JPWO2021027813A5 - - Google Patents

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Publication number
JPWO2021027813A5
JPWO2021027813A5 JP2022508803A JP2022508803A JPWO2021027813A5 JP WO2021027813 A5 JPWO2021027813 A5 JP WO2021027813A5 JP 2022508803 A JP2022508803 A JP 2022508803A JP 2022508803 A JP2022508803 A JP 2022508803A JP WO2021027813 A5 JPWO2021027813 A5 JP WO2021027813A5
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JP
Japan
Prior art keywords
formula
asenapine
acid
mixtures
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022508803A
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English (en)
Japanese (ja)
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JP2022543894A (ja
Publication date
Priority claimed from CN201910744003.9A external-priority patent/CN110606852B/zh
Application filed filed Critical
Publication of JP2022543894A publication Critical patent/JP2022543894A/ja
Publication of JPWO2021027813A5 publication Critical patent/JPWO2021027813A5/ja
Pending legal-status Critical Current

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JP2022508803A 2019-08-13 2020-08-11 アセナピンを調製する方法 Pending JP2022543894A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910744003.9 2019-08-13
CN201910744003.9A CN110606852B (zh) 2019-08-13 2019-08-13 制备阿塞那平的方法
PCT/CN2020/108452 WO2021027813A1 (zh) 2019-08-13 2020-08-11 制备阿塞那平的方法

Publications (2)

Publication Number Publication Date
JP2022543894A JP2022543894A (ja) 2022-10-14
JPWO2021027813A5 true JPWO2021027813A5 (zh) 2023-08-14

Family

ID=68890111

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022508803A Pending JP2022543894A (ja) 2019-08-13 2020-08-11 アセナピンを調製する方法

Country Status (6)

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US (2) US11535628B2 (zh)
EP (1) EP4015519A4 (zh)
JP (1) JP2022543894A (zh)
KR (1) KR20220052954A (zh)
CN (2) CN110606852B (zh)
WO (1) WO2021027813A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110606852B (zh) * 2019-08-13 2021-02-05 浙江奥翔药业股份有限公司 制备阿塞那平的方法
DE102020207642A1 (de) * 2020-06-19 2021-12-23 Lts Lohmann Therapie-Systeme Ag Verfahren zur herstellung von asenapin in form seiner freien base
CN114605280A (zh) * 2022-03-31 2022-06-10 海南普利制药股份有限公司 一种制备碘帕醇中间体的改进方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7605526A (nl) 1976-05-24 1977-11-28 Akzo Nv Nieuwe tetracyclische derivaten.
US7750167B2 (en) * 2006-07-05 2010-07-06 N.V. Organon Process for the preparation of asenapine and intermediate products used in said process
TW200817414A (en) * 2006-07-05 2008-04-16 Organon Nv Process for the preparation of asenapine and intermediate products used in said process
WO2012038975A2 (en) * 2010-09-22 2012-03-29 Msn Laboratories Limited Process for the preparation of (3ars,12brs)-5-chloro-2-methyl-2,3,3a12b-tetrahydro-1hdibenzo[2,3:6,7] oxepino [4,5-c]pyrrole maleate and it's pharmaceutical composition thereof
US20130274466A1 (en) * 2010-09-27 2013-10-17 Alphora Research Inc. Process for the preparation of tetracyclic derivatives and intermediate products used in the process
CN102229613B (zh) * 2011-04-27 2013-08-07 上海华升生物科技有限公司 阿森纳平的合成工艺
EP2524921A1 (en) * 2011-05-17 2012-11-21 Sandoz AG Novel Crystalline Salts of Asenapine
WO2013061247A1 (en) * 2011-10-24 2013-05-02 Alembic Pharmaceuticals Limited Novel process for the preparation of asenapine
KR101637177B1 (ko) * 2014-03-14 2016-07-07 건일제약 주식회사 8-히드록시클로미프라민 또는 이의 약학적으로 허용가능한 염의 제조방법
CN104974167B (zh) * 2014-04-02 2019-01-04 洋浦慧谷医药有限公司 阿塞那平的制备方法以及用于制备阿塞那平的中间体
CN104974168B (zh) * 2014-04-02 2019-01-04 洋浦慧谷医药有限公司 阿塞那平的制备方法以及用于制备阿塞那平的中间体
CN107759609A (zh) * 2016-08-22 2018-03-06 天津市汉康医药生物技术有限公司 一种阿塞那平的纯化方法
CN110606852B (zh) * 2019-08-13 2021-02-05 浙江奥翔药业股份有限公司 制备阿塞那平的方法

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