JPWO2021070696A5 - - Google Patents
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- Publication number
- JPWO2021070696A5 JPWO2021070696A5 JP2021551358A JP2021551358A JPWO2021070696A5 JP WO2021070696 A5 JPWO2021070696 A5 JP WO2021070696A5 JP 2021551358 A JP2021551358 A JP 2021551358A JP 2021551358 A JP2021551358 A JP 2021551358A JP WO2021070696 A5 JPWO2021070696 A5 JP WO2021070696A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- cyclic peptide
- peptide according
- sequence represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 26
- 102000001189 Cyclic Peptides Human genes 0.000 claims 18
- 108010069514 Cyclic Peptides Proteins 0.000 claims 18
- 150000001413 amino acids Chemical class 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 3
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 3
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 2
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 102000043321 human CTLA4 Human genes 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims 1
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 1
- 239000012275 CTLA-4 inhibitor Substances 0.000 claims 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000054189 human CD80 Human genes 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019185266 | 2019-10-08 | ||
| JP2019185266 | 2019-10-08 | ||
| PCT/JP2020/037100 WO2021070696A1 (ja) | 2019-10-08 | 2020-09-30 | Ｃｔｌａ－４阻害活性を有する環状ペプチド、及びその用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021070696A1 JPWO2021070696A1 (https=) | 2021-04-15 |
| JPWO2021070696A5 true JPWO2021070696A5 (https=) | 2022-06-21 |
| JP7477182B2 JP7477182B2 (ja) | 2024-05-01 |
Family
ID=75437884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021551358A Active JP7477182B2 (ja) | 2019-10-08 | 2020-09-30 | Ｃｔｌａ－４阻害活性を有する環状ペプチド、及びその用途 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US12565517B2 (https=) |
| EP (1) | EP4043076B1 (https=) |
| JP (1) | JP7477182B2 (https=) |
| WO (1) | WO2021070696A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20250154200A1 (en) * | 2021-12-20 | 2025-05-15 | Kansas State University Research Foundation | Cyclic peptide for cancer immunotherapy |
| CN115636872B (zh) * | 2022-06-24 | 2026-02-24 | 中国农业科学院生物技术研究所 | 木糖酸肽类化合物及其在抗寄生虫药物中的应用 |
| CN116178490A (zh) * | 2022-07-08 | 2023-05-30 | 北京工商大学 | 一种高活性淀粉酶抑制活性肽及其制备方法和应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6084067A (en) | 1993-07-26 | 2000-07-04 | Dana-Farber Cancer Institute | CTLA4/CD28 ligands and uses therefor |
| CA2167091A1 (en) | 1993-07-26 | 1995-02-02 | Gordon J. Freeman | B7-2: ctl a4/cd 28 counter receptor |
| JP5605602B2 (ja) | 2007-03-26 | 2014-10-15 | 国立大学法人 東京大学 | 環状ペプチド化合物の合成方法 |
| JP4931135B2 (ja) | 2007-05-02 | 2012-05-16 | 国立大学法人 東京大学 | リボソームディスプレイ |
| EP2646552B1 (en) | 2010-12-02 | 2017-07-05 | Pieris Pharmaceuticals GmbH | Muteins of human lipocalin 2 with affinity for ctla-4 |
| EP2647721B1 (en) | 2010-12-03 | 2019-02-27 | The University of Tokyo | Peptide with safer secondary structure, peptide library, and production methods for same |
| JP5948673B2 (ja) | 2011-03-10 | 2016-07-06 | ジーンフロンティア株式会社 | リポ多糖混入量を低減した蛋白質合成用組成物、該組成物を用いた蛋白質製造方法 |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| TW202446781A (zh) | 2011-12-28 | 2024-12-01 | 日商中外製藥股份有限公司 | 胜肽化合物之製造方法 |
| GB201311475D0 (en) | 2013-06-27 | 2013-08-14 | Alligator Bioscience Ab | Polypeptides |
| JP6890830B2 (ja) | 2015-05-01 | 2021-06-23 | ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ | Ｃｔｌａ−４アンタゴニストによる、免疫応答の増強方法 |
| EP3467107B1 (en) | 2016-06-07 | 2022-06-01 | Kaneka Corporation | Ribosome display complex and production method therefor |
| WO2017217545A1 (ja) | 2016-06-16 | 2017-12-21 | 国立大学法人東京大学 | プレキシンの結合調節剤 |
| JP7134677B2 (ja) | 2018-04-05 | 2022-09-12 | 日本信号株式会社 | 駐車位置記憶システム |
-
2020
- 2020-09-30 US US17/767,550 patent/US12565517B2/en active Active
- 2020-09-30 JP JP2021551358A patent/JP7477182B2/ja active Active
- 2020-09-30 EP EP20874686.7A patent/EP4043076B1/en active Active
- 2020-09-30 WO PCT/JP2020/037100 patent/WO2021070696A1/ja not_active Ceased
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