KR100452062B1 - - Google Patents

Info

Publication number
KR100452062B1
KR100452062B1 KR10-1998-0706784A KR19980706784A KR100452062B1 KR 100452062 B1 KR100452062 B1 KR 100452062B1 KR 19980706784 A KR19980706784 A KR 19980706784A KR 100452062 B1 KR100452062 B1 KR 100452062B1
Authority
KR
South Korea
Prior art keywords
nnr4
coor1
pxr
amidino
sic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR10-1998-0706784A
Other languages
English (en)
Korean (ko)
Other versions
KR19990087372A (ko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26232562&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100452062(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR9602604A external-priority patent/FR2745569B1/fr
Priority claimed from FR9609557A external-priority patent/FR2751972B1/fr
Application filed filed Critical
Publication of KR19990087372A publication Critical patent/KR19990087372A/ko
Application granted granted Critical
Publication of KR100452062B1 publication Critical patent/KR100452062B1/ko
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1019980706784A 1996-03-01 1997-02-28 아미디늄류 관련 화합물, 이를 함유한 약학조성물, 및 이의용도 Granted KR19990087372A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9602604A FR2745569B1 (fr) 1996-03-01 1996-03-01 Composes apparentes a la famille des amidiniums, compositions pharmaceutiques les contenant et leurs applications
FR96/02,604 1996-03-01
FR96/09,557 1996-07-30
FR9609557A FR2751972B1 (fr) 1996-07-30 1996-07-30 Composes apparentes a la famille des amidiniums, compositions pharmaceutiques les contenant et leurs applications

Publications (2)

Publication Number Publication Date
KR19990087372A KR19990087372A (ko) 1999-12-27
KR100452062B1 true KR100452062B1 (https=) 2005-04-08

Family

ID=26232562

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019980706784A Granted KR19990087372A (ko) 1996-03-01 1997-02-28 아미디늄류 관련 화합물, 이를 함유한 약학조성물, 및 이의용도

Country Status (18)

Country Link
US (2) US6143729A (https=)
EP (1) EP0888379B1 (https=)
JP (1) JP4271260B2 (https=)
KR (1) KR19990087372A (https=)
AT (1) ATE198599T1 (https=)
AU (1) AU723998B2 (https=)
BR (1) BRPI9707889B8 (https=)
CZ (1) CZ295225B6 (https=)
DE (1) DE69703878T2 (https=)
DK (1) DK0888379T3 (https=)
ES (1) ES2154453T3 (https=)
GR (1) GR3035205T3 (https=)
HU (1) HU228072B1 (https=)
IL (1) IL125926A (https=)
NO (1) NO311806B1 (https=)
PT (1) PT888379E (https=)
SK (1) SK283575B6 (https=)
WO (1) WO1997031935A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6884430B1 (en) 1997-02-10 2005-04-26 Aventis Pharma S.A. Formulation of stabilized cationic transfection agent(s) /nucleic acid particles
FR2763943B1 (fr) * 1997-05-28 1999-07-09 Rhone Poulenc Rorer Sa Composes, leur preparation et leur utilisation pour le transfert d'acides nucleiques dans les cellules
BR9909350A (pt) * 1998-04-02 2000-12-12 Aventis Pharma Sa Compostos, composição, utilização de um composto, e, processos para preparação dos compostos, para transferência de ácido nucleicos para as células e para tratamento de doenças por meio de administração de um ácido nucleico
FR2777017B1 (fr) * 1998-04-02 2002-08-23 Rhone Poulenc Rorer Sa Nouveaux agents de transfert d'acides nucleiques, compositions les contenant et leurs applications
DE10109898A1 (de) * 2001-02-21 2002-09-05 Novosom Gmbh Lipide mit veränderlicher Ladung
AU2002257904B2 (en) * 2001-05-14 2007-12-06 Gencell S.A. Polythiourea lipid derivatives
FR2824557B1 (fr) * 2001-05-14 2003-08-29 Aventis Pharma Sa Derives lipidiques de polythiouree
FR2829136B1 (fr) * 2001-08-29 2006-11-17 Aventis Pharma Sa Derives lipidiques d'aminoglycosides
AU2003205545A1 (en) 2002-01-17 2003-07-30 York Refrigeration Aps Submerged evaporator with integrated heat exchanger
JP4980893B2 (ja) * 2005-04-28 2012-07-18 日本曹達株式会社 新規なグアニジン化合物、製造方法及びそれらを含有する殺菌性組成物
US20100035974A1 (en) * 2006-10-04 2010-02-11 Centre National De La Recherche Scientifique (Cnrs Compositions comprising a sirna and lipidic 4,5-disubstituted 2-deoxystreptamine ring aminoglycoside derivatives and uses thereof
TW201019969A (en) * 2008-11-17 2010-06-01 Enzon Pharmaceuticals Inc Branched cationic lipids for nucleic acids delivery system

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283185A (en) * 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
EP0730405A4 (en) * 1993-11-24 1997-02-19 Megabios Corp AMPHIPHILE GUANIDINE DERIVATIVES
US5777153A (en) * 1994-07-08 1998-07-07 Gilead Sciences, Inc. Cationic lipids
US6071890A (en) * 1994-12-09 2000-06-06 Genzyme Corporation Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
US5811406A (en) * 1995-06-07 1998-09-22 Regents Of The University Of California Dry powder formulations of polynucleotide complexes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. Biol. Chem. Vol.270(52): 313941-31396 (1995) *

Also Published As

Publication number Publication date
AU723998B2 (en) 2000-09-07
DK0888379T3 (da) 2001-01-29
ATE198599T1 (de) 2001-01-15
WO1997031935A1 (fr) 1997-09-04
CZ277298A3 (cs) 1998-12-16
NO983691L (no) 1998-08-12
JP2000506136A (ja) 2000-05-23
US6143729A (en) 2000-11-07
ES2154453T3 (es) 2001-04-01
IL125926A (en) 2004-09-27
EP0888379A1 (fr) 1999-01-07
NO983691D0 (no) 1998-08-12
NO311806B1 (no) 2002-01-28
BR9707889B1 (pt) 2010-03-23
CZ295225B6 (cs) 2005-06-15
DE69703878D1 (de) 2001-02-15
SK118298A3 (en) 1999-02-11
HUP9902465A3 (en) 2009-10-28
SK283575B6 (sk) 2003-09-11
AU1930497A (en) 1997-09-16
BRPI9707889B8 (pt) 2016-11-08
IL125926A0 (en) 1999-04-11
DE69703878T2 (de) 2001-04-26
HUP9902465A1 (hu) 1999-12-28
US6316422B1 (en) 2001-11-13
HU228072B1 (en) 2012-09-28
PT888379E (pt) 2001-05-31
EP0888379B1 (fr) 2001-01-10
KR19990087372A (ko) 1999-12-27
GR3035205T3 (en) 2001-04-30
BR9707889A (pt) 2000-01-04
JP4271260B2 (ja) 2009-06-03

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