ES2119190T3 - Procedimiento para producir un compuesto de lignano. - Google Patents
Procedimiento para producir un compuesto de lignano.Info
- Publication number
- ES2119190T3 ES2119190T3 ES94912092T ES94912092T ES2119190T3 ES 2119190 T3 ES2119190 T3 ES 2119190T3 ES 94912092 T ES94912092 T ES 94912092T ES 94912092 T ES94912092 T ES 94912092T ES 2119190 T3 ES2119190 T3 ES 2119190T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- general formula
- producing
- lower alkyl
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- -1 lignan compound Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 238000007259 addition reaction Methods 0.000 abstract 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229930013686 lignan Natural products 0.000 abstract 1
- 235000009408 lignans Nutrition 0.000 abstract 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8994493 | 1993-04-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2119190T3 true ES2119190T3 (es) | 1998-10-01 |
Family
ID=13984820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94912092T Expired - Lifetime ES2119190T3 (es) | 1993-04-16 | 1994-04-12 | Procedimiento para producir un compuesto de lignano. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5488134A (enExample) |
| EP (1) | EP0646570B1 (enExample) |
| JP (1) | JP3411036B2 (enExample) |
| KR (1) | KR100277242B1 (enExample) |
| CN (1) | CN1046937C (enExample) |
| AT (1) | ATE167662T1 (enExample) |
| AU (1) | AU666819B2 (enExample) |
| CA (1) | CA2138264C (enExample) |
| DE (1) | DE69411243T2 (enExample) |
| DK (1) | DK0646570T3 (enExample) |
| ES (1) | ES2119190T3 (enExample) |
| TW (1) | TW255886B (enExample) |
| WO (1) | WO1994024087A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2121060C (en) * | 1993-04-16 | 2004-04-06 | Sachio Mori | Preparation of lignan analogues |
| US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| KR100376281B1 (ko) * | 1995-12-26 | 2003-09-26 | 에스케이케미칼주식회사 | 리그난의 제조방법 |
| SK283869B6 (sk) | 1997-09-29 | 2004-03-02 | Meiji Seika Kaisha, Ltd. | Tricyklické triazolobenzazepínové deriváty, spôsob ich prípravy a antialergické prostriedky |
| EP1342475A1 (en) | 1998-12-23 | 2003-09-10 | G.D. Searle LLC. | Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications |
| PT1140190E (pt) | 1998-12-23 | 2003-02-28 | Searle Llc | Combinacoes de inibidores do transporte ileal dos acidos biliares e agentes sequestrantes dos acidos biliares usadas para problemas cardiovasculares |
| WO2000038722A1 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle & Co. | COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS |
| JP2002533408A (ja) | 1998-12-23 | 2002-10-08 | ジー．ディー．サール エルエルシー | 心臓血管に適用するためのコレステリルエステル転送タンパク質阻害剤およびニコチン酸誘導体の組み合わせ |
| DE69908645T2 (de) | 1998-12-23 | 2004-05-13 | G.D. Searle Llc, Chicago | Kombinationen von cholesteryl ester transfer protein inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen |
| EP1140185B1 (en) | 1998-12-23 | 2003-06-04 | G.D. Searle LLC. | Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications |
| JP2002533413A (ja) | 1998-12-23 | 2002-10-08 | ジー．ディー．サール エルエルシー | 心臓血管に適用するための回腸胆汁酸輸送阻害剤およびフィブリン酸誘導体の組み合わせ |
| US6794544B2 (en) | 2000-03-10 | 2004-09-21 | Pharmacia Corporation | Method for the preparation of tetrahydrobenzothiepines |
| WO2001068096A2 (en) * | 2000-03-10 | 2001-09-20 | Pharmacia Corporation | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders |
| MXPA04003524A (es) | 2001-11-02 | 2004-07-23 | Searle Llc | Compuestos de benzotiepina monofluorados y difluorados novedosos como inhibidores de transporte de acido biliar co-dependiente de sodio apical (asbt) y captacion de taurocolato. |
| BR0306643A (pt) | 2002-01-17 | 2004-10-19 | Pharmacia Corp | Novos compostos de hidroxi alquil/aril ou ceto tiepina como inibidores do transporte co-dependente de ácido biliar-sódio apical |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| EP2575821B1 (en) | 2010-05-26 | 2015-08-12 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| MX369466B (es) | 2011-10-28 | 2019-11-08 | Lumena Pharmaceuticals Inc | Inhibidores de la recirculación de ácidos biliares para el tratamiento de enfermedades hepáticas colestásicas pediátricas. |
| JP6217939B2 (ja) | 2011-10-28 | 2017-10-25 | ルメナ ファーマシューティカルズ エルエルシー | 高胆汁血症および胆汁うっ滞性肝疾患の処置のための胆汁酸再利用阻害剤 |
| EP2968262A1 (en) | 2013-03-15 | 2016-01-20 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease |
| RU2015139731A (ru) | 2013-03-15 | 2017-04-20 | ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи | Ингибиторы рециркуляции желчных кислот для лечения первичного склерозирующего холангита и воспалительного заболевания кишечника |
| MX2021009622A (es) | 2019-02-12 | 2021-11-04 | Mirum Pharmaceuticals Inc | Metodos para tratar la colestasis. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0372422A (ja) * | 1989-05-16 | 1991-03-27 | Tanabe Seiyaku Co Ltd | 抗脂血剤 |
| JPH03157351A (ja) * | 1989-11-13 | 1991-07-05 | Tanabe Seiyaku Co Ltd | ナフタレン誘導体及びその製法 |
| ATE175954T1 (de) * | 1991-10-17 | 1999-02-15 | Shionogi & Co | Verfahren zum herstellen von lignin-analoga und ausgangsprodukte dafür |
-
1994
- 1994-04-12 DK DK94912092T patent/DK0646570T3/da active
- 1994-04-12 AT AT94912092T patent/ATE167662T1/de not_active IP Right Cessation
- 1994-04-12 EP EP94912092A patent/EP0646570B1/en not_active Expired - Lifetime
- 1994-04-12 WO PCT/JP1994/000612 patent/WO1994024087A1/ja not_active Ceased
- 1994-04-12 CN CN94190286A patent/CN1046937C/zh not_active Expired - Fee Related
- 1994-04-12 KR KR1019940704565A patent/KR100277242B1/ko not_active Expired - Fee Related
- 1994-04-12 JP JP52298294A patent/JP3411036B2/ja not_active Expired - Fee Related
- 1994-04-12 DE DE69411243T patent/DE69411243T2/de not_active Expired - Fee Related
- 1994-04-12 CA CA002138264A patent/CA2138264C/en not_active Expired - Fee Related
- 1994-04-12 ES ES94912092T patent/ES2119190T3/es not_active Expired - Lifetime
- 1994-04-12 US US08/356,199 patent/US5488134A/en not_active Expired - Fee Related
- 1994-04-12 AU AU64379/94A patent/AU666819B2/en not_active Ceased
- 1994-04-18 TW TW083103432A patent/TW255886B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69411243D1 (de) | 1998-07-30 |
| TW255886B (enExample) | 1995-09-01 |
| ATE167662T1 (de) | 1998-07-15 |
| KR100277242B1 (ko) | 2001-02-01 |
| DK0646570T3 (da) | 1998-10-26 |
| US5488134A (en) | 1996-01-30 |
| CN1109685A (zh) | 1995-10-04 |
| KR950701902A (ko) | 1995-05-17 |
| WO1994024087A1 (fr) | 1994-10-27 |
| EP0646570A1 (en) | 1995-04-05 |
| EP0646570A4 (en) | 1995-08-09 |
| AU666819B2 (en) | 1996-02-22 |
| CN1046937C (zh) | 1999-12-01 |
| CA2138264C (en) | 2004-04-06 |
| DE69411243T2 (de) | 1998-11-19 |
| JP3411036B2 (ja) | 2003-05-26 |
| CA2138264A1 (en) | 1994-10-27 |
| AU6437994A (en) | 1994-11-08 |
| EP0646570B1 (en) | 1998-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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