JPWO2020002598A5 - - Google Patents
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- JPWO2020002598A5 JPWO2020002598A5 JP2020567587A JP2020567587A JPWO2020002598A5 JP WO2020002598 A5 JPWO2020002598 A5 JP WO2020002598A5 JP 2020567587 A JP2020567587 A JP 2020567587A JP 2020567587 A JP2020567587 A JP 2020567587A JP WO2020002598 A5 JPWO2020002598 A5 JP WO2020002598A5
- Authority
- JP
- Japan
- Prior art keywords
- reaction vessel
- bioreactor
- dna
- magnetic particles
- appendix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000006243 chemical reaction Methods 0.000 claims description 86
- 239000006249 magnetic particle Substances 0.000 claims description 60
- 230000005291 magnetic effect Effects 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 18
- 239000000872 buffer Substances 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 8
- 238000000338 in vitro Methods 0.000 claims description 7
- 238000010584 magnetic trap Methods 0.000 claims description 7
- 238000004140 cleaning Methods 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 5
- 230000033001 locomotion Effects 0.000 claims description 5
- 238000013518 transcription Methods 0.000 claims description 5
- 230000035897 transcription Effects 0.000 claims description 5
- 235000011178 triphosphate Nutrition 0.000 claims description 5
- 239000001226 triphosphate Substances 0.000 claims description 5
- 230000001419 dependent effect Effects 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims description 4
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims description 3
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 claims description 3
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000002342 ribonucleoside Substances 0.000 claims description 3
- 230000006820 DNA synthesis Effects 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000002907 paramagnetic material Substances 0.000 claims description 2
- 238000005086 pumping Methods 0.000 claims description 2
- 108020004414 DNA Proteins 0.000 description 48
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 26
- 239000011324 bead Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 101150077194 CAP1 gene Proteins 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 101100438378 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) fac-1 gene Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 102000007327 Protamines Human genes 0.000 description 1
- 108010007568 Protamines Proteins 0.000 description 1
- 102000009609 Pyrophosphatases Human genes 0.000 description 1
- 108010009413 Pyrophosphatases Proteins 0.000 description 1
- 229940122208 Ribonuclease inhibitor Drugs 0.000 description 1
- 102100037968 Ribonuclease inhibitor Human genes 0.000 description 1
- 101710141795 Ribonuclease inhibitor Proteins 0.000 description 1
- 108091028664 Ribonucleotide Proteins 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 238000005251 capillar electrophoresis Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- -1 modified ribonucleoside triphosphate Chemical class 0.000 description 1
- 239000002362 mulch Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 230000008488 polyadenylation Effects 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 229940048914 protamine Drugs 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 239000003161 ribonuclease inhibitor Substances 0.000 description 1
- 239000002336 ribonucleotide Substances 0.000 description 1
- 125000002652 ribonucleotide group Chemical group 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2018067504 | 2018-06-28 | ||
| EPPCT/EP2018/067504 | 2018-06-28 | ||
| PCT/EP2019/067323 WO2020002598A1 (en) | 2018-06-28 | 2019-06-28 | Bioreactor for rna in vitro transcription |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021528051A JP2021528051A (ja) | 2021-10-21 |
| JPWO2020002598A5 true JPWO2020002598A5 (enExample) | 2022-01-21 |
| JP7352581B2 JP7352581B2 (ja) | 2023-09-28 |
Family
ID=62837899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020567587A Active JP7352581B2 (ja) | 2018-06-28 | 2019-06-28 | Ｒｎａインビトロ転写用バイオリアクター |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US12371646B2 (enExample) |
| EP (2) | EP3814495B1 (enExample) |
| JP (1) | JP7352581B2 (enExample) |
| KR (1) | KR20210027368A (enExample) |
| AU (1) | AU2019293714C1 (enExample) |
| BR (1) | BR112020025601A8 (enExample) |
| CA (1) | CA3102135A1 (enExample) |
| IL (1) | IL279759B1 (enExample) |
| MX (1) | MX2020013148A (enExample) |
| RU (1) | RU2765877C1 (enExample) |
| SG (1) | SG11202011097YA (enExample) |
| WO (1) | WO2020002598A1 (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012019630A1 (en) | 2010-08-13 | 2012-02-16 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein |
| WO2013120499A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen |
| CA2859452C (en) | 2012-03-27 | 2021-12-21 | Curevac Gmbh | Artificial nucleic acid molecules for improved protein or peptide expression |
| AU2014310935B2 (en) | 2013-08-21 | 2019-11-21 | CureVac SE | Combination vaccine |
| CN105517569A (zh) | 2013-08-21 | 2016-04-20 | 库瑞瓦格股份公司 | 狂犬病疫苗 |
| SG11201510746WA (en) | 2013-08-21 | 2016-03-30 | Curevac Ag | Respiratory syncytial virus (rsv) vaccine |
| WO2015135558A1 (en) | 2014-03-12 | 2015-09-17 | Curevac Gmbh | Combination of vaccination and ox40 agonists |
| ES2946969T3 (es) | 2014-12-12 | 2023-07-28 | CureVac SE | Moléculas de ácido nucleico artificiales para una expresión proteica mejorada |
| EP3294885B1 (en) | 2015-05-08 | 2020-07-01 | CureVac Real Estate GmbH | Method for producing rna |
| WO2016193206A1 (en) | 2015-05-29 | 2016-12-08 | Curevac Ag | A method for producing and purifying rna, comprising at least one step of tangential flow filtration |
| WO2017081110A1 (en) | 2015-11-09 | 2017-05-18 | Curevac Ag | Rotavirus vaccines |
| EP3319622B1 (en) | 2015-12-22 | 2020-02-12 | CureVac AG | Method for producing rna molecule compositions |
| BR112018016755A2 (en) | 2016-02-17 | 2018-12-26 | Curevac Ag | Zica virus vaccine |
| WO2017149139A1 (en) | 2016-03-03 | 2017-09-08 | Curevac Ag | Rna analysis by total hydrolysis |
| EP3452101A2 (en) | 2016-05-04 | 2019-03-13 | CureVac AG | Rna encoding a therapeutic protein |
| EP4631970A3 (en) | 2016-05-04 | 2026-01-07 | CureVac SE | Nucleic acid molecules and uses thereof |
| US11464847B2 (en) | 2016-12-23 | 2022-10-11 | Curevac Ag | Lassa virus vaccine |
| WO2018115527A2 (en) | 2016-12-23 | 2018-06-28 | Curevac Ag | Mers coronavirus vaccine |
| MX2019011215A (es) | 2017-03-24 | 2020-02-12 | Curevac Ag | Ácidos nucleicos que codifican proteínas asociadas a crispr y usos de los mismos. |
| EP3625363A1 (en) | 2017-05-17 | 2020-03-25 | CureVac Real Estate GmbH | Method for determining at least one quality parameter of an rna sample |
| US11602557B2 (en) | 2017-08-22 | 2023-03-14 | Cure Vac SE | Bunyavirales vaccine |
| US11692002B2 (en) | 2017-11-08 | 2023-07-04 | CureVac SE | RNA sequence adaptation |
| US11931406B2 (en) | 2017-12-13 | 2024-03-19 | CureVac SE | Flavivirus vaccine |
| CN111511928A (zh) | 2017-12-21 | 2020-08-07 | 库瑞瓦格股份公司 | 偶联到单一支持物或标签的线性双链dna和用于制备所述线性双链dna的方法 |
| KR20210003811A (ko) | 2018-04-17 | 2021-01-14 | 큐어백 아게 | 백신 접종을 위한 신규 rsv rna 분자 및 조성물 |
| EP3814495B1 (en) | 2018-06-28 | 2023-06-07 | CureVac RNA Printer GmbH | Bioreactor for rna in vitro transcription |
| US11421226B2 (en) * | 2018-10-17 | 2022-08-23 | Ramot At Tel-Aviv University Ltd. | Programmable artificial cell |
| WO2020127959A1 (en) | 2018-12-21 | 2020-06-25 | Curevac Ag | Methods for rna analysis |
| US11241493B2 (en) | 2020-02-04 | 2022-02-08 | Curevac Ag | Coronavirus vaccine |
| DE112021000012C9 (de) | 2020-02-04 | 2025-02-06 | CureVac SE | Coronavirus-Vakzine |
| US12194089B2 (en) | 2020-02-04 | 2025-01-14 | CureVac SE | Coronavirus vaccine |
| US12194157B2 (en) | 2020-04-09 | 2025-01-14 | Finncure Oy | Carrier for targeted delivery to a host |
| AU2021252164A1 (en) | 2020-04-09 | 2022-12-15 | Finncure Oy | Mimetic nanoparticles for preventing the spreading and lowering the infection rate of novel coronaviruses |
| CN115667509A (zh) * | 2020-05-01 | 2023-01-31 | 螺旋纳米技术公司 | 用于rna合成的组合物和方法 |
| GB2597436B (en) * | 2020-05-12 | 2025-03-26 | Makatsoris Charalampos | A method and apparatus for RNA synthesis |
| CN120138084A (zh) * | 2020-05-12 | 2025-06-13 | 查拉拉姆波斯·马卡里奥斯 | 用于合成基于rna的治疗剂的方法和模块化设备 |
| AU2021279312A1 (en) | 2020-05-29 | 2022-12-15 | CureVac SE | Nucleic acid based combination vaccines |
| US20240066114A1 (en) | 2020-08-31 | 2024-02-29 | CureVac SE | Multivalent nucleic acid based coronavirus vaccines |
| US20240246056A1 (en) | 2020-09-01 | 2024-07-25 | CureVac RNA Printer GmbH | Manufacturing device for a pharmaceutical product |
| IL301890A (en) | 2020-10-14 | 2023-06-01 | George Mason Res Foundation Inc | Ionizing fats and methods of production and use thereof |
| JP2023552003A (ja) * | 2020-10-23 | 2023-12-13 | スピンドル バイオテック インク． | Ｒｎａ合成のための組成物および方法 |
| IL302970A (en) | 2020-11-27 | 2023-07-01 | CureVac RNA Printer GmbH | An apparatus for preparing a DNA product using capillary polymerase chain reaction |
| JP2024502210A (ja) | 2020-12-22 | 2024-01-17 | キュアバック エスイー | ＳＡＲＳ－ＣｏＶ－２バリアントに対するＲＮＡワクチン |
| WO2022137133A1 (en) | 2020-12-22 | 2022-06-30 | Curevac Ag | Rna vaccine against sars-cov-2 variants |
| CN117377491A (zh) | 2021-03-26 | 2024-01-09 | 葛兰素史克生物有限公司 | 免疫原性组合物 |
| US20240368654A1 (en) * | 2021-06-07 | 2024-11-07 | University Of Massachusetts | Apparatus and method for continuous production of rna |
| BE1030468B1 (fr) | 2022-04-20 | 2023-11-21 | Quantoom Biosciences S A | Système et méthode pour la production d’arn |
| CN119234155A (zh) | 2022-04-15 | 2024-12-31 | 广通生物科学公司 | 用于生产rna的系统和方法 |
| CN114540444B (zh) * | 2022-04-23 | 2022-08-09 | 江苏申基生物科技有限公司 | 一种加帽组合物及其制备方法和体外转录反应体系 |
| CN115106356B (zh) * | 2022-07-06 | 2023-06-06 | 眉山市城投中恒能环保科技有限公司 | 一种用于餐厨垃圾回收的处理方法及处理系统 |
| WO2024068545A1 (en) | 2022-09-26 | 2024-04-04 | Glaxosmithkline Biologicals Sa | Influenza virus vaccines |
| EP4344769B1 (en) * | 2022-09-30 | 2025-03-19 | Technische Universität Clausthal | System for continuous manufacture of biomolecules |
| WO2024089638A1 (en) | 2022-10-28 | 2024-05-02 | Glaxosmithkline Biologicals Sa | Nucleic acid based vaccine |
| CN116180478A (zh) * | 2023-02-28 | 2023-05-30 | 江苏理文造纸有限公司 | 一种利用秸秆自动化造纸装置 |
| WO2024194266A1 (en) | 2023-03-17 | 2024-09-26 | Quantoom Biosciences S.A. | Device and method for producing nucleic acid molecules |
| WO2024209418A1 (en) * | 2023-04-07 | 2024-10-10 | BioNTech SE | Heating and cooling jacket for fluid vessels |
| WO2024235451A1 (en) | 2023-05-16 | 2024-11-21 | CureVac RNA Printer GmbH | Improved rna in vitro transcription using dna beads |
| WO2025022178A2 (en) * | 2023-07-24 | 2025-01-30 | Apte Zachary Schulz | In-situ mrna vaccine production method and device |
| WO2025040263A1 (en) | 2023-08-24 | 2025-02-27 | CureVac Manufacturing GmbH | Purification process for in vitro amplified dna |
| WO2025071355A1 (ko) * | 2023-09-27 | 2025-04-03 | 포항공과대학교 산학협력단 | 미세 유체 반응 장치 및 이를 이용한 mrna 합성 방법 |
| WO2025132839A1 (en) | 2023-12-21 | 2025-06-26 | Glaxosmithkline Biologicals Sa | Influenza virus vaccines |
| WO2025144938A1 (en) | 2023-12-26 | 2025-07-03 | Emmune, Inc. | Systems for nucleic acid transfer |
| GB202406294D0 (en) | 2024-05-06 | 2024-06-19 | Thermo Fisher Scientific Baltics Uab | Methods and compositions for producing capped mRNA |
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| CN120115054B (zh) * | 2025-05-08 | 2025-08-05 | 南京航空航天大学 | 一种月面基地夹层壳体粉末混粉方法及夹层壳体结构 |
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-
2019
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- 2019-06-28 JP JP2020567587A patent/JP7352581B2/ja active Active
- 2019-06-28 IL IL279759A patent/IL279759B1/en unknown
- 2019-06-28 BR BR112020025601A patent/BR112020025601A8/pt not_active IP Right Cessation
- 2019-06-28 SG SG11202011097YA patent/SG11202011097YA/en unknown
- 2019-06-28 AU AU2019293714A patent/AU2019293714C1/en active Active
- 2019-06-28 CA CA3102135A patent/CA3102135A1/en active Pending
- 2019-06-28 US US17/254,853 patent/US12371646B2/en active Active
- 2019-06-28 MX MX2020013148A patent/MX2020013148A/es unknown
- 2019-06-28 EP EP23175456.5A patent/EP4273266A3/en not_active Withdrawn
- 2019-06-28 WO PCT/EP2019/067323 patent/WO2020002598A1/en not_active Ceased
- 2019-06-28 RU RU2020141236A patent/RU2765877C1/ru active
-
2025
- 2025-06-20 US US19/244,186 patent/US20250313788A1/en active Pending
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