KR100240385B1 - 재조합 bpi 단백질, bpi 단백질의 용도 및 그의 제조방법 - Google Patents

재조합 bpi 단백질, bpi 단백질의 용도 및 그의 제조방법 Download PDF

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Publication number
KR100240385B1
KR100240385B1 KR1019930700379A KR930700379A KR100240385B1 KR 100240385 B1 KR100240385 B1 KR 100240385B1 KR 1019930700379 A KR1019930700379 A KR 1019930700379A KR 930700379 A KR930700379 A KR 930700379A KR 100240385 B1 KR100240385 B1 KR 100240385B1
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South Korea
Prior art keywords
bpi
endotoxin
bpi protein
sample
protein
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Expired - Fee Related
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KR1019930700379A
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English (en)
Korean (ko)
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KR930701597A (ko
Inventor
엔. 마라 마리안
더블유. 스콧트 란달
Original Assignee
란달러블유. 스콧트
인사이트 파마슈티칼스 인크
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Publication of KR930701597A publication Critical patent/KR930701597A/ko
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Publication of KR100240385B1 publication Critical patent/KR100240385B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4742—Bactericidal/Permeability-increasing protein [BPI]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
    • F02B—INTERNAL-COMBUSTION PISTON ENGINES; COMBUSTION ENGINES IN GENERAL
    • F02B75/00—Other engines
    • F02B75/02—Engines characterised by their cycles, e.g. six-stroke
    • F02B2075/022—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle
    • F02B2075/027—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle four

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
KR1019930700379A 1990-08-13 1991-08-13 재조합 bpi 단백질, bpi 단백질의 용도 및 그의 제조방법 Expired - Fee Related KR100240385B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US56701690A 1990-08-13 1990-08-13
US567,016 1990-08-13
US07/681,551 US5171739A (en) 1989-02-14 1991-04-05 Treatment of endotoxin-associated shock and preventation thereof using a BPI protein
US681,551 1991-04-05
PCT/US1991/005758 WO1992003535A1 (en) 1990-08-13 1991-08-13 Recombinant bpi proteins, uses of bpi proteins, and methods of preparing same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019997002675A Division KR100274424B1 (ko) 1990-08-13 1991-08-13 생물학적 유체 시료중의 bpi 단백질의 존재 또는 양을 결정하기 위한 키트

Publications (2)

Publication Number Publication Date
KR930701597A KR930701597A (ko) 1993-06-12
KR100240385B1 true KR100240385B1 (ko) 2000-02-01

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ID=27074338

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019930700379A Expired - Fee Related KR100240385B1 (ko) 1990-08-13 1991-08-13 재조합 bpi 단백질, bpi 단백질의 용도 및 그의 제조방법
KR1019997002675A Expired - Fee Related KR100274424B1 (ko) 1990-08-13 1991-08-13 생물학적 유체 시료중의 bpi 단백질의 존재 또는 양을 결정하기 위한 키트

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019997002675A Expired - Fee Related KR100274424B1 (ko) 1990-08-13 1991-08-13 생물학적 유체 시료중의 bpi 단백질의 존재 또는 양을 결정하기 위한 키트

Country Status (7)

Country Link
US (1) US5171739A (enExample)
EP (2) EP0544832A1 (enExample)
JP (3) JPH06504267A (enExample)
KR (2) KR100240385B1 (enExample)
AU (1) AU660427B2 (enExample)
CA (1) CA2088496A1 (enExample)
WO (1) WO1992003535A1 (enExample)

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Also Published As

Publication number Publication date
EP1088890A3 (en) 2001-07-25
EP0544832A4 (enExample) 1994-04-27
KR100274424B1 (ko) 2000-11-15
JP2004148104A (ja) 2004-05-27
EP1088890A2 (en) 2001-04-04
AU8850191A (en) 1992-03-17
AU660427B2 (en) 1995-06-29
US5171739A (en) 1992-12-15
JP2003028873A (ja) 2003-01-29
JPH06504267A (ja) 1994-05-19
EP0544832A1 (en) 1993-06-09
JP3493022B2 (ja) 2004-02-03
WO1992003535A1 (en) 1992-03-05
CA2088496A1 (en) 1992-02-14
KR930701597A (ko) 1993-06-12

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