타이드 - Google Patents

선택적 환형 펩타이드 Download PDF

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Publication number
KR100483300B1
KR100483300B1 KR10-2003-7002931A KR20037002931A KR100483300B1 KR 100483300 B1 KR100483300 B1 KR 100483300B1 KR 20037002931 A KR20037002931 A KR 20037002931A KR 100483300 B1 KR100483300 B1 KR 100483300B1
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KR
South Korea
Prior art keywords
lys
asp
hydrogen
phe
trp
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR10-2003-7002931A
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English (en)
Korean (ko)
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KR20030061788A (ko
Inventor
첸리
층아드리안와이-힝
추신-지
단호왈리드
스위스토크조셉
왕야오
야갈로프케이쓰알란
Original Assignee
에프. 호프만-라 로슈 아게
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Publication of KR20030061788A publication Critical patent/KR20030061788A/ko
Application granted granted Critical
Publication of KR100483300B1 publication Critical patent/KR100483300B1/ko
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/68—Melanocyte-stimulating hormone [MSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR10-2003-7002931A 2000-08-30 2001-08-21 선택적 환형 펩타이드 Expired - Fee Related KR100483300B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22918400P 2000-08-30 2000-08-30
US60/229,184 2000-08-30
PCT/EP2001/009630 WO2002018437A2 (en) 2000-08-30 2001-08-21 Cyclic peptides having melanocortin-4 receptor agonist activity

Publications (2)

Publication Number Publication Date
KR20030061788A KR20030061788A (ko) 2003-07-22
KR100483300B1 true KR100483300B1 (ko) 2005-04-15

Family

ID=22860145

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2003-7002931A Expired - Fee Related KR100483300B1 (ko) 2000-08-30 2001-08-21 선택적 환형 펩타이드

Country Status (35)

Country Link
US (1) US7045591B2 (https=)
EP (1) EP1315750B1 (https=)
JP (1) JP4217069B2 (https=)
KR (1) KR100483300B1 (https=)
CN (1) CN100491396C (https=)
AR (2) AR030504A1 (https=)
AT (1) ATE353918T1 (https=)
AU (2) AU2001284026B2 (https=)
BR (1) BR0113637A (https=)
CA (1) CA2420058C (https=)
CY (1) CY1106562T1 (https=)
CZ (1) CZ2003584A3 (https=)
DE (1) DE60126624T2 (https=)
DK (1) DK1315750T3 (https=)
EC (1) ECSP034503A (https=)
ES (1) ES2280393T3 (https=)
HR (1) HRP20030126B1 (https=)
HU (1) HUP0303078A3 (https=)
IL (2) IL154575A0 (https=)
JO (1) JO2454B1 (https=)
MA (1) MA27681A1 (https=)
MX (1) MXPA03001721A (https=)
MY (1) MY137457A (https=)
NO (1) NO20030916L (https=)
NZ (1) NZ523989A (https=)
PA (1) PA8527201A1 (https=)
PE (1) PE20020483A1 (https=)
PL (1) PL366630A1 (https=)
PT (1) PT1315750E (https=)
RU (1) RU2239642C1 (https=)
SI (1) SI1315750T1 (https=)
TW (1) TWI248941B (https=)
WO (1) WO2002018437A2 (https=)
YU (1) YU15603A (https=)
ZA (1) ZA200301015B (https=)

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EP1409521A2 (en) * 2001-07-12 2004-04-21 Merck & Co., Inc. Cyclic peptides as potent and selective melanocortin-4 receptor agonists
CA2462200A1 (en) 2001-08-10 2003-02-20 Palatin Technologies, Inc. Peptidomimetics of biologically active metallopeptides
US7456184B2 (en) 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
US7732451B2 (en) 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
US7655658B2 (en) 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
US7354923B2 (en) 2001-08-10 2008-04-08 Palatin Technologies, Inc. Piperazine melanocortin-specific compounds
US7718802B2 (en) 2001-08-10 2010-05-18 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
WO2004005324A2 (en) 2002-07-09 2004-01-15 Palatin Technologies, Inc. Peptide composition for treatment of sexual dysfunction
US7727990B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine and keto-piperazine compounds
US7968548B2 (en) 2003-05-01 2011-06-28 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine compounds with diamine groups
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
KR20060026011A (ko) 2003-05-09 2006-03-22 노보 노르디스크 에이/에스 비만 치료용 펩티드
BRPI0409976A (pt) * 2003-05-09 2006-05-09 Novo Nordisk As composto, métodos para retardar a progressão de igt diabetes do tipo 2, para retardar a progressão de diabetes do tipo 2 para diabetes que requer insulina, para tratar obesidade ou prevenir excesso de peso para regular o apetite para induzir saciedade, para prevenir ganho de peso após se ter tido sucesso em perder peso, para aumentar dispêndio de energia, para tratar uma doença ou estado e para tratar bulimia, composição farmacêutica, e, uso de um composto
CA2530024A1 (en) * 2003-06-19 2005-01-06 Eli Lilly And Company Melanocortin receptor 4(mc4) agonists and their uses
WO2005000338A1 (en) * 2003-06-19 2005-01-06 Eli Lilly And Company Uses of melanocortin-3 receptor (mc3r) agonist peptides
US7084111B2 (en) 2003-06-23 2006-08-01 University Of Florida Research Foundation, Inc. Melanocortin receptor templates, peptides, and use thereof
EP1670815A2 (en) * 2003-09-30 2006-06-21 Novo Nordisk A/S Melanocortin receptor agonists
US7550602B1 (en) 2004-01-14 2009-06-23 Palatin Technologies, Inc. Small molecule compositions for sexual dysfunction
US6974187B2 (en) * 2004-01-28 2005-12-13 Tachi-S Co., Ltd. Vehicle seat structure
US20070123453A1 (en) * 2004-03-29 2007-05-31 Heiman Mark L Uses of melanocortin-4 receptor (mc4r) agonist peptides administered by continuous infusion
KR101176758B1 (ko) * 2004-04-08 2012-08-23 아스테라스 세이야쿠 가부시키가이샤 화합물 ｗｓ727713
US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
EP1809665A2 (en) * 2004-11-04 2007-07-25 Novo Nordisk A/S Mc4r selective peptides and their use in the treatment of obesity
JP2008519008A (ja) * 2004-11-04 2008-06-05 ノボ ノルディスク アクティーゼルスカブ 肥満症の治療に使用するためのペプチド
EP1809666A2 (en) * 2004-11-04 2007-07-25 Novo Nordisk A/S Peptides for use in the treating obesity
JP2008519009A (ja) * 2004-11-04 2008-06-05 ノボ ノルディスク アクティーゼルスカブ 肥満症の治療に使用するためのペプチド
CN101203527A (zh) * 2005-05-31 2008-06-18 耶路撒冷希伯来大学伊森姆研究发展公司 主链环化的促黑皮质素激素（αMSH）类似物
US20090042790A1 (en) * 2005-06-13 2009-02-12 Nastech Pharmaceutical Company Inc. Transmucosal delivery of peptide derivatives
US20080015304A1 (en) 2006-07-13 2008-01-17 Klaus Hintzer Aqueous emulsion polymerization process for producing fluoropolymers
US7671112B2 (en) * 2005-07-15 2010-03-02 3M Innovative Properties Company Method of making fluoropolymer dispersion
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US7834017B2 (en) 2006-08-11 2010-11-16 Palatin Technologies, Inc. Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
EP2125862A1 (en) * 2006-12-29 2009-12-02 F. Hoffmann-Roche AG Methods for the synthesis of cyclic peptides
CN101605728B (zh) * 2007-02-16 2013-07-24 3M创新有限公司 用于从水中去除含氟化合物的系统和方法
US20080264864A1 (en) * 2007-04-27 2008-10-30 3M Innovative Properties Company PROCESS FOR REMOVING FLUORINATED EMULSIFIER FROM FLUOROPOLMER DISPERSIONS USING AN ANION-EXCHANGE RESIN AND A pH-DEPENDENT SURFACTANT AND FLUOROPOLYMER DISPERSIONS CONTAINING A pH-DEPENDENT SURFACTANT
ES2618315T3 (es) 2007-05-25 2017-06-21 Ipsen Pharma S.A.S. Ligandos del receptor de melanocortina modificados con hidantoína
US8258313B2 (en) 2007-07-19 2012-09-04 Tokuyama Corporation Compound having hydantoin ring and method of producing the same
ES2464102T3 (es) 2008-03-27 2014-05-30 Grünenthal GmbH Derivados de 4-aminociclohexano sustituidos
EP2280941B1 (de) * 2008-03-27 2015-05-06 Grünenthal GmbH (hetero-)aryl-cyclohexan-derivate
KR101687037B1 (ko) 2008-06-09 2016-12-15 팔라틴 테크놀로지스 인코포레이티드 성기능 장애 치료용 멜라노코르틴 수용체-특이적 펩티드
TW201002340A (en) * 2008-06-09 2010-01-16 Palatin Technologies Inc Melanocortin receptor-specific peptides for treatment of obesity
KR101726893B1 (ko) 2009-06-08 2017-04-13 팔라틴 테크놀로지스 인코포레이티드 멜라노코르틴 수용체-특이적 펩티드
WO2010144341A2 (en) 2009-06-08 2010-12-16 Palatin Technologies, Inc. Lactam-bridged melanocortin receptor-specific peptides
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JP2013511554A (ja) 2009-11-23 2013-04-04 パラティン テクノロジーズ，インコーポレイテッド メラノコルチン−１受容体特異的線状ペプチド
RU2020120797A (ru) 2013-03-15 2020-07-02 Ритм Фармасьютикалз, Инк. Пептидные композиции
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US20180022780A1 (en) * 2014-09-26 2018-01-25 Bayer Pharma Aktiengesellschaft Stabilization adrenomedullin derivatives and use thereof
US11542302B2 (en) 2015-10-15 2023-01-03 Arizona Board Of Regents On Behalf Of The University Of Arizona Modulators of melanocortin receptors for the treatment of depression and anxiety
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US10899793B2 (en) 2016-05-27 2021-01-26 Regents Of The University Of Minnesota Melanocortin ligands and methods of use thereof
US20190255142A1 (en) * 2016-10-17 2019-08-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Novel modulators of melanocortin receptors for the treatment of depression and anxiety
US11124541B2 (en) 2016-10-18 2021-09-21 Regents Of The University Of Minnesota Chimeric melanocortin ligands and methods of use thereof
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CN106496005B (zh) * 2016-10-20 2019-04-09 上海毕得医药科技有限公司 一种4-(4-氯苯基)环己酮的合成方法
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CN118530294B (zh) * 2024-05-10 2025-02-14 浙江大学 一种芳基二胺固载连接子、其前体以及制备方法和应用

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Also Published As

Publication number Publication date
CN1451017A (zh) 2003-10-22
AR030504A1 (es) 2003-08-20
DE60126624D1 (de) 2007-03-29
PT1315750E (pt) 2007-05-31
IL154575A0 (en) 2003-09-17
WO2002018437A3 (en) 2002-06-06
MA27681A1 (fr) 2006-01-02
SI1315750T1 (sl) 2007-06-30
CY1106562T1 (el) 2012-01-25
TWI248941B (en) 2006-02-11
AR061422A2 (es) 2008-08-27
DK1315750T3 (da) 2007-06-11
JP4217069B2 (ja) 2009-01-28
US7045591B2 (en) 2006-05-16
ECSP034503A (es) 2003-04-25
NO20030916D0 (no) 2003-02-27
YU15603A (sh) 2006-05-25
AU2001284026B2 (en) 2007-03-01
JO2454B1 (en) 2008-10-09
BR0113637A (pt) 2004-02-25
HRP20030126A2 (en) 2005-10-31
ZA200301015B (en) 2004-05-05
JP2004507558A (ja) 2004-03-11
ATE353918T1 (de) 2007-03-15
WO2002018437A2 (en) 2002-03-07
CZ2003584A3 (cs) 2003-08-13
CN100491396C (zh) 2009-05-27
HUP0303078A2 (hu) 2003-12-29
PA8527201A1 (es) 2002-04-25
KR20030061788A (ko) 2003-07-22
PE20020483A1 (es) 2002-06-06
AU8402601A (en) 2002-03-13
RU2239642C1 (ru) 2004-11-10
ES2280393T3 (es) 2007-09-16
CA2420058A1 (en) 2002-03-07
NO20030916L (no) 2003-02-27
CA2420058C (en) 2009-04-07
NZ523989A (en) 2004-08-27
HRP20030126B1 (en) 2009-01-31
EP1315750A2 (en) 2003-06-04
MY137457A (en) 2009-01-30
US20020143141A1 (en) 2002-10-03
EP1315750B1 (en) 2007-02-14
MXPA03001721A (es) 2003-05-27
DE60126624T2 (de) 2007-11-22
HUP0303078A3 (en) 2012-02-28
IL154575A (en) 2008-12-29
PL366630A1 (en) 2005-02-07

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