KR20220119730A - 인슐린 유도체 - Google Patents

인슐린 유도체 Download PDF

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Publication number
KR20220119730A
KR20220119730A KR1020227026305A KR20227026305A KR20220119730A KR 20220119730 A KR20220119730 A KR 20220119730A KR 1020227026305 A KR1020227026305 A KR 1020227026305A KR 20227026305 A KR20227026305 A KR 20227026305A KR 20220119730 A KR20220119730 A KR 20220119730A
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KR
South Korea
Prior art keywords
human insulin
γglu
desb30 human
insulin
docosandioyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020227026305A
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English (en)
Korean (ko)
Inventor
종루 간
웨이 천
이닝 장
팡카이 슈에
링위 차이
지앙홍 니우
빈 무
Original Assignee
간 앤 리 파마슈티칼스 컴퍼니, 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 간 앤 리 파마슈티칼스 컴퍼니, 리미티드 filed Critical 간 앤 리 파마슈티칼스 컴퍼니, 리미티드
Publication of KR20220119730A publication Critical patent/KR20220119730A/ko
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020227026305A 2019-12-30 2020-12-29 인슐린 유도체 Pending KR20220119730A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201911398378.0 2019-12-30
CN201911398378 2019-12-30
CN202011057926.6 2020-09-29
CN202011057926 2020-09-29
PCT/CN2020/141023 WO2021136296A1 (zh) 2019-12-30 2020-12-29 胰岛素衍生物

Publications (1)

Publication Number Publication Date
KR20220119730A true KR20220119730A (ko) 2022-08-30

Family

ID=76687317

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020227026305A Pending KR20220119730A (ko) 2019-12-30 2020-12-29 인슐린 유도체
KR1020227024018A Pending KR20220121833A (ko) 2019-12-30 2020-12-29 인슐린 유도체

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020227024018A Pending KR20220121833A (ko) 2019-12-30 2020-12-29 인슐린 유도체

Country Status (10)

Country Link
US (5) US20240025957A1 (https=)
EP (3) EP4086280A4 (https=)
JP (3) JP2023510206A (https=)
KR (2) KR20220119730A (https=)
CN (12) CN114901683B (https=)
AU (2) AU2020417892A1 (https=)
BR (2) BR112022013009A2 (https=)
CA (2) CA3166494A1 (https=)
MX (2) MX2022008174A (https=)
WO (3) WO2021136293A1 (https=)

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CN119529057A (zh) * 2019-12-30 2025-02-28 甘李药业股份有限公司 长效glp-1化合物
AU2020417892A1 (en) 2019-12-30 2022-08-25 Gan & Lee Pharmaceuticals Co., Ltd. Insulin derivative
WO2022159395A1 (en) 2021-01-20 2022-07-28 Viking Therapeutics, Inc. Compositions and methods for the treatment of metabolic and liver disorders
KR20240013778A (ko) * 2021-05-24 2024-01-30 선샤인 레이크 파르마 컴퍼니 리미티드 신규한 아실화된 인슐린 유사체
JP2024522904A (ja) * 2021-06-25 2024-06-21 ガン アンド リー ファーマシューティカルズ カンパニー リミテッド アシル化インスリンを含む医薬組成物
MX2024003236A (es) 2021-09-15 2024-06-19 Viking Therapeutics Inc Composiciones y metodos para el tratamiento de trastornos metabolicos y hepaticos.
CN116162147B (zh) * 2021-11-24 2023-10-03 成都奥达生物科技有限公司 一种长效胰岛素类似物
CN118574842A (zh) * 2022-01-28 2024-08-30 甘李药业股份有限公司 酰化胰岛素
CN120731085A (zh) * 2023-03-02 2025-09-30 甘李药业股份有限公司 一种glp-1化合物的医药用途
EP4722236A1 (en) * 2023-05-24 2026-04-08 The United Bio-Technology (Hengqin) Co., Ltd. Insulin derivative and use thereof
CN116327890B (zh) * 2023-05-29 2023-12-08 北京先为达生物科技有限公司 口服递送的组合物及其应用
CN116789801B (zh) * 2023-08-21 2023-11-14 南京赛诺生物技术有限公司 新型胰岛素衍生物及其用途
WO2025077751A1 (zh) * 2023-10-09 2025-04-17 甘李药业股份有限公司 Glp-1肽组合物及其用途
WO2025098457A1 (zh) * 2023-11-07 2025-05-15 甘李药业股份有限公司 用于降糖的酰化胰岛素
WO2025098502A1 (zh) * 2023-11-08 2025-05-15 甘李药业股份有限公司 包含胰岛素衍生物的药物组合物的治疗用途
WO2025228255A1 (zh) * 2024-04-28 2025-11-06 正大天晴药业集团股份有限公司 酰化人胰岛素类似物

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JP7432361B2 (ja) 2016-08-02 2024-02-16 江蘇恒瑞医薬股▲ふん▼有限公司 ヒトインスリンまたはそのアナログのアシル化誘導体
TWI700091B (zh) 2016-12-16 2020-08-01 丹麥商諾佛 儂迪克股份有限公司 含胰島素醫藥組成物
JOP20190273A1 (ar) * 2017-05-26 2019-11-24 Lilly Co Eli مركب إنسولين معالج بأسيل
AU2020417892A1 (en) 2019-12-30 2022-08-25 Gan & Lee Pharmaceuticals Co., Ltd. Insulin derivative
CN119529057A (zh) * 2019-12-30 2025-02-28 甘李药业股份有限公司 长效glp-1化合物
CN118574842A (zh) * 2022-01-28 2024-08-30 甘李药业股份有限公司 酰化胰岛素

Also Published As

Publication number Publication date
CN118420743A (zh) 2024-08-02
CN114901682B (zh) 2024-04-16
JP2023510206A (ja) 2023-03-13
EP4086279A4 (en) 2024-08-07
JP2025161829A (ja) 2025-10-24
CN118480114A (zh) 2024-08-13
CN114901683A (zh) 2022-08-12
US20250228919A1 (en) 2025-07-17
BR112022013150A2 (pt) 2023-02-28
EP4086280A1 (en) 2022-11-09
AU2020418205A1 (en) 2022-08-04
CN114901681A (zh) 2022-08-12
US20230126068A1 (en) 2023-04-27
KR20220121833A (ko) 2022-09-01
MX2022008130A (es) 2022-10-03
CN114901683B (zh) 2024-09-13
CN118420744A (zh) 2024-08-02
AU2020417892A1 (en) 2022-08-25
EP4086278A4 (en) 2024-08-07
JP2023510219A (ja) 2023-03-13
CN114901682A (zh) 2022-08-12
EP4086280A4 (en) 2024-05-29
US12576136B2 (en) 2026-03-17
CN114901681B (zh) 2024-04-09
CN118894922A (zh) 2024-11-05
EP4086279A1 (en) 2022-11-09
CA3166495A1 (en) 2021-07-08
WO2021136296A1 (zh) 2021-07-08
BR112022013009A2 (pt) 2022-09-06
US20250032589A1 (en) 2025-01-30
CA3166494A1 (en) 2021-07-08
CN118598978A (zh) 2024-09-06
WO2021136302A1 (zh) 2021-07-08
CN118206632A (zh) 2024-06-18
WO2021136293A1 (zh) 2021-07-08
CN118666989A (zh) 2024-09-20
US20240025957A1 (en) 2024-01-25
EP4086278A1 (en) 2022-11-09
CN118772259A (zh) 2024-10-15
US20240239862A1 (en) 2024-07-18
CN118754967A (zh) 2024-10-11
MX2022008174A (es) 2022-08-02

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