|
US2318394A
(en)
|
1941-08-22 |
1943-05-04 |
Raymond T Moloney |
Game apparatus
|
|
US2705482A
(en)
|
1951-04-19 |
1955-04-05 |
Glenn T Randol |
Mechanical self-adjusting valve lifter
|
|
US4897355A
(en)
|
1985-01-07 |
1990-01-30 |
Syntex (U.S.A.) Inc. |
N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US5206344A
(en)
|
1985-06-26 |
1993-04-27 |
Cetus Oncology Corporation |
Interleukin-2 muteins and polymer conjugation thereof
|
|
US4766106A
(en)
|
1985-06-26 |
1988-08-23 |
Cetus Corporation |
Solubilization of proteins for pharmaceutical compositions using polymer conjugation
|
|
US5128257A
(en)
|
1987-08-31 |
1992-07-07 |
Baer Bradford W |
Electroporation apparatus and process
|
|
WO1989006555A1
(en)
|
1988-01-21 |
1989-07-27 |
Massachusetts Institute Of Technology |
Transport of molecules across tissue using electroporation
|
|
US6362325B1
(en)
|
1988-11-07 |
2002-03-26 |
Advanced Research And Technology Institute, Inc. |
Murine 4-1BB gene
|
|
US6303121B1
(en)
|
1992-07-30 |
2001-10-16 |
Advanced Research And Technology |
Method of using human receptor protein 4-1BB
|
|
US4902502A
(en)
|
1989-01-23 |
1990-02-20 |
Cetus Corporation |
Preparation of a polymer/interleukin-2 conjugate
|
|
US5089261A
(en)
|
1989-01-23 |
1992-02-18 |
Cetus Corporation |
Preparation of a polymer/interleukin-2 conjugate
|
|
ZA902710B
(en)
|
1989-05-22 |
1991-12-24 |
Univ Georgia Res Found |
Enzyme luminescence assay
|
|
US5279833A
(en)
|
1990-04-04 |
1994-01-18 |
Yale University |
Liposomal transfection of nucleic acids into animal cells
|
|
US5264618A
(en)
|
1990-04-19 |
1993-11-23 |
Vical, Inc. |
Cationic lipids for intracellular delivery of biologically active molecules
|
|
AU7979491A
(en)
|
1990-05-03 |
1991-11-27 |
Vical, Inc. |
Intracellular delivery of biologically active substances by means of self-assembling lipid complexes
|
|
CA2019758C
(en)
|
1990-06-25 |
2001-09-04 |
Kevin L. Firth |
Improved electroporation device and method
|
|
US5137817A
(en)
|
1990-10-05 |
1992-08-11 |
Amoco Corporation |
Apparatus and method for electroporation
|
|
US5173158A
(en)
|
1991-07-22 |
1992-12-22 |
Schmukler Robert E |
Apparatus and methods for electroporation and electrofusion
|
|
US5304120A
(en)
|
1992-07-01 |
1994-04-19 |
Btx Inc. |
Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
|
|
US5273525A
(en)
|
1992-08-13 |
1993-12-28 |
Btx Inc. |
Injection and electroporation apparatus for drug and gene delivery
|
|
US5318514A
(en)
|
1992-08-17 |
1994-06-07 |
Btx, Inc. |
Applicator for the electroporation of drugs and genes into surface cells
|
|
DK0672141T3
(da)
|
1992-10-23 |
2003-06-10 |
Immunex Corp |
Fremgangsmåder til fremstilling af opløselige, oligomere proteiner
|
|
GB9317380D0
(en)
|
1993-08-20 |
1993-10-06 |
Therexsys Ltd |
Transfection process
|
|
US5821332A
(en)
|
1993-11-03 |
1998-10-13 |
The Board Of Trustees Of The Leland Stanford Junior University |
Receptor on the surface of activated CD4+ T-cells: ACT-4
|
|
US6989434B1
(en)
|
1994-02-11 |
2006-01-24 |
Invitrogen Corporation |
Reagents for intracellular delivery of macromolecules
|
|
US5691188A
(en)
|
1994-02-14 |
1997-11-25 |
American Cyanamid Company |
Transformed yeast cells expressing heterologous G-protein coupled receptor
|
|
CA2193954A1
(en)
|
1994-06-27 |
1996-01-04 |
Vu L. Truong |
Targeted gene delivery system
|
|
US5908635A
(en)
|
1994-08-05 |
1999-06-01 |
The United States Of America As Represented By The Department Of Health And Human Services |
Method for the liposomal delivery of nucleic acids
|
|
US5484720A
(en)
|
1994-09-08 |
1996-01-16 |
Genentech, Inc. |
Methods for calcium phosphate transfection
|
|
US5830430A
(en)
|
1995-02-21 |
1998-11-03 |
Imarx Pharmaceutical Corp. |
Cationic lipids and the use thereof
|
|
ATE226641T1
(de)
|
1995-04-08 |
2002-11-15 |
Lg Chemical Ltd |
Humaner 4-1bb spezifischer humaner antikörper und diesen produzierende zellinie
|
|
US5981501A
(en)
|
1995-06-07 |
1999-11-09 |
Inex Pharmaceuticals Corp. |
Methods for encapsulating plasmids in lipid bilayers
|
|
US6010613A
(en)
|
1995-12-08 |
2000-01-04 |
Cyto Pulse Sciences, Inc. |
Method of treating materials with pulsed electrical fields
|
|
US5849902A
(en)
|
1996-09-26 |
1998-12-15 |
Oligos Etc. Inc. |
Three component chimeric antisense oligonucleotides
|
|
PL188749B1
(pl)
|
1996-10-11 |
2005-04-29 |
Bristol Myers Squibb Co |
Zastosowanie przeciwciała anty-4-1BB i kompozycjaleku
|
|
CA2277278A1
(en)
|
1997-01-10 |
1998-07-16 |
Life Technologies, Inc. |
Embryonic stem cell serum replacement
|
|
DK0973928T3
(da)
|
1997-03-11 |
2010-08-09 |
Univ Minnesota |
DNA-baseret transposonsystem til indføring af nukleinsyre i DNA i en celle
|
|
GB9710809D0
(en)
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
|
US6475994B2
(en)
|
1998-01-07 |
2002-11-05 |
Donald A. Tomalia |
Method and articles for transfection of genetic material
|
|
US6312700B1
(en)
|
1998-02-24 |
2001-11-06 |
Andrew D. Weinberg |
Method for enhancing an antigen specific immune response with OX-40L
|
|
AU746454B2
(en)
|
1998-03-02 |
2002-05-02 |
Massachusetts Institute Of Technology |
Poly zinc finger proteins with improved linkers
|
|
US7013219B2
(en)
|
1999-01-12 |
2006-03-14 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US6794136B1
(en)
|
2000-11-20 |
2004-09-21 |
Sangamo Biosciences, Inc. |
Iterative optimization in the design of binding proteins
|
|
US20030104526A1
(en)
|
1999-03-24 |
2003-06-05 |
Qiang Liu |
Position dependent recognition of GNN nucleotide triplets by zinc fingers
|
|
US7030215B2
(en)
|
1999-03-24 |
2006-04-18 |
Sangamo Biosciences, Inc. |
Position dependent recognition of GNN nucleotide triplets by zinc fingers
|
|
US7189705B2
(en)
|
2000-04-20 |
2007-03-13 |
The University Of British Columbia |
Methods of enhancing SPLP-mediated transfection using endosomal membrane destabilizers
|
|
US6627442B1
(en)
|
2000-08-31 |
2003-09-30 |
Virxsys Corporation |
Methods for stable transduction of cells with hiv-derived viral vectors
|
|
EP1353701B1
(de)
|
2000-10-31 |
2011-12-21 |
PR Pharmaceuticals, Inc. |
Verfahren zur herstellung von formulierungen zur verbesserten abgabe von bioaktiven molekülen
|
|
US7550140B2
(en)
|
2002-06-13 |
2009-06-23 |
Crucell Holland B.V. |
Antibody to the human OX40 receptor
|
|
US6887673B2
(en)
|
2002-07-30 |
2005-05-03 |
Bristol-Myers Squibb Company |
Humanized antibodies against human 4-1BB
|
|
EP2336293B1
(de)
|
2003-10-08 |
2016-02-10 |
Wilson Wolf Manufacturing Corporation |
Zellkulturverfahren und Vorrichtungen mit Nutzung gasdurchlässiger Materialien
|
|
US7288638B2
(en)
|
2003-10-10 |
2007-10-30 |
Bristol-Myers Squibb Company |
Fully human antibodies against human 4-1BB
|
|
CA2585776A1
(en)
|
2004-10-29 |
2006-05-11 |
University Of Southern California |
Combination cancer immunotherapy with co-stimulatory molecules
|
|
EP1877090B1
(de)
|
2005-05-06 |
2014-01-15 |
Providence Health System |
Trimeres ox40-immunglobulin-fusionsprotein und verwendungsverfahren
|
|
TWI466269B
(zh)
|
2006-07-14 |
2014-12-21 |
Semiconductor Energy Lab |
非揮發性記憶體
|
|
EP1894940A1
(de)
|
2006-08-28 |
2008-03-05 |
Apogenix GmbH |
TNF Superfamilie Fusionsproteine
|
|
RU2009135824A
(ru)
|
2007-02-27 |
2011-04-10 |
Дженентек, Инк. (Us) |
Антитела-антагонисты против ох40 и их применение в лечении воспалительных и аутоиммунных заболеваний
|
|
CA2692802C
(en)
|
2007-07-10 |
2017-05-30 |
Oliver Hill |
Tnf superfamily collectin fusion proteins
|
|
EP2205740A2
(de)
|
2007-10-02 |
2010-07-14 |
Rxi Pharmaceuticals Corp. |
Dreiteilige rnai-konstrukte
|
|
BRPI0820875B1
(pt)
|
2007-12-14 |
2021-10-19 |
Bristol-Myers Squibb Company |
Molécula de ligação isolada, anticorpo monoclonal humano, composição, molécula de ácido nucleico, vetor e célula hospedeira
|
|
JP5697993B2
(ja)
|
2008-02-11 |
2015-04-08 |
アールエックスアイ ファーマシューティカルズ コーポレーション |
修飾ＲＮＡｉポリヌクレオチドおよびその使用
|
|
US8592557B2
(en)
|
2008-06-17 |
2013-11-26 |
Apogenix Gmbh |
Multimeric TNF receptor fusion proteins and nucleic acids encoding same
|
|
CA2731388C
(en)
|
2008-07-21 |
2018-05-01 |
Apogenix Gmbh |
Tnfsf single chain molecules
|
|
US8796443B2
(en)
|
2008-09-22 |
2014-08-05 |
Rxi Pharmaceuticals Corporation |
Reduced size self-delivering RNAi compounds
|
|
WO2010042433A1
(en)
|
2008-10-06 |
2010-04-15 |
Bristol-Myers Squibb Company |
Combination of cd137 antibody and ctla-4 antibody for the treatment of proliferative diseases
|
|
WO2010078966A1
(en)
|
2009-01-09 |
2010-07-15 |
Apogenix Gmbh |
Fusion proteins forming trimers
|
|
US20130115617A1
(en)
|
2009-12-08 |
2013-05-09 |
John R. Wilson |
Methods of cell culture for adoptive cell therapy
|
|
CA2783550A1
(en)
|
2009-12-08 |
2011-06-16 |
Wilson Wolf Manufacturing Corporation |
Improved methods of cell culture for adoptive cell therapy
|
|
US8956860B2
(en)
|
2009-12-08 |
2015-02-17 |
Juan F. Vera |
Methods of cell culture for adoptive cell therapy
|
|
EP2550000A4
(de)
|
2010-03-24 |
2014-03-26 |
Advirna Inc |
Selbstfreisetzende rnai-verbindungen von reduzierter grösse
|
|
CN103200945B
(zh)
|
2010-03-24 |
2016-07-06 |
雷克西制药公司 |
眼部症候中的rna干扰
|
|
KR102453078B1
(ko)
|
2010-03-24 |
2022-10-11 |
피오 파마슈티칼스 코프. |
진피 및 섬유증성 적응증에서의 ｒｎａ 간섭
|
|
AU2011256838B2
(en)
|
2010-05-17 |
2014-10-09 |
Sangamo Therapeutics, Inc. |
Novel DNA-binding proteins and uses thereof
|
|
JP2013534417A
(ja)
|
2010-06-14 |
2013-09-05 |
アイオワ ステート ユニバーシティ リサーチ ファウンデーション，インコーポレーティッド |
Ｔａｌエフェクターとｆｏｋｉの融合タンパク質のヌクレアーゼ活性
|
|
NZ629913A
(en)
|
2010-08-23 |
2016-01-29 |
Univ Texas |
Anti-ox40 antibodies and methods of using the same
|
|
HUE041958T2
(hu)
|
2010-09-09 |
2019-06-28 |
Pfizer |
4-IBB-t kötõ molekulák
|
|
US8962804B2
(en)
|
2010-10-08 |
2015-02-24 |
City Of Hope |
Meditopes and meditope-binding antibodies and uses thereof
|
|
KR102349549B1
(ko)
|
2010-11-12 |
2022-01-11 |
넥타르 테라퓨틱스 |
Ｉｌ-2 부분 및 중합체의 접합체
|
|
WO2012129201A1
(en)
|
2011-03-22 |
2012-09-27 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Methods of growing tumor infiltrating lymphocytes in gas-permeable containers
|
|
JP5996630B2
(ja)
|
2011-04-05 |
2016-09-21 |
セレクティスＣｅｌｌｅｃｔｉｓ |
コンパクトｔａｌｅ−ヌクレアーゼを作製する方法及びその使用
|
|
US20140234320A1
(en)
|
2011-06-20 |
2014-08-21 |
La Jolla Institute For Allergy And Immunology |
Modulators of 4-1bb and immune responses
|
|
CN103946238B
(zh)
|
2011-08-23 |
2016-10-12 |
德克萨斯州立大学董事会 |
抗ox40抗体及使用其的方法
|
|
US10421960B2
(en)
|
2011-09-16 |
2019-09-24 |
The Trustees Of The University Of Pennsylvania |
RNA engineered T cells for the treatment of cancer
|
|
GB201116092D0
(en)
|
2011-09-16 |
2011-11-02 |
Bioceros B V |
Antibodies and uses thereof
|
|
PL2768942T3
(pl)
|
2011-10-17 |
2020-05-18 |
Massachusetts Institute Of Technology |
Dostarczanie dokomórkowe
|
|
JP6386447B2
(ja)
|
2012-05-18 |
2018-09-05 |
ウィルソン ウォルフ マニュファクチャリング コーポレイションＷｉｌｓｏｎ Ｗｏｌｆ Ｍａｎｕｆａｃｔｕｒｉｎｇ Ｃｏｒｐｏｒａｔｉｏｎ |
養子細胞療法のための改良された細胞培養法
|
|
HUE064187T2
(hu)
|
2012-05-25 |
2024-02-28 |
Cellectis |
Eljárás immunterápiára alkalmas allogén és immunszupresszív-rezisztens T-sejt módosítására
|
|
US10815500B2
(en)
|
2012-06-05 |
2020-10-27 |
Cellectis |
Transcription activator-like effector (TALE) fusion protein
|
|
AU2013274416B2
(en)
|
2012-06-11 |
2019-07-04 |
Wilson Wolf Manufacturing, LLC |
Improved methods of cell culture for adoptive cell therapy
|
|
KR20150105635A
(ko)
|
2012-12-12 |
2015-09-17 |
더 브로드 인스티튜트, 인코퍼레이티드 |
서열 조작을 위한 crispr-cas 성분 시스템, 방법 및 조성물
|
|
WO2014093694A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
CN113528577A
(zh)
|
2012-12-12 |
2021-10-22 |
布罗德研究所有限公司 |
用于序列操纵的系统、方法和优化的指导组合物的工程化
|
|
AU2013359212B2
(en)
|
2012-12-12 |
2017-01-19 |
Massachusetts Institute Of Technology |
Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
|
|
PL2931898T3
(pl)
|
2012-12-12 |
2016-09-30 |
Le Cong |
Projektowanie i optymalizacja systemów, sposoby i kompozycje do manipulacji sekwencją z domenami funkcjonalnymi
|
|
JP6416131B2
(ja)
|
2013-03-01 |
2018-10-31 |
アメリカ合衆国 |
濃縮された腫瘍反応性ｔ細胞集団を腫瘍から作製する方法
|
|
LT2976361T
(lt)
|
2013-03-18 |
2018-10-25 |
Biocerox Products B.V. |
Humanizuoti antikūnai prieš receptorių cd134 (ox40) ir jų naudojimas
|
|
US11311575B2
(en)
|
2013-05-13 |
2022-04-26 |
Cellectis |
Methods for engineering highly active T cell for immunotherapy
|
|
EP3004320A4
(de)
|
2013-06-24 |
2017-05-17 |
Wilson Wolf Manufacturing Corporation |
Vorrichtung mit geschlossenem system und verfahren für gasdurchlässiges zellkulturverfahren
|
|
RU2744194C2
(ru)
|
2013-12-02 |
2021-03-03 |
Фио Фармасьютикалс Корп |
Иммунотерапия рака
|
|
US20150190506A1
(en)
|
2013-12-17 |
2015-07-09 |
Genentech, Inc. |
Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists
|
|
WO2015119923A1
(en)
|
2014-02-04 |
2015-08-13 |
Pfizer Inc. |
Combination of a pd-1 antagonist and a 4-abb agonist for treating cancer
|
|
CN106574244B
(zh)
|
2014-06-11 |
2022-01-07 |
保利比奥斯博特有限责任公司 |
用细胞因子组合物扩增淋巴细胞用于主动细胞免疫治疗
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
JP6925984B2
(ja)
|
2015-07-09 |
2021-08-25 |
マサチューセッツ インスティテュート オブ テクノロジー |
無核細胞への物質の送達
|
|
CA3002744A1
(en)
|
2015-10-19 |
2017-04-27 |
Rxi Pharmaceuticals Corporation |
Reduced size self-delivering nucleic acid compounds targeting long non-coding rna
|
|
EP3402890A1
(de)
|
2016-01-12 |
2018-11-21 |
SQZ Biotechnologies Company |
Intrazelluläre verabreichung von komplexen
|
|
MX2019004707A
(es)
*
|
2016-10-26 |
2019-08-12 |
Iovance Biotherapeutics Inc |
Reestimulacion de linfocitos infiltrantes de tumor crioconservados.
|
|
TWI788307B
(zh)
*
|
2016-10-31 |
2023-01-01 |
美商艾歐凡斯生物治療公司 |
用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
|
|
JOP20190224A1
(ar)
|
2017-03-29 |
2019-09-26 |
Iovance Biotherapeutics Inc |
عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي
|