|
US5658920A
(en)
|
1991-01-16 |
1997-08-19 |
Daiichi Pharmaceutical Co., Ltd. |
Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound
|
|
US6504029B1
(en)
|
1995-04-10 |
2003-01-07 |
Daiichi Pharmaceutical Co., Ltd. |
Condensed-hexacyclic compounds and a process therefor
|
|
HUP9901092A3
(en)
|
1995-08-02 |
2001-11-28 |
Univ Newcastle Ventures Ltd |
Benzimidazole compounds and their pharmaceutical use
|
|
DE69707860T2
(de)
|
1996-04-26 |
2002-04-11 |
Daiichi Seiyaku Co |
Verfahren zur herstellung von tetrahydroindolizinen
|
|
TW527183B
(en)
|
1996-06-06 |
2003-04-11 |
Daiichi Seiyaku Co |
Drug complex
|
|
TW409058B
(en)
|
1996-06-06 |
2000-10-21 |
Daiichi Seiyaku Co |
Method for preparation of a drug complex
|
|
IN189180B
(US07847105-20101207-C00016.png)
|
1997-07-09 |
2003-01-04 |
Chong Kun Dang Corp |
|
|
WO1999061061A1
(fr)
|
1998-05-22 |
1999-12-02 |
Daiichi Pharmaceutical Co., Ltd. |
Composites medicamenteux
|
|
EA003790B1
(ru)
|
1998-10-30 |
2003-10-30 |
Дайити Фармасьютикал Ко., Лтд. |
Соединение сдлс и способ его измерения
|
|
EP1391457B1
(de)
|
1998-11-03 |
2013-12-25 |
AbbVie Deutschland GmbH & Co KG |
Substituierte 2-Phenylbenzimidazole und deren Verwendung als PARP Inhibitoren
|
|
PL210415B1
(pl)
|
1999-01-11 |
2012-01-31 |
Agouron Pharma |
Pochodne indolu, środek farmaceutyczny i zastosowanie pochodnych indolu
|
|
DE19920936A1
(de)
|
1999-05-07 |
2000-11-09 |
Basf Ag |
Heterozyklisch substituierte Benzimidazole, deren Herstellung und Anwendung
|
|
ECSP003637A
(es)
|
1999-08-31 |
2002-03-25 |
Agouron Pharma |
Inhibidores triciclicos de poli (adp-ribosa) polimerasas
|
|
US6699876B2
(en)
|
1999-11-18 |
2004-03-02 |
Les Laboratoires Servier |
Camptothecin analogue compounds
|
|
CA2396513A1
(en)
|
1999-12-13 |
2001-06-14 |
Yanzhi Zhang |
Pseudomycin phosphate prodrugs
|
|
US6815435B2
(en)
|
2000-07-13 |
2004-11-09 |
Daiichi Pharmaceutical Co., Ltd. |
Pharmaceutical compositions containing DDS compounds
|
|
US7151102B2
(en)
|
2000-10-30 |
2006-12-19 |
Kudos Pharmaceuticals Limited |
Phthalazinone derivatives
|
|
US7771727B2
(en)
|
2002-03-01 |
2010-08-10 |
The Administrators Of The Tulane Educational Fund |
Conjugates of therapeutic or cytotoxic agents and biologically active peptides
|
|
KR100951499B1
(ko)
|
2002-03-20 |
2010-04-07 |
브리스톨-마이어스 스큅 컴퍼니 |
플루오로옥신돌의 포스페이트 전구약물
|
|
DE60335359D1
(de)
|
2002-04-30 |
2011-01-27 |
Kudos Pharm Ltd |
Phthalazinonderivate
|
|
US7449464B2
(en)
|
2003-03-12 |
2008-11-11 |
Kudos Pharmaceuticals Limited |
Phthalazinone derivatives
|
|
BRPI0408996A
(pt)
|
2003-03-31 |
2006-03-28 |
Pfizer |
saia de inibidores tricìclicos de poli(adpp-ribose) polimerases
|
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
|
BRPI0410260A
(pt)
|
2003-05-14 |
2006-05-16 |
Immunogen Inc |
composição conjugada para medicamento
|
|
CN1956722A
(zh)
|
2003-05-20 |
2007-05-02 |
伊缪诺金公司 |
含有新的美登素类的改进的细胞毒剂
|
|
US7276497B2
(en)
|
2003-05-20 |
2007-10-02 |
Immunogen Inc. |
Cytotoxic agents comprising new maytansinoids
|
|
GB0317466D0
(en)
|
2003-07-25 |
2003-08-27 |
Univ Sheffield |
Use
|
|
WO2005012305A2
(en)
|
2003-07-25 |
2005-02-10 |
Cancer Research Technology Limited |
Tricyclic parp inhibitors
|
|
DK2305221T3
(en)
|
2003-12-01 |
2015-08-24 |
Kudos Pharm Ltd |
DNA damage repair inhibitors for the treatment of cancer
|
|
WO2005082023A2
(en)
|
2004-02-23 |
2005-09-09 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
|
WO2006012527A1
(en)
*
|
2004-07-23 |
2006-02-02 |
Endocyte, Inc. |
Bivalent linkers and conjugates thereof
|
|
BRPI0515567A
(pt)
|
2004-09-22 |
2008-07-29 |
Pfizer |
combinações terapêuticas compreendendo inibidor de poli (adp-ribose) polimerase
|
|
BRPI0516766A
(pt)
|
2004-09-22 |
2008-09-16 |
Pfizer |
formas polimórficas e amorfas do sal de fosfato de 8-flúor-2{4-[(metilamino)metil]fenil}-1,3,4,5-tetraidro- 6h-azepino[5,4,3-cd]indol-6-ona, composição farmacêutica, formas de dosagens e respectivo uso
|
|
KR100876520B1
(ko)
|
2004-09-22 |
2008-12-31 |
화이자 인코포레이티드 |
폴리(ａｄｐ-리보오스) 폴리머라제 억제제의 제조 방법
|
|
PT1819359E
(pt)
|
2004-12-09 |
2015-05-28 |
Janssen Biotech Inc |
Imunoconjugados anti-integrina, métodos para a sua produção e sua utilização
|
|
ES2399267T3
(es)
|
2005-01-18 |
2013-03-27 |
The Board Of Governors For Higher Education State Of Rhode Island And Providence Plantations |
Suministro selectivo de moléculas al interior de las células o marcación de células en zonas enfermas de tejidos usando un péptido transmembrana sensible a su entorno
|
|
US7301019B2
(en)
|
2005-01-21 |
2007-11-27 |
Immunogen, Inc. |
Method for the preparation of maytansinoid esters
|
|
ES2503719T3
(es)
|
2005-02-11 |
2014-10-07 |
Immunogen, Inc. |
Procedimiento para preparar conjugados de anticuerpos y de maitansinoides
|
|
EA200702239A1
(ru)
|
2005-04-15 |
2008-10-30 |
Иммьюноджен, Инк. |
Уничтожение гетерогенной или смешанной клеточной популяции в опухолях
|
|
IL305084A
(en)
|
2005-08-24 |
2023-10-01 |
Immunogen Inc |
A process for preparing purified drug compounds
|
|
EP1957477B1
(en)
|
2005-09-29 |
2011-12-07 |
Abbott Laboratories |
1h-benzimidazole-4-carboxamides substituted with phenyl at the 2-position are potent parp inhibitors
|
|
ATE540956T1
(de)
|
2005-11-08 |
2012-01-15 |
Immunogen Inc |
Verfahren zur herstellung von maytansinol
|
|
SI2338487T1
(sl)
|
2006-01-17 |
2014-01-31 |
Abbott Laboratories |
Kombinacijska terapija z inhibitorji PARP
|
|
UY30639A1
(es)
|
2006-10-17 |
2008-05-31 |
Kudos Pharm Ltd |
Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones
|
|
JP4611444B2
(ja)
|
2007-01-10 |
2011-01-12 |
イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー |
ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）阻害剤としてのアミド置換インダゾール
|
|
WO2008114114A2
(en)
|
2007-03-16 |
2008-09-25 |
Pfizer Products Inc. |
Poly(adp-ribose) polymerases inhibitor for treating ophthalmic condition
|
|
EP3569251A1
(en)
*
|
2007-06-25 |
2019-11-20 |
Endocyte, Inc. |
Conjugates containing hydrophilic spacer linkers
|
|
US8067613B2
(en)
|
2007-07-16 |
2011-11-29 |
Abbott Laboratories |
Benzimidazole poly(ADP ribose)polymerase inhibitors
|
|
EP3656403B1
(en)
*
|
2007-08-17 |
2022-05-11 |
Purdue Research Foundation |
Preparation process of psma binding ligand-linker conjugates
|
|
BRPI0911442A2
(pt)
|
2008-04-30 |
2019-03-12 |
Immunogen, Inc. |
conjugados potentes e ligantes hidrofílicos
|
|
LT2437790T
(lt)
|
2009-06-03 |
2019-06-10 |
Immunogen, Inc. |
Konjugavimo būdai
|
|
WO2011066418A1
(en)
|
2009-11-25 |
2011-06-03 |
Academia Sinica |
The tumor-selective anti-cancer prodrug bqc-g
|
|
RS59494B1
(sr)
|
2010-02-12 |
2019-12-31 |
Pfizer |
Soli i polimorfi 8-fluoro-2-{4-[(metilamino)metil]fenil}-1,3,4,5-tetrahidro-6h-azepino[5,4, 3-cd]indol-6-ona
|
|
WO2011106639A1
(en)
*
|
2010-02-25 |
2011-09-01 |
Purdue Research Foundation |
Psma binding ligand-linker conjugates and methods for using
|
|
HUE026235T2
(en)
|
2010-03-31 |
2016-06-28 |
Gilead Pharmasset Llc |
Crystalline (S) -isopropyl 2 - (((S) - (((2R, 3R, 4R, 5R) -5- (2,4-dioxo-3,4-dihydropyrimidin-1 (2H) -IL) - 4-Fluoro-3-hydroxy-4-methyltetrahydrofuran-2-IL) methoxy) (phenoxy) phosphoryl) amino) propanoate
|
|
EP2566335B1
(en)
|
2010-05-05 |
2016-06-29 |
Prolynx Llc |
Controlled release of active compounds from macromolecular conjugates
|
|
EP4098272A3
(en)
|
2010-07-13 |
2023-03-08 |
University of Rhode Island Board of Trustees |
Compositions comprising a ph-sensitive membrane insertion polipeptide
|
|
WO2012021790A1
(en)
|
2010-08-13 |
2012-02-16 |
Rhode Island Board Of Governors For Higher Education |
Liposome compositions and methods of use thereof
|
|
BR112013010853A2
(pt)
|
2010-11-03 |
2016-08-16 |
Immunogen Inc |
"agentes citotóxicos compreendendo derivados de ansamitocina, composição farmacêutica e uso destes"
|
|
WO2012135517A2
(en)
|
2011-03-29 |
2012-10-04 |
Immunogen, Inc. |
Preparation of maytansinoid antibody conjugates by a one-step process
|
|
KR20220009505A
(ko)
|
2011-03-29 |
2022-01-24 |
이뮤노젠 아이엔씨 |
일-단계 방법에 의한 메이탄시노이드 항체 접합체의 제조
|
|
SI2750713T1
(sl)
|
2011-10-14 |
2016-01-29 |
Medimmune Limited |
Pirolobenzodiazepini in njihovi konjugati
|
|
BR122021014365B1
(pt)
|
2012-10-11 |
2022-07-05 |
Daiichi Sankyo Company, Limited |
Conjugado de anticorpo-fármaco, fármacos e composição farmacêutica compreendendo os mesmos, e uso
|
|
WO2014061277A1
(ja)
|
2012-10-19 |
2014-04-24 |
第一三共株式会社 |
親水性構造を含むリンカーで結合させた抗体－薬物コンジュゲート
|
|
US9180203B2
(en)
|
2012-10-23 |
2015-11-10 |
The Johns Hopkins University |
Self-assembling drug amphiphiles and methods for synthesis and use
|
|
WO2014093343A2
(en)
|
2012-12-10 |
2014-06-19 |
Massachusetts Institute Of Technology |
Multistage nanoparticle drug delivery system for the treatment of solid tumors
|
|
WO2014134483A2
(en)
|
2013-02-28 |
2014-09-04 |
Immunogen, Inc. |
Conjugates comprising cell-binding agents and cytotoxic agents
|
|
IL290330B2
(en)
|
2013-12-19 |
2023-09-01 |
Seagen Inc |
Methylene carbamate binders for use with drug-targeting conjugates
|
|
JP6663350B2
(ja)
|
2014-01-16 |
2020-03-11 |
クロヴィス・オンコロジー，インコーポレーテッド |
ヘテロ接合性の喪失を示す乳癌または卵巣癌の患者を治療するためのｐａｒｐ阻害剤の使用
|
|
JP2017114763A
(ja)
|
2014-03-26 |
2017-06-29 |
第一三共株式会社 |
抗ｃｄ９８抗体−薬物コンジュゲート
|
|
KR102186027B1
(ko)
|
2014-04-10 |
2020-12-03 |
다이이치 산쿄 유럽 게엠베하 |
항her3 항체-약물 콘주게이트
|
|
EP3130608B1
(en)
|
2014-04-10 |
2019-09-04 |
Daiichi Sankyo Co., Ltd. |
(anti-her2 antibody)-drug conjugate
|
|
EP3182975A4
(en)
|
2014-08-22 |
2018-04-18 |
Clovis Oncology, Inc. |
High dosage strength tablets of rucaparib
|
|
CN106470697B
(zh)
|
2014-09-16 |
2019-10-25 |
兴盟生物医药(苏州)有限公司 |
抗egfr抗体以及其用途
|
|
KR20170088905A
(ko)
|
2014-11-19 |
2017-08-02 |
이뮤노젠 아이엔씨 |
세포 결합 작용제-세포독성 작용제 접합체를 제조하기 위한 공정
|
|
MA43354A
(fr)
|
2015-10-16 |
2018-08-22 |
Genentech Inc |
Conjugués médicamenteux à pont disulfure encombré
|
|
HUE049775T2
(hu)
|
2015-11-24 |
2020-10-28 |
Theravance Biopharma R&D Ip Llc |
Gasztrointesztinális gyulladásos betegség kezelésére szolgáló JAK inhibitor vegyület elõgyógyszerei
|
|
KR102498258B1
(ko)
|
2016-01-20 |
2023-02-10 |
삼성디스플레이 주식회사 |
표시 장치
|
|
US20170267727A1
(en)
|
2016-03-04 |
2017-09-21 |
Lehigh University |
Conjugates of pH Low Insertion Peptide and Monomethyl Auristatins in the Treatment of Solid Tumors
|
|
US10064855B2
(en)
|
2016-03-08 |
2018-09-04 |
Los Gatos Pharmaceuticals, Inc. |
Composite nanoparticles and uses thereof
|
|
WO2017180834A1
(en)
|
2016-04-13 |
2017-10-19 |
Tarveda Therapeutics, Inc. |
Neurotensin receptor binding conjugates and formulations thereof
|
|
GB201608885D0
(en)
|
2016-05-20 |
2016-07-06 |
Univ Birmingham |
Treatment
|
|
US20190133980A1
(en)
|
2016-06-02 |
2019-05-09 |
Yale University |
Compositions and methods for targeting and treating homologous recombination-deficient tumors
|
|
US20210283281A1
(en)
|
2016-07-29 |
2021-09-16 |
Memorial Sloan Kettering Cancer Center |
Radiolabeled ligands for targeted pet/spect imaging and methods of their use
|
|
AU2017311927B2
(en)
|
2016-08-16 |
2021-06-03 |
National Institute Of Advanced Industrial Science And Technology |
Malignant tumor target peptide
|
|
US11738096B2
(en)
|
2016-09-22 |
2023-08-29 |
Yale University |
Method of detecting diseased or damaged tissue with a pH-triggered polypeptide fluorophore composition
|
|
CA3066384A1
(en)
|
2017-06-09 |
2018-12-13 |
Rhode Island Council On Postsecondary Education |
Linked and other ph-triggered compounds
|
|
US11318212B2
(en)
|
2017-08-31 |
2022-05-03 |
Daiichi Sankyo Company, Limited |
Method for producing antibody-drug conjugate
|
|
JP7356450B2
(ja)
|
2018-01-05 |
2023-10-04 |
サイブレクサ １・インコーポレイテッド |
酸性または低酸素の疾患組織を含む疾患の治療のための化合物、組成物、及び方法
|
|
KR20200109345A
(ko)
|
2018-01-12 |
2020-09-22 |
프로린크스 엘엘시 |
상승적 암 치료
|
|
US20210187118A1
(en)
|
2018-05-18 |
2021-06-24 |
Daiichi Sankyo Co., Ltd. |
Anti-muc1 antibody-drug conjugate
|
|
TW202015740A
(zh)
|
2018-06-07 |
2020-05-01 |
美商西雅圖遺傳學公司 |
喜樹鹼結合物
|
|
CN109232719B
(zh)
|
2018-09-21 |
2021-06-29 |
中国科学院理化技术研究所 |
一种pH响应的抗菌肽及其制备方法和应用
|
|
WO2020160009A1
(en)
|
2019-01-28 |
2020-08-06 |
Rhode Island Council On Postsecondary Education |
Phlip® targeted delivery of potent cytotoxic compounds
|
|
JP7210770B2
(ja)
|
2019-03-29 |
2023-01-23 |
メドイミューン・リミテッド |
化合物及びその複合体
|
|
JP2022541747A
(ja)
|
2019-07-10 |
2022-09-27 |
サイブレクサ ３，インコーポレイテッド |
治療薬としての微小管標的化剤のペプチドコンジュゲート
|
