|
US3845770A
(en)
|
1972-06-05 |
1974-11-05 |
Alza Corp |
Osmatic dispensing device for releasing beneficial agent
|
|
US4326525A
(en)
|
1980-10-14 |
1982-04-27 |
Alza Corporation |
Osmotic device that improves delivery properties of agent in situ
|
|
US5364620A
(en)
|
1983-12-22 |
1994-11-15 |
Elan Corporation, Plc |
Controlled absorption diltiazem formulation for once daily administration
|
|
US5023252A
(en)
|
1985-12-04 |
1991-06-11 |
Conrex Pharmaceutical Corporation |
Transdermal and trans-membrane delivery of drugs
|
|
US4992445A
(en)
|
1987-06-12 |
1991-02-12 |
American Cyanamid Co. |
Transdermal delivery of pharmaceuticals
|
|
US5001139A
(en)
|
1987-06-12 |
1991-03-19 |
American Cyanamid Company |
Enchancers for the transdermal flux of nivadipine
|
|
US4902514A
(en)
|
1988-07-21 |
1990-02-20 |
Alza Corporation |
Dosage form for administering nilvadipine for treating cardiovascular symptoms
|
|
EP2359833A1
(en)
|
2003-04-25 |
2011-08-24 |
Gilead Sciences, Inc. |
Antiviral phosphonate analogs
|
|
ME03423B
(me)
|
2004-07-27 |
2020-01-20 |
Gilead Sciences Inc |
Fosfonatni analozi jedinjenja hiv inhibitora
|
|
ATE516026T1
(de)
|
2005-02-21 |
2011-07-15 |
Shionogi & Co |
Bicyclisches carbamoylpyridonderivat mit hiv- integrase-hemmender wirkung
|
|
CN101146811B
(zh)
|
2005-03-31 |
2012-01-11 |
P.安杰莱蒂分子生物学研究所 |
Hiv整合酶抑制剂
|
|
US8129385B2
(en)
|
2005-04-28 |
2012-03-06 |
Shionogi & Co., Ltd. |
Substituted 5-hydroxy-3,4,6,9,9a, 10-hexanhydro-2h-1-oxa04a,8a-diaza-anthracene-6,10-dioness
|
|
JP2006342115A
(ja)
|
2005-06-10 |
2006-12-21 |
Shionogi & Co Ltd |
Ｈｉｖインテグラーゼ阻害活性を有する多環性化合物
|
|
US20080214527A1
(en)
|
2005-08-04 |
2008-09-04 |
Takashi Kawasuji |
Hiv Integrase Inhibitors
|
|
JP2009513640A
(ja)
|
2005-10-27 |
2009-04-02 |
メルク エンド カムパニー インコーポレーテッド |
Ｈｉｖインテグラーゼインヒビター
|
|
EA200801144A1
(ru)
|
2005-10-27 |
2008-10-30 |
Сионоги Энд Ко., Лтд. |
Полициклическое карбамоилпиридоновое производное, обладающее ингибиторной активностью в отношении интегразы вич
|
|
TW200811153A
(en)
|
2006-06-23 |
2008-03-01 |
Japan Tobacco Inc |
6-(heterocyclyl-substituted benzyl)-4-oxoquinoline compound and use thereof as HIV integrase inhibitor
|
|
US20100056516A1
(en)
|
2006-07-17 |
2010-03-04 |
Williams Peter D |
1-hydroxy naphthyridine compounds as anti-hiv agents
|
|
WO2008048538A1
(en)
|
2006-10-18 |
2008-04-24 |
Merck & Co., Inc. |
Hiv integrase inhibitors
|
|
MX2010005334A
(es)
|
2007-11-16 |
2010-05-27 |
Boehringer Ingelheim Int |
Inhibidores de la replicacion del virus de la inmunodeficiencia humana.
|
|
CN101918372B
(zh)
|
2008-01-08 |
2014-03-26 |
默沙东公司 |
用于制备n-取代的羟基嘧啶酮羧酰胺类化合物的方法
|
|
US8129398B2
(en)
|
2008-03-19 |
2012-03-06 |
Bristol-Myers Squibb Company |
HIV integrase inhibitors
|
|
TWI443098B
(zh)
|
2008-03-24 |
2014-07-01 |
Medivation Technologies Inc |
吡啶并〔３，４－ｂ〕吲哚及使用方法
|
|
WO2009154870A1
(en)
|
2008-05-05 |
2009-12-23 |
Merck & Co., Inc. |
Hiv integrase inhibitors
|
|
JP5539978B2
(ja)
|
2008-07-02 |
2014-07-02 |
アベキサ・リミテッド |
チアゾピリミジノンおよびその使用
|
|
EP2330902B1
(en)
|
2008-07-25 |
2012-11-14 |
GlaxoSmithKline LLC |
Chemical compounds
|
|
EP2320909B8
(en)
|
2008-07-25 |
2016-03-30 |
VIIV Healthcare Company |
Chemical compounds
|
|
WO2010011819A1
(en)
|
2008-07-25 |
2010-01-28 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
WO2010011818A1
(en)
|
2008-07-25 |
2010-01-28 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
WO2010011815A1
(en)
|
2008-07-25 |
2010-01-28 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
SI2320908T1
(sl)
|
2008-07-25 |
2014-05-30 |
Viiv Healthcare Company |
Predzdravila dolutegravirja
|
|
WO2010042392A2
(en)
|
2008-10-06 |
2010-04-15 |
Merck & Co., Inc. |
Hiv integrase inhibitors
|
|
ES2467108T3
(es)
|
2008-12-09 |
2014-06-11 |
Gilead Sciences, Inc. |
Moduladores de receptores tipo toll
|
|
CA2744019C
(en)
|
2008-12-11 |
2017-03-14 |
Shionogi & Co., Ltd. |
Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates
|
|
EP2391212A4
(en)
|
2009-01-28 |
2012-08-08 |
|
BROKEN COMPOUNDS AS HIV INTEGRASE INHIBITORS
|
|
US8338441B2
(en)
|
2009-05-15 |
2012-12-25 |
Gilead Sciences, Inc. |
Inhibitors of human immunodeficiency virus replication
|
|
LT2444400T
(lt)
|
2009-06-15 |
2018-06-11 |
Shionogi & Co., Ltd. |
Pakeistasis policiklinis karbamoilpiridono darinys
|
|
WO2011011483A1
(en)
|
2009-07-22 |
2011-01-27 |
Glaxosmithkline Llc |
Chemical compounds
|
|
WO2011025683A1
(en)
|
2009-08-26 |
2011-03-03 |
Merck Sharp & Dohme Corp. |
Hiv integrase inhibitors
|
|
WO2011045330A1
(en)
|
2009-10-13 |
2011-04-21 |
Tibotec Pharmaceuticals |
Macrocyclic integrase inhibitors
|
|
PE20121524A1
(es)
|
2010-01-27 |
2012-12-03 |
Viiv Healthcare Co |
Combinaciones de compuestos que comprenden inhibidores de la integrasa de vih y otros agentes terapeuticos
|
|
PE20130010A1
(es)
|
2010-02-26 |
2013-02-05 |
Japan Tobacco Inc |
Derivado de 1,3,4,8-tetrahidro-2h-pirido[1,2-a]pirazina como inhibidor de la integrasa del vih
|
|
RU2567385C2
(ru)
|
2010-04-02 |
2015-11-10 |
ЯНССЕН Ар ЭНД Ди АЙРЛЭНД |
Макроциклические ингибиторы интегразы
|
|
WO2011129095A1
(ja)
|
2010-04-12 |
2011-10-20 |
塩野義製薬株式会社 |
インテグラーゼ阻害活性を有するピリドン誘導体
|
|
WO2011139637A1
(en)
|
2010-05-03 |
2011-11-10 |
Philadelphia Health & Education Corporation |
Small-molecule modulators of hiv-1 capsid stability and methods thereof
|
|
KR20130124291A
(ko)
|
2010-07-02 |
2013-11-13 |
길리애드 사이언시즈, 인코포레이티드 |
Ｈｉｖ 항바이러스 화합물로서의 2-퀴놀리닐-아세트산 유도체
|
|
AP2013006706A0
(en)
|
2010-07-02 |
2013-02-28 |
Gilead Sciences Inc |
Napht-2-ylacetic acid derivatives to treat AIDS
|
|
US20140011995A1
(en)
|
2010-08-05 |
2014-01-09 |
Yukihito Sumino |
Process for Preparing Compound Having HIV Integrase Inhibitory Activity
|
|
TWI577377B
(zh)
|
2010-09-16 |
2017-04-11 |
Ｖｉｉｖ醫療保健公司 |
醫藥組合物
|
|
EP2632454A1
(en)
|
2010-10-29 |
2013-09-04 |
Merck Sharp & Dohme Corp. |
Hiv integrase inhibitors
|
|
US8835411B2
(en)
|
2010-12-10 |
2014-09-16 |
Bristol-Myers Squibb Company |
HIV integrase inhibitors
|
|
BR112013027096A2
(pt)
|
2011-04-21 |
2016-12-27 |
Gilead Sciences Inc |
compostos de benzotiazol e seu uso farmacêutico
|
|
EP2729448B1
(en)
|
2011-07-06 |
2015-09-09 |
Gilead Sciences, Inc. |
Compounds for the treatment of hiv
|
|
CN102863512B
(zh)
|
2011-07-07 |
2016-04-20 |
上海泓博智源医药技术有限公司 |
抗病毒化合物
|
|
EP2774928B1
(en)
|
2011-10-12 |
2017-08-30 |
Shionogi & Co., Ltd. |
Polycyclic pyridone derivative having integrase-inhibiting activity
|
|
US9399645B2
(en)
|
2011-12-20 |
2016-07-26 |
Boehringer Ingelheim International Gmbh |
Inhibitors of HIV replication
|
|
ES2571479T3
(es)
|
2012-04-20 |
2016-05-25 |
Gilead Sciences Inc |
Derivados del ácido benzotiazol-6-il acético y su uso para tratar una infección por VIH
|
|
WO2014004279A1
(en)
|
2012-06-25 |
2014-01-03 |
Sunpower Corporation |
Brace for solar module array
|
|
WO2014008636A1
(en)
|
2012-07-11 |
2014-01-16 |
Merck Sharp & Dohme Corp. |
Macrocyclic compounds as hiv integrase inhibitors
|
|
US20150166520A1
(en)
|
2012-07-20 |
2015-06-18 |
Merck Sharp & Dohme Corp. |
Amido-substituted pyrimidinone derivatives useful for the treatment of hiv infection
|
|
US8906929B2
(en)
|
2012-08-16 |
2014-12-09 |
Bristol-Myers Squibb Company |
Inhibitors of human immunodeficiency virus replication
|
|
DE102012220513B4
(de)
|
2012-11-12 |
2023-02-16 |
Bayerische Motoren Werke Aktiengesellschaft |
Verfahren und Vorrichtung zur Herstellung eines Druckgussteils
|
|
EP2931730B1
(en)
|
2012-12-17 |
2019-08-07 |
Merck Sharp & Dohme Corp. |
4-pyridinonetriazine derivatives as hiv integrase inhibitors
|
|
EA030003B1
(ru)
|
2012-12-21 |
2018-06-29 |
Джилид Сайэнс, Инк. |
Полициклическое карбамоилпиридоновое соединение и его фармацевтическое применение для лечения вич-инфекции
|
|
US20140221378A1
(en)
|
2012-12-27 |
2014-08-07 |
Japan Tobacco Inc. |
SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND PHARMACEUTICAL USE OF SAME AS HIV INTEGRASE INHIBITOR
|
|
EP2986291B1
(en)
|
2013-04-16 |
2020-05-27 |
Merck Sharp & Dohme Corp. |
4-pyridone derivative compounds and uses thereof as hiv integrase inhibitors
|
|
AU2014267951A1
(en)
|
2013-05-17 |
2015-11-19 |
Merck Sharp & Dohme Corp. |
Fused Tricyclic Heterocyclic compounds as HIV integrase inhibitors
|
|
US9951079B2
(en)
|
2013-06-13 |
2018-04-24 |
Merck Sharp & Dohme Corp. |
Fused tricyclic heterocyclic compounds as HIV integrase inhibitors
|
|
NO2865735T3
(https=)
|
2013-07-12 |
2018-07-21 |
|
|
|
SI3019503T1
(sl)
|
2013-07-12 |
2017-11-30 |
Gilead Sciences, Inc. |
Policiklične karbamoilpiridonske spojine in njihova uporaba za zdravljenje HIV infekcij
|
|
WO2015039348A1
(en)
|
2013-09-23 |
2015-03-26 |
Merck Sharp & Dohme Corp. |
Tetracyclic heterocycle compounds useful as hiv integrase inhibitors
|
|
MD4794B1
(ro)
|
2013-09-27 |
2022-02-28 |
Merck Sharp & Dohme Corp |
Derivaţi de chinolizină substituiţi utili ca inhibitori de integrază HIV
|
|
WO2015089847A1
(en)
|
2013-12-20 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
Spirocyclic heterocycle compounds useful as hiv integrase inhibitors
|
|
NO2717902T3
(https=)
|
2014-06-20 |
2018-06-23 |
|
|
|
WO2016027879A1
(ja)
|
2014-08-22 |
2016-02-25 |
塩野義製薬株式会社 |
インテグラーゼ阻害活性を有する多環性ピリドン誘導体
|
|
KR20170045308A
(ko)
|
2014-08-27 |
2017-04-26 |
비브 헬스케어 유케이 (넘버5) 리미티드 |
인간 면역결핍 바이러스 복제의 억제제로서 이미다조[1,2-a]피리딘 유도체
|
|
EP3229804B1
(en)
|
2014-12-09 |
2020-05-06 |
Merck Sharp & Dohme Corp. |
Spirocyclic heterocycle compounds useful as hiv integrase inhibitors
|
|
WO2016090545A1
(en)
|
2014-12-09 |
2016-06-16 |
Merck Sharp & Dohme Corp. |
Spirocyclic heterocycle compounds useful as hiv integrate inhibitors
|
|
TWI695003B
(zh)
|
2014-12-23 |
2020-06-01 |
美商基利科學股份有限公司 |
多環胺甲醯基吡啶酮化合物及其醫藥用途
|
|
WO2016154527A1
(en)
|
2015-03-26 |
2016-09-29 |
Merck Sharp & Dohme Corp. |
Phosphate-substituted quinolizine derivatives useful as hiv integrase inhibitors
|
|
JP6402259B2
(ja)
*
|
2015-04-02 |
2018-10-10 |
ギリアード サイエンシーズ， インコーポレイテッド |
多環式カルバモイルピリドン化合物およびそれらの薬学的使用
|
|
WO2016187788A1
(en)
|
2015-05-25 |
2016-12-01 |
Merck Sharp & Dohme Corp. |
Fused tricyclic heterocyclic compounds useful for treating hiv infection
|
|
WO2017087256A1
(en)
|
2015-11-17 |
2017-05-26 |
Merck Sharp & Dohme Corp. |
Spirocyclic pyridotriazine derivatives useful as hiv integrase inhibitors
|
|
US10548910B2
(en)
|
2015-11-17 |
2020-02-04 |
Merck Sharp & Dohme Corp. |
Amido-substituted pyridotriazine derivatives useful as HIV integrase inhibitors
|
|
WO2017106071A1
(en)
|
2015-12-15 |
2017-06-22 |
Merck Sharp & Dohme Corp. |
Spirocyclic quinolizine derivatives useful as hiv integrase inhibitors
|
|
WO2017113288A1
(en)
|
2015-12-31 |
2017-07-06 |
Merck Sharp & Dohme Corp. |
Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
|
|
EP4299133A3
(en)
|
2016-06-23 |
2024-03-13 |
VIIV Healthcare Company |
Compositions and methods for the delivery of therapeutics
|
|
US10934312B2
(en)
|
2016-12-02 |
2021-03-02 |
Merck Sharp & Dohme Corp. |
Tricyclic heterocycle compounds useful as HIV integrase inhibitors
|
|
JOP20190130A1
(ar)
|
2016-12-02 |
2019-06-02 |
Merck Sharp & Dohme |
مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv)
|
|
WO2018109786A1
(en)
|
2016-12-16 |
2018-06-21 |
Cipla Limited |
Novel polymoprphs and salts of polycyclic carbamoyl pyridone derivatives
|
|
WO2018140368A1
(en)
|
2017-01-26 |
2018-08-02 |
Merck Sharp & Dohme Corp. |
Substituted quinolizine derivatives useful as hiv integrase inhibitors
|
|
UY37592A
(es)
*
|
2017-02-06 |
2018-08-31 |
Gilead Sciences Inc |
Compuestos inhibidores del vih
|
|
MX2020003242A
(es)
|
2017-09-22 |
2020-09-18 |
Jubilant Epipad LLC |
Compuestos heterociclicos como inhibidores de pad.
|
|
EP3752144B1
(en)
|
2018-02-15 |
2022-12-28 |
Merck Sharp & Dohme LLC |
Tricyclic heterocycle compounds useful as hiv integrase inhibitors
|
|
CN112088005A
(zh)
|
2018-04-27 |
2020-12-15 |
默沙东公司 |
可用作hiv整合酶抑制剂的三环杂环化合物
|
|
CN110526930B
(zh)
|
2018-05-23 |
2022-06-03 |
莫云芬 |
抗hiv病毒的含硫多环-羟基吡啶酮甲酰胺类似物及其应用
|
|
AU2019277547B2
(en)
|
2018-05-31 |
2024-10-10 |
Shionogi & Co., Ltd. |
Polycyclic pyridone derivative
|
|
CN112204029B
(zh)
|
2018-05-31 |
2024-03-01 |
豪夫迈·罗氏有限公司 |
治疗性化合物
|
|
EP4257137A3
(en)
|
2018-05-31 |
2023-11-01 |
Shionogi & Co., Ltd |
Polycyclic carbamoylpyridone derivatives for the treatment of hiv
|
|
EP3801543B1
(en)
|
2018-06-05 |
2024-09-11 |
Merck Sharp & Dohme LLC |
Tricyclic heterocycle compounds useful as hiv integrase inhibitors
|
|
WO2019244066A2
(en)
|
2018-06-19 |
2019-12-26 |
VIIV Healthcare UK (No.5) Limited |
Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
|
|
WO2020003093A1
(en)
|
2018-06-25 |
2020-01-02 |
VIIV Healthcare UK (No.5) Limited |
Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
|
|
EP3815689A4
(en)
|
2018-06-27 |
2022-04-20 |
National University Corporation Hokkaido University |
ARENAVIRUS GROWTH INHIBITOR WITH POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE
|
|
MX2021004182A
(es)
|
2018-10-10 |
2021-09-08 |
Janssen Biopharma Inc |
Inhibidores macrocíclicos de endonucleasa de la gripe.
|
|
ES2970251T3
(es)
|
2018-10-22 |
2024-05-27 |
Univ Nebraska |
Profármacos antivirales y nanoformulaciones de los mismos
|
|
WO2020112931A1
(en)
|
2018-11-29 |
2020-06-04 |
Board Of Regents Of The University Of Nebraska |
Antiviral prodrugs and nanoformulations thereof
|
|
WO2020197991A1
(en)
|
2019-03-22 |
2020-10-01 |
Gilead Sciences, Inc. |
Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use
|
|
WO2020221294A1
(zh)
*
|
2019-04-30 |
2020-11-05 |
上海拓界生物医药科技有限公司 |
桥环-3,4-二氢-吡啶并[1,2-a]吡嗪-1,8-二酮化合物及其药物用途
|
|
RU2717101C1
(ru)
|
2019-06-03 |
2020-03-18 |
Андрей Александрович Иващенко |
Анелированные 9-гидрокси-1,8-диоксо-1,3,4,8-тетрагидро-2Н-пиридо[1,2-a]пиразин-7-карбоксамиды - ингибиторы интегразы ВИЧ, способы их получения и применения
|
|
ES3060737T3
(en)
|
2019-07-11 |
2026-03-27 |
Nanjing Zenshine Pharmaceuticals Co Ltd |
Compounds useful to treat influenza virus infections
|
|
WO2021093846A1
(zh)
|
2019-11-13 |
2021-05-20 |
上海拓界生物医药科技有限公司 |
新型四环杂环化合物及其药物用途
|
|
US12577241B2
(en)
|
2019-11-28 |
2026-03-17 |
Shionogi & Co., Ltd. |
Polycyclic pyridopyrazine derivative
|
|
TWI902729B
(zh)
|
2019-11-28 |
2025-11-01 |
日商鹽野義製藥股份有限公司 |
以組合整合酶阻礙劑及抗ｈｉｖ藥為特徵之ｈｉｖ感染症的預防及治療用醫藥
|
|
IL295677B1
(en)
|
2020-02-24 |
2026-04-01 |
Gilead Sciences Inc |
Tetracyclic compounds for the treatment of HIV infection
|
|
CA3192145A1
(en)
|
2020-09-30 |
2022-04-07 |
Gilead Sciences, Inc. |
Bridged tricyclic carbamoylpyridone compounds and uses thereof
|
|
TW202227445A
(zh)
|
2020-10-30 |
2022-07-16 |
大陸商上海拓界生物醫藥科技有限公司 |
抑制基因缺陷的ｈｉｖ病毒的用途
|
|
FI4196479T3
(fi)
|
2021-01-19 |
2024-01-17 |
Gilead Sciences Inc |
Substituoituja pyridotriatsiiniyhdisteitä ja niiden käyttöjä
|
|
EP4294813B1
(en)
|
2021-02-16 |
2025-09-10 |
Merck Sharp & Dohme LLC |
Tetracyclic heterocycle compounds useful as hiv integrase inhibitors
|
|
TWI856796B
(zh)
|
2022-04-06 |
2024-09-21 |
美商基利科學股份有限公司 |
橋聯三環胺甲醯基吡啶酮化合物及其用途
|