JPWO2021136296A5 - - Google Patents
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- Publication number
- JPWO2021136296A5 JPWO2021136296A5 JP2022540871A JP2022540871A JPWO2021136296A5 JP WO2021136296 A5 JPWO2021136296 A5 JP WO2021136296A5 JP 2022540871 A JP2022540871 A JP 2022540871A JP 2022540871 A JP2022540871 A JP 2022540871A JP WO2021136296 A5 JPWO2021136296 A5 JP WO2021136296A5
- Authority
- JP
- Japan
- Prior art keywords
- human insulin
- γglu
- desb30 human
- docosandioyl
- eicosandioyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911398378.0 | 2019-12-30 | ||
| CN201911398378 | 2019-12-30 | ||
| CN202011057926.6 | 2020-09-29 | ||
| CN202011057926 | 2020-09-29 | ||
| PCT/CN2020/141023 WO2021136296A1 (zh) | 2019-12-30 | 2020-12-29 | 胰岛素衍生物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023510219A JP2023510219A (ja) | 2023-03-13 |
| JP2023510219A5 JP2023510219A5 (https=) | 2026-01-21 |
| JPWO2021136296A5 true JPWO2021136296A5 (https=) | 2026-01-21 |
Family
ID=76687317
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022540767A Pending JP2023510206A (ja) | 2019-12-30 | 2020-12-29 | インスリン誘導体 |
| JP2022540871A Pending JP2023510219A (ja) | 2019-12-30 | 2020-12-29 | インスリン誘導体 |
| JP2025128114A Pending JP2025161829A (ja) | 2019-12-30 | 2025-07-31 | インスリン誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022540767A Pending JP2023510206A (ja) | 2019-12-30 | 2020-12-29 | インスリン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025128114A Pending JP2025161829A (ja) | 2019-12-30 | 2025-07-31 | インスリン誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US20240025957A1 (https=) |
| EP (3) | EP4086280A4 (https=) |
| JP (3) | JP2023510206A (https=) |
| KR (2) | KR20220119730A (https=) |
| CN (12) | CN114901683B (https=) |
| AU (2) | AU2020417892A1 (https=) |
| BR (2) | BR112022013009A2 (https=) |
| CA (2) | CA3166494A1 (https=) |
| MX (2) | MX2022008174A (https=) |
| WO (3) | WO2021136293A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119529057A (zh) * | 2019-12-30 | 2025-02-28 | 甘李药业股份有限公司 | 长效glp-1化合物 |
| AU2020417892A1 (en) | 2019-12-30 | 2022-08-25 | Gan & Lee Pharmaceuticals Co., Ltd. | Insulin derivative |
| WO2022159395A1 (en) | 2021-01-20 | 2022-07-28 | Viking Therapeutics, Inc. | Compositions and methods for the treatment of metabolic and liver disorders |
| KR20240013778A (ko) * | 2021-05-24 | 2024-01-30 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 신규한 아실화된 인슐린 유사체 |
| JP2024522904A (ja) * | 2021-06-25 | 2024-06-21 | ガン アンド リー ファーマシューティカルズ カンパニー リミテッド | アシル化インスリンを含む医薬組成物 |
| MX2024003236A (es) | 2021-09-15 | 2024-06-19 | Viking Therapeutics Inc | Composiciones y metodos para el tratamiento de trastornos metabolicos y hepaticos. |
| CN116162147B (zh) * | 2021-11-24 | 2023-10-03 | 成都奥达生物科技有限公司 | 一种长效胰岛素类似物 |
| CN118574842A (zh) * | 2022-01-28 | 2024-08-30 | 甘李药业股份有限公司 | 酰化胰岛素 |
| CN120731085A (zh) * | 2023-03-02 | 2025-09-30 | 甘李药业股份有限公司 | 一种glp-1化合物的医药用途 |
| EP4722236A1 (en) * | 2023-05-24 | 2026-04-08 | The United Bio-Technology (Hengqin) Co., Ltd. | Insulin derivative and use thereof |
| CN116327890B (zh) * | 2023-05-29 | 2023-12-08 | 北京先为达生物科技有限公司 | 口服递送的组合物及其应用 |
| CN116789801B (zh) * | 2023-08-21 | 2023-11-14 | 南京赛诺生物技术有限公司 | 新型胰岛素衍生物及其用途 |
| WO2025077751A1 (zh) * | 2023-10-09 | 2025-04-17 | 甘李药业股份有限公司 | Glp-1肽组合物及其用途 |
| WO2025098457A1 (zh) * | 2023-11-07 | 2025-05-15 | 甘李药业股份有限公司 | 用于降糖的酰化胰岛素 |
| WO2025098502A1 (zh) * | 2023-11-08 | 2025-05-15 | 甘李药业股份有限公司 | 包含胰岛素衍生物的药物组合物的治疗用途 |
| WO2025228255A1 (zh) * | 2024-04-28 | 2025-11-06 | 正大天晴药业集团股份有限公司 | 酰化人胰岛素类似物 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ199391A (en) | 1981-01-02 | 1985-12-13 | Genentech Inc | Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin |
| DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| DK336188D0 (da) | 1988-06-20 | 1988-06-20 | Nordisk Gentofte | Propeptider |
| KR910700262A (ko) | 1988-12-23 | 1991-03-14 | 안네 제케르 | 사람 인슐린 유사체 |
| PT93057B (pt) | 1989-02-09 | 1995-12-29 | Lilly Co Eli | Processo para a preparacao de analogos da insulina |
| CZ287945B6 (cs) | 1993-09-17 | 2001-03-14 | Novo Nordisk A/S | Inzulinový derivát a farmaceutický prostředek s jeho obsahem pro léčení diabetu |
| AU1272295A (en) | 1993-12-17 | 1995-07-03 | Novo Nordisk A/S | Proinsulin-like compounds |
| US6500645B1 (en) | 1994-06-17 | 2002-12-31 | Novo Nordisk A/S | N-terminally extended proteins expressed in yeast |
| KR0150565B1 (ko) | 1995-02-15 | 1998-08-17 | 김정재 | 유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법 |
| EP0741188A3 (en) | 1995-05-05 | 1999-07-14 | Eli Lilly And Company | Single chain insulin with high bioactivity |
| MXPA06001283A (es) | 2003-08-05 | 2006-04-11 | Novo Nordisk As | Derivados de insulina novedosos. |
| EP1991576B1 (en) * | 2006-02-27 | 2010-09-29 | Novo Nordisk A/S | Insulin derivatives |
| MX2008014061A (es) | 2006-05-09 | 2008-11-14 | Novo Nordisk As | Derivado de insulina. |
| ES2542146T3 (es) | 2006-07-31 | 2015-07-31 | Novo Nordisk A/S | Insulinas extendidas PEGiladas. |
| WO2009010428A1 (en) | 2007-07-16 | 2009-01-22 | Novo Nordisk A/S | Protease stabilized, pegylated insulin analogues |
| EP2178910B1 (en) * | 2007-08-15 | 2014-10-08 | Novo Nordisk A/S | Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids |
| KR20100053561A (ko) * | 2007-08-15 | 2010-05-20 | 노보 노르디스크 에이/에스 | 아실 및 알킬렌 글리콜 부분을 갖는 인슐린 유사체 |
| WO2009030774A1 (en) * | 2007-09-05 | 2009-03-12 | Novo Nordisk A/S | Truncated glp-1 derivatives and their therapeutical use |
| CN102037008B (zh) | 2008-03-18 | 2016-08-31 | 诺沃-诺迪斯克有限公司 | 蛋白酶稳定化的、酰化胰岛素类似物 |
| EP2552950A1 (en) | 2010-03-26 | 2013-02-06 | Novo Nordisk A/S | Novel glucagon analogues |
| CN103596584B (zh) * | 2011-06-15 | 2016-12-14 | 诺沃—诺迪斯克有限公司 | 多取代的胰岛素 |
| RU2014127270A (ru) | 2011-12-15 | 2016-02-10 | Шанхай Хэнжуй Фармасьютикал Ко., Лтд. | Аналог человеческого инсулина и его ацилированное производное |
| US9481721B2 (en) | 2012-04-11 | 2016-11-01 | Novo Nordisk A/S | Insulin formulations |
| US20150111820A1 (en) * | 2012-07-09 | 2015-04-23 | Novo Nordisk A/S | Novel use of insulin derivatives |
| JP2017506640A (ja) | 2014-02-14 | 2017-03-09 | セントローズ， エルエルシー | 細胞外標的化薬物共役体 |
| AR099569A1 (es) * | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
| CN105820233B (zh) | 2015-01-04 | 2021-06-15 | 甘李药业股份有限公司 | 一种胰岛素衍生物的制备方法 |
| US20180000742A1 (en) * | 2015-01-29 | 2018-01-04 | Novo Nordisk A/S | Pharmaceutical Composition for Oral Insulin Administration Comprising a Tablet Core and a Polyvinyl Alcohol Coating |
| MX2018002223A (es) * | 2015-08-25 | 2018-03-23 | Novo Nordisk As | Derivados de insulina novedosos y usos medicos de los mismos. |
| US10651467B2 (en) * | 2015-08-27 | 2020-05-12 | Haldor Topsøe A/S | High tap density lithium positive electrode active material, intermediate and process of preparation |
| JP7432361B2 (ja) | 2016-08-02 | 2024-02-16 | 江蘇恒瑞医薬股▲ふん▼有限公司 | ヒトインスリンまたはそのアナログのアシル化誘導体 |
| TWI700091B (zh) | 2016-12-16 | 2020-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 含胰島素醫藥組成物 |
| JOP20190273A1 (ar) * | 2017-05-26 | 2019-11-24 | Lilly Co Eli | مركب إنسولين معالج بأسيل |
| AU2020417892A1 (en) | 2019-12-30 | 2022-08-25 | Gan & Lee Pharmaceuticals Co., Ltd. | Insulin derivative |
| CN119529057A (zh) * | 2019-12-30 | 2025-02-28 | 甘李药业股份有限公司 | 长效glp-1化合物 |
| CN118574842A (zh) * | 2022-01-28 | 2024-08-30 | 甘李药业股份有限公司 | 酰化胰岛素 |
-
2020
- 2020-12-29 AU AU2020417892A patent/AU2020417892A1/en active Pending
- 2020-12-29 CN CN202080091328.2A patent/CN114901683B/zh active Active
- 2020-12-29 JP JP2022540767A patent/JP2023510206A/ja active Pending
- 2020-12-29 WO PCT/CN2020/141018 patent/WO2021136293A1/zh not_active Ceased
- 2020-12-29 CN CN202410254314.8A patent/CN118420743A/zh active Pending
- 2020-12-29 CN CN202410312576.5A patent/CN118666989A/zh active Pending
- 2020-12-29 KR KR1020227026305A patent/KR20220119730A/ko active Pending
- 2020-12-29 EP EP20910739.0A patent/EP4086280A4/en active Pending
- 2020-12-29 CA CA3166494A patent/CA3166494A1/en active Pending
- 2020-12-29 KR KR1020227024018A patent/KR20220121833A/ko active Pending
- 2020-12-29 CN CN202410286752.2A patent/CN118598978A/zh active Pending
- 2020-12-29 CN CN202410254905.5A patent/CN118420744A/zh active Pending
- 2020-12-29 WO PCT/CN2020/141023 patent/WO2021136296A1/zh not_active Ceased
- 2020-12-29 CN CN202411113581.XA patent/CN118754967A/zh active Pending
- 2020-12-29 CN CN202080091153.5A patent/CN114901681B/zh active Active
- 2020-12-29 BR BR112022013009A patent/BR112022013009A2/pt unknown
- 2020-12-29 US US17/758,108 patent/US20240025957A1/en active Pending
- 2020-12-29 CN CN202411113751.4A patent/CN118772259A/zh active Pending
- 2020-12-29 EP EP20910566.7A patent/EP4086279A4/en active Pending
- 2020-12-29 CA CA3166495A patent/CA3166495A1/en active Pending
- 2020-12-29 EP EP20908882.2A patent/EP4086278A4/en active Pending
- 2020-12-29 BR BR112022013150A patent/BR112022013150A2/pt unknown
- 2020-12-29 WO PCT/CN2020/141056 patent/WO2021136302A1/zh not_active Ceased
- 2020-12-29 US US17/758,101 patent/US20240239862A1/en active Pending
- 2020-12-29 CN CN202410288928.8A patent/CN118206632A/zh active Pending
- 2020-12-29 CN CN202411112792.1A patent/CN118894922A/zh active Pending
- 2020-12-29 AU AU2020418205A patent/AU2020418205A1/en active Pending
- 2020-12-29 JP JP2022540871A patent/JP2023510219A/ja active Pending
- 2020-12-29 MX MX2022008174A patent/MX2022008174A/es unknown
- 2020-12-29 CN CN202080091196.3A patent/CN114901682B/zh active Active
- 2020-12-29 CN CN202410312489.XA patent/CN118480114A/zh active Pending
- 2020-12-29 MX MX2022008130A patent/MX2022008130A/es unknown
- 2020-12-29 US US17/758,089 patent/US12576136B2/en active Active
-
2024
- 2024-09-18 US US18/889,097 patent/US20250032589A1/en not_active Abandoned
-
2025
- 2025-02-12 US US19/052,262 patent/US20250228919A1/en not_active Abandoned
- 2025-07-31 JP JP2025128114A patent/JP2025161829A/ja active Pending
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