KR100277242B1 - 리그난계 화합물의 제조방법 - Google Patents

리그난계 화합물의 제조방법 Download PDF

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Publication number
KR100277242B1
KR100277242B1 KR1019940704565A KR19940704565A KR100277242B1 KR 100277242 B1 KR100277242 B1 KR 100277242B1 KR 1019940704565 A KR1019940704565 A KR 1019940704565A KR 19940704565 A KR19940704565 A KR 19940704565A KR 100277242 B1 KR100277242 B1 KR 100277242B1
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KR
South Korea
Prior art keywords
compound
synthesis
reaction
iii
mixture
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1019940704565A
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English (en)
Korean (ko)
Other versions
KR950701902A (ko
Inventor
사찌오 모리
쇼죠 다께찌
시로 기다
Original Assignee
시오노 요시히코
시오노기 세이야쿠 가부시키가이샤
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Publication of KR950701902A publication Critical patent/KR950701902A/ko
Application granted granted Critical
Publication of KR100277242B1 publication Critical patent/KR100277242B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
KR1019940704565A 1993-04-16 1994-04-12 리그난계 화합물의 제조방법 Expired - Fee Related KR100277242B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP93-89944 1993-04-16
JP8994493 1993-04-16
PCT/JP1994/000612 WO1994024087A1 (fr) 1993-04-16 1994-04-12 Procede pour produire un compose de lignane

Publications (2)

Publication Number Publication Date
KR950701902A KR950701902A (ko) 1995-05-17
KR100277242B1 true KR100277242B1 (ko) 2001-02-01

Family

ID=13984820

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940704565A Expired - Fee Related KR100277242B1 (ko) 1993-04-16 1994-04-12 리그난계 화합물의 제조방법

Country Status (13)

Country Link
US (1) US5488134A (enExample)
EP (1) EP0646570B1 (enExample)
JP (1) JP3411036B2 (enExample)
KR (1) KR100277242B1 (enExample)
CN (1) CN1046937C (enExample)
AT (1) ATE167662T1 (enExample)
AU (1) AU666819B2 (enExample)
CA (1) CA2138264C (enExample)
DE (1) DE69411243T2 (enExample)
DK (1) DK0646570T3 (enExample)
ES (1) ES2119190T3 (enExample)
TW (1) TW255886B (enExample)
WO (1) WO1994024087A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2121060C (en) * 1993-04-16 2004-04-06 Sachio Mori Preparation of lignan analogues
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
KR100376281B1 (ko) * 1995-12-26 2003-09-26 에스케이케미칼주식회사 리그난의 제조방법
RU2198885C2 (ru) 1997-09-29 2003-02-20 Мейдзи Сейка Кайся Лтд. Производные трициклического триазолобензазепина, способы их получения, фармацевтическая композиция и способ лечения аллергических заболеваний, промежуточные соединения и способы их получения
AU2157400A (en) 1998-12-23 2000-07-31 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications
EP1140190B1 (en) 1998-12-23 2002-11-20 G.D. Searle LLC. Combinations of ileal bile acid transport inhibitors and bile acid sequestering agents for cardiovascular indications
ATE240120T1 (de) 1998-12-23 2003-05-15 Searle Llc Kombinationen von ileumgallensäuretransports inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen
IL143949A0 (en) 1998-12-23 2002-04-21 Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
DK1140185T3 (da) 1998-12-23 2003-09-29 Searle Llc Kombinationer af cholesterylestertransferhæmmere og galdesyre kompleksdannende forbindelser til hjertekar indikationer
WO2000038726A1 (en) 1998-12-23 2000-07-06 G.D. Searle Llc Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
WO2000038721A1 (en) 1998-12-23 2000-07-06 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
US20020061888A1 (en) * 2000-03-10 2002-05-23 Keller Bradley T. Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
HK1052183A1 (zh) 2000-03-10 2003-09-05 Pharmacia Corporation 制造tetrahydrobenzothiepines的方法
JP2005518347A (ja) 2001-11-02 2005-06-23 ジー．ディー． サール エルエルシー 頂端ナトリウム共依存性胆汁酸輸送（ａｓｂｔ）およびタウロコール酸塩取り込みの阻害剤としての新規一および二フッ化ベンゾチエピン化合物
BR0306643A (pt) 2002-01-17 2004-10-19 Pharmacia Corp Novos compostos de hidroxi alquil/aril ou ceto tiepina como inibidores do transporte co-dependente de ácido biliar-sódio apical
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
EP4137137A1 (en) 2010-05-26 2023-02-22 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
US20140323412A1 (en) 2011-10-28 2014-10-30 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
SG10201909122QA (en) 2011-10-28 2019-11-28 Lumena Pharmaceuticals Inc Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
CA2907214A1 (en) 2013-03-15 2014-09-18 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease
CA2907230A1 (en) 2013-03-15 2014-09-18 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease
JP7562546B2 (ja) 2019-02-12 2024-10-07 ミルム ファーマシューティカルズ インコーポレイテッド 胆汁うっ滞性肝疾患を有する小児対象の成長を増加させる方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0372422A (ja) * 1989-05-16 1991-03-27 Tanabe Seiyaku Co Ltd 抗脂血剤
JPH03157351A (ja) * 1989-11-13 1991-07-05 Tanabe Seiyaku Co Ltd ナフタレン誘導体及びその製法
DK0701991T3 (da) * 1991-10-17 1999-09-13 Shionogi & Co Fremgangsmåde til fremstilling af lignananaloger og udgangsmaterialer dertil

Also Published As

Publication number Publication date
ES2119190T3 (es) 1998-10-01
JP3411036B2 (ja) 2003-05-26
AU6437994A (en) 1994-11-08
KR950701902A (ko) 1995-05-17
DE69411243T2 (de) 1998-11-19
CA2138264A1 (en) 1994-10-27
DE69411243D1 (de) 1998-07-30
EP0646570A1 (en) 1995-04-05
US5488134A (en) 1996-01-30
AU666819B2 (en) 1996-02-22
CN1046937C (zh) 1999-12-01
CN1109685A (zh) 1995-10-04
EP0646570A4 (en) 1995-08-09
ATE167662T1 (de) 1998-07-15
WO1994024087A1 (fr) 1994-10-27
CA2138264C (en) 2004-04-06
TW255886B (enExample) 1995-09-01
EP0646570B1 (en) 1998-06-24
DK0646570T3 (da) 1998-10-26

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