JP2022530647A - 統合的ストレス経路の置換シクロアルキルモジュレーター - Google Patents
統合的ストレス経路の置換シクロアルキルモジュレーター Download PDFInfo
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- JP2022530647A JP2022530647A JP2021564465A JP2021564465A JP2022530647A JP 2022530647 A JP2022530647 A JP 2022530647A JP 2021564465 A JP2021564465 A JP 2021564465A JP 2021564465 A JP2021564465 A JP 2021564465A JP 2022530647 A JP2022530647 A JP 2022530647A
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- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
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- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962840945P | 2019-04-30 | 2019-04-30 | |
| US62/840,945 | 2019-04-30 | ||
| PCT/US2020/030817 WO2020223536A1 (en) | 2019-04-30 | 2020-04-30 | Substituted cyclolakyls as modulators of the integrated stress pathway |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022530647A true JP2022530647A (ja) | 2022-06-30 |
| JP2022530647A5 JP2022530647A5 (https=) | 2023-05-12 |
| JPWO2020223536A5 JPWO2020223536A5 (https=) | 2023-05-12 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021564465A Pending JP2022530647A (ja) | 2019-04-30 | 2020-04-30 | 統合的ストレス経路の置換シクロアルキルモジュレーター |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20210363136A1 (https=) |
| EP (1) | EP3962899A1 (https=) |
| JP (1) | JP2022530647A (https=) |
| KR (1) | KR20220016467A (https=) |
| CN (1) | CN114401952A (https=) |
| AR (1) | AR118836A1 (https=) |
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Cited By (1)
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| JP2023548169A (ja) * | 2020-10-30 | 2023-11-15 | カリコ ライフ サイエンシーズ エルエルシー | 統合的ストレス経路の調節剤 |
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| CA3071024A1 (en) | 2017-08-09 | 2019-02-14 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| CN111201245B (zh) | 2017-09-01 | 2024-04-05 | 戴纳立制药公司 | 化合物、组合物和方法 |
| WO2019090088A1 (en) | 2017-11-02 | 2019-05-09 | Calico Life Sciences Llc | Modulators of the integrated stress pathway |
| CN111757739A (zh) | 2017-12-13 | 2020-10-09 | 普拉西斯生物技术有限责任公司 | 整合应激反应路径抑制剂 |
| AU2019282253A1 (en) | 2018-06-05 | 2020-11-26 | Altos Labs, Inc. | Inhibitors of integrated stress response pathway |
| TW202545902A (zh) | 2018-10-11 | 2025-12-01 | 美商嘉來克生命科學有限責任公司 | 整合應激路徑之前藥調節劑 |
| EP3924341A4 (en) | 2019-02-13 | 2022-11-02 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| SG11202108552QA (en) | 2019-02-13 | 2021-09-29 | Denali Therapeutics Inc | Compounds, compositions and methods |
| WO2020252207A1 (en) | 2019-06-12 | 2020-12-17 | Praxis Biotech LLC | Modulators of integrated stress response pathway |
| CN115190813B (zh) | 2020-03-11 | 2024-10-15 | 埃沃特克国际有限责任公司 | 整合应激反应途径的调节剂 |
| EP4232153A1 (en) | 2020-10-22 | 2023-08-30 | Evotec International GmbH | Modulators of the integrated stress response pathway |
| RS66455B1 (sr) | 2020-10-22 | 2025-02-28 | Evotec Int Gmbh | Modulatori puta integrisanog odgovora na stres |
| EP4232447A1 (en) | 2020-10-22 | 2023-08-30 | Evotec International GmbH | Modulators of the integrated stress response pathway |
| TWI863059B (zh) * | 2021-12-23 | 2024-11-21 | 李長榮化學工業股份有限公司 | 二胺化合物及其製備方法、二胺化合物形成的高分子及其用途 |
| EP4452952A4 (en) * | 2021-12-25 | 2025-12-03 | Council Of Scient And Industrial Research An Indian Registered Body Incorporated Under Regn Of Soc A | PREPARATION OF QUINAZOLINEDIONES AND THEIR USE |
| CN114839296B (zh) * | 2022-05-13 | 2023-12-22 | 普研(上海)标准技术服务有限公司 | 食品中牛肉酮的检测方法 |
| CN116768877B (zh) * | 2022-05-30 | 2026-03-31 | 中国药科大学 | Isr抑制剂及其制备方法和应用 |
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| UY37958A (es) * | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
| UY37957A (es) * | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
| WO2019183589A1 (en) * | 2018-03-23 | 2019-09-26 | Denali Therapeutics Inc. | Modulators of eukaryotic initiation factor 2 |
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| WO2017193034A1 (en) * | 2016-05-05 | 2017-11-09 | Calico Life Sciences | Modulators of the integrated stress pathway |
| WO2017193063A1 (en) * | 2016-05-05 | 2017-11-09 | Calico Life Sciences | Modulators of the integrated stress pathway |
| WO2018225093A1 (en) * | 2017-06-07 | 2018-12-13 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds as atf4 pathway inhibitors |
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| JP2022533023A (ja) * | 2019-04-30 | 2022-07-21 | カリコ ライフ サイエンシーズ エルエルシー | 統合的ストレス経路の調節剤としての置換シクロアルキル |
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| JP2023548169A (ja) * | 2020-10-30 | 2023-11-15 | カリコ ライフ サイエンシーズ エルエルシー | 統合的ストレス経路の調節剤 |
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| AU2020266592A1 (en) | 2021-12-02 |
| AU2026200630A1 (en) | 2026-02-19 |
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| MX2021013193A (es) | 2022-02-22 |
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| US20240018133A1 (en) | 2024-01-18 |
| WO2020223536A1 (en) | 2020-11-05 |
| KR20220016467A (ko) | 2022-02-09 |
| IL287660A (en) | 2021-12-01 |
| UY38685A (es) | 2020-11-30 |
| AU2020266592B2 (en) | 2026-02-12 |
| US20210363136A1 (en) | 2021-11-25 |
| BR112021021754A2 (pt) | 2022-02-08 |
| CN114401952A (zh) | 2022-04-26 |
| AR118836A1 (es) | 2021-11-03 |
| SG11202111970WA (en) | 2021-11-29 |
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