MX9800041A - Procedimiento mejorado para sintetizar intermediarios de carbapenem. - Google Patents
Procedimiento mejorado para sintetizar intermediarios de carbapenem.Info
- Publication number
- MX9800041A MX9800041A MX9800041A MX9800041A MX9800041A MX 9800041 A MX9800041 A MX 9800041A MX 9800041 A MX9800041 A MX 9800041A MX 9800041 A MX9800041 A MX 9800041A MX 9800041 A MX9800041 A MX 9800041A
- Authority
- MX
- Mexico
- Prior art keywords
- improved process
- synthesizing
- carbapenem intermediates
- synthesizing carbapenem
- intermediates
- Prior art date
Links
- 230000002194 synthesizing effect Effects 0.000 title abstract 2
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- -1 triethylsilyl Chemical group 0.000 abstract 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se describe un procedimiento para sintetizar un compuesto de la formula (1) o (2), en donde R representa H o metilo y P representa trietilsililo o trimetilsililo; se hace reaccionar un compuesto del a formula (3) o (4), con P-CI en donde P es tal como se definio más arriba, en presencia de una base y de un solvente sustancialmente no reactivo, para producir (1) o (2). (ver formulas).
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58595P | 1995-06-28 | 1995-06-28 | |
US000585 | 1995-06-28 | ||
GBGB9602921.0A GB9602921D0 (en) | 1996-02-13 | 1996-02-13 | Improved process for synthesizing carbapenem intermediates |
GB9602921.0 | 1996-02-13 | ||
PCT/US1996/010783 WO1997001564A1 (en) | 1995-06-28 | 1996-06-24 | Improved process for synthesizing carbapenem intermediates |
Publications (2)
Publication Number | Publication Date |
---|---|
MX9800041A true MX9800041A (es) | 1998-08-30 |
MXPA98000041A MXPA98000041A (es) | 1998-11-12 |
Family
ID=
Also Published As
Publication number | Publication date |
---|---|
CN1193322A (zh) | 1998-09-16 |
BR9609338A (pt) | 1999-05-11 |
HUP9903016A3 (en) | 2000-04-28 |
AR002507A1 (es) | 1998-03-25 |
JPH11513979A (ja) | 1999-11-30 |
AU6392196A (en) | 1997-01-30 |
SK176597A3 (en) | 1998-07-08 |
CZ419097A3 (cs) | 1998-07-15 |
EA199800096A1 (ru) | 1998-08-27 |
EP0836607A1 (en) | 1998-04-22 |
WO1997001564A1 (en) | 1997-01-16 |
AU696543B2 (en) | 1998-09-10 |
CA2224439A1 (en) | 1997-01-16 |
HUP9903016A2 (hu) | 2000-03-28 |
KR19990028406A (ko) | 1999-04-15 |
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