JPWO2020223536A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2020223536A5 JPWO2020223536A5 JP2021564465A JP2021564465A JPWO2020223536A5 JP WO2020223536 A5 JPWO2020223536 A5 JP WO2020223536A5 JP 2021564465 A JP2021564465 A JP 2021564465A JP 2021564465 A JP2021564465 A JP 2021564465A JP WO2020223536 A5 JPWO2020223536 A5 JP WO2020223536A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- disease
- syndrome
- halo
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 190
- 150000001875 compounds Chemical class 0.000 claims description 149
- 229910052739 hydrogen Inorganic materials 0.000 claims description 135
- 239000001257 hydrogen Substances 0.000 claims description 124
- 208000017169 kidney disease Diseases 0.000 claims description 102
- 150000002431 hydrogen Chemical class 0.000 claims description 75
- 125000005843 halogen group Chemical group 0.000 claims description 66
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 53
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 52
- 208000011580 syndromic disease Diseases 0.000 claims description 46
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 45
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 44
- 201000010099 disease Diseases 0.000 claims description 42
- 125000001153 fluoro group Chemical group F* 0.000 claims description 40
- 125000004429 atom Chemical group 0.000 claims description 39
- 125000000623 heterocyclic group Chemical group 0.000 claims description 36
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 35
- 229910052757 nitrogen Inorganic materials 0.000 claims description 32
- 208000009304 Acute Kidney Injury Diseases 0.000 claims description 30
- -1 1,3-dioxolanyl ring Chemical group 0.000 claims description 24
- 208000033626 Renal failure acute Diseases 0.000 claims description 24
- 201000011040 acute kidney failure Diseases 0.000 claims description 22
- 229910052799 carbon Inorganic materials 0.000 claims description 21
- 208000022461 Glomerular disease Diseases 0.000 claims description 20
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 18
- 150000003839 salts Chemical class 0.000 claims description 18
- 206010028980 Neoplasm Diseases 0.000 claims description 17
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 16
- 150000001204 N-oxides Chemical class 0.000 claims description 16
- 208000002903 Thalassemia Diseases 0.000 claims description 16
- 125000004474 heteroalkylene group Chemical group 0.000 claims description 16
- 210000003734 kidney Anatomy 0.000 claims description 16
- 239000012453 solvate Substances 0.000 claims description 16
- 208000005980 beta thalassemia Diseases 0.000 claims description 15
- 206010011878 Deafness Diseases 0.000 claims description 14
- 206010018364 Glomerulonephritis Diseases 0.000 claims description 14
- 206010029155 Nephropathy toxic Diseases 0.000 claims description 14
- 208000016354 hearing loss disease Diseases 0.000 claims description 14
- 201000011510 cancer Diseases 0.000 claims description 13
- UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical group C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 claims description 12
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims description 12
- 208000001647 Renal Insufficiency Diseases 0.000 claims description 12
- 230000000694 effects Effects 0.000 claims description 12
- 201000006370 kidney failure Diseases 0.000 claims description 12
- 230000035772 mutation Effects 0.000 claims description 12
- 231100000417 nephrotoxicity Toxicity 0.000 claims description 12
- 230000007694 nephrotoxicity Effects 0.000 claims description 12
- 125000004043 oxo group Chemical group O=* 0.000 claims description 12
- 230000037361 pathway Effects 0.000 claims description 12
- 125000001424 substituent group Chemical group 0.000 claims description 12
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical group C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims description 11
- 125000003545 alkoxy group Chemical group 0.000 claims description 11
- 208000005615 Interstitial Cystitis Diseases 0.000 claims description 10
- 206010034277 Pemphigoid Diseases 0.000 claims description 10
- 208000004880 Polyuria Diseases 0.000 claims description 10
- 206010047115 Vasculitis Diseases 0.000 claims description 10
- 125000002619 bicyclic group Chemical group 0.000 claims description 10
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims description 10
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 10
- 230000035619 diuresis Effects 0.000 claims description 10
- 206010025135 lupus erythematosus Diseases 0.000 claims description 10
- 230000004770 neurodegeneration Effects 0.000 claims description 10
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 10
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims description 10
- 125000003118 aryl group Chemical group 0.000 claims description 9
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 9
- HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical group C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 claims description 8
- SHXWCVYOXRDMCX-UHFFFAOYSA-N 3,4-methylenedioxymethamphetamine Chemical compound CNC(C)CC1=CC=C2OCOC2=C1 SHXWCVYOXRDMCX-UHFFFAOYSA-N 0.000 claims description 8
- 208000031212 Autoimmune polyendocrinopathy Diseases 0.000 claims description 8
- 206010010356 Congenital anomaly Diseases 0.000 claims description 8
- 208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 claims description 8
- 208000007465 Giant cell arteritis Diseases 0.000 claims description 8
- 206010020772 Hypertension Diseases 0.000 claims description 8
- 206010058799 Mitochondrial encephalomyopathy Diseases 0.000 claims description 8
- 201000004681 Psoriasis Diseases 0.000 claims description 8
- 230000001363 autoimmune Effects 0.000 claims description 8
- 201000005206 focal segmental glomerulosclerosis Diseases 0.000 claims description 8
- 230000010370 hearing loss Effects 0.000 claims description 8
- 231100000888 hearing loss Toxicity 0.000 claims description 8
- 208000012268 mitochondrial disease Diseases 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 8
- 125000004076 pyridyl group Chemical group 0.000 claims description 8
- 201000000306 sarcoidosis Diseases 0.000 claims description 8
- 206010043207 temporal arteritis Diseases 0.000 claims description 8
- 230000001988 toxicity Effects 0.000 claims description 8
- 231100000419 toxicity Toxicity 0.000 claims description 8
- 125000001072 heteroaryl group Chemical group 0.000 claims description 7
- YRLORWPBJZEGBX-UHFFFAOYSA-N 3,4-dihydro-2h-1,4-benzoxazine Chemical group C1=CC=C2NCCOC2=C1 YRLORWPBJZEGBX-UHFFFAOYSA-N 0.000 claims description 6
- QRCGFTXRXYMJOS-UHFFFAOYSA-N 4h-1,4-benzoxazin-3-one Chemical group C1=CC=C2NC(=O)COC2=C1 QRCGFTXRXYMJOS-UHFFFAOYSA-N 0.000 claims description 6
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 6
- 208000032671 Allergic granulomatous angiitis Diseases 0.000 claims description 6
- 206010003591 Ataxia Diseases 0.000 claims description 6
- 208000023275 Autoimmune disease Diseases 0.000 claims description 6
- 208000009299 Benign Mucous Membrane Pemphigoid Diseases 0.000 claims description 6
- 208000006344 Churg-Strauss Syndrome Diseases 0.000 claims description 6
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 6
- 208000011231 Crohn disease Diseases 0.000 claims description 6
- 206010016654 Fibrosis Diseases 0.000 claims description 6
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims description 6
- 208000032982 Hemorrhagic Fever with Renal Syndrome Diseases 0.000 claims description 6
- 241000725303 Human immunodeficiency virus Species 0.000 claims description 6
- 208000019025 Hypokalemia Diseases 0.000 claims description 6
- 208000014919 IgG4-related retroperitoneal fibrosis Diseases 0.000 claims description 6
- 206010038979 Retroperitoneal fibrosis Diseases 0.000 claims description 6
- 206010039710 Scleroderma Diseases 0.000 claims description 6
- 208000021386 Sjogren Syndrome Diseases 0.000 claims description 6
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 6
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 6
- 206010046851 Uveitis Diseases 0.000 claims description 6
- 208000036142 Viral infection Diseases 0.000 claims description 6
- 206010047642 Vitiligo Diseases 0.000 claims description 6
- 206010000496 acne Diseases 0.000 claims description 6
- 208000012998 acute renal failure Diseases 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 6
- 231100000895 deafness Toxicity 0.000 claims description 6
- 201000001981 dermatomyositis Diseases 0.000 claims description 6
- 206010012601 diabetes mellitus Diseases 0.000 claims description 6
- 230000004761 fibrosis Effects 0.000 claims description 6
- 230000003176 fibrotic effect Effects 0.000 claims description 6
- 230000003890 fistula Effects 0.000 claims description 6
- 229910052736 halogen Inorganic materials 0.000 claims description 6
- 208000007475 hemolytic anemia Diseases 0.000 claims description 6
- 208000002557 hidradenitis Diseases 0.000 claims description 6
- 201000007162 hidradenitis suppurativa Diseases 0.000 claims description 6
- 201000008319 inclusion body myositis Diseases 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 208000027866 inflammatory disease Diseases 0.000 claims description 6
- 201000006334 interstitial nephritis Diseases 0.000 claims description 6
- 208000036546 leukodystrophy Diseases 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 208000030159 metabolic disease Diseases 0.000 claims description 6
- 206010065579 multifocal motor neuropathy Diseases 0.000 claims description 6
- 201000006417 multiple sclerosis Diseases 0.000 claims description 6
- 206010028417 myasthenia gravis Diseases 0.000 claims description 6
- 201000008383 nephritis Diseases 0.000 claims description 6
- 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 claims description 6
- 208000024896 potassium deficiency disease Diseases 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 125000003373 pyrazinyl group Chemical group 0.000 claims description 6
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 6
- 208000017520 skin disease Diseases 0.000 claims description 6
- 208000002320 spinal muscular atrophy Diseases 0.000 claims description 6
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 6
- 210000001635 urinary tract Anatomy 0.000 claims description 6
- 210000002700 urine Anatomy 0.000 claims description 6
- 230000009385 viral infection Effects 0.000 claims description 6
- 101100072149 Drosophila melanogaster eIF2alpha gene Proteins 0.000 claims description 5
- 208000023178 Musculoskeletal disease Diseases 0.000 claims description 5
- 208000016097 disease of metabolism Diseases 0.000 claims description 5
- 208000030533 eye disease Diseases 0.000 claims description 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 5
- LBUJPTNKIBCYBY-UHFFFAOYSA-N 1,2,3,4-tetrahydroquinoline Chemical group C1=CC=C2CCCNC2=C1 LBUJPTNKIBCYBY-UHFFFAOYSA-N 0.000 claims description 4
- FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical group C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 claims description 4
- MGKPCLNUSDGXGT-UHFFFAOYSA-N 1-benzofuran-3-one Chemical group C1=CC=C2C(=O)COC2=C1 MGKPCLNUSDGXGT-UHFFFAOYSA-N 0.000 claims description 4
- MGSHXMOLUWTMGP-UHFFFAOYSA-N 3'-carboxy-alpha-chromanol Chemical group C1=CC=C2C(O)CCOC2=C1 MGSHXMOLUWTMGP-UHFFFAOYSA-N 0.000 claims description 4
- MSTDXOZUKAQDRL-UHFFFAOYSA-N 4-Chromanone Chemical group C1=CC=C2C(=O)CCOC2=C1 MSTDXOZUKAQDRL-UHFFFAOYSA-N 0.000 claims description 4
- 208000007122 AIDS-Associated Nephropathy Diseases 0.000 claims description 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 4
- 208000010444 Acidosis Diseases 0.000 claims description 4
- 208000026872 Addison Disease Diseases 0.000 claims description 4
- 108700037006 Adenine phosphoribosyltransferase deficiency Proteins 0.000 claims description 4
- 208000008190 Agammaglobulinemia Diseases 0.000 claims description 4
- 208000028185 Angioedema Diseases 0.000 claims description 4
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims description 4
- 208000003343 Antiphospholipid Syndrome Diseases 0.000 claims description 4
- 201000001320 Atherosclerosis Diseases 0.000 claims description 4
- 208000035913 Atypical hemolytic uremic syndrome Diseases 0.000 claims description 4
- 208000036075 Autosomal dominant tubulointerstitial kidney disease Diseases 0.000 claims description 4
- 208000004884 Balkan Nephropathy Diseases 0.000 claims description 4
- 208000009137 Behcet syndrome Diseases 0.000 claims description 4
- 208000029574 C3 glomerulopathy Diseases 0.000 claims description 4
- 241000218236 Cannabis Species 0.000 claims description 4
- 208000005024 Castleman disease Diseases 0.000 claims description 4
- 201000000915 Chronic Progressive External Ophthalmoplegia Diseases 0.000 claims description 4
- 208000030939 Chronic inflammatory demyelinating polyneuropathy Diseases 0.000 claims description 4
- 208000015943 Coeliac disease Diseases 0.000 claims description 4
- 208000028698 Cognitive impairment Diseases 0.000 claims description 4
- 206010011777 Cystinosis Diseases 0.000 claims description 4
- 208000024940 Dent disease Diseases 0.000 claims description 4
- 201000004624 Dermatitis Diseases 0.000 claims description 4
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 4
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims description 4
- 208000021866 Dressler syndrome Diseases 0.000 claims description 4
- 206010067601 Dysmyelination Diseases 0.000 claims description 4
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims description 4
- 208000001640 Fibromyalgia Diseases 0.000 claims description 4
- 206010016717 Fistula Diseases 0.000 claims description 4
- 208000007522 Fused Kidney Diseases 0.000 claims description 4
- 208000024869 Goodpasture syndrome Diseases 0.000 claims description 4
- 208000035895 Guillain-Barré syndrome Diseases 0.000 claims description 4
- 206010070737 HIV associated nephropathy Diseases 0.000 claims description 4
- 102000001554 Hemoglobins Human genes 0.000 claims description 4
- 108010054147 Hemoglobins Proteins 0.000 claims description 4
- 208000032759 Hemolytic-Uremic Syndrome Diseases 0.000 claims description 4
- 201000004331 Henoch-Schoenlein purpura Diseases 0.000 claims description 4
- 206010019617 Henoch-Schonlein purpura Diseases 0.000 claims description 4
- 208000005176 Hepatitis C Diseases 0.000 claims description 4
- 208000032087 Hereditary Leber Optic Atrophy Diseases 0.000 claims description 4
- 208000037147 Hypercalcaemia Diseases 0.000 claims description 4
- 208000013038 Hypocalcemia Diseases 0.000 claims description 4
- 206010020983 Hypogammaglobulinaemia Diseases 0.000 claims description 4
- 206010021036 Hyponatraemia Diseases 0.000 claims description 4
- 208000029663 Hypophosphatemia Diseases 0.000 claims description 4
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 4
- 208000031814 IgA Vasculitis Diseases 0.000 claims description 4
- 208000010159 IgA glomerulonephritis Diseases 0.000 claims description 4
- 206010021263 IgA nephropathy Diseases 0.000 claims description 4
- 208000028622 Immune thrombocytopenia Diseases 0.000 claims description 4
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims description 4
- 208000002260 Keloid Diseases 0.000 claims description 4
- 206010023330 Keloid scar Diseases 0.000 claims description 4
- 208000023768 LCAT deficiency Diseases 0.000 claims description 4
- 201000000639 Leber hereditary optic neuropathy Diseases 0.000 claims description 4
- 208000003465 Lecithin Cholesterol Acyltransferase Deficiency Diseases 0.000 claims description 4
- 208000006136 Leigh Disease Diseases 0.000 claims description 4
- 208000017507 Leigh syndrome Diseases 0.000 claims description 4
- 208000034800 Leukoencephalopathies Diseases 0.000 claims description 4
- 206010024434 Lichen sclerosus Diseases 0.000 claims description 4
- 208000012309 Linear IgA disease Diseases 0.000 claims description 4
- 208000005777 Lupus Nephritis Diseases 0.000 claims description 4
- 201000009035 MERRF syndrome Diseases 0.000 claims description 4
- 208000004451 Membranoproliferative Glomerulonephritis Diseases 0.000 claims description 4
- 206010049567 Miller Fisher syndrome Diseases 0.000 claims description 4
- 208000014844 Mitochondrial neurogastrointestinal encephalomyopathy Diseases 0.000 claims description 4
- 208000003250 Mixed connective tissue disease Diseases 0.000 claims description 4
- 208000012192 Mucous membrane pemphigoid Diseases 0.000 claims description 4
- 208000034578 Multiple myelomas Diseases 0.000 claims description 4
- 208000003510 Nephrogenic Fibrosing Dermopathy Diseases 0.000 claims description 4
- 206010067467 Nephrogenic systemic fibrosis Diseases 0.000 claims description 4
- 206010029148 Nephrolithiasis Diseases 0.000 claims description 4
- 206010029164 Nephrotic syndrome Diseases 0.000 claims description 4
- 206010053869 POEMS syndrome Diseases 0.000 claims description 4
- 206010048705 Paraneoplastic cerebellar degeneration Diseases 0.000 claims description 4
- 208000000733 Paroxysmal Hemoglobinuria Diseases 0.000 claims description 4
- 208000008223 Pemphigoid Gestationis Diseases 0.000 claims description 4
- 208000031845 Pernicious anaemia Diseases 0.000 claims description 4
- 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 claims description 4
- 241000101040 Pityriasis Species 0.000 claims description 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 4
- 208000030331 Posterior urethral valve Diseases 0.000 claims description 4
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims description 4
- 206010061481 Renal injury Diseases 0.000 claims description 4
- 102100028255 Renin Human genes 0.000 claims description 4
- 108090000783 Renin Proteins 0.000 claims description 4
- 208000005793 Restless legs syndrome Diseases 0.000 claims description 4
- 206010039020 Rhabdomyolysis Diseases 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 206010042276 Subacute endocarditis Diseases 0.000 claims description 4
- 206010042742 Sympathetic ophthalmia Diseases 0.000 claims description 4
- 244000269722 Thea sinensis Species 0.000 claims description 4
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims description 4
- 206010043561 Thrombocytopenic purpura Diseases 0.000 claims description 4
- 208000034841 Thrombotic Microangiopathies Diseases 0.000 claims description 4
- 206010051526 Tolosa-Hunt syndrome Diseases 0.000 claims description 4
- 208000025865 Ulcer Diseases 0.000 claims description 4
- 208000025851 Undifferentiated connective tissue disease Diseases 0.000 claims description 4
- 208000017379 Undifferentiated connective tissue syndrome Diseases 0.000 claims description 4
- 206010065584 Urethral stenosis Diseases 0.000 claims description 4
- 102000018614 Uromodulin Human genes 0.000 claims description 4
- 108010027007 Uromodulin Proteins 0.000 claims description 4
- 208000024780 Urticaria Diseases 0.000 claims description 4
- 230000005856 abnormality Effects 0.000 claims description 4
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 4
- 208000004631 alopecia areata Diseases 0.000 claims description 4
- 201000006288 alpha thalassemia Diseases 0.000 claims description 4
- 206010002022 amyloidosis Diseases 0.000 claims description 4
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 4
- 206010003246 arthritis Diseases 0.000 claims description 4
- 201000008937 atopic dermatitis Diseases 0.000 claims description 4
- 208000010668 atopic eczema Diseases 0.000 claims description 4
- 208000027625 autoimmune inner ear disease Diseases 0.000 claims description 4
- 235000013405 beer Nutrition 0.000 claims description 4
- BNBQRQQYDMDJAH-UHFFFAOYSA-N benzodioxan Chemical group C1=CC=C2OCCOC2=C1 BNBQRQQYDMDJAH-UHFFFAOYSA-N 0.000 claims description 4
- 208000000594 bullous pemphigoid Diseases 0.000 claims description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 4
- 230000002490 cerebral effect Effects 0.000 claims description 4
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical group C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 claims description 4
- QZHPTGXQGDFGEN-UHFFFAOYSA-N chromene Chemical group C1=CC=C2C=C[CH]OC2=C1 QZHPTGXQGDFGEN-UHFFFAOYSA-N 0.000 claims description 4
- 201000005795 chronic inflammatory demyelinating polyneuritis Diseases 0.000 claims description 4
- 208000020832 chronic kidney disease Diseases 0.000 claims description 4
- 208000025302 chronic primary adrenal insufficiency Diseases 0.000 claims description 4
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims description 4
- 208000010877 cognitive disease Diseases 0.000 claims description 4
- 201000003278 cryoglobulinemia Diseases 0.000 claims description 4
- 239000013078 crystal Substances 0.000 claims description 4
- 230000008021 deposition Effects 0.000 claims description 4
- 208000035475 disorder Diseases 0.000 claims description 4
- 230000004064 dysfunction Effects 0.000 claims description 4
- 210000002472 endoplasmic reticulum Anatomy 0.000 claims description 4
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims description 4
- 201000001155 extrinsic allergic alveolitis Diseases 0.000 claims description 4
- 229910052731 fluorine Inorganic materials 0.000 claims description 4
- 231100000854 focal segmental glomerulosclerosis Toxicity 0.000 claims description 4
- 231100000852 glomerular disease Toxicity 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 208000006750 hematuria Diseases 0.000 claims description 4
- 208000018645 hepatic veno-occlusive disease Diseases 0.000 claims description 4
- 201000011200 hepatorenal syndrome Diseases 0.000 claims description 4
- 241000411851 herbal medicine Species 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 208000022098 hypersensitivity pneumonitis Diseases 0.000 claims description 4
- 230000000705 hypocalcaemia Effects 0.000 claims description 4
- 206010021198 ichthyosis Diseases 0.000 claims description 4
- 208000015446 immunoglobulin a vasculitis Diseases 0.000 claims description 4
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical group C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 claims description 4
- 231100000268 induced nephrotoxicity Toxicity 0.000 claims description 4
- 210000001117 keloid Anatomy 0.000 claims description 4
- 201000011486 lichen planus Diseases 0.000 claims description 4
- 208000002780 macular degeneration Diseases 0.000 claims description 4
- 201000001441 melanoma Diseases 0.000 claims description 4
- 210000004379 membrane Anatomy 0.000 claims description 4
- 208000005264 motor neuron disease Diseases 0.000 claims description 4
- 208000017445 musculoskeletal system disease Diseases 0.000 claims description 4
- LOWLISSVPQGXNV-UHFFFAOYSA-N n-(2,3-dihydrochromen-4-ylidene)hydroxylamine Chemical group C1=CC=C2C(=NO)CCOC2=C1 LOWLISSVPQGXNV-UHFFFAOYSA-N 0.000 claims description 4
- 208000008795 neuromyelitis optica Diseases 0.000 claims description 4
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims description 4
- 208000027134 non-immunoglobulin-mediated membranoproliferative glomerulonephritis Diseases 0.000 claims description 4
- 230000003204 osmotic effect Effects 0.000 claims description 4
- 208000033808 peripheral neuropathy Diseases 0.000 claims description 4
- 231100000572 poisoning Toxicity 0.000 claims description 4
- 230000000607 poisoning effect Effects 0.000 claims description 4
- 201000008171 proliferative glomerulonephritis Diseases 0.000 claims description 4
- 201000001474 proteinuria Diseases 0.000 claims description 4
- 208000009954 pyoderma gangrenosum Diseases 0.000 claims description 4
- 230000005855 radiation Effects 0.000 claims description 4
- 208000007056 sickle cell anemia Diseases 0.000 claims description 4
- 201000010153 skin papilloma Diseases 0.000 claims description 4
- 230000035882 stress Effects 0.000 claims description 4
- 208000008467 subacute bacterial endocarditis Diseases 0.000 claims description 4
- 238000002560 therapeutic procedure Methods 0.000 claims description 4
- 231100000397 ulcer Toxicity 0.000 claims description 4
- 210000000626 ureter Anatomy 0.000 claims description 4
- 201000001988 urethral stricture Diseases 0.000 claims description 4
- 208000037157 Azotemia Diseases 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- 239000002955 immunomodulating agent Substances 0.000 claims description 3
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 208000009852 uremia Diseases 0.000 claims description 3
- SDQJTWBNWQABLE-UHFFFAOYSA-N 1h-quinazoline-2,4-dione Chemical group C1=CC=C2C(=O)NC(=O)NC2=C1 SDQJTWBNWQABLE-UHFFFAOYSA-N 0.000 claims description 2
- XWWYZFUBBJHKSP-UHFFFAOYSA-N 2,3-dihydro-1h-quinazolin-4-one Chemical group C1=CC=C2C(=O)NCNC2=C1 XWWYZFUBBJHKSP-UHFFFAOYSA-N 0.000 claims description 2
- KPUSZZFAYGWAHZ-UHFFFAOYSA-N 3-azabicyclo[2.2.2]octane Chemical compound C1CC2CCC1NC2 KPUSZZFAYGWAHZ-UHFFFAOYSA-N 0.000 claims description 2
- CONVAEXWACQJSA-UHFFFAOYSA-N 3-oxabicyclo[2.2.2]octane Chemical compound C1CC2CCC1OC2 CONVAEXWACQJSA-UHFFFAOYSA-N 0.000 claims description 2
- DSQNVVJBWVVVNO-UHFFFAOYSA-N 4h-chromen-4-ol Chemical compound C1=CC=C2C(O)C=COC2=C1 DSQNVVJBWVVVNO-UHFFFAOYSA-N 0.000 claims description 2
- YPWFNLSXQIGJCK-UHFFFAOYSA-N 7-oxabicyclo[2.2.1]heptane Chemical compound C1CC2CCC1O2 YPWFNLSXQIGJCK-UHFFFAOYSA-N 0.000 claims description 2
- XGWFJBFNAQHLEF-UHFFFAOYSA-N 9-anthroic acid Chemical compound C1=CC=C2C(C(=O)O)=C(C=CC=C3)C3=CC2=C1 XGWFJBFNAQHLEF-UHFFFAOYSA-N 0.000 claims description 2
- 206010058808 Abdominal compartment syndrome Diseases 0.000 claims description 2
- 206010063409 Acarodermatitis Diseases 0.000 claims description 2
- 208000022330 Acquired cystic kidney disease Diseases 0.000 claims description 2
- 208000003918 Acute Kidney Tubular Necrosis Diseases 0.000 claims description 2
- 206010000748 Acute febrile neutrophilic dermatosis Diseases 0.000 claims description 2
- 208000032035 Acute focal bacterial nephritis Diseases 0.000 claims description 2
- 206010069688 Acute phosphate nephropathy Diseases 0.000 claims description 2
- 206010072609 Adenine phosphoribosyl transferase deficiency Diseases 0.000 claims description 2
- 201000011374 Alagille syndrome Diseases 0.000 claims description 2
- 208000023434 Alpers-Huttenlocher syndrome Diseases 0.000 claims description 2
- 208000024985 Alport syndrome Diseases 0.000 claims description 2
- 206010001889 Alveolitis Diseases 0.000 claims description 2
- 208000024827 Alzheimer disease Diseases 0.000 claims description 2
- 206010001935 American trypanosomiasis Diseases 0.000 claims description 2
- 102100032187 Androgen receptor Human genes 0.000 claims description 2
- 206010051810 Angiomyolipoma Diseases 0.000 claims description 2
- 108010064733 Angiotensins Proteins 0.000 claims description 2
- 102000015427 Angiotensins Human genes 0.000 claims description 2
- 208000000103 Anorexia Nervosa Diseases 0.000 claims description 2
- 102100030762 Apolipoprotein L1 Human genes 0.000 claims description 2
- 206010003210 Arteriosclerosis Diseases 0.000 claims description 2
- 208000022211 Arteriovenous Malformations Diseases 0.000 claims description 2
- 206010003226 Arteriovenous fistula Diseases 0.000 claims description 2
- 206010003267 Arthritis reactive Diseases 0.000 claims description 2
- 206010003402 Arthropod sting Diseases 0.000 claims description 2
- 102000007371 Ataxin-3 Human genes 0.000 claims description 2
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims description 2
- 206010064539 Autoimmune myocarditis Diseases 0.000 claims description 2
- 206010069002 Autoimmune pancreatitis Diseases 0.000 claims description 2
- 206010061666 Autonomic neuropathy Diseases 0.000 claims description 2
- 208000027580 BK-virus nephropathy Diseases 0.000 claims description 2
- 208000008035 Back Pain Diseases 0.000 claims description 2
- 201000001321 Bardet-Biedl syndrome Diseases 0.000 claims description 2
- 201000005943 Barth syndrome Diseases 0.000 claims description 2
- 208000012904 Bartter disease Diseases 0.000 claims description 2
- 208000010062 Bartter syndrome Diseases 0.000 claims description 2
- 206010004146 Basal cell carcinoma Diseases 0.000 claims description 2
- 208000023328 Basedow disease Diseases 0.000 claims description 2
- 208000025760 Benign familial haematuria Diseases 0.000 claims description 2
- 206010004265 Benign familial pemphigus Diseases 0.000 claims description 2
- 235000016068 Berberis vulgaris Nutrition 0.000 claims description 2
- 241000335053 Beta vulgaris Species 0.000 claims description 2
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims description 2
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims description 2
- 206010069632 Bladder dysfunction Diseases 0.000 claims description 2
- 206010062656 Bladder tamponade Diseases 0.000 claims description 2
- 241000181212 Bourbon virus Species 0.000 claims description 2
- 241000167854 Bourreria succulenta Species 0.000 claims description 2
- 208000013165 Bowen disease Diseases 0.000 claims description 2
- 208000019337 Bowen disease of the skin Diseases 0.000 claims description 2
- 201000006390 Brachial Plexus Neuritis Diseases 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 208000023635 C1q nephropathy Diseases 0.000 claims description 2
- 201000005965 CAKUT Diseases 0.000 claims description 2
- 201000002829 CREST Syndrome Diseases 0.000 claims description 2
- 229940122739 Calcineurin inhibitor Drugs 0.000 claims description 2
- 101710192106 Calcineurin-binding protein cabin-1 Proteins 0.000 claims description 2
- 102100024123 Calcineurin-binding protein cabin-1 Human genes 0.000 claims description 2
- 206010007246 Carboxyhaemoglobinaemia Diseases 0.000 claims description 2
- 208000004990 Cardiorenal syndrome Diseases 0.000 claims description 2
- 208000034103 Castleman-Kojima disease Diseases 0.000 claims description 2
- 208000002177 Cataract Diseases 0.000 claims description 2
- 206010053684 Cerebrohepatorenal syndrome Diseases 0.000 claims description 2
- 208000024699 Chagas disease Diseases 0.000 claims description 2
- 206010008531 Chills Diseases 0.000 claims description 2
- 206010008609 Cholangitis sclerosing Diseases 0.000 claims description 2
- 206010008796 Chromaturia Diseases 0.000 claims description 2
- 208000013725 Chronic Kidney Disease-Mineral and Bone disease Diseases 0.000 claims description 2
- 208000010007 Cogan syndrome Diseases 0.000 claims description 2
- 208000011038 Cold agglutinin disease Diseases 0.000 claims description 2
- 206010009868 Cold type haemolytic anaemia Diseases 0.000 claims description 2
- 108010078777 Colistin Proteins 0.000 claims description 2
- 102000008186 Collagen Human genes 0.000 claims description 2
- 108010035532 Collagen Proteins 0.000 claims description 2
- 102100035325 Complement factor H-related protein 5 Human genes 0.000 claims description 2
- 208000034958 Congenital erythropoietic porphyria Diseases 0.000 claims description 2
- 208000026091 Congenital hearing disease Diseases 0.000 claims description 2
- 206010060737 Congenital nephrotic syndrome Diseases 0.000 claims description 2
- 206010010741 Conjunctivitis Diseases 0.000 claims description 2
- 206010011258 Coxsackie myocarditis Diseases 0.000 claims description 2
- 208000025436 Cramp-fasciculation syndrome Diseases 0.000 claims description 2
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims description 2
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims description 2
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims description 2
- 208000019707 Cryoglobulinemic vasculitis Diseases 0.000 claims description 2
- 208000026292 Cystic Kidney disease Diseases 0.000 claims description 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims description 2
- 206010011778 Cystinuria Diseases 0.000 claims description 2
- 206010011793 Cystitis haemorrhagic Diseases 0.000 claims description 2
- 206010011796 Cystitis interstitial Diseases 0.000 claims description 2
- 241000271305 Daphne laureola Species 0.000 claims description 2
- 208000002506 Darier Disease Diseases 0.000 claims description 2
- ZBNZXTGUTAYRHI-UHFFFAOYSA-N Dasatinib Chemical compound C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1Cl ZBNZXTGUTAYRHI-UHFFFAOYSA-N 0.000 claims description 2
- 206010011903 Deafness traumatic Diseases 0.000 claims description 2
- 206010012289 Dementia Diseases 0.000 claims description 2
- 208000016192 Demyelinating disease Diseases 0.000 claims description 2
- 206010012305 Demyelination Diseases 0.000 claims description 2
- 206010012442 Dermatitis contact Diseases 0.000 claims description 2
- 206010012455 Dermatitis exfoliative Diseases 0.000 claims description 2
- 206010012468 Dermatitis herpetiformis Diseases 0.000 claims description 2
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 2
- 208000004986 Diffuse Cerebral Sclerosis of Schilder Diseases 0.000 claims description 2
- 208000004132 Diffuse mesangial sclerosis Diseases 0.000 claims description 2
- 208000006926 Discoid Lupus Erythematosus Diseases 0.000 claims description 2
- 201000010374 Down Syndrome Diseases 0.000 claims description 2
- 208000001708 Dupuytren contracture Diseases 0.000 claims description 2
- 208000014094 Dystonic disease Diseases 0.000 claims description 2
- 201000004315 EAST syndrome Diseases 0.000 claims description 2
- 201000011001 Ebola Hemorrhagic Fever Diseases 0.000 claims description 2
- 206010063044 Ectopic kidney Diseases 0.000 claims description 2
- 206010014172 Ectopic ureter Diseases 0.000 claims description 2
- 206010060742 Endocrine ophthalmopathy Diseases 0.000 claims description 2
- 201000009273 Endometriosis Diseases 0.000 claims description 2
- 206010014954 Eosinophilic fasciitis Diseases 0.000 claims description 2
- 208000035751 Epidemic nephropathy Diseases 0.000 claims description 2
- 206010014989 Epidermolysis bullosa Diseases 0.000 claims description 2
- 208000025127 Erdheim-Chester disease Diseases 0.000 claims description 2
- 206010015226 Erythema nodosum Diseases 0.000 claims description 2
- 208000007209 Erythropoietic Porphyria Diseases 0.000 claims description 2
- 208000000289 Esophageal Achalasia Diseases 0.000 claims description 2
- 208000004332 Evans syndrome Diseases 0.000 claims description 2
- HTQBXNHDCUEHJF-XWLPCZSASA-N Exenatide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 HTQBXNHDCUEHJF-XWLPCZSASA-N 0.000 claims description 2
- 108010011459 Exenatide Proteins 0.000 claims description 2
- 208000010368 Extramammary Paget Disease Diseases 0.000 claims description 2
- 206010015995 Eyelid ptosis Diseases 0.000 claims description 2
- 208000024720 Fabry Disease Diseases 0.000 claims description 2
- 208000037574 Familial benign chronic pemphigus Diseases 0.000 claims description 2
- 208000026019 Fanconi renotubular syndrome Diseases 0.000 claims description 2
- 201000006328 Fanconi syndrome Diseases 0.000 claims description 2
- 206010016803 Fluid overload Diseases 0.000 claims description 2
- 208000010006 Fraser Syndrome Diseases 0.000 claims description 2
- 201000011240 Frontotemporal dementia Diseases 0.000 claims description 2
- 208000009432 Galloway-Mowat syndrome Diseases 0.000 claims description 2
- 201000006004 Gitelman syndrome Diseases 0.000 claims description 2
- 208000010412 Glaucoma Diseases 0.000 claims description 2
- 206010061431 Glial scar Diseases 0.000 claims description 2
- 206010018341 Gliosis Diseases 0.000 claims description 2
- 206010018372 Glomerulonephritis membranous Diseases 0.000 claims description 2
- 208000015023 Graves' disease Diseases 0.000 claims description 2
- 208000033509 HANAC syndrome Diseases 0.000 claims description 2
- 206010018852 Haematoma Diseases 0.000 claims description 2
- 206010061192 Haemorrhagic fever Diseases 0.000 claims description 2
- 208000027655 Hailey-Hailey disease Diseases 0.000 claims description 2
- 208000006342 Hajdu-Cheney syndrome Diseases 0.000 claims description 2
- 208000008913 Hantavirus Infections Diseases 0.000 claims description 2
- 208000021727 Hantavirus hemorrhagic fever with renal syndrome Diseases 0.000 claims description 2
- 206010019263 Heart block congenital Diseases 0.000 claims description 2
- 208000012925 Hemoglobin H disease Diseases 0.000 claims description 2
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims description 2
- 208000036066 Hemophagocytic Lymphohistiocytosis Diseases 0.000 claims description 2
- 108010061414 Hepatocyte Nuclear Factor 1-beta Proteins 0.000 claims description 2
- 102000012046 Hepatocyte Nuclear Factor 1-beta Human genes 0.000 claims description 2
- 102100022123 Hepatocyte nuclear factor 1-beta Human genes 0.000 claims description 2
- 208000009889 Herpes Simplex Diseases 0.000 claims description 2
- 206010019939 Herpes gestationis Diseases 0.000 claims description 2
- 208000007514 Herpes zoster Diseases 0.000 claims description 2
- 206010020112 Hirsutism Diseases 0.000 claims description 2
- 208000032672 Histiocytosis haematophagic Diseases 0.000 claims description 2
- 101100323521 Homo sapiens APOL1 gene Proteins 0.000 claims description 2
- 101000775732 Homo sapiens Androgen receptor Proteins 0.000 claims description 2
- 101000878134 Homo sapiens Complement factor H-related protein 5 Proteins 0.000 claims description 2
- 101001045758 Homo sapiens Hepatocyte nuclear factor 1-beta Proteins 0.000 claims description 2
- 101000984044 Homo sapiens LIM homeobox transcription factor 1-beta Proteins 0.000 claims description 2
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims description 2
- 101001113490 Homo sapiens Poly(A)-specific ribonuclease PARN Proteins 0.000 claims description 2
- 101001067100 Homo sapiens Uroporphyrinogen-III synthase Proteins 0.000 claims description 2
- 241000702617 Human parvovirus B19 Species 0.000 claims description 2
- 241000829111 Human polyomavirus 1 Species 0.000 claims description 2
- 208000023105 Huntington disease Diseases 0.000 claims description 2
- 208000006031 Hydrops Fetalis Diseases 0.000 claims description 2
- 206010020529 Hydrops foetalis Diseases 0.000 claims description 2
- 206010020571 Hyperaldosteronism Diseases 0.000 claims description 2
- 208000008454 Hyperhidrosis Diseases 0.000 claims description 2
- 208000002682 Hyperkalemia Diseases 0.000 claims description 2
- 206010020669 Hypermagnesaemia Diseases 0.000 claims description 2
- 208000029422 Hypernatremia Diseases 0.000 claims description 2
- 208000008852 Hyperoxaluria Diseases 0.000 claims description 2
- 201000001431 Hyperuricemia Diseases 0.000 claims description 2
- 206010020919 Hypervolaemia Diseases 0.000 claims description 2
- 206010021027 Hypomagnesaemia Diseases 0.000 claims description 2
- 206010021131 Hypouricaemia Diseases 0.000 claims description 2
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims description 2
- 201000003838 Idiopathic interstitial pneumonia Diseases 0.000 claims description 2
- 208000021330 IgG4-related disease Diseases 0.000 claims description 2
- 208000024934 IgG4-related mediastinitis Diseases 0.000 claims description 2
- 108091008036 Immune checkpoint proteins Proteins 0.000 claims description 2
- 102000037982 Immune checkpoint proteins Human genes 0.000 claims description 2
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- 208000031781 Immunoglobulin G4 related sclerosing disease Diseases 0.000 claims description 2
- 208000004187 Immunoglobulin G4-Related Disease Diseases 0.000 claims description 2
- 208000020340 Immunotactoid glomerulopathy Diseases 0.000 claims description 2
- 206010021531 Impetigo Diseases 0.000 claims description 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 2
- 201000006347 Intellectual Disability Diseases 0.000 claims description 2
- 206010022530 Intercapillary glomerulosclerosis Diseases 0.000 claims description 2
- 208000029523 Interstitial Lung disease Diseases 0.000 claims description 2
- 208000002623 Intra-Abdominal Hypertension Diseases 0.000 claims description 2
- 201000008645 Joubert syndrome Diseases 0.000 claims description 2
- 208000003456 Juvenile Arthritis Diseases 0.000 claims description 2
- 201000002531 Karyomegalic interstitial nephritis Diseases 0.000 claims description 2
- 208000011200 Kawasaki disease Diseases 0.000 claims description 2
- 206010023369 Keratosis follicular Diseases 0.000 claims description 2
- 206010066295 Keratosis pilaris Diseases 0.000 claims description 2
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 claims description 2
- 208000000913 Kidney Calculi Diseases 0.000 claims description 2
- 201000003129 Kidney Papillary Necrosis Diseases 0.000 claims description 2
- 206010023423 Kidney hypermobility Diseases 0.000 claims description 2
- 241000110847 Kochia Species 0.000 claims description 2
- 208000016028 Korean hemorrhagic fever Diseases 0.000 claims description 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims description 2
- 239000002067 L01XE06 - Dasatinib Substances 0.000 claims description 2
- 239000002146 L01XE16 - Crizotinib Substances 0.000 claims description 2
- 102100025457 LIM homeobox transcription factor 1-beta Human genes 0.000 claims description 2
- 201000010743 Lambert-Eaton myasthenic syndrome Diseases 0.000 claims description 2
- 206010056715 Laurence-Moon-Bardet-Biedl syndrome Diseases 0.000 claims description 2
- 208000032514 Leukocytoclastic vasculitis Diseases 0.000 claims description 2
- 208000026709 Liddle syndrome Diseases 0.000 claims description 2
- 208000022435 Light chain deposition disease Diseases 0.000 claims description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 2
- 208000008930 Low Back Pain Diseases 0.000 claims description 2
- 208000004852 Lung Injury Diseases 0.000 claims description 2
- 208000016604 Lyme disease Diseases 0.000 claims description 2
- 208000009564 MELAS Syndrome Diseases 0.000 claims description 2
- 208000002569 Machado-Joseph Disease Diseases 0.000 claims description 2
- 208000002720 Malnutrition Diseases 0.000 claims description 2
- 208000002805 Mediastinal fibrosis Diseases 0.000 claims description 2
- 229920000877 Melamine resin Polymers 0.000 claims description 2
- 208000027530 Meniere disease Diseases 0.000 claims description 2
- 208000036626 Mental retardation Diseases 0.000 claims description 2
- 206010027417 Metabolic acidosis Diseases 0.000 claims description 2
- 206010027423 Metabolic alkalosis Diseases 0.000 claims description 2
- 206010027635 Milk-alkali syndrome Diseases 0.000 claims description 2
- 206010052641 Mitochondrial DNA mutation Diseases 0.000 claims description 2
- 208000035155 Mitochondrial DNA-associated Leigh syndrome Diseases 0.000 claims description 2
- 102000006404 Mitochondrial Proteins Human genes 0.000 claims description 2
- 108010058682 Mitochondrial Proteins Proteins 0.000 claims description 2
- 201000002169 Mitochondrial myopathy Diseases 0.000 claims description 2
- 208000026072 Motor neurone disease Diseases 0.000 claims description 2
- 102100034256 Mucin-1 Human genes 0.000 claims description 2
- 208000001089 Multiple system atrophy Diseases 0.000 claims description 2
- 102000016943 Muramidase Human genes 0.000 claims description 2
- 108010014251 Muramidase Proteins 0.000 claims description 2
- 208000008238 Muscle Spasticity Diseases 0.000 claims description 2
- 206010028289 Muscle atrophy Diseases 0.000 claims description 2
- 208000000112 Myalgia Diseases 0.000 claims description 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 2
- 206010028594 Myocardial fibrosis Diseases 0.000 claims description 2
- 201000002481 Myositis Diseases 0.000 claims description 2
- XKLMZUWKNUAPSZ-UHFFFAOYSA-N N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide Chemical compound COC1=CC=CC=C1OCC(O)CN1CCN(CC(=O)NC=2C(=CC=CC=2C)C)CC1 XKLMZUWKNUAPSZ-UHFFFAOYSA-N 0.000 claims description 2
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 2
- 208000013233 NARP syndrome Diseases 0.000 claims description 2
- 206010029158 Nephroptosis Diseases 0.000 claims description 2
- 206010029229 Neuralgic amyotrophy Diseases 0.000 claims description 2
- 208000000693 Neurogenic Urinary Bladder Diseases 0.000 claims description 2
- 206010029279 Neurogenic bladder Diseases 0.000 claims description 2
- 206010071579 Neuronal neuropathy Diseases 0.000 claims description 2
- 208000002946 Noise-Induced Hearing Loss Diseases 0.000 claims description 2
- 241000557624 Nucifraga Species 0.000 claims description 2
- 208000008589 Obesity Diseases 0.000 claims description 2
- 206010030113 Oedema Diseases 0.000 claims description 2
- 206010030136 Oesophageal achalasia Diseases 0.000 claims description 2
- 208000003435 Optic Neuritis Diseases 0.000 claims description 2
- 206010061323 Optic neuropathy Diseases 0.000 claims description 2
- 201000002892 Oroticaciduria Diseases 0.000 claims description 2
- 241000150452 Orthohantavirus Species 0.000 claims description 2
- 206010031127 Orthostatic hypotension Diseases 0.000 claims description 2
- 206010031243 Osteogenesis imperfecta Diseases 0.000 claims description 2
- 206010031252 Osteomyelitis Diseases 0.000 claims description 2
- 206010033266 Ovarian Hyperstimulation Syndrome Diseases 0.000 claims description 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 2
- 208000025174 PANDAS Diseases 0.000 claims description 2
- 208000021155 Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infection Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 208000018737 Parkinson disease Diseases 0.000 claims description 2
- 206010034016 Paronychia Diseases 0.000 claims description 2
- 208000004788 Pars Planitis Diseases 0.000 claims description 2
- 208000013234 Pearson syndrome Diseases 0.000 claims description 2
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 claims description 2
- 201000011152 Pemphigus Diseases 0.000 claims description 2
- 241000721454 Pemphigus Species 0.000 claims description 2
- 208000004362 Penile Induration Diseases 0.000 claims description 2
- 206010034464 Periarthritis Diseases 0.000 claims description 2
- 206010034531 Perinephric abscess Diseases 0.000 claims description 2
- 208000020758 Peyronie disease Diseases 0.000 claims description 2
- 244000046052 Phaseolus vulgaris Species 0.000 claims description 2
- 235000010627 Phaseolus vulgaris Nutrition 0.000 claims description 2
- QPFYXYFORQJZEC-FOCLMDBBSA-N Phenazopyridine Chemical compound NC1=NC(N)=CC=C1\N=N\C1=CC=CC=C1 QPFYXYFORQJZEC-FOCLMDBBSA-N 0.000 claims description 2
- 208000000766 Pityriasis Lichenoides Diseases 0.000 claims description 2
- 102100023715 Poly(A)-specific ribonuclease PARN Human genes 0.000 claims description 2
- 206010065159 Polychondritis Diseases 0.000 claims description 2
- 206010036069 Polydipsia psychogenic Diseases 0.000 claims description 2
- 206010036072 Polyglandular autoimmune syndrome type I Diseases 0.000 claims description 2
- 206010036073 Polyglandular autoimmune syndrome type II Diseases 0.000 claims description 2
- 206010064115 Polyglandular autoimmune syndrome type III Diseases 0.000 claims description 2
- 206010065381 Polyomavirus-associated nephropathy Diseases 0.000 claims description 2
- 206010036186 Porphyria non-acute Diseases 0.000 claims description 2
- 208000031732 Post-Lyme Disease Syndrome Diseases 0.000 claims description 2
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims description 2
- 208000032319 Primary lateral sclerosis Diseases 0.000 claims description 2
- 208000024777 Prion disease Diseases 0.000 claims description 2
- 208000037534 Progressive hemifacial atrophy Diseases 0.000 claims description 2
- 206010036805 Progressive massive fibrosis Diseases 0.000 claims description 2
- 206010063181 Propofol infusion syndrome Diseases 0.000 claims description 2
- 241000241413 Propolis Species 0.000 claims description 2
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims description 2
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims description 2
- 206010068513 Pulmonary renal syndrome Diseases 0.000 claims description 2
- 206010037596 Pyelonephritis Diseases 0.000 claims description 2
- 208000012322 Raynaud phenomenon Diseases 0.000 claims description 2
- 206010065427 Reflux nephropathy Diseases 0.000 claims description 2
- 208000004531 Renal Artery Obstruction Diseases 0.000 claims description 2
- 201000003604 Renal agenesis Diseases 0.000 claims description 2
- 206010038366 Renal aneurysm Diseases 0.000 claims description 2
- 206010064655 Renal aplasia Diseases 0.000 claims description 2
- 206010049942 Renal artery dissection Diseases 0.000 claims description 2
- 206010038378 Renal artery stenosis Diseases 0.000 claims description 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims description 2
- 201000003221 Renal coloboma syndrome Diseases 0.000 claims description 2
- 206010038422 Renal cortical necrosis Diseases 0.000 claims description 2
- 206010038423 Renal cyst Diseases 0.000 claims description 2
- 206010068033 Renal fusion anomaly Diseases 0.000 claims description 2
- 206010062237 Renal impairment Diseases 0.000 claims description 2
- 206010038470 Renal infarct Diseases 0.000 claims description 2
- 208000034955 Renal or urinary tract malformation Diseases 0.000 claims description 2
- 206010038540 Renal tubular necrosis Diseases 0.000 claims description 2
- 206010063837 Reperfusion injury Diseases 0.000 claims description 2
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims description 2
- 206010038934 Retinopathy proliferative Diseases 0.000 claims description 2
- 241001303601 Rosacea Species 0.000 claims description 2
- 240000000111 Saccharum officinarum Species 0.000 claims description 2
- 235000007201 Saccharum officinarum Nutrition 0.000 claims description 2
- 241000447727 Scabies Species 0.000 claims description 2
- 206010039705 Scleritis Diseases 0.000 claims description 2
- 206010062553 Scleroderma renal crisis Diseases 0.000 claims description 2
- 208000034189 Sclerosis Diseases 0.000 claims description 2
- 208000000859 Sickle cell trait Diseases 0.000 claims description 2
- 201000010001 Silicosis Diseases 0.000 claims description 2
- 208000036834 Spinocerebellar ataxia type 3 Diseases 0.000 claims description 2
- 208000010265 Sweet syndrome Diseases 0.000 claims description 2
- 206010042674 Swelling Diseases 0.000 claims description 2
- 201000009594 Systemic Scleroderma Diseases 0.000 claims description 2
- 206010042953 Systemic sclerosis Diseases 0.000 claims description 2
- 208000012169 TAFRO syndrome Diseases 0.000 claims description 2
- 208000001106 Takayasu Arteritis Diseases 0.000 claims description 2
- 206010052779 Transplant rejections Diseases 0.000 claims description 2
- 206010069363 Traumatic lung injury Diseases 0.000 claims description 2
- 241000223109 Trypanosoma cruzi Species 0.000 claims description 2
- 208000026911 Tuberous sclerosis complex Diseases 0.000 claims description 2
- 206010048302 Tubulointerstitial nephritis Diseases 0.000 claims description 2
- 206010045170 Tumour lysis syndrome Diseases 0.000 claims description 2
- 206010046298 Upper motor neurone lesion Diseases 0.000 claims description 2
- 208000006353 Ureterocele Diseases 0.000 claims description 2
- 206010046437 Urethral caruncle Diseases 0.000 claims description 2
- 206010046530 Urinary bladder rupture Diseases 0.000 claims description 2
- 206010046543 Urinary incontinence Diseases 0.000 claims description 2
- 102100034397 Uroporphyrinogen-III synthase Human genes 0.000 claims description 2
- 108010059993 Vancomycin Proteins 0.000 claims description 2
- 102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 claims description 2
- 208000012634 Venoocclusive liver disease Diseases 0.000 claims description 2
- 208000033774 Ventricular Remodeling Diseases 0.000 claims description 2
- 206010047370 Vesicoureteric reflux Diseases 0.000 claims description 2
- 208000025749 Vogt-Koyanagi-Harada disease Diseases 0.000 claims description 2
- 208000034705 Vogt-Koyanagi-Harada syndrome Diseases 0.000 claims description 2
- 206010047700 Vomiting Diseases 0.000 claims description 2
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims description 2
- 241000710886 West Nile virus Species 0.000 claims description 2
- 208000006269 X-Linked Bulbo-Spinal Atrophy Diseases 0.000 claims description 2
- 201000004525 Zellweger Syndrome Diseases 0.000 claims description 2
- 208000036813 Zellweger spectrum disease Diseases 0.000 claims description 2
- YKOWBJJOJNGCAD-SHYZEUOFSA-N [(2r,3s,5r)-3-hydroxy-5-[4-(hydroxyamino)-2-oxopyrimidin-1-yl]oxolan-2-yl]methyl dihydrogen phosphate Chemical compound O=C1N=C(NO)C=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)C1 YKOWBJJOJNGCAD-SHYZEUOFSA-N 0.000 claims description 2
- 238000009825 accumulation Methods 0.000 claims description 2
- 201000000621 achalasia Diseases 0.000 claims description 2
- 230000007950 acidosis Effects 0.000 claims description 2
- 208000026545 acidosis disease Diseases 0.000 claims description 2
- 208000007782 acroosteolysis dominant type Diseases 0.000 claims description 2
- 208000009621 actinic keratosis Diseases 0.000 claims description 2
- 208000002552 acute disseminated encephalomyelitis Diseases 0.000 claims description 2
- 229940035674 anesthetics Drugs 0.000 claims description 2
- 238000011225 antiretroviral therapy Methods 0.000 claims description 2
- 208000005838 apparent mineralocorticoid excess syndrome Diseases 0.000 claims description 2
- 208000011775 arteriosclerosis disease Diseases 0.000 claims description 2
- 230000005744 arteriovenous malformation Effects 0.000 claims description 2
- 206010003230 arteritis Diseases 0.000 claims description 2
- 230000001746 atrial effect Effects 0.000 claims description 2
- 208000006424 autoimmune oophoritis Diseases 0.000 claims description 2
- 206010071578 autoimmune retinopathy Diseases 0.000 claims description 2
- 208000029407 autoimmune urticaria Diseases 0.000 claims description 2
- 230000005784 autoimmunity Effects 0.000 claims description 2
- 230000008959 autophagy deficiency Effects 0.000 claims description 2
- 208000023351 autosomal dominant familial hematuria-retinal arteriolar tortuosity-contractures syndrome Diseases 0.000 claims description 2
- 201000003974 autosomal dominant hypocalcemia Diseases 0.000 claims description 2
- 230000003376 axonal effect Effects 0.000 claims description 2
- 206010003882 axonal neuropathy Diseases 0.000 claims description 2
- 238000007681 bariatric surgery Methods 0.000 claims description 2
- 210000002469 basement membrane Anatomy 0.000 claims description 2
- 150000008366 benzophenones Chemical class 0.000 claims description 2
- MKCBRYIXFFGIKN-UHFFFAOYSA-N bicyclo[1.1.1]pentane Chemical compound C1C2CC1C2 MKCBRYIXFFGIKN-UHFFFAOYSA-N 0.000 claims description 2
- JSMRMEYFZHIPJV-UHFFFAOYSA-N bicyclo[2.1.1]hexane Chemical compound C1C2CC1CC2 JSMRMEYFZHIPJV-UHFFFAOYSA-N 0.000 claims description 2
- GPRLTFBKWDERLU-UHFFFAOYSA-N bicyclo[2.2.2]octane Chemical compound C1CC2CCC1CC2 GPRLTFBKWDERLU-UHFFFAOYSA-N 0.000 claims description 2
- LPCWKMYWISGVSK-UHFFFAOYSA-N bicyclo[3.2.1]octane Chemical compound C1C2CCC1CCC2 LPCWKMYWISGVSK-UHFFFAOYSA-N 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 208000029028 brain injury Diseases 0.000 claims description 2
- 229940084891 byetta Drugs 0.000 claims description 2
- 208000025616 calcium-alkali syndrome Diseases 0.000 claims description 2
- 229930003827 cannabinoid Natural products 0.000 claims description 2
- 239000003557 cannabinoid Substances 0.000 claims description 2
- 230000009787 cardiac fibrosis Effects 0.000 claims description 2
- 108010021331 carfilzomib Proteins 0.000 claims description 2
- BLMPQMFVWMYDKT-NZTKNTHTSA-N carfilzomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)[C@]1(C)OC1)NC(=O)CN1CCOCC1)CC1=CC=CC=C1 BLMPQMFVWMYDKT-NZTKNTHTSA-N 0.000 claims description 2
- 229960002438 carfilzomib Drugs 0.000 claims description 2
- 230000030833 cell death Effects 0.000 claims description 2
- 210000003169 central nervous system Anatomy 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 235000019693 cherries Nutrition 0.000 claims description 2
- 208000007413 cholesterol embolism Diseases 0.000 claims description 2
- OTAFHZMPRISVEM-UHFFFAOYSA-N chromone Chemical group C1=CC=C2C(=O)C=COC2=C1 OTAFHZMPRISVEM-UHFFFAOYSA-N 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 208000013507 chronic prostatitis Diseases 0.000 claims description 2
- 208000024376 chronic urticaria Diseases 0.000 claims description 2
- 201000010002 cicatricial pemphigoid Diseases 0.000 claims description 2
- 208000031214 ciliopathy Diseases 0.000 claims description 2
- 229960003920 cocaine Drugs 0.000 claims description 2
- 229960003346 colistin Drugs 0.000 claims description 2
- 229920001436 collagen Polymers 0.000 claims description 2
- 230000000536 complexating effect Effects 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims description 2
- 208000023124 congenital anomaly of kidney and urinary tract Diseases 0.000 claims description 2
- 201000004395 congenital heart block Diseases 0.000 claims description 2
- 208000010247 contact dermatitis Diseases 0.000 claims description 2
- 229910000365 copper sulfate Inorganic materials 0.000 claims description 2
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 2
- KTEIFNKAUNYNJU-GFCCVEGCSA-N crizotinib Chemical compound O([C@H](C)C=1C(=C(F)C=CC=1Cl)Cl)C(C(=NC=1)N)=CC=1C(=C1)C=NN1C1CCNCC1 KTEIFNKAUNYNJU-GFCCVEGCSA-N 0.000 claims description 2
- 229960005061 crizotinib Drugs 0.000 claims description 2
- 208000017563 cutaneous Paget disease Diseases 0.000 claims description 2
- 208000004921 cutaneous lupus erythematosus Diseases 0.000 claims description 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 2
- 230000001086 cytosolic effect Effects 0.000 claims description 2
- 229960002448 dasatinib Drugs 0.000 claims description 2
- 208000006602 delta-Thalassemia Diseases 0.000 claims description 2
- 208000022401 dense deposit disease Diseases 0.000 claims description 2
- 201000010064 diabetes insipidus Diseases 0.000 claims description 2
- 208000033679 diabetic kidney disease Diseases 0.000 claims description 2
- 238000000502 dialysis Methods 0.000 claims description 2
- 235000015872 dietary supplement Nutrition 0.000 claims description 2
- 208000027180 double uterus-hemivagina-renal agenesis syndrome Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 206010013663 drug dependence Diseases 0.000 claims description 2
- 208000010118 dystonia Diseases 0.000 claims description 2
- 206010014599 encephalitis Diseases 0.000 claims description 2
- 201000002491 encephalomyelitis Diseases 0.000 claims description 2
- 206010014665 endocarditis Diseases 0.000 claims description 2
- 230000002327 eosinophilic effect Effects 0.000 claims description 2
- 208000007150 epidermolysis bullosa simplex Diseases 0.000 claims description 2
- 201000008220 erythropoietic protoporphyria Diseases 0.000 claims description 2
- 235000020650 eye health related herbal supplements Nutrition 0.000 claims description 2
- 208000002980 facial hemiatrophy Diseases 0.000 claims description 2
- 201000000080 familial hypocalciuric hypercalcemia Diseases 0.000 claims description 2
- 201000007249 familial juvenile hyperuricemic nephropathy Diseases 0.000 claims description 2
- 201000004954 familial nephrotic syndrome Diseases 0.000 claims description 2
- 208000030376 fibronectin glomerulopathy Diseases 0.000 claims description 2
- 239000003193 general anesthetic agent Substances 0.000 claims description 2
- 230000002068 genetic effect Effects 0.000 claims description 2
- 210000004392 genitalia Anatomy 0.000 claims description 2
- 208000018090 giant cell myocarditis Diseases 0.000 claims description 2
- 230000001434 glomerular Effects 0.000 claims description 2
- 235000020350 green smoothie Nutrition 0.000 claims description 2
- 210000002768 hair cell Anatomy 0.000 claims description 2
- 239000000118 hair dye Substances 0.000 claims description 2
- 208000029629 hantavirus infectious disease Diseases 0.000 claims description 2
- 238000003306 harvesting Methods 0.000 claims description 2
- 229940029169 harvoni Drugs 0.000 claims description 2
- 208000019622 heart disease Diseases 0.000 claims description 2
- 230000008642 heat stress Effects 0.000 claims description 2
- 210000001907 heinz body Anatomy 0.000 claims description 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 2
- 208000034737 hemoglobinopathy Diseases 0.000 claims description 2
- 208000014752 hemophagocytic syndrome Diseases 0.000 claims description 2
- 201000002802 hemorrhagic cystitis Diseases 0.000 claims description 2
- 230000002440 hepatic effect Effects 0.000 claims description 2
- 208000003215 hereditary nephritis Diseases 0.000 claims description 2
- 201000008298 histiocytosis Diseases 0.000 claims description 2
- 150000004677 hydrates Chemical class 0.000 claims description 2
- 229960004171 hydroxychloroquine Drugs 0.000 claims description 2
- XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 claims description 2
- 230000000148 hypercalcaemia Effects 0.000 claims description 2
- 208000030915 hypercalcemia disease Diseases 0.000 claims description 2
- 230000037315 hyperhidrosis Effects 0.000 claims description 2
- 201000005991 hyperphosphatemia Diseases 0.000 claims description 2
- 201000006362 hypersensitivity vasculitis Diseases 0.000 claims description 2
- 206010020871 hypertrophic cardiomyopathy Diseases 0.000 claims description 2
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 claims description 2
- 229960001101 ifosfamide Drugs 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 208000023692 inborn mitochondrial myopathy Diseases 0.000 claims description 2
- 229960000598 infliximab Drugs 0.000 claims description 2
- 206010022000 influenza Diseases 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 claims description 2
- 208000014674 injury Diseases 0.000 claims description 2
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims description 2
- PXZQEOJJUGGUIB-UHFFFAOYSA-N isoindolin-1-one Chemical group C1=CC=C2C(=O)NCC2=C1 PXZQEOJJUGGUIB-UHFFFAOYSA-N 0.000 claims description 2
- GWVMLCQWXVFZCN-UHFFFAOYSA-N isoindoline Chemical group C1=CC=C2CNCC2=C1 GWVMLCQWXVFZCN-UHFFFAOYSA-N 0.000 claims description 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims description 2
- 230000000366 juvenile effect Effects 0.000 claims description 2
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims description 2
- 201000004607 keratosis follicularis Diseases 0.000 claims description 2
- 229960003299 ketamine Drugs 0.000 claims description 2
- 208000005430 kidney cortex necrosis Diseases 0.000 claims description 2
- 206010023497 kuru Diseases 0.000 claims description 2
- 208000006443 lactic acidosis Diseases 0.000 claims description 2
- 201000010901 lateral sclerosis Diseases 0.000 claims description 2
- 229940029174 ledipasvir / sofosbuvir Drugs 0.000 claims description 2
- 208000003173 lipoprotein glomerulopathy Diseases 0.000 claims description 2
- 229910052744 lithium Inorganic materials 0.000 claims description 2
- 231100000515 lung injury Toxicity 0.000 claims description 2
- 201000004151 lysinuric protein intolerance Diseases 0.000 claims description 2
- 229960000274 lysozyme Drugs 0.000 claims description 2
- 235000010335 lysozyme Nutrition 0.000 claims description 2
- 239000004325 lysozyme Substances 0.000 claims description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 2
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 2
- 201000004792 malaria Diseases 0.000 claims description 2
- 230000036210 malignancy Effects 0.000 claims description 2
- 201000005857 malignant hypertension Diseases 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 230000001071 malnutrition Effects 0.000 claims description 2
- 235000000824 malnutrition Nutrition 0.000 claims description 2
- 230000008774 maternal effect Effects 0.000 claims description 2
- 208000003531 maternally-inherited Leigh syndrome Diseases 0.000 claims description 2
- JDSHMPZPIAZGSV-UHFFFAOYSA-N melamine Chemical compound NC1=NC(N)=NC(N)=N1 JDSHMPZPIAZGSV-UHFFFAOYSA-N 0.000 claims description 2
- 201000008350 membranous glomerulonephritis Diseases 0.000 claims description 2
- 231100000855 membranous nephropathy Toxicity 0.000 claims description 2
- 208000005135 methemoglobinemia Diseases 0.000 claims description 2
- 229960000485 methotrexate Drugs 0.000 claims description 2
- 206010063344 microscopic polyangiitis Diseases 0.000 claims description 2
- 238000000386 microscopy Methods 0.000 claims description 2
- 210000000110 microvilli Anatomy 0.000 claims description 2
- 210000003470 mitochondria Anatomy 0.000 claims description 2
- 201000002697 mitochondrial DNA depletion syndrome Diseases 0.000 claims description 2
- 201000011540 mitochondrial DNA depletion syndrome 4a Diseases 0.000 claims description 2
- 230000004065 mitochondrial dysfunction Effects 0.000 claims description 2
- 208000022084 motor paralysis Diseases 0.000 claims description 2
- 239000002324 mouth wash Substances 0.000 claims description 2
- 229940051866 mouthwash Drugs 0.000 claims description 2
- 208000001725 mucocutaneous lymph node syndrome Diseases 0.000 claims description 2
- 201000000585 muscular atrophy Diseases 0.000 claims description 2
- 201000006938 muscular dystrophy Diseases 0.000 claims description 2
- 206010028537 myelofibrosis Diseases 0.000 claims description 2
- 230000002071 myeloproliferative effect Effects 0.000 claims description 2
- 208000010125 myocardial infarction Diseases 0.000 claims description 2
- JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 claims description 2
- 201000003631 narcolepsy Diseases 0.000 claims description 2
- 230000009826 neoplastic cell growth Effects 0.000 claims description 2
- 201000000173 nephrocalcinosis Diseases 0.000 claims description 2
- 208000011392 nephropathic cystinosis Diseases 0.000 claims description 2
- 208000009928 nephrosis Diseases 0.000 claims description 2
- 231100001027 nephrosis Toxicity 0.000 claims description 2
- 208000004296 neuralgia Diseases 0.000 claims description 2
- 210000004498 neuroglial cell Anatomy 0.000 claims description 2
- 208000018360 neuromuscular disease Diseases 0.000 claims description 2
- 201000001119 neuropathy Diseases 0.000 claims description 2
- 230000007823 neuropathy Effects 0.000 claims description 2
- 208000004235 neutropenia Diseases 0.000 claims description 2
- 201000006790 nonsyndromic deafness Diseases 0.000 claims description 2
- UMRZSTCPUPJPOJ-KNVOCYPGSA-N norbornane Chemical compound C1C[C@H]2CC[C@@H]1C2 UMRZSTCPUPJPOJ-KNVOCYPGSA-N 0.000 claims description 2
- 208000015380 nutritional deficiency disease Diseases 0.000 claims description 2
- 235000020824 obesity Nutrition 0.000 claims description 2
- 208000015200 ocular cicatricial pemphigoid Diseases 0.000 claims description 2
- 208000020911 optic nerve disease Diseases 0.000 claims description 2
- 201000005737 orchitis Diseases 0.000 claims description 2
- 206010031129 orthostatic proteinuria Diseases 0.000 claims description 2
- 231100000763 ototoxin Toxicity 0.000 claims description 2
- 125000002971 oxazolyl group Chemical group 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 229960005489 paracetamol Drugs 0.000 claims description 2
- 201000001976 pemphigus vulgaris Diseases 0.000 claims description 2
- 208000029308 periodic paralysis Diseases 0.000 claims description 2
- 206010035653 pneumoconiosis Diseases 0.000 claims description 2
- 210000000557 podocyte Anatomy 0.000 claims description 2
- 201000006292 polyarteritis nodosa Diseases 0.000 claims description 2
- 208000030761 polycystic kidney disease Diseases 0.000 claims description 2
- 206010036067 polydipsia Diseases 0.000 claims description 2
- 208000005987 polymyositis Diseases 0.000 claims description 2
- XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 claims description 2
- KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 claims description 2
- 208000001061 polyostotic fibrous dysplasia Diseases 0.000 claims description 2
- 230000002980 postoperative effect Effects 0.000 claims description 2
- 201000011461 pre-eclampsia Diseases 0.000 claims description 2
- 230000035935 pregnancy Effects 0.000 claims description 2
- 201000009395 primary hyperaldosteronism Diseases 0.000 claims description 2
- 208000011511 primary membranoproliferative glomerulonephritis Diseases 0.000 claims description 2
- 208000003476 primary myelofibrosis Diseases 0.000 claims description 2
- 201000000742 primary sclerosing cholangitis Diseases 0.000 claims description 2
- 229960003387 progesterone Drugs 0.000 claims description 2
- 239000000186 progesterone Substances 0.000 claims description 2
- 201000002241 progressive bulbar palsy Diseases 0.000 claims description 2
- 230000000750 progressive effect Effects 0.000 claims description 2
- 201000008752 progressive muscular atrophy Diseases 0.000 claims description 2
- 229940069949 propolis Drugs 0.000 claims description 2
- 201000007094 prostatitis Diseases 0.000 claims description 2
- 201000000196 pseudobulbar palsy Diseases 0.000 claims description 2
- 208000006078 pseudohypoparathyroidism Diseases 0.000 claims description 2
- 201000003004 ptosis Diseases 0.000 claims description 2
- 230000002685 pulmonary effect Effects 0.000 claims description 2
- 208000005069 pulmonary fibrosis Diseases 0.000 claims description 2
- 208000002212 pyonephrosis Diseases 0.000 claims description 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 2
- 229940070891 pyridium Drugs 0.000 claims description 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 2
- 229960000213 ranolazine Drugs 0.000 claims description 2
- 201000008158 rapidly progressive glomerulonephritis Diseases 0.000 claims description 2
- 206010037844 rash Diseases 0.000 claims description 2
- 208000002574 reactive arthritis Diseases 0.000 claims description 2
- 230000000306 recurrent effect Effects 0.000 claims description 2
- 230000011514 reflex Effects 0.000 claims description 2
- 238000010992 reflux Methods 0.000 claims description 2
- 206010038351 renal abscess Diseases 0.000 claims description 2
- 230000008085 renal dysfunction Effects 0.000 claims description 2
- 208000007278 renal glycosuria Diseases 0.000 claims description 2
- 201000005966 renal hypoplasia Diseases 0.000 claims description 2
- 201000006409 renal osteodystrophy Diseases 0.000 claims description 2
- 229920005989 resin Polymers 0.000 claims description 2
- 239000011347 resin Substances 0.000 claims description 2
- 201000003068 rheumatic fever Diseases 0.000 claims description 2
- 201000004700 rosacea Diseases 0.000 claims description 2
- 208000005687 scabies Diseases 0.000 claims description 2
- 201000004409 schistosomiasis Diseases 0.000 claims description 2
- 208000010157 sclerosing cholangitis Diseases 0.000 claims description 2
- 230000003248 secreting effect Effects 0.000 claims description 2
- 210000002955 secretory cell Anatomy 0.000 claims description 2
- 208000018019 sickle cell-hemoglobin c disease syndrome Diseases 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- 208000018198 spasticity Diseases 0.000 claims description 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims description 2
- 238000011476 stem cell transplantation Methods 0.000 claims description 2
- 208000011117 substance-related disease Diseases 0.000 claims description 2
- 230000008961 swelling Effects 0.000 claims description 2
- 230000002889 sympathetic effect Effects 0.000 claims description 2
- 230000009885 systemic effect Effects 0.000 claims description 2
- 230000002123 temporal effect Effects 0.000 claims description 2
- 229960004556 tenofovir Drugs 0.000 claims description 2
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 claims description 2
- 210000001550 testis Anatomy 0.000 claims description 2
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims description 2
- 125000000335 thiazolyl group Chemical group 0.000 claims description 2
- 231100000331 toxic Toxicity 0.000 claims description 2
- 230000002588 toxic effect Effects 0.000 claims description 2
- 238000002054 transplantation Methods 0.000 claims description 2
- 208000009174 transverse myelitis Diseases 0.000 claims description 2
- 230000008733 trauma Effects 0.000 claims description 2
- 201000008827 tuberculosis Diseases 0.000 claims description 2
- 208000009999 tuberous sclerosis Diseases 0.000 claims description 2
- 208000010380 tumor lysis syndrome Diseases 0.000 claims description 2
- 206010051250 ureteritis Diseases 0.000 claims description 2
- 208000000143 urethritis Diseases 0.000 claims description 2
- 208000019206 urinary tract infection Diseases 0.000 claims description 2
- 201000002327 urinary tract obstruction Diseases 0.000 claims description 2
- 229960003165 vancomycin Drugs 0.000 claims description 2
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims description 2
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 claims description 2
- 230000001457 vasomotor Effects 0.000 claims description 2
- 210000003462 vein Anatomy 0.000 claims description 2
- 210000001631 vena cava inferior Anatomy 0.000 claims description 2
- 201000008618 vesicoureteral reflux Diseases 0.000 claims description 2
- 208000031355 vesicoureteral reflux 1 Diseases 0.000 claims description 2
- QTXVAVXCBMYBJW-UHFFFAOYSA-N warfarin Chemical compound OC=1OC2=CC=CC=C2C(=O)C=1C(CC(=O)C)C1=CC=CC=C1 QTXVAVXCBMYBJW-UHFFFAOYSA-N 0.000 claims description 2
- 229960005080 warfarin Drugs 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 210000004885 white matter Anatomy 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 16
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 9
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 6
- JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 claims 5
- 108010081348 HRT1 protein Hairy Proteins 0.000 claims 5
- 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 claims 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 5
- 125000004793 2,2,2-trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 claims 4
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims 2
- 208000015891 sexual disease Diseases 0.000 claims 2
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 208000012201 sexual and gender identity disease Diseases 0.000 claims 1
- 208000014001 urinary system disease Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 description 24
- 125000002947 alkylene group Chemical group 0.000 description 8
- YUCFVHQCAFKDQG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH] YUCFVHQCAFKDQG-UHFFFAOYSA-N 0.000 description 5
- 125000003342 alkenyl group Chemical group 0.000 description 2
- 208000022873 Ocular disease Diseases 0.000 description 1
- 208000019802 Sexually transmitted disease Diseases 0.000 description 1
- 208000008453 delta beta-thalassemia Diseases 0.000 description 1
- 210000002346 musculoskeletal system Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962840945P | 2019-04-30 | 2019-04-30 | |
| US62/840,945 | 2019-04-30 | ||
| PCT/US2020/030817 WO2020223536A1 (en) | 2019-04-30 | 2020-04-30 | Substituted cyclolakyls as modulators of the integrated stress pathway |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022530647A JP2022530647A (ja) | 2022-06-30 |
| JP2022530647A5 JP2022530647A5 (https=) | 2023-05-12 |
| JPWO2020223536A5 true JPWO2020223536A5 (https=) | 2023-05-12 |
Family
ID=71465400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021564465A Pending JP2022530647A (ja) | 2019-04-30 | 2020-04-30 | 統合的ストレス経路の置換シクロアルキルモジュレーター |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20210363136A1 (https=) |
| EP (1) | EP3962899A1 (https=) |
| JP (1) | JP2022530647A (https=) |
| KR (1) | KR20220016467A (https=) |
| CN (1) | CN114401952A (https=) |
| AR (1) | AR118836A1 (https=) |
| AU (2) | AU2020266592B2 (https=) |
| BR (1) | BR112021021754A2 (https=) |
| CA (1) | CA3138144A1 (https=) |
| IL (1) | IL287660A (https=) |
| MX (1) | MX2021013193A (https=) |
| SG (1) | SG11202111970WA (https=) |
| TW (1) | TW202106671A (https=) |
| UY (1) | UY38685A (https=) |
| WO (1) | WO2020223536A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3071024A1 (en) | 2017-08-09 | 2019-02-14 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| CN111201245B (zh) | 2017-09-01 | 2024-04-05 | 戴纳立制药公司 | 化合物、组合物和方法 |
| WO2019090088A1 (en) | 2017-11-02 | 2019-05-09 | Calico Life Sciences Llc | Modulators of the integrated stress pathway |
| CN111757739A (zh) | 2017-12-13 | 2020-10-09 | 普拉西斯生物技术有限责任公司 | 整合应激反应路径抑制剂 |
| AU2019282253A1 (en) | 2018-06-05 | 2020-11-26 | Altos Labs, Inc. | Inhibitors of integrated stress response pathway |
| TW202545902A (zh) | 2018-10-11 | 2025-12-01 | 美商嘉來克生命科學有限責任公司 | 整合應激路徑之前藥調節劑 |
| EP3924341A4 (en) | 2019-02-13 | 2022-11-02 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| SG11202108552QA (en) | 2019-02-13 | 2021-09-29 | Denali Therapeutics Inc | Compounds, compositions and methods |
| WO2020252207A1 (en) | 2019-06-12 | 2020-12-17 | Praxis Biotech LLC | Modulators of integrated stress response pathway |
| CN115190813B (zh) | 2020-03-11 | 2024-10-15 | 埃沃特克国际有限责任公司 | 整合应激反应途径的调节剂 |
| EP4232153A1 (en) | 2020-10-22 | 2023-08-30 | Evotec International GmbH | Modulators of the integrated stress response pathway |
| RS66455B1 (sr) | 2020-10-22 | 2025-02-28 | Evotec Int Gmbh | Modulatori puta integrisanog odgovora na stres |
| EP4232447A1 (en) | 2020-10-22 | 2023-08-30 | Evotec International GmbH | Modulators of the integrated stress response pathway |
| IL302440A (en) * | 2020-10-30 | 2023-06-01 | Calico Life Sciences Llc | Combined pressure pathway modulators |
| TWI863059B (zh) * | 2021-12-23 | 2024-11-21 | 李長榮化學工業股份有限公司 | 二胺化合物及其製備方法、二胺化合物形成的高分子及其用途 |
| EP4452952A4 (en) * | 2021-12-25 | 2025-12-03 | Council Of Scient And Industrial Research An Indian Registered Body Incorporated Under Regn Of Soc A | PREPARATION OF QUINAZOLINEDIONES AND THEIR USE |
| CN114839296B (zh) * | 2022-05-13 | 2023-12-22 | 普研(上海)标准技术服务有限公司 | 食品中牛肉酮的检测方法 |
| CN116768877B (zh) * | 2022-05-30 | 2026-03-31 | 中国药科大学 | Isr抑制剂及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI763668B (zh) * | 2016-05-05 | 2022-05-11 | 美商嘉來克生命科學有限責任公司 | 整合應激途徑之調節劑 |
| TW201808888A (zh) * | 2016-05-05 | 2018-03-16 | 嘉來克生命科學有限責任公司 | 整合應激途徑之調節劑 |
| WO2018225093A1 (en) * | 2017-06-07 | 2018-12-13 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds as atf4 pathway inhibitors |
| UY37956A (es) * | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
| UY37958A (es) * | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
| UY37957A (es) * | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
| WO2019183589A1 (en) * | 2018-03-23 | 2019-09-26 | Denali Therapeutics Inc. | Modulators of eukaryotic initiation factor 2 |
| PE20220572A1 (es) * | 2019-04-30 | 2022-04-20 | Calico Life Sciences Llc | Moduladores de la via integrada del estres |
-
2020
- 2020-04-30 SG SG11202111970WA patent/SG11202111970WA/en unknown
- 2020-04-30 AR ARP200101239A patent/AR118836A1/es not_active Application Discontinuation
- 2020-04-30 TW TW109114677A patent/TW202106671A/zh unknown
- 2020-04-30 JP JP2021564465A patent/JP2022530647A/ja active Pending
- 2020-04-30 BR BR112021021754A patent/BR112021021754A2/pt not_active Application Discontinuation
- 2020-04-30 WO PCT/US2020/030817 patent/WO2020223536A1/en not_active Ceased
- 2020-04-30 KR KR1020217039167A patent/KR20220016467A/ko not_active Withdrawn
- 2020-04-30 EP EP20736803.6A patent/EP3962899A1/en active Pending
- 2020-04-30 CN CN202080048079.9A patent/CN114401952A/zh active Pending
- 2020-04-30 MX MX2021013193A patent/MX2021013193A/es unknown
- 2020-04-30 AU AU2020266592A patent/AU2020266592B2/en active Active
- 2020-04-30 CA CA3138144A patent/CA3138144A1/en active Pending
- 2020-04-30 US US16/863,737 patent/US20210363136A1/en not_active Abandoned
- 2020-05-04 UY UY0001038685A patent/UY38685A/es not_active Application Discontinuation
-
2021
- 2021-10-28 IL IL287660A patent/IL287660A/en unknown
-
2023
- 2023-09-07 US US18/462,918 patent/US20240018133A1/en active Pending
-
2026
- 2026-01-29 AU AU2026200630A patent/AU2026200630A1/en not_active Withdrawn