ECSP034503A - Peptidos selectivos ciclicos - Google Patents

Peptidos selectivos ciclicos

Info

Publication number
ECSP034503A
ECSP034503A EC2003004503A ECSP034503A ECSP034503A EC SP034503 A ECSP034503 A EC SP034503A EC 2003004503 A EC2003004503 A EC 2003004503A EC SP034503 A ECSP034503 A EC SP034503A EC SP034503 A ECSP034503 A EC SP034503A
Authority
EC
Ecuador
Prior art keywords
selective peptides
peptides
cycle selective
cycle
bridges
Prior art date
Application number
EC2003004503A
Other languages
English (en)
Inventor
Xin Jie Chu
Li Chen
Wai Hing Cheung
Waleed Danho
Joseph Swistok
Yao Wang
Alan Yagaloff
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ECSP034503A publication Critical patent/ECSP034503A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/68—Melanocyte-stimulating hormone [MSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a péptidos ciclados mediante puentes disulfuro o puentes lactama, con actividad agonista para el receptor de la melanomiento-4 (MC4-R), de utilidad para el tratamiento de la obesidad.
EC2003004503A 2000-08-30 2003-03-06 Peptidos selectivos ciclicos ECSP034503A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22918400P 2000-08-30 2000-08-30

Publications (1)

Publication Number Publication Date
ECSP034503A true ECSP034503A (es) 2003-04-25

Family

ID=22860145

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2003004503A ECSP034503A (es) 2000-08-30 2003-03-06 Peptidos selectivos ciclicos

Country Status (35)

Country Link
US (1) US7045591B2 (es)
EP (1) EP1315750B1 (es)
JP (1) JP4217069B2 (es)
KR (1) KR100483300B1 (es)
CN (1) CN100491396C (es)
AR (2) AR030504A1 (es)
AT (1) ATE353918T1 (es)
AU (2) AU2001284026B2 (es)
BR (1) BR0113637A (es)
CA (1) CA2420058C (es)
CY (1) CY1106562T1 (es)
CZ (1) CZ2003584A3 (es)
DE (1) DE60126624T2 (es)
DK (1) DK1315750T3 (es)
EC (1) ECSP034503A (es)
ES (1) ES2280393T3 (es)
HR (1) HRP20030126B1 (es)
HU (1) HUP0303078A3 (es)
IL (2) IL154575A0 (es)
JO (1) JO2454B1 (es)
MA (1) MA27681A1 (es)
MX (1) MXPA03001721A (es)
MY (1) MY137457A (es)
NO (1) NO20030916D0 (es)
NZ (1) NZ523989A (es)
PA (1) PA8527201A1 (es)
PE (1) PE20020483A1 (es)
PL (1) PL366630A1 (es)
PT (1) PT1315750E (es)
RU (1) RU2239642C1 (es)
SI (1) SI1315750T1 (es)
TW (1) TWI248941B (es)
WO (1) WO2002018437A2 (es)
YU (1) YU15603A (es)
ZA (1) ZA200301015B (es)

Families Citing this family (60)

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WO2003006604A2 (en) * 2001-07-12 2003-01-23 Merck & Co., Inc. Cyclic peptides as potent and selective melanocortin-4 receptor agonists
US7456184B2 (en) 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
US7354923B2 (en) 2001-08-10 2008-04-08 Palatin Technologies, Inc. Piperazine melanocortin-specific compounds
US7732451B2 (en) 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
US7655658B2 (en) 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
JP2005504043A (ja) 2001-08-10 2005-02-10 パラチン テクノロジーズ インク． 生物学的に活性な金属ペプチド類のペプチド模倣体類
US7718802B2 (en) 2001-08-10 2010-05-18 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
WO2004005324A2 (en) 2002-07-09 2004-01-15 Palatin Technologies, Inc. Peptide composition for treatment of sexual dysfunction
US7968548B2 (en) 2003-05-01 2011-06-28 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine compounds with diamine groups
US7727990B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine and keto-piperazine compounds
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
KR20060026011A (ko) 2003-05-09 2006-03-22 노보 노르디스크 에이/에스 비만 치료용 펩티드
AU2004235872A1 (en) * 2003-05-09 2004-11-18 Novo Nordisk A/S Peptides for use in treating obesity
JP2006527772A (ja) * 2003-06-19 2006-12-07 イーライ リリー アンド カンパニー メラノコルチン３受容体（ｍｃ３ｒ）作用薬ペプチドの用途
JP2006527773A (ja) * 2003-06-19 2006-12-07 イーライ リリー アンド カンパニー メラノコルチン受容体４（ｍｃ４）作用薬とその用途
US7084111B2 (en) 2003-06-23 2006-08-01 University Of Florida Research Foundation, Inc. Melanocortin receptor templates, peptides, and use thereof
RU2381233C2 (ru) * 2003-09-30 2010-02-10 Ново Нордиск А/С Агонисты рецептора меланокортина
US7550602B1 (en) 2004-01-14 2009-06-23 Palatin Technologies, Inc. Small molecule compositions for sexual dysfunction
US6974187B2 (en) * 2004-01-28 2005-12-13 Tachi-S Co., Ltd. Vehicle seat structure
US20070123453A1 (en) * 2004-03-29 2007-05-31 Heiman Mark L Uses of melanocortin-4 receptor (mc4r) agonist peptides administered by continuous infusion
KR20070008682A (ko) * 2004-04-08 2007-01-17 아스테라스 세이야쿠 가부시키가이샤 화합물 ｗｓ727713
US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US20080306008A1 (en) * 2004-11-04 2008-12-11 Nova Nordisk A/S Peptides for Use in the Treatment of Obesity
EP1812471A2 (en) * 2004-11-04 2007-08-01 Novo Nordisk A/S Peptides for use in treating of obesity
EP1809665A2 (en) * 2004-11-04 2007-07-25 Novo Nordisk A/S Mc4r selective peptides and their use in the treatment of obesity
JP2008519007A (ja) * 2004-11-04 2008-06-05 ノボ ノルディスク アクティーゼルスカブ 肥満症の治療に使用するためのペプチド
CA2609951A1 (en) * 2005-05-31 2006-12-07 Yissum Research Development Company Of The Hebrew University Of Jerusale M Backbone cyclized melanocortin stimulating hormone (.alpha.s) analogs
AU2006257792A1 (en) * 2005-06-13 2006-12-21 Mdrna, Inc. Transmucosal delivery of peptide derivatives
US20080015304A1 (en) 2006-07-13 2008-01-17 Klaus Hintzer Aqueous emulsion polymerization process for producing fluoropolymers
US20070025902A1 (en) * 2005-07-15 2007-02-01 3M Innovative Properties Company Recovery of fluorinated carboxylic acid from adsorbent particles
GB2430437A (en) * 2005-09-27 2007-03-28 3M Innovative Properties Co Method of making a fluoropolymer
US7834017B2 (en) 2006-08-11 2010-11-16 Palatin Technologies, Inc. Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
CA2673229A1 (en) * 2006-12-29 2008-07-10 F. Hoffmann-La Roche Ag Methods for the synthesis of cyclic peptides
WO2008101137A1 (en) * 2007-02-16 2008-08-21 3M Innovative Properties Company System and process for the removal of fluorochemicals from water
US20080264864A1 (en) * 2007-04-27 2008-10-30 3M Innovative Properties Company PROCESS FOR REMOVING FLUORINATED EMULSIFIER FROM FLUOROPOLMER DISPERSIONS USING AN ANION-EXCHANGE RESIN AND A pH-DEPENDENT SURFACTANT AND FLUOROPOLYMER DISPERSIONS CONTAINING A pH-DEPENDENT SURFACTANT
ES2618315T3 (es) 2007-05-25 2017-06-21 Ipsen Pharma S.A.S. Ligandos del receptor de melanocortina modificados con hidantoína
US8258313B2 (en) 2007-07-19 2012-09-04 Tokuyama Corporation Compound having hydantoin ring and method of producing the same
KR20120075499A (ko) 2008-03-27 2012-07-06 그뤼넨탈 게엠베하 치환된 4-아미노사이클로헥산 유도체
CN102046597B (zh) * 2008-03-27 2013-09-11 格吕伦塔尔有限公司 (杂)芳基环己烷衍生物
AU2009257631B2 (en) 2008-06-09 2014-07-24 Palatin Technologies, Inc. Melanocortin receptor-specific peptides for treatment of sexual dysfunction
WO2009151383A1 (en) * 2008-06-09 2009-12-17 Palatin Technologies, Inc. Melanocortin receptor-specific peptides for the treatment of obesity and other diseases associated with melanocortin receptor function
UY32690A (es) 2009-06-08 2011-01-31 Astrazeneca Ab Péptidos específicos para receptores de melanocortina
WO2010144344A2 (en) 2009-06-08 2010-12-16 Palatin Technologies, Inc. Melanocortin receptor-specific peptides
EP2440572B1 (en) 2009-06-08 2017-04-05 Palatin Technologies, Inc. Lactam-bridged melanocortin receptor-specific peptides
EA021897B1 (ru) 2009-11-23 2015-09-30 Палатин Текнолоджиз, Инк. Циклические пептиды, специфичные к рецептору меланокортина-1
MX2012005859A (es) 2009-11-23 2012-12-17 Palatin Technologies Inc Peptidos lineales especificos del receptor de melanocortina-1.
CN118271400A (zh) 2013-03-15 2024-07-02 节奏制药公司 肽组合物
GB201416351D0 (en) 2014-09-16 2014-10-29 Shire Internat Gmbh Heterocyclic derivatives
GB201416352D0 (en) 2014-09-16 2014-10-29 Shire Internat Gmbh Spirocyclic derivatives
KR20170062490A (ko) * 2014-09-26 2017-06-07 바이엘 파마 악티엔게젤샤프트 안정화된 아드레노메둘린 유도체 및 그의 용도
US11542302B2 (en) 2015-10-15 2023-01-03 Arizona Board Of Regents On Behalf Of The University Of Arizona Modulators of melanocortin receptors for the treatment of depression and anxiety
WO2017066754A1 (en) 2015-10-15 2017-04-20 The Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for the treatment of depression and anxiety
WO2018074999A1 (en) * 2016-10-17 2018-04-26 The Arizona Board Of Regents On Behalf Of The University Of Arizona Novel modulators of melanocortin receptors for the treatment of depression and anxiety
US10899793B2 (en) 2016-05-27 2021-01-26 Regents Of The University Of Minnesota Melanocortin ligands and methods of use thereof
US11124541B2 (en) 2016-10-18 2021-09-21 Regents Of The University Of Minnesota Chimeric melanocortin ligands and methods of use thereof
CN106496005B (zh) * 2016-10-20 2019-04-09 上海毕得医药科技有限公司 一种4-(4-氯苯基)环己酮的合成方法
CN106496008A (zh) * 2016-10-20 2017-03-15 上海毕得医药科技有限公司 一种合成4‑(4‑氯苯基)环己酮的方法
US10745444B2 (en) * 2017-04-17 2020-08-18 National Tsing Hua University Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same
US11332499B2 (en) 2018-08-16 2022-05-17 Regents Of The University Of Minnesota Cyclic peptides and methods of use thereof
CN118530294B (zh) * 2024-05-10 2025-02-14 浙江大学 一种芳基二胺固载连接子、其前体以及制备方法和应用

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Also Published As

Publication number Publication date
PA8527201A1 (es) 2002-04-25
WO2002018437A2 (en) 2002-03-07
PE20020483A1 (es) 2002-06-06
DE60126624T2 (de) 2007-11-22
RU2239642C1 (ru) 2004-11-10
KR100483300B1 (ko) 2005-04-15
JP4217069B2 (ja) 2009-01-28
KR20030061788A (ko) 2003-07-22
TWI248941B (en) 2006-02-11
ZA200301015B (en) 2004-05-05
CA2420058C (en) 2009-04-07
NO20030916L (no) 2003-02-27
WO2002018437A3 (en) 2002-06-06
BR0113637A (pt) 2004-02-25
ATE353918T1 (de) 2007-03-15
PL366630A1 (en) 2005-02-07
HUP0303078A3 (en) 2012-02-28
IL154575A0 (en) 2003-09-17
JO2454B1 (en) 2008-10-09
NZ523989A (en) 2004-08-27
AU8402601A (en) 2002-03-13
HUP0303078A2 (hu) 2003-12-29
PT1315750E (pt) 2007-05-31
SI1315750T1 (sl) 2007-06-30
HRP20030126B1 (en) 2009-01-31
JP2004507558A (ja) 2004-03-11
YU15603A (sh) 2006-05-25
DE60126624D1 (de) 2007-03-29
CN1451017A (zh) 2003-10-22
MXPA03001721A (es) 2003-05-27
IL154575A (en) 2008-12-29
HRP20030126A2 (en) 2005-10-31
AR030504A1 (es) 2003-08-20
CZ2003584A3 (cs) 2003-08-13
NO20030916D0 (no) 2003-02-27
AR061422A2 (es) 2008-08-27
CA2420058A1 (en) 2002-03-07
DK1315750T3 (da) 2007-06-11
EP1315750A2 (en) 2003-06-04
US20020143141A1 (en) 2002-10-03
AU2001284026B2 (en) 2007-03-01
ES2280393T3 (es) 2007-09-16
US7045591B2 (en) 2006-05-16
MY137457A (en) 2009-01-30
MA27681A1 (fr) 2006-01-02
CN100491396C (zh) 2009-05-27
CY1106562T1 (el) 2012-01-25
EP1315750B1 (en) 2007-02-14

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