CN1046937C - 木酚素系化合物的制备方法 - Google Patents

木酚素系化合物的制备方法 Download PDF

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Publication number
CN1046937C
CN1046937C CN94190286A CN94190286A CN1046937C CN 1046937 C CN1046937 C CN 1046937C CN 94190286 A CN94190286 A CN 94190286A CN 94190286 A CN94190286 A CN 94190286A CN 1046937 C CN1046937 C CN 1046937C
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China
Prior art keywords
compound
formula
reaction
synthesis
reference example
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Expired - Fee Related
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CN94190286A
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English (en)
Chinese (zh)
Other versions
CN1109685A (zh
Inventor
森幸雄
武智正三
木田士郎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
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Shionogi and Co Ltd
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Publication of CN1109685A publication Critical patent/CN1109685A/zh
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Publication of CN1046937C publication Critical patent/CN1046937C/zh
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
CN94190286A 1993-04-16 1994-04-12 木酚素系化合物的制备方法 Expired - Fee Related CN1046937C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP89944/93 1993-04-16
JP8994493 1993-04-16

Publications (2)

Publication Number Publication Date
CN1109685A CN1109685A (zh) 1995-10-04
CN1046937C true CN1046937C (zh) 1999-12-01

Family

ID=13984820

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94190286A Expired - Fee Related CN1046937C (zh) 1993-04-16 1994-04-12 木酚素系化合物的制备方法

Country Status (13)

Country Link
US (1) US5488134A (enExample)
EP (1) EP0646570B1 (enExample)
JP (1) JP3411036B2 (enExample)
KR (1) KR100277242B1 (enExample)
CN (1) CN1046937C (enExample)
AT (1) ATE167662T1 (enExample)
AU (1) AU666819B2 (enExample)
CA (1) CA2138264C (enExample)
DE (1) DE69411243T2 (enExample)
DK (1) DK0646570T3 (enExample)
ES (1) ES2119190T3 (enExample)
TW (1) TW255886B (enExample)
WO (1) WO1994024087A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2121060C (en) * 1993-04-16 2004-04-06 Sachio Mori Preparation of lignan analogues
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
KR100376281B1 (ko) * 1995-12-26 2003-09-26 에스케이케미칼주식회사 리그난의 제조방법
SK283869B6 (sk) 1997-09-29 2004-03-02 Meiji Seika Kaisha, Ltd. Tricyklické triazolobenzazepínové deriváty, spôsob ich prípravy a antialergické prostriedky
EP1342475A1 (en) 1998-12-23 2003-09-10 G.D. Searle LLC. Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
PT1140190E (pt) 1998-12-23 2003-02-28 Searle Llc Combinacoes de inibidores do transporte ileal dos acidos biliares e agentes sequestrantes dos acidos biliares usadas para problemas cardiovasculares
WO2000038722A1 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS
JP2002533408A (ja) 1998-12-23 2002-10-08 ジー．ディー．サール エルエルシー 心臓血管に適用するためのコレステリルエステル転送タンパク質阻害剤およびニコチン酸誘導体の組み合わせ
DE69908645T2 (de) 1998-12-23 2004-05-13 G.D. Searle Llc, Chicago Kombinationen von cholesteryl ester transfer protein inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen
EP1140185B1 (en) 1998-12-23 2003-06-04 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
JP2002533413A (ja) 1998-12-23 2002-10-08 ジー．ディー．サール エルエルシー 心臓血管に適用するための回腸胆汁酸輸送阻害剤およびフィブリン酸誘導体の組み合わせ
US6794544B2 (en) 2000-03-10 2004-09-21 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
WO2001068096A2 (en) * 2000-03-10 2001-09-20 Pharmacia Corporation Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
MXPA04003524A (es) 2001-11-02 2004-07-23 Searle Llc Compuestos de benzotiepina monofluorados y difluorados novedosos como inhibidores de transporte de acido biliar co-dependiente de sodio apical (asbt) y captacion de taurocolato.
BR0306643A (pt) 2002-01-17 2004-10-19 Pharmacia Corp Novos compostos de hidroxi alquil/aril ou ceto tiepina como inibidores do transporte co-dependente de ácido biliar-sódio apical
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
EP2575821B1 (en) 2010-05-26 2015-08-12 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
MX369466B (es) 2011-10-28 2019-11-08 Lumena Pharmaceuticals Inc Inhibidores de la recirculación de ácidos biliares para el tratamiento de enfermedades hepáticas colestásicas pediátricas.
JP6217939B2 (ja) 2011-10-28 2017-10-25 ルメナ ファーマシューティカルズ エルエルシー 高胆汁血症および胆汁うっ滞性肝疾患の処置のための胆汁酸再利用阻害剤
EP2968262A1 (en) 2013-03-15 2016-01-20 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease
RU2015139731A (ru) 2013-03-15 2017-04-20 ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи Ингибиторы рециркуляции желчных кислот для лечения первичного склерозирующего холангита и воспалительного заболевания кишечника
MX2021009622A (es) 2019-02-12 2021-11-04 Mirum Pharmaceuticals Inc Metodos para tratar la colestasis.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0372422A (ja) * 1989-05-16 1991-03-27 Tanabe Seiyaku Co Ltd 抗脂血剤
JPH03157351A (ja) * 1989-11-13 1991-07-05 Tanabe Seiyaku Co Ltd ナフタレン誘導体及びその製法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE175954T1 (de) * 1991-10-17 1999-02-15 Shionogi & Co Verfahren zum herstellen von lignin-analoga und ausgangsprodukte dafür

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0372422A (ja) * 1989-05-16 1991-03-27 Tanabe Seiyaku Co Ltd 抗脂血剤
JPH03157351A (ja) * 1989-11-13 1991-07-05 Tanabe Seiyaku Co Ltd ナフタレン誘導体及びその製法

Also Published As

Publication number Publication date
DE69411243D1 (de) 1998-07-30
TW255886B (enExample) 1995-09-01
ATE167662T1 (de) 1998-07-15
KR100277242B1 (ko) 2001-02-01
DK0646570T3 (da) 1998-10-26
US5488134A (en) 1996-01-30
CN1109685A (zh) 1995-10-04
KR950701902A (ko) 1995-05-17
WO1994024087A1 (fr) 1994-10-27
EP0646570A1 (en) 1995-04-05
EP0646570A4 (en) 1995-08-09
AU666819B2 (en) 1996-02-22
ES2119190T3 (es) 1998-10-01
CA2138264C (en) 2004-04-06
DE69411243T2 (de) 1998-11-19
JP3411036B2 (ja) 2003-05-26
CA2138264A1 (en) 1994-10-27
AU6437994A (en) 1994-11-08
EP0646570B1 (en) 1998-06-24

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