CN114901682A - 胰岛素衍生物 - Google Patents
胰岛素衍生物 Download PDFInfo
- Publication number
- CN114901682A CN114901682A CN202080091196.3A CN202080091196A CN114901682A CN 114901682 A CN114901682 A CN 114901682A CN 202080091196 A CN202080091196 A CN 202080091196A CN 114901682 A CN114901682 A CN 114901682A
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- epsilon
- human insulin
- desb30 human
- gammaglu
- insulin
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Abstract
一种胰岛素衍生物，其药物制剂、其与长效GLP‑1化合物的药物组合物、及所述酰化胰岛素、药物制剂和药物组合物的医药用途。所述胰岛素衍生物相比于德谷胰岛素或其它胰岛素衍生物，具有预料不到的显著增加的药效、具有更长的持续作用时间、更长的体内半衰期、良好的生物利用率、及具有更好的物理稳定性、化学稳定性。
Description
PCT国内申请，说明书已公开。
Claims (54)
- PCT国内申请，权利要求书已公开。
Priority Applications (3)
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| CN202410254905.5A CN118420744A (zh) | 2019-12-30 | 2020-12-29 | 胰岛素衍生物 |
| CN202410312576.5A CN118666989A (zh) | 2019-12-30 | 2020-12-29 | 胰岛素衍生物 |
| CN202410312489.XA CN118480114A (zh) | 2019-12-30 | 2020-12-29 | 胰岛素衍生物 |
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| CN2020110579266 | 2020-09-29 | ||
| PCT/CN2020/141018 WO2021136293A1 (zh) | 2019-12-30 | 2020-12-29 | 胰岛素衍生物 |
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| CN202410254905.5A Division CN118420744A (zh) | 2019-12-30 | 2020-12-29 | 胰岛素衍生物 |
| CN202410312576.5A Division CN118666989A (zh) | 2019-12-30 | 2020-12-29 | 胰岛素衍生物 |
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| EP (3) | EP4086279A4 (zh) |
| JP (2) | JP2023510219A (zh) |
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| CN116789801A (zh) * | 2023-08-21 | 2023-09-22 | 南京赛诺生物技术有限公司 | 新型胰岛素衍生物及其用途 |
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| AU2020418207A1 (en) * | 2019-12-30 | 2022-08-25 | Gan & Lee Pharmaceuticals Co., Ltd. | Long-acting GLP-1 compound |
| MX2023008330A (es) | 2021-01-20 | 2024-01-18 | Viking Therapeutics Inc | Agonistas del receptor dual gip/glp-1 de molécula pequeña, composiciones farmacéuticas y preparación de las mismas para usarse en el tratamiento de trastornos metabólicos y hepáticos. |
| CA3217734A1 (en) * | 2021-05-24 | 2022-12-01 | Baoye ZHENG | A novel acylated insulin analog |
| EP4361174A1 (en) * | 2021-06-25 | 2024-05-01 | Gan & Lee Pharmaceuticals Co., Ltd. | Acylated insulin-containing pharmaceutical composition |
| CN116162147B (zh) * | 2021-11-24 | 2023-10-03 | 成都奥达生物科技有限公司 | 一种长效胰岛素类似物 |
| CN118574842A (zh) * | 2022-01-28 | 2024-08-30 | 甘李药业股份有限公司 | 酰化胰岛素 |
| WO2024179606A1 (zh) * | 2023-03-02 | 2024-09-06 | 甘李药业股份有限公司 | 一种glp-1化合物的医药用途 |
| CN116327890B (zh) * | 2023-05-29 | 2023-12-08 | 北京先为达生物科技有限公司 | 口服递送的组合物及其应用 |
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| CN101784563A (zh) * | 2007-08-15 | 2010-07-21 | 诺沃-诺迪斯克有限公司 | 具有包括含亚烷基二醇的氨基酸的重复单位的酰基部分的胰岛素 |
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