KR0175674B1 - 아미노알킬피롤리디닐티오카르바페넴 유도체 - Google Patents

아미노알킬피롤리디닐티오카르바페넴 유도체 Download PDF

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Publication number
KR0175674B1
KR0175674B1 KR1019930702228A KR930702228A KR0175674B1 KR 0175674 B1 KR0175674 B1 KR 0175674B1 KR 1019930702228 A KR1019930702228 A KR 1019930702228A KR 930702228 A KR930702228 A KR 930702228A KR 0175674 B1 KR0175674 B1 KR 0175674B1
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KR
South Korea
Prior art keywords
group
pyrrolidine
carbafen
ylthio
methyl
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Expired - Fee Related
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KR1019930702228A
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English (en)
Korean (ko)
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KR930703322A (ko
Inventor
스스무 나까가와
신지 가또
사또시 무라세
오사무 오까모또
류지 미또모
가쓰미 야마모또
고지 야마다
히로시 후까쓰
Original Assignee
도야마 노리유끼
반유세이야꾸 가부시끼가이샤
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Publication of KR930703322A publication Critical patent/KR930703322A/ko
Application granted granted Critical
Publication of KR0175674B1 publication Critical patent/KR0175674B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • External Artificial Organs (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Hydrogenated Pyridines (AREA)
KR1019930702228A 1991-11-27 1992-11-26 아미노알킬피롤리디닐티오카르바페넴 유도체 Expired - Fee Related KR0175674B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP33588891 1991-11-27
JP91-335888 1991-11-27
JP92-215613 1992-07-21
JP21561392 1992-07-21
PCT/JP1992/001544 WO1993011128A1 (en) 1991-11-27 1992-11-26 Aminoalkylpyrrolidinylthiocarbapenem derivatives

Publications (2)

Publication Number Publication Date
KR930703322A KR930703322A (ko) 1993-11-29
KR0175674B1 true KR0175674B1 (ko) 1999-03-20

Family

ID=26520964

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930702228A Expired - Fee Related KR0175674B1 (ko) 1991-11-27 1992-11-26 아미노알킬피롤리디닐티오카르바페넴 유도체

Country Status (18)

Country Link
US (1) US5550121A (https=)
EP (1) EP0545290B1 (https=)
KR (1) KR0175674B1 (https=)
CN (1) CN1032061C (https=)
AT (1) ATE195736T1 (https=)
AU (2) AU651505B2 (https=)
BG (1) BG97965A (https=)
CA (1) CA2083980C (https=)
CZ (1) CZ150193A3 (https=)
DE (1) DE69231375T2 (https=)
FI (1) FI933346A7 (https=)
HU (2) HUT64345A (https=)
IL (1) IL103807A0 (https=)
MX (1) MX9206838A (https=)
PL (1) PL300122A1 (https=)
TW (1) TW209220B (https=)
WO (1) WO1993011128A1 (https=)
YU (1) YU100792A (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5317016A (en) * 1991-08-20 1994-05-31 Shionogi Seiyaku Kabushiki Kaisha Pyrrolidylthiocarbapenem derivative
JP3848693B2 (ja) * 1994-07-06 2006-11-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 新規カルバペネム誘導体
US7041660B2 (en) 1999-07-06 2006-05-09 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives
TWI250160B (en) 1999-07-06 2006-03-01 Sankyo Co Crystalline 1-methylcarbapenem compound
TW200815442A (en) * 2006-04-28 2008-04-01 Kaneka Corp Improved method for the crystallization of intermediates of carbapenem antibiotics

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1281720C (en) * 1984-11-08 1991-03-19 Makoto Sunagawa Carbapenem compounds and production thereof
FI81576C (fi) * 1984-12-25 1990-11-12 Sankyo Co Foerfarande foer framstaellning av derivat av 6-(1-hydroxietyl)-2-(1,2-disubstituerade-4-pyrrolidinyltio)-2- karbapenem-3-karboxylsyra, vilka aer anvaendbara som laekemedel.
EP0243686B1 (en) * 1986-03-27 1992-07-15 Sumitomo Pharmaceuticals Company, Limited Beta-lactam compounds, and their production
DE69013131T2 (de) * 1989-12-29 1995-05-24 Banyu Pharma Co Ltd 2-(2-Cyclopropylpyrrolidin-4-ylthio)carbapenemderivate.
JPH05255332A (ja) * 1991-11-27 1993-10-05 Banyu Pharmaceut Co Ltd アルキルアミノアルキルピロリジニルチオカルバペネム誘導体

Also Published As

Publication number Publication date
BG97965A (bg) 1994-05-27
AU2963292A (en) 1993-06-03
CZ150193A3 (en) 1994-03-16
CA2083980C (en) 2003-04-29
FI933346A0 (fi) 1993-07-26
PL300122A1 (en) 1994-04-18
CA2083980A1 (en) 1993-05-28
EP0545290B1 (en) 2000-08-23
HU210817A9 (en) 1995-08-28
WO1993011128A1 (en) 1993-06-10
CN1073176A (zh) 1993-06-16
AU651505B2 (en) 1994-07-21
FI933346A7 (fi) 1993-07-26
MX9206838A (es) 1993-05-31
HUT64345A (en) 1993-12-28
DE69231375D1 (de) 2000-09-28
IL103807A0 (en) 1993-04-04
US5550121A (en) 1996-08-27
YU100792A (sh) 1995-10-24
TW209220B (https=) 1993-07-11
HU9302170D0 (en) 1993-10-28
AU667786B2 (en) 1996-04-04
EP0545290A1 (en) 1993-06-09
CN1032061C (zh) 1996-06-19
KR930703322A (ko) 1993-11-29
DE69231375T2 (de) 2001-03-01
ATE195736T1 (de) 2000-09-15
AU7589494A (en) 1995-01-27

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