AU651505B2 - Aminoalkylpyrrolidinylthiocarbapenem derivatives - Google Patents

Aminoalkylpyrrolidinylthiocarbapenem derivatives Download PDF

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Publication number
AU651505B2
AU651505B2 AU29632/92A AU2963292A AU651505B2 AU 651505 B2 AU651505 B2 AU 651505B2 AU 29632/92 A AU29632/92 A AU 29632/92A AU 2963292 A AU2963292 A AU 2963292A AU 651505 B2 AU651505 B2 AU 651505B2
Authority
AU
Australia
Prior art keywords
group
carbapen
carboxylic acid
hydrogen atom
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU29632/92A
Other languages
English (en)
Other versions
AU2963292A (en
Inventor
Hiroshi Fukatsu
Shinji Kato
Ryuji Mitomo
Satoshi Murase
Susumu Nakagawa
Osamu Okamoto
Koji Yamada
Katsumi Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Publication of AU2963292A publication Critical patent/AU2963292A/en
Application granted granted Critical
Publication of AU651505B2 publication Critical patent/AU651505B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • External Artificial Organs (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Hydrogenated Pyridines (AREA)
AU29632/92A 1991-11-27 1992-11-25 Aminoalkylpyrrolidinylthiocarbapenem derivatives Ceased AU651505B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP33588891 1991-11-27
JP3-335888 1991-11-27
JP4-215613 1992-07-21
JP21561392 1992-07-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU75894/94A Division AU667786B2 (en) 1991-11-27 1994-10-18 Pyrrolidine derivatives

Publications (2)

Publication Number Publication Date
AU2963292A AU2963292A (en) 1993-06-03
AU651505B2 true AU651505B2 (en) 1994-07-21

Family

ID=26520964

Family Applications (2)

Application Number Title Priority Date Filing Date
AU29632/92A Ceased AU651505B2 (en) 1991-11-27 1992-11-25 Aminoalkylpyrrolidinylthiocarbapenem derivatives
AU75894/94A Ceased AU667786B2 (en) 1991-11-27 1994-10-18 Pyrrolidine derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU75894/94A Ceased AU667786B2 (en) 1991-11-27 1994-10-18 Pyrrolidine derivatives

Country Status (18)

Country Link
US (1) US5550121A (https=)
EP (1) EP0545290B1 (https=)
KR (1) KR0175674B1 (https=)
CN (1) CN1032061C (https=)
AT (1) ATE195736T1 (https=)
AU (2) AU651505B2 (https=)
BG (1) BG97965A (https=)
CA (1) CA2083980C (https=)
CZ (1) CZ150193A3 (https=)
DE (1) DE69231375T2 (https=)
FI (1) FI933346A7 (https=)
HU (2) HUT64345A (https=)
IL (1) IL103807A0 (https=)
MX (1) MX9206838A (https=)
PL (1) PL300122A1 (https=)
TW (1) TW209220B (https=)
WO (1) WO1993011128A1 (https=)
YU (1) YU100792A (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5317016A (en) * 1991-08-20 1994-05-31 Shionogi Seiyaku Kabushiki Kaisha Pyrrolidylthiocarbapenem derivative
JP3848693B2 (ja) * 1994-07-06 2006-11-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 新規カルバペネム誘導体
US7041660B2 (en) 1999-07-06 2006-05-09 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives
TWI250160B (en) 1999-07-06 2006-03-01 Sankyo Co Crystalline 1-methylcarbapenem compound
TW200815442A (en) * 2006-04-28 2008-04-01 Kaneka Corp Improved method for the crystallization of intermediates of carbapenem antibiotics

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1281720C (en) * 1984-11-08 1991-03-19 Makoto Sunagawa Carbapenem compounds and production thereof
FI81576C (fi) * 1984-12-25 1990-11-12 Sankyo Co Foerfarande foer framstaellning av derivat av 6-(1-hydroxietyl)-2-(1,2-disubstituerade-4-pyrrolidinyltio)-2- karbapenem-3-karboxylsyra, vilka aer anvaendbara som laekemedel.
EP0243686B1 (en) * 1986-03-27 1992-07-15 Sumitomo Pharmaceuticals Company, Limited Beta-lactam compounds, and their production
DE69013131T2 (de) * 1989-12-29 1995-05-24 Banyu Pharma Co Ltd 2-(2-Cyclopropylpyrrolidin-4-ylthio)carbapenemderivate.
JPH05255332A (ja) * 1991-11-27 1993-10-05 Banyu Pharmaceut Co Ltd アルキルアミノアルキルピロリジニルチオカルバペネム誘導体

Also Published As

Publication number Publication date
BG97965A (bg) 1994-05-27
AU2963292A (en) 1993-06-03
CZ150193A3 (en) 1994-03-16
CA2083980C (en) 2003-04-29
FI933346A0 (fi) 1993-07-26
PL300122A1 (en) 1994-04-18
CA2083980A1 (en) 1993-05-28
EP0545290B1 (en) 2000-08-23
HU210817A9 (en) 1995-08-28
WO1993011128A1 (en) 1993-06-10
CN1073176A (zh) 1993-06-16
FI933346A7 (fi) 1993-07-26
MX9206838A (es) 1993-05-31
HUT64345A (en) 1993-12-28
DE69231375D1 (de) 2000-09-28
IL103807A0 (en) 1993-04-04
US5550121A (en) 1996-08-27
YU100792A (sh) 1995-10-24
TW209220B (https=) 1993-07-11
HU9302170D0 (en) 1993-10-28
AU667786B2 (en) 1996-04-04
EP0545290A1 (en) 1993-06-09
KR0175674B1 (ko) 1999-03-20
CN1032061C (zh) 1996-06-19
KR930703322A (ko) 1993-11-29
DE69231375T2 (de) 2001-03-01
ATE195736T1 (de) 2000-09-15
AU7589494A (en) 1995-01-27

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired