CN1046937C - 木酚素系化合物的制备方法 - Google Patents

木酚素系化合物的制备方法 Download PDF

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Publication number
CN1046937C
CN1046937C CN94190286A CN94190286A CN1046937C CN 1046937 C CN1046937 C CN 1046937C CN 94190286 A CN94190286 A CN 94190286A CN 94190286 A CN94190286 A CN 94190286A CN 1046937 C CN1046937 C CN 1046937C
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CN
China
Prior art keywords
compound
formula
reaction
synthesis
reference example
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN94190286A
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English (en)
Chinese (zh)
Other versions
CN1109685A (zh
Inventor
森幸雄
武智正三
木田士郎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
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Shionogi and Co Ltd
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Publication of CN1109685A publication Critical patent/CN1109685A/zh
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Publication of CN1046937C publication Critical patent/CN1046937C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
CN94190286A 1993-04-16 1994-04-12 木酚素系化合物的制备方法 Expired - Fee Related CN1046937C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8994493 1993-04-16
JP89944/93 1993-04-16

Publications (2)

Publication Number Publication Date
CN1109685A CN1109685A (zh) 1995-10-04
CN1046937C true CN1046937C (zh) 1999-12-01

Family

ID=13984820

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94190286A Expired - Fee Related CN1046937C (zh) 1993-04-16 1994-04-12 木酚素系化合物的制备方法

Country Status (13)

Country Link
US (1) US5488134A (enExample)
EP (1) EP0646570B1 (enExample)
JP (1) JP3411036B2 (enExample)
KR (1) KR100277242B1 (enExample)
CN (1) CN1046937C (enExample)
AT (1) ATE167662T1 (enExample)
AU (1) AU666819B2 (enExample)
CA (1) CA2138264C (enExample)
DE (1) DE69411243T2 (enExample)
DK (1) DK0646570T3 (enExample)
ES (1) ES2119190T3 (enExample)
TW (1) TW255886B (enExample)
WO (1) WO1994024087A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2121060C (en) * 1993-04-16 2004-04-06 Sachio Mori Preparation of lignan analogues
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
KR100376281B1 (ko) * 1995-12-26 2003-09-26 에스케이케미칼주식회사 리그난의 제조방법
TR200000808T2 (tr) 1997-09-29 2000-08-21 Meiji Seika Kaisha, Ltd. Triscyklik triyazolobenzazepin türevler, bunları üretme süreci ve anti alerjik.
CZ20012342A3 (cs) 1998-12-23 2001-12-12 G. D. Searle Llc Kombinace inhibitorů transportu ľlučové kyseliny v ileu a derivátů kyseliny fibrové pro kardiovaskulární indikace
CA2356422C (en) 1998-12-23 2008-09-16 G.D. Searle Llc Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
AU2157500A (en) 1998-12-23 2000-07-31 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
US6462091B1 (en) 1998-12-23 2002-10-08 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications
ATE242007T1 (de) 1998-12-23 2003-06-15 Searle Llc Kombinationen von cholesteryl ester transfer protein inhibitoren und nicotinsäure derivaten für kardiovaskuläre indikationen
ES2201827T3 (es) 1998-12-23 2004-03-16 G.D. Searle Llc Combinaciones de inhibidores de la proteina de transferencia de ester de colesterilo y de derivados de acido fibrico para indicaciones cardiovasculares.
HUP0104745A3 (en) 1998-12-23 2003-01-28 G D Searle Llc Chicago Combinations of ileal bile acid transport inhibitors and bile acid sequestring agents for cardiovascular indications
WO2001068096A2 (en) * 2000-03-10 2001-09-20 Pharmacia Corporation Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
WO2001068637A2 (en) 2000-03-10 2001-09-20 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
MXPA04003524A (es) 2001-11-02 2004-07-23 Searle Llc Compuestos de benzotiepina monofluorados y difluorados novedosos como inhibidores de transporte de acido biliar co-dependiente de sodio apical (asbt) y captacion de taurocolato.
AU2003207431A1 (en) 2002-01-17 2003-09-02 Pharmacia Corporation Novel alkyl/aryl hydroxy or keto thiepines.
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
EP2995317A1 (en) 2010-05-26 2016-03-16 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
US20140323412A1 (en) 2011-10-28 2014-10-30 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
DK2771003T3 (en) 2011-10-28 2017-07-17 Lumena Pharmaceuticals Llc Bile acid recycling inhibitors for the treatment of pediatric cholestatic liver disease
KR20160003664A (ko) 2013-03-15 2016-01-11 루메나 파마수티컬즈, 인코포레이티드 바렛 식도 및 위식도 역류 질환 치료용 담즙산 재순환 억제제
EP2968230A2 (en) 2013-03-15 2016-01-20 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease
KR20210137466A (ko) 2019-02-12 2021-11-17 미룸 파마슈티컬스, 인크. 담즙정체성 간 질환을 갖는 소아 대상체에서 성장을 증가시키는 방법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0372422A (ja) * 1989-05-16 1991-03-27 Tanabe Seiyaku Co Ltd 抗脂血剤
JPH03157351A (ja) * 1989-11-13 1991-07-05 Tanabe Seiyaku Co Ltd ナフタレン誘導体及びその製法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2839805B2 (ja) * 1991-10-17 1998-12-16 塩野義製薬株式会社 リグナン類縁体及びその製造方法ならびに抗高脂血症剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0372422A (ja) * 1989-05-16 1991-03-27 Tanabe Seiyaku Co Ltd 抗脂血剤
JPH03157351A (ja) * 1989-11-13 1991-07-05 Tanabe Seiyaku Co Ltd ナフタレン誘導体及びその製法

Also Published As

Publication number Publication date
ES2119190T3 (es) 1998-10-01
DE69411243D1 (de) 1998-07-30
KR950701902A (ko) 1995-05-17
EP0646570A1 (en) 1995-04-05
EP0646570B1 (en) 1998-06-24
JP3411036B2 (ja) 2003-05-26
ATE167662T1 (de) 1998-07-15
TW255886B (enExample) 1995-09-01
EP0646570A4 (en) 1995-08-09
AU6437994A (en) 1994-11-08
WO1994024087A1 (fr) 1994-10-27
CN1109685A (zh) 1995-10-04
KR100277242B1 (ko) 2001-02-01
CA2138264A1 (en) 1994-10-27
DK0646570T3 (da) 1998-10-26
US5488134A (en) 1996-01-30
DE69411243T2 (de) 1998-11-19
AU666819B2 (en) 1996-02-22
CA2138264C (en) 2004-04-06

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