KR100261528B1 - 신규한9-아미노-7-(치환아미노)-6-데메틸-6-데옥시테트라사이클린 및 그의 생성 방법 - Google Patents

신규한9-아미노-7-(치환아미노)-6-데메틸-6-데옥시테트라사이클린 및 그의 생성 방법 Download PDF

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Publication number
KR100261528B1
KR100261528B1 KR1019920018123A KR920018123A KR100261528B1 KR 100261528 B1 KR100261528 B1 KR 100261528B1 KR 1019920018123 A KR1019920018123 A KR 1019920018123A KR 920018123 A KR920018123 A KR 920018123A KR 100261528 B1 KR100261528 B1 KR 100261528B1
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KR
South Korea
Prior art keywords
methylpropyl
ethyl
dimethylamino
alkyl
dioxo
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1019920018123A
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English (en)
Korean (ko)
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KR930007895A (ko
Inventor
조오지프제이라브카
파이크-엥섬
야코브글루즈만
빙제이리이
Original Assignee
윌리암 에이취 캘넌, 에곤 이 버그
아메리칸사이아나미드컴파니
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Publication of KR930007895A publication Critical patent/KR930007895A/ko
Application granted granted Critical
Publication of KR100261528B1 publication Critical patent/KR100261528B1/ko
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Spinning Or Twisting Of Yarns (AREA)
  • Moulding By Coating Moulds (AREA)
  • Tires In General (AREA)
KR1019920018123A 1991-10-04 1992-10-02 신규한9-아미노-7-(치환아미노)-6-데메틸-6-데옥시테트라사이클린 및 그의 생성 방법 Expired - Fee Related KR100261528B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/771,697 US5281628A (en) 1991-10-04 1991-10-04 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
US07/771,697 1991-10-04

Publications (2)

Publication Number Publication Date
KR930007895A KR930007895A (ko) 1993-05-20
KR100261528B1 true KR100261528B1 (ko) 2000-07-15

Family

ID=25092681

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920018123A Expired - Fee Related KR100261528B1 (ko) 1991-10-04 1992-10-02 신규한9-아미노-7-(치환아미노)-6-데메틸-6-데옥시테트라사이클린 및 그의 생성 방법

Country Status (25)

Country Link
US (3) US5281628A (enExample)
EP (1) EP0535346B1 (enExample)
JP (1) JP3183729B2 (enExample)
KR (1) KR100261528B1 (enExample)
CN (1) CN1053182C (enExample)
AT (1) ATE129697T1 (enExample)
AU (1) AU651734B2 (enExample)
CA (1) CA2079703C (enExample)
CZ (1) CZ285015B6 (enExample)
DE (1) DE69205792T2 (enExample)
DK (1) DK0535346T3 (enExample)
ES (1) ES2081005T3 (enExample)
FI (1) FI111716B (enExample)
GR (1) GR3017978T3 (enExample)
HK (1) HK1000319A1 (enExample)
HU (2) HU211214B (enExample)
IL (1) IL103319A (enExample)
MX (1) MX9205573A (enExample)
NO (1) NO300129B1 (enExample)
NZ (1) NZ244556A (enExample)
PH (1) PH30343A (enExample)
PL (2) PL170939B1 (enExample)
SK (1) SK281113B6 (enExample)
TW (1) TW222616B (enExample)
ZA (1) ZA927608B (enExample)

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USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
ES2224098T3 (es) * 1992-05-28 2005-03-01 Centre For Molecular Biology And Medicine, Derivados de quinona para aumentar la bioenergia celular.
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5371076A (en) * 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
MX9603508A (es) * 1994-02-17 1997-03-29 Pfizer Analogos de la doxiciclina.
JP2002501026A (ja) * 1998-01-23 2002-01-15 トルスティーズ オブ トゥフツ カレッジ 薬学的に活性の化合物及びその利用法
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
EP1666454B1 (en) * 1999-09-14 2011-09-07 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6686365B2 (en) * 2000-02-04 2004-02-03 Eli Lilly And Company Pharmaceutical composition
AU2001268475A1 (en) * 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
KR101027625B1 (ko) * 2000-07-07 2011-04-06 파라테크 파마슈티컬스, 인크. 7-치환 테트라사이클린 화합물
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
DK1679305T3 (da) * 2000-07-07 2012-05-29 Tufts College 9-substituerede minocyclinforbindelser
WO2002072532A1 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7, 9-substituted tetracycline compounds
AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP1241160A1 (en) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
EP2332547A1 (en) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Tetracyclines for the treatment of inflammatory bowel disease
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US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
EP2311796A1 (en) 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
WO2003075857A2 (en) * 2002-03-08 2003-09-18 Paratek Pharmaceuticals, Inc. Amino-methyl substituted tetracycline compounds
EA200401232A1 (ru) 2002-03-21 2005-12-29 Пэрэтек Фамэсьютикэлс, Инк. Замещенные соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
KR101089429B1 (ko) 2002-07-12 2011-12-07 파라테크 파마슈티컬스, 인크. 3, 10, 및 12ａ 치환된 테트라시클린 화합물
AU2003300379A1 (en) * 2002-12-27 2004-07-29 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collagen and MMPI
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
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AU2006210406C1 (en) 2005-02-04 2013-03-07 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057034A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
CA2616224A1 (en) * 2005-07-21 2007-02-01 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
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AU2006331688A1 (en) * 2005-12-22 2007-07-05 Wyeth Oral formulations comprising tigecycline
US20070244335A1 (en) * 2006-04-17 2007-10-18 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
SI2016045T1 (sl) * 2006-04-24 2015-03-31 Teva Pharmaceutical Industries, Ltd. 5 Basel Street Kristalinična oblika tigeciklina in postopek za njegovo pripravo
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Also Published As

Publication number Publication date
CZ285015B6 (cs) 1999-05-12
US5401863A (en) 1995-03-28
ATE129697T1 (de) 1995-11-15
DK0535346T3 (da) 1995-12-04
PL170933B1 (pl) 1997-02-28
NO923856L (no) 1993-04-05
DE69205792D1 (de) 1995-12-07
CN1053182C (zh) 2000-06-07
HUT64298A (en) 1993-12-28
JP3183729B2 (ja) 2001-07-09
PL296140A1 (en) 1993-11-02
TW222616B (enExample) 1994-04-21
JPH05239006A (ja) 1993-09-17
HU211214B (en) 1995-11-28
DE69205792T2 (de) 1996-06-20
NO300129B1 (no) 1997-04-14
KR930007895A (ko) 1993-05-20
HU9203143D0 (en) 1992-12-28
EP0535346A1 (en) 1993-04-07
GR3017978T3 (en) 1996-02-29
FI924453A0 (fi) 1992-10-02
AU651734B2 (en) 1994-07-28
CA2079703A1 (en) 1993-04-05
SK297292A3 (en) 1994-12-07
IL103319A0 (en) 1993-03-15
CZ297292A3 (en) 1993-04-14
PH30343A (en) 1997-04-02
NO923856D0 (no) 1992-10-02
FI924453L (fi) 1993-04-05
CA2079703C (en) 2004-07-20
AU2618292A (en) 1993-04-08
US5281628A (en) 1994-01-25
PL170939B1 (pl) 1997-02-28
US5326759A (en) 1994-07-05
CN1071415A (zh) 1993-04-28
EP0535346B1 (en) 1995-11-02
HU211922A9 (en) 1996-01-29
ES2081005T3 (es) 1996-02-16
FI111716B (fi) 2003-09-15
IL103319A (en) 1996-07-23
HK1000319A1 (en) 1998-02-27
ZA927608B (en) 1993-04-13
SK281113B6 (sk) 2000-12-11
MX9205573A (es) 1993-05-01
NZ244556A (en) 1994-06-27

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St.27 status event code: A-5-5-R10-R18-oth-X000