KR100395718B1 - 피라졸로[4,3-ｄ]피리미딘-7-온-3-피리딜술포닐 화합물 및그의 중간체의 제조 방법 - Google Patents

피라졸로[4,3-ｄ]피리미딘-7-온-3-피리딜술포닐 화합물 및그의 중간체의 제조 방법 Download PDF

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Publication number
KR100395718B1
KR100395718B1 KR20000059435A KR20000059435A KR100395718B1 KR 100395718 B1 KR100395718 B1 KR 100395718B1 KR 20000059435 A KR20000059435 A KR 20000059435A KR 20000059435 A KR20000059435 A KR 20000059435A KR 100395718 B1 KR100395718 B1 KR 100395718B1
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South Korea
Prior art keywords
formula
compound
agent
compounds
reaction
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Expired - Fee Related
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KR20000059435A
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English (en)
Korean (ko)
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KR20010050935A (ko
Inventor
케이트 마이클 데브리스
필립 챨스 레베트
죠안나 테레사 니그리
앨버트 쇼 우드
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화이자 인코포레이티드
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Priority claimed from GBGB9924042.6A external-priority patent/GB9924042D0/en
Priority claimed from GB0018667A external-priority patent/GB0018667D0/en
Application filed by 화이자 인코포레이티드 filed Critical 화이자 인코포레이티드
Publication of KR20010050935A publication Critical patent/KR20010050935A/ko
Application granted granted Critical
Publication of KR100395718B1 publication Critical patent/KR100395718B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
KR20000059435A 1999-10-11 2000-10-10 피라졸로[4,3-ｄ]피리미딘-7-온-3-피리딜술포닐 화합물 및그의 중간체의 제조 방법 Expired - Fee Related KR100395718B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9924042.6 1999-10-11
GBGB9924042.6A GB9924042D0 (en) 1999-10-11 1999-10-11 Process for thr preparation of pyrazolo[4,3-D]pyrimidin-7-ones-3-pyridylsulphonyl compounds and intermediates thereof
GB0018667.6 2000-07-28
GB0018667A GB0018667D0 (en) 2000-07-28 2000-07-28 Process for the preparation of pyrazolo [4,3-d] Pyrimidin-7-ones-3-pyridylsulphonyl compounds and intermediates thereof

Publications (2)

Publication Number Publication Date
KR20010050935A KR20010050935A (ko) 2001-06-25
KR100395718B1 true KR100395718B1 (ko) 2003-08-25

Family

ID=26244761

Family Applications (1)

Application Number Title Priority Date Filing Date
KR20000059435A Expired - Fee Related KR100395718B1 (ko) 1999-10-11 2000-10-10 피라졸로[4,3-ｄ]피리미딘-7-온-3-피리딜술포닐 화합물 및그의 중간체의 제조 방법

Country Status (39)

Country Link
EP (1) EP1092720B1 (forum.php)
JP (1) JP2001114783A (forum.php)
KR (1) KR100395718B1 (forum.php)
CN (1) CN1292379A (forum.php)
AR (1) AR029767A1 (forum.php)
AT (1) ATE286899T1 (forum.php)
AU (1) AU6543600A (forum.php)
BG (1) BG104840A (forum.php)
BR (1) BR0004787A (forum.php)
CA (1) CA2322995A1 (forum.php)
CO (1) CO5251476A1 (forum.php)
CZ (1) CZ20003754A3 (forum.php)
DE (1) DE60017330D1 (forum.php)
DZ (1) DZ3096A1 (forum.php)
EA (1) EA003145B1 (forum.php)
EE (1) EE200000537A (forum.php)
EG (1) EG22775A (forum.php)
GT (1) GT200000169A (forum.php)
HR (1) HRP20000674A2 (forum.php)
HU (1) HUP0003979A3 (forum.php)
ID (1) ID27539A (forum.php)
IL (1) IL138913A0 (forum.php)
IN (1) IN190477B (forum.php)
IS (1) IS5654A (forum.php)
MA (1) MA25867A1 (forum.php)
MX (1) MXPA00009936A (forum.php)
NO (1) NO316072B1 (forum.php)
NZ (1) NZ507431A (forum.php)
OA (1) OA11495A (forum.php)
PA (1) PA8504601A1 (forum.php)
PE (1) PE20010682A1 (forum.php)
PL (1) PL343140A1 (forum.php)
SG (1) SG97950A1 (forum.php)
SK (1) SK15052000A3 (forum.php)
SV (1) SV2002000194A (forum.php)
TN (1) TNSN00195A1 (forum.php)
TR (1) TR200002959A2 (forum.php)
UY (1) UY26388A1 (forum.php)
YU (1) YU59100A (forum.php)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008153282A1 (en) * 2007-06-09 2008-12-18 Dong-A Pharmaceutical. Co., Ltd Pharmaceutical compositions for the treatment of chronic heart failure comprising pyrazolopyrimidinone derivative compound

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU59100A (sh) * 1999-10-11 2003-10-31 Pfizer Inc. Postupak za dobijanje pirazolo (4,3-d) pirimidin-7-ona-3-piridilsulfonil jedinjenja i njihova intermedijera
TWI265925B (en) 1999-10-11 2006-11-11 Pfizer Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them
US6809200B2 (en) * 2000-07-28 2004-10-26 Pfizer Inc. Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-one compounds and intermediates thereof
JP2006219373A (ja) * 2003-06-13 2006-08-24 Daiichi Asubio Pharma Co Ltd Ｐｄｅ７阻害作用を有するピリジニルピラゾロピリミジノン誘導体
EP1951668B1 (en) * 2005-11-16 2010-04-14 F.Hoffmann-La Roche Ag Novel process for the preparation of thoc
WO2012114222A1 (en) * 2011-02-23 2012-08-30 Pfizer Inc. IMIDAZO[5,1-f][1,2,4]TRIAZINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
CA3227887A1 (en) * 2016-11-21 2018-05-24 Adama Agan Ltd. Process for preparing methoxy methyl pyridine dicarboxylate

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999054333A1 (en) * 1998-04-20 1999-10-28 Pfizer Inc. Pyrazolopyrimidinone cgmp pde5 inhibitors for the treatment of sexual dysfunction
KR20000035324A (ko) * 1998-11-11 2000-06-26 유충식 발기부전 치료에 효과를 갖는 피라졸로피리미디논 화합물
EP1092720A2 (en) * 1999-10-11 2001-04-18 Pfizer Limited Process for the preparation of pyrazolo [4,3-d] pyrimidin-7-ones-3-pyridylsulphonyl compounds and intermediates thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100441229B1 (ko) * 1997-04-25 2004-07-22 화이자 인코포레이티드 타입 5 시클릭 구아노신 3',5'-모노포스페이트 포스포디에스테라제(ｃＧＭＰ ＰＤＥ5)를 억제하는 성기능 장애 치료용 피라졸로피리미디논
GB9823101D0 (en) * 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999054333A1 (en) * 1998-04-20 1999-10-28 Pfizer Inc. Pyrazolopyrimidinone cgmp pde5 inhibitors for the treatment of sexual dysfunction
KR20000035324A (ko) * 1998-11-11 2000-06-26 유충식 발기부전 치료에 효과를 갖는 피라졸로피리미디논 화합물
EP1092720A2 (en) * 1999-10-11 2001-04-18 Pfizer Limited Process for the preparation of pyrazolo [4,3-d] pyrimidin-7-ones-3-pyridylsulphonyl compounds and intermediates thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008153282A1 (en) * 2007-06-09 2008-12-18 Dong-A Pharmaceutical. Co., Ltd Pharmaceutical compositions for the treatment of chronic heart failure comprising pyrazolopyrimidinone derivative compound

Also Published As

Publication number Publication date
EA200000924A3 (ru) 2001-06-25
EP1092720B1 (en) 2005-01-12
ID27539A (id) 2001-04-12
NO20005104L (no) 2001-04-17
EG22775A (en) 2003-08-31
BR0004787A (pt) 2001-05-22
CO5251476A1 (es) 2003-02-28
MXPA00009936A (es) 2002-10-23
PE20010682A1 (es) 2001-07-04
JP2001114783A (ja) 2001-04-24
HU0003979D0 (en) 2000-12-28
NO316072B1 (no) 2003-12-08
IS5654A (is) 2001-04-12
EP1092720A2 (en) 2001-04-18
SV2002000194A (es) 2002-01-23
HRP20000674A2 (en) 2001-08-31
TNSN00195A1 (fr) 2005-11-10
PL343140A1 (en) 2001-04-23
OA11495A (en) 2004-05-05
EP1092720A3 (en) 2001-09-19
HUP0003979A3 (en) 2002-03-28
EE200000537A (et) 2001-06-15
NZ507431A (en) 2002-09-27
DZ3096A1 (fr) 2004-06-20
SK15052000A3 (sk) 2003-01-09
BG104840A (bg) 2001-10-31
IL138913A0 (en) 2001-11-25
GT200000169A (es) 2002-04-03
DE60017330D1 (de) 2005-02-17
CN1292379A (zh) 2001-04-25
EA200000924A2 (ru) 2001-04-23
IN190477B (forum.php) 2003-08-02
TR200002959A2 (tr) 2001-07-23
KR20010050935A (ko) 2001-06-25
MA25867A1 (fr) 2003-10-01
ATE286899T1 (de) 2005-01-15
EA003145B1 (ru) 2003-02-27
SG97950A1 (en) 2003-08-20
AR029767A1 (es) 2003-07-16
UY26388A1 (es) 2001-05-31
YU59100A (sh) 2003-10-31
PA8504601A1 (es) 2002-02-21
AU6543600A (en) 2001-04-12
NO20005104D0 (no) 2000-10-10
HUP0003979A2 (hu) 2001-12-28
CA2322995A1 (en) 2001-04-11
CZ20003754A3 (cs) 2002-06-12

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