DK1315750T3 - Cykliske peptider med melanocortin-4-receptoragonistaktivitet - Google Patents

Cykliske peptider med melanocortin-4-receptoragonistaktivitet

Info

Publication number
DK1315750T3
DK1315750T3 DK01962958T DK01962958T DK1315750T3 DK 1315750 T3 DK1315750 T3 DK 1315750T3 DK 01962958 T DK01962958 T DK 01962958T DK 01962958 T DK01962958 T DK 01962958T DK 1315750 T3 DK1315750 T3 DK 1315750T3
Authority
DK
Denmark
Prior art keywords
melanocortin
receptor agonist
agonist activity
cyclic peptides
peptides
Prior art date
Application number
DK01962958T
Other languages
Danish (da)
English (en)
Inventor
Li Chen
Adrian Wai-Hing Cheung
Xin-Jie Chu
Waleed Danho
Joseph Swistok
Yao Wang
Keith Alan Yagaloff
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1315750T3 publication Critical patent/DK1315750T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/68—Melanocyte-stimulating hormone [MSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK01962958T 2000-08-30 2001-08-21 Cykliske peptider med melanocortin-4-receptoragonistaktivitet DK1315750T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22918400P 2000-08-30 2000-08-30
PCT/EP2001/009630 WO2002018437A2 (en) 2000-08-30 2001-08-21 Cyclic peptides having melanocortin-4 receptor agonist activity

Publications (1)

Publication Number Publication Date
DK1315750T3 true DK1315750T3 (da) 2007-06-11

Family

ID=22860145

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01962958T DK1315750T3 (da) 2000-08-30 2001-08-21 Cykliske peptider med melanocortin-4-receptoragonistaktivitet

Country Status (35)

Country Link
US (1) US7045591B2 (es)
EP (1) EP1315750B1 (es)
JP (1) JP4217069B2 (es)
KR (1) KR100483300B1 (es)
CN (1) CN100491396C (es)
AR (2) AR030504A1 (es)
AT (1) ATE353918T1 (es)
AU (2) AU2001284026B2 (es)
BR (1) BR0113637A (es)
CA (1) CA2420058C (es)
CY (1) CY1106562T1 (es)
CZ (1) CZ2003584A3 (es)
DE (1) DE60126624T2 (es)
DK (1) DK1315750T3 (es)
EC (1) ECSP034503A (es)
ES (1) ES2280393T3 (es)
HR (1) HRP20030126B1 (es)
HU (1) HUP0303078A3 (es)
IL (2) IL154575A0 (es)
JO (1) JO2454B1 (es)
MA (1) MA27681A1 (es)
MX (1) MXPA03001721A (es)
MY (1) MY137457A (es)
NO (1) NO20030916D0 (es)
NZ (1) NZ523989A (es)
PA (1) PA8527201A1 (es)
PE (1) PE20020483A1 (es)
PL (1) PL366630A1 (es)
PT (1) PT1315750E (es)
RU (1) RU2239642C1 (es)
SI (1) SI1315750T1 (es)
TW (1) TWI248941B (es)
WO (1) WO2002018437A2 (es)
YU (1) YU15603A (es)
ZA (1) ZA200301015B (es)

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US7718802B2 (en) 2001-08-10 2010-05-18 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US7456184B2 (en) * 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
US7732451B2 (en) 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
US7354923B2 (en) * 2001-08-10 2008-04-08 Palatin Technologies, Inc. Piperazine melanocortin-specific compounds
CA2462200A1 (en) 2001-08-10 2003-02-20 Palatin Technologies, Inc. Peptidomimetics of biologically active metallopeptides
US7655658B2 (en) 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
BR0305628A (pt) 2002-07-09 2004-09-08 Palatin Technologies Inc Composição farmacêutica para tratar disfunção sexual num mamìfero compreendendo peptìdeo e seu uso
US7968548B2 (en) 2003-05-01 2011-06-28 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine compounds with diamine groups
US7727990B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine and keto-piperazine compounds
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
MXPA05011830A (es) 2003-05-09 2006-01-26 Novo Nordisk As Peptidos para uso en el tratamiento de la obesidad.
WO2004099246A2 (en) * 2003-05-09 2004-11-18 Novo Nordisk A/S Peptides for use in treating obesity
CA2530024A1 (en) * 2003-06-19 2005-01-06 Eli Lilly And Company Melanocortin receptor 4(mc4) agonists and their uses
CA2527881A1 (en) * 2003-06-19 2005-01-06 Eli Lilly And Company Uses of melanocortin-3 receptor (mc3r) agonist peptides
US7084111B2 (en) 2003-06-23 2006-08-01 University Of Florida Research Foundation, Inc. Melanocortin receptor templates, peptides, and use thereof
CA2539596A1 (en) 2003-09-30 2005-04-07 Kilian Waldemar Conde-Frieboes Melanocortin receptor agonists
US7550602B1 (en) 2004-01-14 2009-06-23 Palatin Technologies, Inc. Small molecule compositions for sexual dysfunction
US6974187B2 (en) * 2004-01-28 2005-12-13 Tachi-S Co., Ltd. Vehicle seat structure
CA2557739A1 (en) * 2004-03-29 2005-11-03 Eli Lilly And Company Uses of melanocortin-4 receptor (mc4r) agonist peptides administered by continuous infusion
CN1977040B (zh) * 2004-04-08 2011-01-12 安斯泰来制药株式会社 化合物ws727713
US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
WO2006048450A2 (en) * 2004-11-04 2006-05-11 Novo Nordisk A/S Peptides for use in the treating obesity
CN101052649A (zh) * 2004-11-04 2007-10-10 诺和诺德公司 用于治疗肥胖的肽类
CN101052648A (zh) * 2004-11-04 2007-10-10 诺和诺德公司 用于治疗肥胖的新颖的肽类
JP2008519009A (ja) * 2004-11-04 2008-06-05 ノボ ノルディスク アクティーゼルスカブ 肥満症の治療に使用するためのペプチド
US20080242600A1 (en) * 2005-05-31 2008-10-02 Chaim Gilon Backbone Cyclized Melanocortin Stimulating Hormone (Alpha Msh) Analogs
WO2006135930A2 (en) * 2005-06-13 2006-12-21 Nastech Pharmaceutical Company Inc. Transmucosal delivery of peptide derivatives
US20080015304A1 (en) 2006-07-13 2008-01-17 Klaus Hintzer Aqueous emulsion polymerization process for producing fluoropolymers
US7795332B2 (en) * 2005-07-15 2010-09-14 3M Innovative Properties Company Method of removing fluorinated carboxylic acid from aqueous liquid
GB2430437A (en) * 2005-09-27 2007-03-28 3M Innovative Properties Co Method of making a fluoropolymer
US7834017B2 (en) 2006-08-11 2010-11-16 Palatin Technologies, Inc. Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
WO2008080845A1 (en) * 2006-12-29 2008-07-10 F. Hoffmann-La Roche Ag Methods for the synthesis of cyclic peptides
BRPI0807109A2 (pt) * 2007-02-16 2014-05-06 3M Innovative Properties Co Sistema e processo para a remoção de fluoroquiímicos da água
US20080264864A1 (en) 2007-04-27 2008-10-30 3M Innovative Properties Company PROCESS FOR REMOVING FLUORINATED EMULSIFIER FROM FLUOROPOLMER DISPERSIONS USING AN ANION-EXCHANGE RESIN AND A pH-DEPENDENT SURFACTANT AND FLUOROPOLYMER DISPERSIONS CONTAINING A pH-DEPENDENT SURFACTANT
CA2689016C (en) * 2007-05-25 2014-08-12 Ipsen Pharma S.A.S. Melanocortin receptor ligands modified with hydantoin
US8258313B2 (en) 2007-07-19 2012-09-04 Tokuyama Corporation Compound having hydantoin ring and method of producing the same
EP2502907B1 (de) 2008-03-27 2018-08-29 Grünenthal GmbH Substituierte 4-Aminocyclohexan-Derivate
AR071066A1 (es) * 2008-03-27 2010-05-26 Gruenenthal Chemie Derivados de (hetero) aril-ciclohexano
CN102131514B (zh) 2008-06-09 2014-08-20 帕拉丁科技公司 用于治疗性功能障碍的黑皮质素受体特异性肽
TW201002340A (en) * 2008-06-09 2010-01-16 Palatin Technologies Inc Melanocortin receptor-specific peptides for treatment of obesity
WO2010144341A2 (en) 2009-06-08 2010-12-16 Palatin Technologies, Inc. Lactam-bridged melanocortin receptor-specific peptides
WO2010144344A2 (en) * 2009-06-08 2010-12-16 Palatin Technologies, Inc. Melanocortin receptor-specific peptides
UY32690A (es) 2009-06-08 2011-01-31 Astrazeneca Ab Péptidos específicos para receptores de melanocortina
EA021897B1 (ru) 2009-11-23 2015-09-30 Палатин Текнолоджиз, Инк. Циклические пептиды, специфичные к рецептору меланокортина-1
KR20120102716A (ko) 2009-11-23 2012-09-18 팔라틴 테크놀로지스 인코포레이티드 멜라노코르틴-1 수용체 특이적 선형 펩티드
TR201815173T4 (tr) * 2013-03-15 2018-11-21 Rhythm Pharmaceuticals Inc Peptit bileşimleri.
GB201416351D0 (en) * 2014-09-16 2014-10-29 Shire Internat Gmbh Heterocyclic derivatives
GB201416352D0 (en) * 2014-09-16 2014-10-29 Shire Internat Gmbh Spirocyclic derivatives
AU2015323769A1 (en) * 2014-09-26 2017-04-13 Bayer Pharma Aktiengesellschaft Stabilized adrenomedullin derivatives and use thereof
WO2017066754A1 (en) 2015-10-15 2017-04-20 The Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for the treatment of depression and anxiety
US11542302B2 (en) 2015-10-15 2023-01-03 Arizona Board Of Regents On Behalf Of The University Of Arizona Modulators of melanocortin receptors for the treatment of depression and anxiety
US10899793B2 (en) 2016-05-27 2021-01-26 Regents Of The University Of Minnesota Melanocortin ligands and methods of use thereof
US20190255142A1 (en) * 2016-10-17 2019-08-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Novel modulators of melanocortin receptors for the treatment of depression and anxiety
US11124541B2 (en) 2016-10-18 2021-09-21 Regents Of The University Of Minnesota Chimeric melanocortin ligands and methods of use thereof
CN106496005B (zh) * 2016-10-20 2019-04-09 上海毕得医药科技有限公司 一种4-(4-氯苯基)环己酮的合成方法
CN106496008A (zh) * 2016-10-20 2017-03-15 上海毕得医药科技有限公司 一种合成4‑(4‑氯苯基)环己酮的方法
US10745444B2 (en) * 2017-04-17 2020-08-18 National Tsing Hua University Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same
US11332499B2 (en) 2018-08-16 2022-05-17 Regents Of The University Of Minnesota Cyclic peptides and methods of use thereof

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Also Published As

Publication number Publication date
SI1315750T1 (sl) 2007-06-30
CY1106562T1 (el) 2012-01-25
HRP20030126B1 (en) 2009-01-31
JO2454B1 (en) 2008-10-09
HUP0303078A2 (hu) 2003-12-29
US7045591B2 (en) 2006-05-16
ZA200301015B (en) 2004-05-05
CA2420058A1 (en) 2002-03-07
MA27681A1 (fr) 2006-01-02
CN100491396C (zh) 2009-05-27
AU8402601A (en) 2002-03-13
DE60126624T2 (de) 2007-11-22
BR0113637A (pt) 2004-02-25
MY137457A (en) 2009-01-30
HUP0303078A3 (en) 2012-02-28
MXPA03001721A (es) 2003-05-27
PL366630A1 (en) 2005-02-07
HRP20030126A2 (en) 2005-10-31
ATE353918T1 (de) 2007-03-15
NO20030916L (no) 2003-02-27
KR20030061788A (ko) 2003-07-22
AR030504A1 (es) 2003-08-20
JP2004507558A (ja) 2004-03-11
TWI248941B (en) 2006-02-11
IL154575A0 (en) 2003-09-17
JP4217069B2 (ja) 2009-01-28
RU2239642C1 (ru) 2004-11-10
NZ523989A (en) 2004-08-27
CZ2003584A3 (cs) 2003-08-13
EP1315750B1 (en) 2007-02-14
CA2420058C (en) 2009-04-07
ECSP034503A (es) 2003-04-25
CN1451017A (zh) 2003-10-22
AU2001284026B2 (en) 2007-03-01
AR061422A2 (es) 2008-08-27
DE60126624D1 (de) 2007-03-29
WO2002018437A3 (en) 2002-06-06
US20020143141A1 (en) 2002-10-03
EP1315750A2 (en) 2003-06-04
PT1315750E (pt) 2007-05-31
ES2280393T3 (es) 2007-09-16
IL154575A (en) 2008-12-29
PE20020483A1 (es) 2002-06-06
PA8527201A1 (es) 2002-04-25
KR100483300B1 (ko) 2005-04-15
WO2002018437A2 (en) 2002-03-07
NO20030916D0 (no) 2003-02-27
YU15603A (sh) 2006-05-25

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