MX9601017A - Derivados sustituidos de tiazolo [3,2-a] azepina. - Google Patents

Derivados sustituidos de tiazolo [3,2-a] azepina.

Info

Publication number
MX9601017A
MX9601017A MX9601017A MX9601017A MX9601017A MX 9601017 A MX9601017 A MX 9601017A MX 9601017 A MX9601017 A MX 9601017A MX 9601017 A MX9601017 A MX 9601017A MX 9601017 A MX9601017 A MX 9601017A
Authority
MX
Mexico
Prior art keywords
alpha
represent
hydrogen
lower alkyl
represents hydrogen
Prior art date
Application number
MX9601017A
Other languages
English (en)
Inventor
Hitoshi Oinuma
Shinji Suda
Naoki Yoneda
Makoto Kotake
Masanori Mizuno
Tomohiro Matsushima
Yoshio Fukuda
Mamoru Saito
Toshiyuki Matsuoka
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6165481A external-priority patent/JPH0827156A/ja
Priority claimed from JP19918094A external-priority patent/JP3444666B2/ja
Priority claimed from JP6306468A external-priority patent/JPH08165293A/ja
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of MX9601017A publication Critical patent/MX9601017A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invencion se relaciona con un derivado substituido de tiazolo[3,2-a]azepina que tiene actividad inhibitoria frente a la anzima conversora de la angiotensina I y a la endopeptidasa neutra. El anterior derivado substituido de tiazolo[3,2-a]azepina está representado por la siguiente formula general (I): (donde R1 representa un átomo de hidrogeno o un grupo protector de un grupo tiol; R2 representa unátomo de hidrogeno, un grupo alquilo inferior, un grupo arilo que puede tener un substituyente, un grupo heteroarilo que puede tener un subtituyente, un grupo alcoxilo inferior o un grupo alquiltio; R3, R4 y R5 pueden ser iguales o diferentes entre sí y representan cada uno un átomo de hidrogeno, un grupo alquilo inferior, un grupo alcoxilo inferior, un grupo alquiltio inferior o similar, con la condicion de que se excluya el caso en el que todos los R3, R4 y R5 sean átomos de hidrogeno; R6 y R7 pueden ser iguales o diferentes entre sí y cada uno representa un átomo de hidrogeno o un grupo alquilo inferior; R8 representa un átomo de hidrogeno o un grupo protector de un grupo carboxilo, y m y n son cada uno independiente 0 o 1
MX9601017A 1994-07-18 1995-06-07 Derivados sustituidos de tiazolo [3,2-a] azepina. MX9601017A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP6165481A JPH0827156A (ja) 1994-07-18 1994-07-18 アミノ酸誘導体の製造方法
JP19918094A JP3444666B2 (ja) 1994-08-24 1994-08-24 （２ｓ， ３ｓ）−３− メチル−２− チオペンタン酸誘導体の製造方法
JP6306468A JPH08165293A (ja) 1994-12-09 1994-12-09 置換チアゾロ［３，２−ａ］アゼピン誘導体
PCT/JP1995/001139 WO1996002549A1 (fr) 1994-07-18 1995-06-07 DERIVE DE THIAZOLO[3,2-α]AZEPINE A SUBSTITUTION

Publications (1)

Publication Number Publication Date
MX9601017A true MX9601017A (es) 1997-10-31

Family

ID=27322514

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9601017A MX9601017A (es) 1994-07-18 1995-06-07 Derivados sustituidos de tiazolo [3,2-a] azepina.

Country Status (17)

Country Link
US (2) US5789403A (es)
EP (1) EP0719779B1 (es)
KR (1) KR100284247B1 (es)
CN (2) CN1053908C (es)
AT (1) ATE254622T1 (es)
AU (1) AU694233B2 (es)
CA (1) CA2171334C (es)
DE (1) DE69532155T2 (es)
DK (1) DK0719779T3 (es)
ES (1) ES2210292T3 (es)
FI (2) FI110001B (es)
HU (1) HU225916B1 (es)
MX (1) MX9601017A (es)
NO (1) NO308077B1 (es)
NZ (1) NZ287557A (es)
PT (1) PT719779E (es)
WO (1) WO1996002549A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
WO1998034636A1 (fr) * 1997-02-05 1998-08-13 Suntory Limited Compositions medicinales pour traiter les cardiopathies induites par l'hypertrophie cardiaque
US9823092B2 (en) 2014-10-31 2017-11-21 Allegro Microsystems, Llc Magnetic field sensor providing a movement detector

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA821904B (en) * 1981-03-23 1983-01-26 Merck & Co Inc Bicyclic lactams as anthihypertensives
US4415496A (en) * 1981-03-23 1983-11-15 Merck & Co., Inc. Bicyclic lactams
US4617301A (en) * 1983-06-22 1986-10-14 Merck & Co., Inc. Sulfoxide and sulfone derivatives of bicyclic lactams as antihypertensives
JPS6056790A (ja) * 1983-09-03 1985-04-02 山陽科学株式会社 荷役用マット
RU2124503C1 (ru) * 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
EP0669936B1 (en) * 1992-10-30 2000-11-22 Merrell Pharmaceuticals Inc. Mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors

Also Published As

Publication number Publication date
CN1134152A (zh) 1996-10-23
ES2210292T3 (es) 2004-07-01
NO961051L (no) 1996-05-10
FI113656B (fi) 2004-05-31
DE69532155T2 (de) 2004-08-19
EP0719779A4 (en) 1996-12-18
KR100284247B1 (ko) 2001-10-24
ATE254622T1 (de) 2003-12-15
HU225916B1 (en) 2007-12-28
WO1996002549A1 (fr) 1996-02-01
US6051705A (en) 2000-04-18
NO308077B1 (no) 2000-07-17
EP0719779A1 (en) 1996-07-03
AU694233B2 (en) 1998-07-16
CA2171334C (en) 2008-10-21
HUT76477A (en) 1997-09-29
NO961051D0 (no) 1996-03-14
CN1053908C (zh) 2000-06-28
CA2171334A1 (en) 1996-02-01
FI110001B (fi) 2002-11-15
NZ287557A (en) 1997-04-24
HU9600679D0 (en) 1996-05-28
CN1262275A (zh) 2000-08-09
FI961199A (fi) 1996-05-13
DK0719779T3 (da) 2004-03-22
PT719779E (pt) 2004-04-30
CN1170832C (zh) 2004-10-13
US5789403A (en) 1998-08-04
FI961199A0 (fi) 1996-03-14
AU2630195A (en) 1996-02-16
FI20011154A (fi) 2001-06-01
DE69532155D1 (de) 2003-12-24
EP0719779B1 (en) 2003-11-19
KR960704898A (ko) 1996-10-09

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Legal Events

Date Code Title Description
FG Grant or registration
PD Change of proprietorship

Owner name: EISAI R& D MANAGEMENT CO., LTD.*

MM Annulment or lapse due to non-payment of fees