KR102934440B1 - 가교된 트리사이클릭 카르바모일피리돈 화합물 및 이의 용도 - Google Patents

가교된 트리사이클릭 카르바모일피리돈 화합물 및 이의 용도

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Publication number
KR102934440B1
KR102934440B1 KR1020237014237A KR20237014237A KR102934440B1 KR 102934440 B1 KR102934440 B1 KR 102934440B1 KR 1020237014237 A KR1020237014237 A KR 1020237014237A KR 20237014237 A KR20237014237 A KR 20237014237A KR 102934440 B1 KR102934440 B1 KR 102934440B1
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alkyl
delete delete
haloalkyl
compound
pharmaceutically acceptable
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KR20230079137A (ko
Inventor
항 추
홍얀 궈
란 지앙
지아야오 리
데이비드 더블유. 린
형-중 편
치아오인 우
홍 양
아담 디. 자들릭
제니퍼 알. 장
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길리애드 사이언시즈, 인코포레이티드
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Priority to KR1020267006323A priority Critical patent/KR20260037176A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020237014237A 2020-09-30 2021-09-29 가교된 트리사이클릭 카르바모일피리돈 화합물 및 이의 용도 Active KR102934440B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020267006323A KR20260037176A (ko) 2020-09-30 2021-09-29 가교된 트리사이클릭 카르바모일피리돈 화합물 및 이의 용도

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063085704P 2020-09-30 2020-09-30
US63/085,704 2020-09-30
PCT/US2021/052683 WO2022072520A1 (en) 2020-09-30 2021-09-29 Bridged tricyclic carbamoylpyridone compounds and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020267006323A Division KR20260037176A (ko) 2020-09-30 2021-09-29 가교된 트리사이클릭 카르바모일피리돈 화합물 및 이의 용도

Publications (2)

Publication Number Publication Date
KR20230079137A KR20230079137A (ko) 2023-06-05
KR102934440B1 true KR102934440B1 (ko) 2026-03-06

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KR1020237014237A Active KR102934440B1 (ko) 2020-09-30 2021-09-29 가교된 트리사이클릭 카르바모일피리돈 화합물 및 이의 용도
KR1020267006323A Pending KR20260037176A (ko) 2020-09-30 2021-09-29 가교된 트리사이클릭 카르바모일피리돈 화합물 및 이의 용도

Family Applications After (1)

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Country Status (11)

Country Link
US (3) US12421235B2 (https=)
EP (1) EP4222152B1 (https=)
JP (2) JP7691494B2 (https=)
KR (2) KR102934440B1 (https=)
CN (1) CN116390924B (https=)
AR (1) AR123648A1 (https=)
AU (2) AU2021351491C1 (https=)
CA (1) CA3192145A1 (https=)
PT (1) PT4222152T (https=)
SI (1) SI4222152T1 (https=)
WO (1) WO2022072520A1 (https=)

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WO2025080863A1 (en) * 2023-10-11 2025-04-17 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and uses thereof
TW202515549A (zh) * 2023-10-11 2025-04-16 美商基利科學股份有限公司 橋聯三環胺甲醯基吡啶酮化合物及其用途
WO2025080850A1 (en) * 2023-10-11 2025-04-17 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and uses thereof
WO2026076265A1 (en) * 2024-10-03 2026-04-09 Gilead Sciences, Inc. Combination therapy comprising bridged tricyclic carbamoylpyridone compounds and p-glycoprotein inhibitors
CN119438457B (zh) * 2024-12-18 2025-12-02 成都迈科康生物科技有限公司 一种测定脂质体佐剂中有关物质的方法及其应用

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