ATE139990T1 - Lignan-analoge, ihre herstellung und hypolipidemische arzneimittel - Google Patents
Lignan-analoge, ihre herstellung und hypolipidemische arzneimittelInfo
- Publication number
- ATE139990T1 ATE139990T1 AT92921331T AT92921331T ATE139990T1 AT E139990 T1 ATE139990 T1 AT E139990T1 AT 92921331 T AT92921331 T AT 92921331T AT 92921331 T AT92921331 T AT 92921331T AT E139990 T1 ATE139990 T1 AT E139990T1
- Authority
- AT
- Austria
- Prior art keywords
- lower alkyl
- chem
- formula
- ring
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/22—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one naphthalene or hydrogenated naphthalene ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Furan Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29811991 | 1991-10-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE139990T1 true ATE139990T1 (de) | 1996-07-15 |
Family
ID=17855421
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92921331T ATE139990T1 (de) | 1991-10-17 | 1992-10-15 | Lignan-analoge, ihre herstellung und hypolipidemische arzneimittel |
| AT95117572T ATE175954T1 (de) | 1991-10-17 | 1992-10-15 | Verfahren zum herstellen von lignin-analoga und ausgangsprodukte dafür |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95117572T ATE175954T1 (de) | 1991-10-17 | 1992-10-15 | Verfahren zum herstellen von lignin-analoga und ausgangsprodukte dafür |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US5420333A (de) |
| EP (2) | EP0597107B1 (de) |
| JP (1) | JP2839805B2 (de) |
| KR (1) | KR100252428B1 (de) |
| AT (2) | ATE139990T1 (de) |
| DE (2) | DE69211994T2 (de) |
| DK (2) | DK0597107T3 (de) |
| ES (2) | ES2129733T3 (de) |
| GR (1) | GR3020461T3 (de) |
| HU (1) | HU211296A9 (de) |
| TW (1) | TW209215B (de) |
| WO (1) | WO1993008155A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994024087A1 (en) * | 1993-04-16 | 1994-10-27 | Shionogi & Co., Ltd. | Process for producing lignan compound |
| FR2707980B1 (fr) * | 1993-07-20 | 1995-09-01 | Adir | Nouveaux cyclohept[b]indoles et cyclooct[b]indoles, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| WO1995035291A1 (fr) * | 1994-06-22 | 1995-12-28 | Shionogi & Co., Ltd. | Procede de production d'un compose de phtalide |
| ID18046A (id) * | 1996-08-20 | 1998-02-19 | Takeda Chemical Industries Ltd | Senyawa siklik campuran, pembuatan dan penngunaannya. |
| JP2002529409A (ja) * | 1998-11-12 | 2002-09-10 | アルテオン インコーポレーテッド | グルコース及び脂質低下化合物類 |
| KR100352269B1 (ko) * | 1999-10-08 | 2002-09-12 | 한국생명공학연구원 | 저밀도 지질 단백질에 대해 항산화 활성을 갖는 리그난계 화합물 |
| FR2800738B1 (fr) | 1999-11-04 | 2002-02-08 | Corning Sa | Naphtopyranes ayant un substituant perfluoroalkyle en position 5, preparation et compositions et matrices (co)polymeres les renfermant |
| US6770024B1 (en) * | 2000-03-28 | 2004-08-03 | Stony Brook Surgical Innovations, Inc. | Implantable counterpulsation cardiac assist device |
| TWI241195B (en) * | 2000-04-10 | 2005-10-11 | Shionogi & Co | Preventive agent for bile acidic diarrhea |
| AU2002224596A1 (en) * | 2000-08-01 | 2002-02-13 | Shionogi And Co., Ltd. | Preventives or remedies for obesity or fatty liver |
| AU2003271115A1 (en) * | 2002-10-08 | 2004-05-04 | Shionogi And Co., Ltd. | Process for producing enone ester |
| US7152611B2 (en) * | 2002-12-30 | 2006-12-26 | International Tape Partners, Llc | Coated multifilament dental devices overcoated with imbedded particulate |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| EP3593802A3 (de) | 2010-05-26 | 2020-03-25 | Satiogen Pharmaceuticals, Inc. | Gallensäurerückflusshemmer zur behandlung von diabetes, adipositas und entzündlichen magen-darm-erkrankungen |
| BR112014010228B1 (pt) | 2011-10-28 | 2020-09-29 | Lumena Pharmaceuticals Llc | Uso de inibidores de reciclagem de ácido biliar para o tratamento de hipercolemia e doença hepática colestática |
| PL2771003T3 (pl) | 2011-10-28 | 2017-10-31 | Lumena Pharmaceuticals Llc | Inhibitory ponownego wykorzystania kwasów żółciowych do leczenia pediatrycznych cholestatycznych chorób wątroby |
| BR112015023646A2 (pt) | 2013-03-15 | 2017-07-18 | Lumena Pharmaceuticals Inc | inibidores de ácidos biliares de reciclagem para tratamento de colangite esclerosante primária e doença inflamatória do intestino |
| RU2015139732A (ru) | 2013-03-15 | 2017-04-24 | ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи | Ингибиторы рециркуляции желчных кислот для лечения пищевода барретта и гастроэзофагеальной рефлюксной болезни |
| AU2020221834A1 (en) | 2019-02-12 | 2021-09-02 | Mirum Pharmaceuticals, Inc. | Genotype and dose-dependent response to an ASBTI in patients with bile salt export pump deficiency |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO170760C (no) * | 1985-01-10 | 1992-12-02 | Tanabe Seiyaku Co | Analogifremgangsmaate for fremstilling av terapeutisk aktive nafthalenderivater |
| JPS6310746A (ja) * | 1986-07-01 | 1988-01-18 | Tanabe Seiyaku Co Ltd | ナフタレン誘導体 |
| JPH0372422A (ja) * | 1989-05-16 | 1991-03-27 | Tanabe Seiyaku Co Ltd | 抗脂血剤 |
-
1992
- 1992-10-15 JP JP4277151A patent/JP2839805B2/ja not_active Expired - Fee Related
- 1992-10-15 ES ES95117572T patent/ES2129733T3/es not_active Expired - Lifetime
- 1992-10-15 US US08/078,205 patent/US5420333A/en not_active Expired - Lifetime
- 1992-10-15 EP EP92921331A patent/EP0597107B1/de not_active Expired - Lifetime
- 1992-10-15 DE DE69211994T patent/DE69211994T2/de not_active Expired - Fee Related
- 1992-10-15 DK DK92921331.2T patent/DK0597107T3/da active
- 1992-10-15 KR KR1019930701814A patent/KR100252428B1/ko not_active IP Right Cessation
- 1992-10-15 ES ES92921331T patent/ES2091488T3/es not_active Expired - Lifetime
- 1992-10-15 DE DE69228262T patent/DE69228262D1/de not_active Expired - Fee Related
- 1992-10-15 AT AT92921331T patent/ATE139990T1/de not_active IP Right Cessation
- 1992-10-15 EP EP95117572A patent/EP0701991B1/de not_active Expired - Lifetime
- 1992-10-15 AT AT95117572T patent/ATE175954T1/de not_active IP Right Cessation
- 1992-10-15 DK DK95117572T patent/DK0701991T3/da active
- 1992-10-15 WO PCT/JP1992/001342 patent/WO1993008155A1/ja active IP Right Grant
- 1992-10-17 TW TW081108267A patent/TW209215B/zh active
-
1994
- 1994-09-07 US US08/301,996 patent/US5449814A/en not_active Expired - Lifetime
-
1995
- 1995-04-18 US US08/423,346 patent/US5731455A/en not_active Expired - Fee Related
- 1995-05-22 US US08/445,506 patent/US5502216A/en not_active Expired - Fee Related
- 1995-06-30 HU HU95P/P00635P patent/HU211296A9/hu unknown
-
1996
- 1996-07-04 GR GR960401618T patent/GR3020461T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5449814A (en) | 1995-09-12 |
| KR930703236A (ko) | 1993-11-29 |
| DK0597107T3 (da) | 1996-07-29 |
| ES2129733T3 (es) | 1999-06-16 |
| ATE175954T1 (de) | 1999-02-15 |
| EP0597107A1 (de) | 1994-05-18 |
| EP0701991B1 (de) | 1999-01-20 |
| EP0701991A1 (de) | 1996-03-20 |
| DK0701991T3 (da) | 1999-09-13 |
| KR100252428B1 (ko) | 2000-04-15 |
| TW209215B (de) | 1993-07-11 |
| US5502216A (en) | 1996-03-26 |
| DE69211994T2 (de) | 1997-02-20 |
| JPH05310634A (ja) | 1993-11-22 |
| DE69228262D1 (de) | 1999-03-04 |
| WO1993008155A1 (en) | 1993-04-29 |
| JP2839805B2 (ja) | 1998-12-16 |
| DE69211994D1 (de) | 1996-08-08 |
| GR3020461T3 (en) | 1996-10-31 |
| US5420333A (en) | 1995-05-30 |
| US5731455A (en) | 1998-03-24 |
| ES2091488T3 (es) | 1996-11-01 |
| HU211296A9 (en) | 1995-11-28 |
| EP0597107B1 (de) | 1996-07-03 |
| EP0597107A4 (de) | 1994-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |