JPWO2019107332A1 - Oral stain remover, oral stain formation inhibitor and oral composition - Google Patents

Abstract

Provided are an oral stain removing agent having an excellent effect of removing stains in the oral cavity, an oral stain forming inhibitor having an excellent effect of suppressing stain formation in the oral cavity, and an oral composition containing these. (A) Oral stain remover containing a polyacrylic acid salt having a weight average molecular weight of 1,000 or more and 20,000 or less, the above-mentioned component (a) and (b) 1% by mass aqueous solution having a pH at 25 ° C. of 1 to An oral stain remover containing one or more chelating agents selected from condensed phosphoric acid, phytic acid, edetic acid, citric acid, malic acid, succinic acid, dicarboxylic acid and salts thereof, which is No. 11 and the above (a). ) And (b) components for oral use. An oral stain formation inhibitor containing the above component (a), an oral stain formation inhibitor containing one or more alginic acid derivatives selected from the above component (a) and (c) alginate and alginate ester, and the above. An oral composition containing the components (a) and (c).

Description

The present invention relates to an oral stain removing agent, an oral stain forming inhibitor, and an oral composition containing these, which can effectively suppress stain adhesion to teeth and are useful for whitening teeth.

Stain, which is a type of stain on teeth, causes a coloring reaction in which saliva, food and drink, and pellicle containing coloring-causing components contained in luxury items, etc. adhere to the tooth surface, and accumulates and accumulates over time and adheres to the tooth surface. As a result, it became a strong colored stain. As a means for suppressing stain adhesion to solve this, a method for removing stain and a method for suppressing stain formation can be considered.

Conventionally, as a means for removing colored stains, it is common to remove by polishing by the physical action of an abrasive blended in the composition, but there is a problem of abrasion of the oral mucosa and dentin at the application site due to an increase in the amount of the abrasive. There was a limit because it could occur. Further, it is known that a stain removing effect can be imparted by using a condensed phosphate such as sodium polyphosphate in combination, but the effect may not be exhibited unless the blending amount of the condensed phosphate is relatively large. In addition, there was a problem that oral mucosal irritation became stronger as the blending amount was increased.

In Patent Document 1 (International Publication No. 2016/194645), by using condensed phosphate in combination with a fatty acid or fatty acid ester having a specific branched chain structure, stains are chemically acted while alleviating oral mucosal irritation. In Patent Document 2 (Japanese Unexamined Patent Publication No. 9-175966), a technique of blending water-soluble pyrophosphate and polyphosphate and removing stain stains on the tooth surface by a chemical action is proposed. However, there was room for improvement in the removal effect.

In addition, a technique for preventing the formation of stains in advance has attracted attention, and the establishment of a technique for suppressing the formation of stains is expected.
As a method for suppressing the formation of stains, methods using various surfactants are proposed in Patent Documents 3 to 5 (Japanese Patent Laid-Open Nos. 2003-81797, 2013-142601, 2015-174830). However, if a relatively large amount of the surfactant is not added, the effect may not be exhibited or the off-flavor derived from the surfactant may occur.

On the other hand, Patent Document 6 (Japanese Unexamined Patent Publication No. 2000-247851) has proposed a technique applying polyacrylic acid having a molecular weight of 20,000 or more as a color-suppressing coating agent that suppresses coloration of teeth due to accumulation of stains. According to Document 7 (Japanese Patent Publication No. 7-29907), a polyacrylic acid polymer or a polyacrylic acid copolymer having a weight average molecular weight of about 3,500 to 7,500 is about 2.5% or more as an anti-dental stone agent. It has been proposed to be incorporated into the oral composition in an amount of.

International Publication No. 2016/194645 Japanese Unexamined Patent Publication No. 9-175966 Japanese Unexamined Patent Publication No. 2003-81797 Japanese Unexamined Patent Publication No. 2013-142061 Japanese Unexamined Patent Publication No. 2015-174830 Japanese Unexamined Patent Publication No. 2000-247851 Special Fair 7-29907 Gazette

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a new oral stain adhesion inhibitor that suppresses stain adhesion to teeth and an oral composition containing the same.

As a result of diligent studies to achieve the above object, the present inventors have found that polyacrylate having a specific weight average molecular weight has a stain removing action and a stain forming inhibitory action in the oral cavity. It was found that it has an excellent effect of suppressing stain adhesion. Furthermore, when a polyacrylate having a specific weight average molecular weight in a specific range is used in combination with a specific chelating agent and / or a specific alginic acid derivative, the stain removing action and / or the stain formation inhibitory action in the oral cavity is enhanced, and the stain is enhanced. It was found that the adhesion suppressing effect was further improved.
In particular, by blending the above-mentioned combination system into an oral composition, a high stain removing effect and / or a stain formation suppressing effect can be given, an excellent stain adhesion suppressing effect can be imparted, and a good usability and a good usability It has been found that a satisfactory effect can be given, and the present invention has been made.

More specifically, as the first invention, the present inventors have an action of polyacrylate having a weight average molecular weight of a specific value or less to remove stain, which is a colored stain firmly adhered to teeth in the oral cavity. However, it has been found that an excellent stain removing effect is exhibited, and that when a specific chelating agent is used in combination, the action of the polyacrylate is enhanced and the stain removing effect is remarkably improved. As a result, by blending the combination system of the polyacrylate and a specific chelating agent into the oral composition, an excellent stain removing effect is imparted, and oral irritation to the oral cavity, particularly the mucous membrane, is caused. We have found that it can suppress and give a good feeling of use with a good scent and taste, and have made the first invention.

Polyacrylic acid or a salt thereof is known as a binder for an oral composition, but generally, a crosslinked polyacrylic acid or a salt thereof having a weight average molecular weight of 100,000 or more and usually about 300,000 is used. ing. Further, the stain is formed by forming colored pellicle by saliva component, food and drink, etc. on the tooth surface, and further laminating and depositing the stain.
On the other hand, in the first invention, (a) polyacrylates having a weight average molecular weight of 1,000 or more and 20,000 or less, particularly linear polyacrylates, have already adhered to the tooth surface. It has been found to have a previously unknown effect of removing strong stains, which results in polyacrylates with a weight average molecular weight of more than 20,000 or weight average molecular weights of 20,000 or less. However, a particularly remarkable action and effect that could not be achieved with polyacrylic acid in the form of salt was obtained.

As shown in Comparative Example I in Tables 1 and 5 described later, the stain removing effect of sodium polyacrylate having a weight average molecular weight of 300,000 or polyacrylic acid having a weight average molecular weight of 6,000 was x. However, as shown in the examples in Tables 1 to 5, the stain removing effect of the component (a) was ◯ or ⊚ or more, which was excellent.
In addition, the stain removal rate by the chelating agent was low, and the removal effect was hardly observed in some cases (comparative example in Table 5 described later). However, as shown in Example I in Tables 3 to 5, in the first invention, when the component (a) and the specific chelating agent described later are used in combination, both act synergistically to remove stains. The effect was remarkably enhanced, and the unpleasant odor caused by the component (a) and the oral irritation and unpleasant taste caused by the component (b) were suppressed, and a good usability could be maintained.

Although the mechanism of action of stain removal in the first invention is not clear, it is assumed that the stain is removed by the component (a) reacting specifically with the stain to facilitate the floating of stains. Guessed. Further, it is presumed that the above action is enhanced when the component (b) is further used in combination.

In addition, as the second invention, the present inventors have an effect that polyacrylic acid having a weight average molecular weight of a specific value or less has an effect of suppressing the formation of stain in the oral cavity, and exhibits an excellent effect of suppressing the formation of stain. Furthermore, it has been found that when a specific alginic acid derivative (alginate or alginate ester) is used in combination, the action of the polyacrylate is enhanced and the effect of suppressing stain formation is remarkably improved. As a result, by blending the combined system of the polyacrylic acid salt and the alginic acid derivative into the oral composition, it is possible to impart an excellent effect of suppressing stain formation and to give a satisfactory feeling of effect. The headline led to the second invention.

In the second invention, (a) polyacrylates having a weight average molecular weight of 1,000 or more and 20,000 or less, particularly linear polyacrylates, are stained on the tooth surface in the oral cavity. It has been found that it has a previously unknown action and effect of suppressing the above, and thus in the form of polyacrylate having a weight average molecular weight of more than 20,000 or a salt having a weight average molecular weight of 20,000 or less. A particularly remarkable effect that could not be achieved with polyacrylic acid that was not obtained was obtained.

As shown in Comparative Example II in Tables 6 and 8 described later, the effect of suppressing stain formation by sodium polyacrylate having a weight average molecular weight of 300,000 or polyacrylic acid having a weight average molecular weight of 6,000 was x. However, as shown in Example II in Tables 6 and 7, the stain formation inhibitory effect of the component (a) was either ◯ or ⊚, which was excellent.
Further, as shown in the comparative examples in Table 8 described later, the effect of suppressing stain formation by alginate and alginate ester was hardly observed, but as shown in the examples in Tables 6 and 7, the second invention Then, when the component (a) and (c) one or more alginic acid derivatives selected from alginate and alginate ester are used in combination, both act synergistically to remarkably enhance the effect of suppressing stain formation, and continue. Even after use, the tooth surface was felt to be smooth, and it was possible to give a feeling of effect that the stain formation was sufficiently suppressed.

Although the details of the mechanism of action of suppressing stain formation in the second invention are not clear, the saliva component, metal ions derived from food and drink, etc. are combined and colored on the tooth surface due to the action peculiar to the component (a). It is speculated that stain formation is suppressed by chemically inhibiting the formation of pellicle and preventing deposition. Further, when the component (c) is used in combination, the above-mentioned action is remarkably enhanced, and at the same time, the adsorptivity and persistence of the component (c) on the tooth surface are improved, and stain formation is continuously suppressed even after continuous use. It is presumed that the actual feeling of the effect will increase.

As described above, Patent Document 6 is the suppression of coloring by coating, and the hydrophilicization of the tooth surface after coating achieves easy removal and prevention of accumulation of stained pellicle (colored pellicle). Patent Document 7 can be achieved by suppressing tartar with a polyacrylic acid polymer or the like with an amount of about 2.5% or more.
On the other hand, the present invention is (a) removal of stains and suppression of stain formation by polyacrylic acid having a specific molecular weight, and suppression of stain adhesion by them, and such effects are inferior to those of polyacrylic acid in non-salt form. On the other hand, even if the amount of the component (a) in the oral composition is 1% by mass or less, it is excellent.

Therefore, the present invention provides the following oral stain remover, oral stain formation inhibitor, and oral composition.
[1]
(A) An oral stain remover containing a polyacrylate having a weight average molecular weight of 1,000 or more and 20,000 or less.
[2]
(A) Polyacrylic acid salt having a weight average molecular weight of 1,000 or more and 20,000 or less, and (b) condensed phosphoric acid, phytic acid, and malic acid having a pH of 1 to 11 at 25 ° C. of a 1 mass% aqueous solution. An oral stain remover containing one or more chelating agents selected from citric acid, malic acid, succinic acid, dicarboxylic acid and salts thereof.
[3]
The oral stain remover according to [2], wherein (a) / (b) has a mass ratio of 0.01 to 50.
[4]
(A) The oral stain remover according to any one of [1] to [3], wherein the polyacrylate component has a weight average molecular weight of 1,000 or more and 10,000 or less.
[5]
(A) Polyacrylic acid salt having a weight average molecular weight of 1,000 or more and 20,000 or less, and (b) condensed phosphoric acid, phytic acid, and malic acid having a pH of 1 to 11 at 25 ° C. of a 1 mass% aqueous solution. An oral composition containing one or more chelating agents selected from citric acid, malic acid, succinic acid, dicarboxylic acid and salts thereof.
[6]
(A) The oral composition according to [5], wherein the weight average molecular weight of the component polyacrylate is 1,000 or more and 10,000 or less.
[7]
The oral composition according to [5] or [6], wherein (a) / (b) has a mass ratio of 0.01 to 50.
[8]
The oral composition according to any one of [5] to [7], which contains 0.01 to 2% by mass of the component (a) and 0.03 to 3% by mass of the component (b).
[9]
The oral composition according to any one of [5] to [8], further (c) containing 0.05 to 2% by mass of one or more alginic acid derivatives selected from alginate and alginic acid ester.
[10]
The oral composition according to any one of [5] to [9] for removing stains.
[11]
The oral composition according to any one of [5] to [10], which is a dentifrice composition.
[12]
(A) An oral stain formation inhibitor containing a polyacrylate having a weight average molecular weight of 1,000 or more and 20,000 or less.
[13]
An oral stain formation inhibitor containing (a) a polyacrylate having a weight average molecular weight of 1,000 or more and 20,000 or less, and (c) one or more alginic acid derivatives selected from alginate and alginate ester.
[14]
The oral stain formation inhibitor according to [13], wherein (a) / (c) has a mass ratio of 0.05 to 5.
[15]
The oral stain formation inhibitor according to any one of [12] to [14], wherein the weight average molecular weight of the polyacrylate is 1,000 or more and 10,000 or less.
[16]
An oral composition containing (a) a polyacrylate having a weight average molecular weight of 1,000 or more and 20,000 or less, and (c) one or more alginic acid derivatives selected from alginate and alginate ester.
[17]
The oral composition according to [16], wherein the weight average molecular weight of the polyacrylate is 1,000 or more and 10,000 or less.
[18]
The oral composition according to [16] or [17], wherein (a) / (c) has a mass ratio of 0.05 to 5.
[19]
The oral composition according to any one of [16] to [18], which contains 0.01 to 2% by mass of the component (a) and 0.05 to 2% by mass of the component (c).
[20]
The oral composition according to any one of [16] to [19] for suppressing stain formation.
[21]
The oral composition according to any one of [16] to [20], which is a dentifrice composition.

According to the present invention, an oral stain removing agent, an oral stain removing agent, and these are contained, which have an oral stain removing action and / or a stain forming suppressing action, thereby exhibiting an excellent stain adhesion suppressing effect. Oral compositions can be provided.
That is, according to the present invention, as the first invention, it is possible to provide an oral stain removing agent having an excellent effect of removing stain in the oral cavity and an oral composition containing the same. Since this oral composition has a high stain removing effect and a good usability, it can effectively suppress stains, and is therefore suitable for whitening the oral cavity and preventing or suppressing oral diseases.
Further, as the second invention, it is possible to provide an oral stain formation inhibitor having an excellent effect of suppressing stain formation in the oral cavity and an oral composition containing the same. This oral composition has a high effect of suppressing stain formation and gives a satisfactory feeling of effect, and thus can effectively suppress stain formation, and is therefore effective for whitening the oral cavity and preventing or suppressing oral diseases.

Hereinafter, the present invention will be described in more detail.
The oral stain remover and oral stain formation inhibitor of the present invention are (a) a polyacrylic acid salt having a weight average molecular weight of 1,000 or more and 20,000 or less, preferably (a) component and (b) 1 mass. One or more chelating agents selected from condensed phosphoric acid, phytic acid, edetic acid, citric acid, malic acid, succinic acid, dicarboxylic acid and salts thereof having a pH of 1 to 11 at 25 ° C. of the% aqueous solution. And / or (c) one or more alginic acid derivatives selected from alginates and alginate esters.
That is, the oral stain remover of the first invention contains the component (a), preferably the components (a) and (b), and the component (a), preferably the component (a) and the component (b) are contained. , The active ingredient for stain removal. The oral stain formation inhibitor of the second invention contains the component (a), preferably the components (a) and (c), and the component (a), preferably the component (a) and the component (c), are contained. It is an active ingredient that suppresses stain formation. Therefore, in the present invention, the components (a), (a) and (b), or the components (a), (b) and (c) have a stain removing action and / or a stain formation suppressing action. However, these actions exert an excellent effect of suppressing the adhesion of stains.
In the present invention, "stain adhesion" means a state in which stain is attached, and "stain adhesion suppression" means a state in which stain is not attached. "Stain removal" means removing the formed sticking stain, and "stain formation suppression" means preventing the stain from sticking.

The polyacrylate of the component (a) has a weight average molecular weight (Mw) of 1,000 or more and 20,000 or less. In this case, the weight average molecular weight is 1,000 or more, preferably 2,000 or more, and 20,000 or less, preferably 10,000 or less, from the viewpoint of the stain removing effect and the stain formation suppressing effect. , More preferably 8,000 or less. When the weight average molecular weight is less than 1,000, the stain removing effect and the stain formation suppressing effect are inferior. If it exceeds 20,000, the stain removing effect and the stain formation suppressing effect are lowered, and a sufficient effect cannot be obtained.

The weight average molecular weight was measured by GPC (gel permeation chromatography) under the method and measurement conditions described in Japanese Patent No. 5740859. Specifically, it is shown below (the same applies hereinafter).
Method for measuring weight average molecular weight;
The weight average molecular weight is a value measured using a gel permeation chromatograph / multi-angle laser light scattering detector (GPC-MALLS), and the conditions are as follows.
Mobile phase: 0.3M NaClO ₄
NaN ₃ aqueous solution column: TSKgelα-M 2 pre-column: TSKguardcolumn α
Standard substance: Polyethylene glycol

The polyacrylate of the component (a) is preferably a linear polyacrylate from the viewpoint of stain removing effect and stain formation suppressing effect.
As the salt, a monovalent salt is preferable, an alkali metal salt or an ammonium salt is more preferable, an alkali metal salt such as a sodium salt or a potassium salt is more preferable, and a sodium salt is particularly preferable.
As such a polyacrylate, a commercially available product sold by Polyscience Co., Ltd. or Toagosei Co., Ltd. can be used.
As a specific commercial product, sodium polyacrylate (Mw: 1,000); linear, manufactured by Polyscience, sodium polyacrylate (Mw: 6,000); linear, manufactured by Toagosei Co., Ltd. , AC-10NP, AC-10NPD, Aron T-50, sodium polyacrylate (Mw: 8,000); linear, manufactured by Polyscience, sodium polyacrylate (Mw: 20,000); linear , Toagosei Co., Ltd., Aron A-20UN, etc. can be used.

The polyacrylate of the component (a) usually has a lower weight average molecular weight than the polyacrylate of the binder used in dentifrices, and is different from the polyacrylate known as a binder. It is a thing.
When a polyacrylic acid salt other than the component (a) is used instead of the component (a), or when a polyacrylic acid in the form of a salt is used, the stain removing effect and the stain formation suppressing effect are inferior, and further. Even if the component (b) is used in combination, the effect is inferior, and even if the component (c) is used in combination, the above effect is inferior and the actual feeling of the effect is poor, and the object of the present invention cannot be achieved.

In the present invention, in the oral stain remover of the first invention, it is preferable to use (b) a specific chelating agent in combination with the component (a) as an active ingredient. When the components (a) and (b) are used in combination, the stain removing effect is further improved.

The component (b) is a chelating agent selected from the following (b1) to (b5). These may be used alone or in combination of two or more. It is also possible to use two or more of the components (b1) to (b5) in combination.
(B1): Condensed phosphorus having a pH of 1% by mass at 25 ° C.
One or more selected from acid and its salt (b2): One or more selected from phytic acid and its salt (b3): One or more selected from edetic acid and its salt (b4): From citric acid and its salt One or more selected (b5): selected from citric acid, succinic acid, dicarboxylic acid and salts thereof
One or more In each of the above (b1) to (b5), the type of salt is not particularly limited, but metal salts such as sodium salt and potassium salt are exemplified, and sodium salt is particularly preferable.

The condensed phosphoric acid and its salt of (b1) have a pH of 11 or less, particularly 10 or less at 25 ° C. of a 1% by mass aqueous solution, and the lower limit is not particularly limited as long as it is pH 1 or more, but may be pH 7 or more.
As the condensed phosphate, a sodium salt or a potassium salt is preferable.
Specifically, linear or cyclic polyphosphates such as sodium or potassium pyrophosphate, sodium or potassium tripolyphosphate, sodium or potassium tetrapolyphosphate, sodium or potassium metaphosphate, sodium or potassium ultraphosphate may be used. ..
Among these, sodium tripolyphosphate (1% by mass aqueous solution, pH 7 to 10 at 25 ° C.), sodium pyrophosphate (1% by mass aqueous solution, pH 7 to 11 at 25 ° C.), sodium metaphosphate (1% by mass aqueous solution, 25 ° C.) PH 1 to 8), sodium ultraphosphate (1% by mass aqueous solution, pH 1 to 7 at 25 ° C.) is preferable, and sodium tripolyphosphate is more preferable.

(B2) is particularly preferably phytic acid, and (b3) is particularly preferably edetate, particularly disodium edetate. In (b4), citric acid and sodium citrate are particularly preferable, and citric acid is particularly preferable.

(B5) is one or more selected from malic acid, succinic acid, dicarboxylic acid and salts thereof.
Examples of the dicarboxylic acid include oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, azelaic acid, sebacic acid, phthalic acid, isophthalic acid, and terephthalic acid.
(B5) is particularly preferably selected from malic acid, succinic acid and salts thereof. In this case, those containing these can also be preferably used.

Further, in (a) / (b) indicating the quantitative ratio of the component (a) and the component (b), the mass ratio is preferably 0.01 to 50, more preferably 0.01 to 10, and particularly preferably 0. It is .01-8. Within this range, the stain removing effect and the feeling of use (oral irritation, odor, taste) are more excellent.

The oral stain remover of the first invention can be obtained by blending the component (a) alone, preferably the component (b) in combination as an active ingredient. Furthermore, if necessary, other components known for oral use may be contained, and in this case, the known components may be blended within a range that does not interfere with the effects of the present invention.

In the present invention, in the oral stain formation inhibitor of the second invention, it is preferable to use one or more alginic acid derivatives selected from (c) alginate and alginate ester in combination with the component (a) as an active ingredient. .. When the components (a) and (c) are used in combination, the effect of suppressing stain formation is further improved.

The component (c) is a salt or ester of alginic acid, which is a polysaccharide.
The alginate may be any of those usually used in oral compositions, but sodium alginate can be used. The sodium alginate preferably has a viscosity of a 1% by mass aqueous solution (BL type viscometer, rotor No. 3, 12 rpm, 20 ° C., measurement time 3 minutes) of 1,000 to 4,000 mPa · s. For example, a commercially available product such as Kimika Argin of Kimika Co., Ltd. can be used.
As the alginate ester, any one usually used for oral compositions may be used, but propylene glycol alginate is particularly preferable. Among them, those having a viscosity of a 1% by mass aqueous solution (BL type viscometer, rotor No. 2, 60 rpm, 20 ° C., measurement time 3 minutes) of 10 to 200 mPa · s are preferable. For example, a commercially available product such as Kimiroid BF of Kimika Co., Ltd. can be used.

Further, (a) / (c) indicating the quantitative ratio of the component (a) and the component (c) can be 0.005 to 20 as a mass ratio, but from the viewpoint of the effect of suppressing stain formation, it is preferably 0. 05-5, more preferably 0.1-2. Within this range, the effect of suppressing stain formation and the actual feeling of the effect are more excellent.

The oral stain formation inhibitor of the second invention can be obtained by blending the component (a) alone, preferably the component (c) in combination as an active ingredient. Furthermore, if necessary, other components known for oral use may be contained, and in this case, the known components may be blended within a range that does not interfere with the effects of the present invention.

In the present invention, when the components (a), (b) and (c) are used in combination as the active ingredients, the stain removing effect and the stain formation suppressing effect are enhanced, the stain adhesion suppressing effect is further improved, and a further excellent action effect is imparted. It is also suitable as an oral stain adhesion inhibitor.

The oral composition of the present invention contains a component (a) and a component (b) and / or a component (c).
In the present invention, the oral composition of the first invention contains the components (a) and (b), and the oral composition of the second invention contains the components (a) and (c). .. When the cavity composition of the present invention contains the components (a), (b) and (c), it is more preferable from the viewpoint of the stain removing effect and the stain formation suppressing effect.
Specific examples of the oral composition include paste-like, gel-like or liquid dentifrices (dentifrices, gel-like dentifrices, liquid dentifrices, liquid dentifrices, etc.), mouthwashes, mouth sprays, coating agents, patches. Etc. can be suitably blended. Above all, it is suitable as a dentifrice composition, particularly as a dentifrice composition. Further, in the first invention, since it has an excellent stain removing effect, it is suitable as an oral composition for removing stains, and in the second invention, it has an excellent effect of suppressing stain formation, so that it is an oral cavity for suppressing stain formation. Suitable as a composition for use. Since the oral composition of the present invention has an excellent stain removing effect and a stain forming suppressing effect, it is also suitable for suppressing stain adhesion.

Here, when the components (a) and (b) are used in combination, it is preferable to specify (a) / (b) in the above-mentioned specific ratio because the stain removing effect is excellent. The blending amount of the component (a) and the component (b) is preferably in the range described below from the viewpoint of stain removing effect and usability, and it is preferable to use the component at a concentration satisfying these.
When the components (a) and (c) are used in combination, it is preferable to specify (a) / (c) in the above-mentioned specific ratio because the effect of suppressing stain formation is excellent. The blending amount of the component (a) and the component (c) is preferably in the range described below from the viewpoint of the effect of suppressing stain formation and the actual feeling of the effect, and it is preferable to use the component at a concentration satisfying these.
When the components (a), (b) and (c) are used in combination, the stain removing effect and the stain formation suppressing effect are excellent. Therefore, (a) / (b) and (a) / (c) are specified above, respectively. It is more preferable to specify the ratio of. The blending amounts of the components (a), (b) and (c) are preferably in the ranges described below from the viewpoints of the stain removing effect and the stain formation suppressing effect, as well as the feeling of use and the actual feeling of the effect, and the above-mentioned components satisfy these. Can be used in concentration.

The blending amount of the component (a) is preferably 0.01 to 2% (mass%, the same applies hereinafter) of the entire composition. When it is 0.01% or more, a sufficient stain removing effect and a stain formation suppressing effect can be obtained. When it is 2% or less, the odor derived from the component (a) is sufficiently suppressed.
Further, when the components (a) and (b) are used in combination, the blending amount of the component (a) is preferably 0.01 to 2%, more preferably 0.03 to 1%, still more preferably 0.03 to 1% of the entire composition. It is 0.03 to 0.8%. When it is 0.01% or more, a sufficient stain removing effect can be obtained. When it is 2% or less, the odor derived from the component (a) is sufficiently suppressed.
When the components (a) and (c) are used in combination, the blending amount of the component (a) is preferably 0.01 to 2%, more preferably 0.05 to 1%, and even more preferably 0. It is 1 to 0.8%. When it is 0.01% or more, a sufficient effect of suppressing stain formation can be obtained. When it is 2% or less, a sufficient effect of suppressing stain formation can be obtained, and the off-taste derived from the component (a) is sufficiently suppressed.

The blending amount of the component (b) is preferably 0.03 to 3%, more preferably 0.1 to 3% of the total composition. When it is 0.03% or more, a sufficient stain removing effect can be obtained. When it is 3% or less, oral irritation can be suppressed and a good odor and taste can be given.
When the component (b1) is blended as the component (b) within the range of the blending amount of the component (b), the preferable blending amount is 0.03 to 1% of the entire composition, particularly 0.03 to 0.03. It is 0.5%. When the components (b2) to (b5) are blended as the component (b), the preferable blending amount of each is 0.03 to 3%, particularly 0.1 to 3% of the total composition. As the components (b1) to (b5), one type can be used in each of the above ranges, or two or more types can be used in combination within the range of the total amount of the component (b).

The blending amount of the component (c) is preferably 0.05 to 2%, more preferably 0.1 to 1% of the total composition. When it is 0.05% or more, a sufficient effect of suppressing stain formation can be obtained. When it is 2% or less, a sufficient feeling of effect can be obtained and a feeling of use is also good. If the component (c) exceeds 2%, the spinnability may be enhanced and the actual feeling of the effect may be lowered.

In the oral composition of the present invention, in addition to the above-mentioned component (a) and further components (b) and (c), known components according to the dosage form and the like can be added as optional components other than these to the effect of the present invention. Can be added as needed as long as it does not interfere with the above. Specifically, the dentifrice contains an abrasive, a binder, a thickener, a surfactant, a sweetener, a preservative, a colorant, a fragrance, and an active ingredient, and these ingredients are mixed with water. , Can be manufactured.

The abrasives include, for example, silica-based abrasives such as silicic anhydride, crystalline silica, amorphous silica, silica gel, and aluminosilicate, calcium tertiary phosphate, calcium tetraphosphate, calcium hydrogen phosphate anhydride, calcium hydrogen phosphate. Calcium phosphate-based abrasives such as dihydrate, zeolite, calcium pyrophosphate, calcium carbonate, sodium hydrogen carbonate, aluminum hydroxide, alumina, magnesium carbonate, magnesium ferric phosphate, zirconium silicate, hydroxyapatite, synthetic resin-based abrasives Can be mentioned. These can be used alone or in combination of two or more, and among them, silica-based abrasives such as silicon dioxide-based abrasives, which are inorganic abrasives, and calcium phosphate-based abrasives, from the viewpoint of oral mucosal irritation and usability. Especially, silicic anhydride is preferable.
The blending amount of the abrasive is preferably 0 to 60% of the entire composition, and when blended, it is preferably 3 to 60%, particularly 5 to 55%. Further, the upper limit is preferably 20% or less, or 15% or less. The amount of the abrasive in the dentifrice is preferably 10 to 55% of the whole composition, and the amount of the abrasive in the mouthwash is preferably 0 to 10%, particularly 0 to 5% of the whole composition.
The oral composition of the present invention has an excellent stain removing effect even when no abrasive is added.

Binders include gums such as xanthan gum, tragacanth gum, gellan gum, kalaya gum, and arabic gum, crosslinked polyacrylic acid salts having a weight average molecular weight of more than 20,000, carrageenan, and sodium carboxymethyl cellulose, methyl cellulose, hydroxyethyl cellulose, and carboxy. Cellulose derivatives such as sodium methylhydroxyethyl cellulose, organic binders such as polyvinyl alcohol, carboxyvinyl polymer and polyvinylpyrrolidone, and inorganic binders such as silica gel, aluminum silica gel, bee gum and laponite can be blended (usually, the blending amount is 0.3 to 0.3 to 10%).

Examples of the viscous agent include sugar alcohols such as sorbitol, maltitol, lactitol, erythritol, and xylitol, and polyhydric alcohols such as propylene glycol, and one or more of them can be blended (the blending amount is usually 5 to 70%). ).

As the surfactant, an anionic surfactant, a nonionic surfactant, and an amphoteric surfactant may be blended. These can be used alone or in combination of two or more.
Examples of the anionic surfactant include an alkyl sulfate having an alkyl group having 12 to 14 carbon atoms and particularly 12, an acyl amino acid salt, an acyl taurine salt and the like. The acyl groups of the acyl amino acid salt and the acyl taurine salt each have 12 to 14 carbon atoms, particularly 12 carbon atoms.
Specific examples of the alkyl sulfate include lauryl sulfate and myristyl sulfate, and examples of the acyl amino acid salt include acyl glutamates such as lauroyl glutamate and myristyl glutamate, and acyl sarcosine salts such as lauroyl sarcosin salt, and acyl taurine. Examples of the salt include lauroyl methyl taurine salt. The salt is preferably an alkali metal salt such as a sodium salt or a potassium salt. In particular, alkyl sulfates, acyl sarcosine salts, and acyl taurine salts are preferable. Among them, an anionic surfactant having a hydrocarbon group (lauryl group) having 12 carbon atoms is preferable, and an alkyl sulfate (sodium salt) is particularly preferable because it is superior to other surfactants in terms of taste. ..
Nonionic surfactants include, for example, polyoxyethylene alkyl ether, polyoxyethylene-polyoxypropylene block copolymer, polyoxyethylene hydrogenated castor oil, glycerin ester polyoxyethylene ether, sucrose fatty acid ester, and alcoholamide. , Polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester and the like. Of these, polyoxyethylene alkyl ether, polyoxyethylene hydrogenated castor oil, alquilolamide, and sorbitan fatty acid ester are preferable in terms of versatility. The polyoxyethylene alkyl ether preferably has an alkyl chain having 14 to 30 carbon atoms, and preferably has an average ethylene oxide molar addition molar number (average addition EO) of 3 to 30. The polyoxyethylene cured castor oil preferably has an average added EO of 10 to 100. The alkylolamide preferably has an alkyl chain having 12 to 14 carbon atoms. The sorbitan fatty acid ester preferably has 12 to 18 carbon atoms, and the polyoxyethylene sorbitan fatty acid ester preferably has 16 to 18 carbon atoms and an average added EO of 10 to 40.
Examples of the amphoteric surfactant include acylaminoacetate betaine having an acyl group having 12 to 14 carbon atoms and fatty acid amide propyl betaine. Examples of the acylaminoacetic acid betaine include lauroyldimethylaminoacetic acid betaine, and examples of the fatty acid amide propyl betaine include coconut oil fatty acid amide propyl betaine.

The blending amount of the surfactant is preferably 0 to 15%, particularly preferably 0.01 to 10%. When an anionic surfactant is blended, the blending amount is preferably 0.1 to 3%, particularly 0.5 to 2%, and when a nonionic surfactant is blended, the blending amount is 0.01. 10% is good.

In the present invention, when a nonionic surfactant, particularly polyoxyethylene hydrogenated castor oil, is used in combination with the component (a), the odor and taste may be deteriorated depending on the amount of the nonionic surfactant added, and the usability may be deteriorated. When the nonionic surfactant is added together with the anionic surfactant such as the above, such deterioration of odor and taste is prevented, and the stain removing effect and the stain formation suppressing effect are further improved without deteriorating the usability.

Examples of sweeteners include sodium saccharin, stebioside, dipotassium glycyrrhizinate, perillartine, thaumatin, neoheseridyldihydrochalcone, and asparatylphenylalanine methyl ester. Examples of the preservative include paraoxybenzoic acid ester and sodium benzoate.
Examples of the colorant include Blue No. 1, Yellow No. 4, Titanium Dioxide and the like.

Fragrances are peppermint oil, sparemint oil, anis oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamon oil, coriander oil, mandarin oil, lime. Oil, lavender oil, rosemary oil, laurel oil, camomill oil, caraway oil, majorum oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute peppermint , Absolute rose, orange flower and other natural fragrances, and fragrances that have been processed (pre-reservoir cut, rear-reservoir cut, distilling, liquid extraction, essence, powder fragrance, etc.) and Mentor, Carvone, Anetol, Methyl salicylate, Synamic aldehyde, 3-l-Mentoxypropane-1,2-diol, Linarol, Linaryl acetate, Limonen, Menton, Menthyl acetate, N-substituted-Paramentan-3-Carboxamide, Pinen, octylaldehyde, citral, pregon, calvier acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexanepropionate, methylanthranilate, ethylmethylphenylglycidate, vanillin, undecalactone, hexanal, isoamyl alcohol , Hexenol, dimethylsulfide, cycloten, furfural, trimethylpyrazine, ethyllactate, ethylthioacetate and other single flavors, as well as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, Known perfume materials used in oral compositions, such as mixed flavors such as fruit mix flavors and tropical fruit flavors, can be used and are not limited to the perfumes of the examples.
Moreover, it is preferable to use 0.000001 to 1% of the above-mentioned fragrance material as the whole composition. As the perfume for perfume using the above perfume material, it is preferable to use 0.001 to 2.0% in the composition.

Optional active ingredients include nonionic bactericides such as isopropylmethylphenol; cationic bactericides such as cetylpyridinium chloride; lysozyme, amylase, protease, lytic enzyme, SOD (superoxide dismutase) and the like. Enzymes; alkali metal monofluorophosphates such as sodium monofluorophosphate and potassium monofluorophosphate; fluorides such as sodium fluoride and stannous fluoride; tranexamic acid, epsilon aminocaproic acid, allantin, allantinchlorohydroxyaluminum, Anti-inflammatory agents such as dihydrocholesterol, glycyrrhizinic acid, and glycyrrhetinic acid; hypersensitivity improvers such as potassium nitrate and aluminum lactate; zinc compounds such as glycerofluoride, chlorofluoride, sodium chloride, zinc chloride, zinc oxide, zinc citrate; Copper compounds such as copper acid and copper sulfate; vitamins such as vitamin A, vitamin B group, vitamin C and vitamin E; and raw medicines such as lysozyme and cha. These active ingredients can be used alone or in combination of two or more, and can be blended in an effective amount within a range that does not interfere with the effects of the present invention.

The pH (25 ° C.) of the oral composition may be in the normal range, preferably pH 5-9, particularly 6-8. A known pH adjuster may be added to adjust the pH, and for example, hydrochloric acid or an alkali metal hydroxide such as sodium hydroxide can be used.
The preferred embodiments of the first and second inventions are shown below.

Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In the following examples,% indicates mass% unless otherwise specified.
The weight average molecular weight (Mw) was measured using a gel permeation chromatograph / multi-angle laser light scattering detector (GPC-MALLS) under the same method and measurement conditions as described above.

[Example I, Comparative Example I]
An oral preparation containing the types and amounts of polyacrylic acid salts shown in Tables 1 to 3 and the component (b) was prepared, and the stain removing effect was evaluated by the following method. The results are also shown in Tables 1 to 3.
Further, the dentifrice composition (dentifrice) having the composition shown in Tables 4 and 5 was prepared by a usual method and filled in an aluminum tube container. The stain removing effect and usability were evaluated by the following methods. The results are also shown in Tables 4 and 5.

(1) Evaluation method of stain removing effect A hydroxyapatite plate (manufactured by HOYA Co., Ltd., diameter φ7.0 mm × thickness 3.5 mm, hereinafter abbreviated as HAP plate) whose surface has been sandblasted in advance is (i). 0.5% aqueous albumin solution, (ii) tannin solution (50 g of Japanese tea (brand: old pine), 5 tea bags (Brisk tea bag manufactured by Lipton)) are extracted with hot water, and after cooling, 12 g of powdered coffee (Nescafe) (Manufactured by the same company) is added, and the solution is prepared to 1,200 mL with purified water, and the solution is immersed in each solution of (iii) 0.56% iron (III) ammonium citrate aqueous solution in order for 30 minutes at room temperature. The operation including the drying step after one cycle of immersion was repeated 8 to 9 times a day, and continued for about 30 days until the stain was sufficiently adhered to the HAP plate to form a strong stain.
The degree of stain adhesion was determined by measuring the L ^* value using a spectrocolorimeter (manufactured by Nippon Denshoku Co., Ltd., SE-2000). The L ₀ ^* value of the HAP plate before the treatment was used as the initial value, and the L ₁ ^* value after the treatment was used as the blank value. Next, the stain-attached HAP plate was diluted 3-fold with artificial saliva (50 mM KCl, 1 mM CaCl ₂ , 0.1 mM MgCl ₂ , 1 mM KH ₂ PO ₄ , pH 7.0) in a dentifrice solution at 37 ° C. for 2 After immersion for 5 minutes, brushing treatment was performed in the same test solution using a flat plate grinder. The brushing process was performed 200 times. After brushing, it was washed with water and the L ₂ ^* value was measured. The stain removal rate was calculated by the following formula, and the stain removal effect was evaluated.
Stain removal rate (%) =
{((L ₁ ^* -L ₀ ^* )-(L ₂ ^* -L ₀ ^* )) / (L ₁ ^* -L ₀ ^* )} x 100
Evaluation Criteria for Stain Removal Effect ◎ ◎ ◎ ◎: Stain removal rate is 50% or more ◎ ◎ ◎: Stain removal rate is 40% or more and less than 50% ◎ ◎: Stain removal rate is 30% or more and less than 40% ◎: Stain removal rate Is 25% or more and less than 30% ○: Stain removal rate is 20% or more and less than 25% Δ: Stain removal rate is 10% or more and less than 20% ×: Stain removal rate is less than 10%

(2) Evaluation method of usability (oral irritation, odor, taste) Ten subject monitors placed the dentifrice composition on a toothbrush and brushed it for 3 minutes to wash the oral cavity. The feeling of use (oral irritation, odor, taste) at that time was sensory evaluated according to the following scoring criteria. The average value of the evaluation points of 10 persons was calculated, and the oral irritation, odor, and taste were judged according to the following evaluation criteria.

Oral stimulus rating criteria 4 points: No irritation in the oral cavity 3 points: Almost no irritation in the oral cavity 2 points: Slight irritation in the oral cavity 1 point: I feel irritation in the oral cavity Evaluation criteria for oral irritation ⊚: Average score 3.0 points or more and 4.0 points or less ○: Average score 2.5 points or more and less than 3.0 points Δ: Average score 1.5 points or more and less than 2.5 points ×: Average score 1.5 points Less than

Smell rating criteria 4 points: No unpleasant odor in the oral cavity 3 points: Almost no unpleasant odor in the oral cavity 2 points: Slightly unpleasant odor in the oral cavity 1 point: Unpleasant odor in the oral cavity Evaluation criteria for odor ◎: Average score 3.5 points or more and 4.0 points or less ○: Average score 3.0 points or more and less than 3.5 points △: Average score 2.0 points or more and less than 3.0 points ×: Average score less than 2.0 points

Taste rating criteria 4 points: No offensive taste in the oral cavity 3 points: Almost no offensive taste in the oral cavity 2 points: Some offensive taste in the oral cavity 1 point: No offensive taste in the oral cavity ◎: Average score 3.5 points or more and 4.0 points or less ○: Average score 3.0 points or more and less than 3.5 points Δ: Average score 2.0 points or more and less than 3.0 points ×: Average score less than 2.0 points

Details of the raw materials used are shown below.
(A) Sodium polyacrylate (Mw: 1,000)
Linear, manufactured by Polyscience (a) Sodium polyacrylate (Mw: 6,000)
Linear, manufactured by Toagosei Co., Ltd., AC-10NP
(A) Sodium polyacrylate (Mw: 8,000)
Linear, manufactured by Polyscience (a) Sodium polyacrylate (Mw: 20,000)
Linear, manufactured by Toagosei Co., Ltd., Aron A-20UN
Sodium polyacrylate (Mw: 300,000, comparative ingredient)
Cross-linked type, polyacrylic acid manufactured by Polyscience (Mw: 6,000, comparative component)
Linear, manufactured by Toagosei Co., Ltd., Aron A-10SL
(B) Citric acid Made by Fuso Chemical Industry Co., Ltd., Product name: Purified citric acid (crystal)
(B) Malic acid (DL-malic acid)
Made by Fuso Chemical Industry Co., Ltd., Product name: Fusou malate (b) Phytic acid (50% liquid product)
Made by Fuso Chemical Industry Co., Ltd., Product name: Phytic acid (b) Disodium edetate Made by Junsei Chemical Co., Ltd. (b) Sodium tripolyphosphate Taihei Chemical Industry Co., Ltd. (b) Sodium metaphosphate Taihei Chemical Industry Co., Ltd. ) Made

＊；フィチン酸の配合量の数値は、純分量である（以下同様）。

*; The numerical value of the blending amount of phytic acid is the pure content (the same applies hereinafter).

[Example II, Comparative Example II]
Oral preparations containing the types and amounts of polyacrylates or alginates shown in Table 6 were prepared by a conventional method, and the stain formation inhibitory effect was evaluated by the following method. The results are also shown in Table 6.
Further, a dentifrice composition (dentifrice) having the compositions shown in Tables 7 and 8 was prepared by a conventional method and filled in an aluminum tube container. The effect of suppressing stain formation and the actual feeling of the effect were evaluated by the following method. The results are also shown in Tables 7 and 8.

(3) Evaluation method of stain formation inhibitory effect A hydroxyapatite plate (manufactured by HOYA Corporation, diameter φ7.0 mm × thickness 3.5 mm, hereinafter abbreviated as HA plate) whose surface has been sandblasted in advance is subjected to spectral color difference. The measurement was performed using a meter (SE-2000 manufactured by Nippon Denshoku Co., Ltd.), and the ΔE value (ΔE ₀ ) of the HA plate before stain formation was determined. (I) The HA plate was immersed in a test solution (centrifugated supernatant of a 3-fold diluted artificial saliva solution for oral preparation) and allowed to stand in a constant temperature bath at 50 ° C. for 10 minutes. Take out the HA plate to remove the water on the surface of the HA plate, (ii) 0.5% aqueous albumin solution, (iii) tannin solution (Japanese tea (brand: old pine) 50 g, tea tea bag (manufactured by Lipton, Brisk tea bag) ) 5 pieces are extracted with hot water, 12 g of powdered coffee (manufactured by Nescafe) is added after cooling, and a solution prepared to 1,200 mL with purified water, (iv) 0.56% aqueous solution of iron (III) ammonium citrate. Each solution was sequentially immersed in a constant temperature bath at 50 ° C. for 10 minutes at room temperature. The immersion operations of (i) to (iv) were repeated 7 times to dry the surface of the HA plate, and the ΔE value (ΔE _{1) of the} HA surface. ) Was measured.
When the same treatment was performed with purified water instead of the test solution, each ΔE value (before the stain preparation solution treatment: ΔE _0b , after the stain preparation solution treatment: ΔE _1b ) was measured in the same manner, and stain formation was performed by the following formula. The suppression rate was calculated to evaluate the effect of suppressing stain formation.
Stain formation inhibition rate (%) =
[(ΔE _1b − ΔE _0b ) − (ΔE ₁ − ΔE ₀ )] / (ΔE _1b − ΔE _0b ) × 100
Evaluation Criteria for Stain Formation Inhibition Effect ◎ ◎: Stain formation inhibition rate is 70% or more ◎: Stain formation inhibition rate is 60% or more and less than 70% ○: Stain formation inhibition rate is 50% or more and less than 60% Δ: Stain formation inhibition rate Is 40% or more and less than 50% ×: Stain formation inhibition rate is less than 40%

(4) Evaluation method of actual effect The tooth surface became smooth after 10 subject monitors took about 1 g of the dentifrice composition on a toothbrush and continued to use the dentifrice for 3 minutes at least twice a day for 30 days. The feeling was evaluated on a 4-point scale according to the following evaluation criteria. The average score of 10 persons was calculated, and the actual feeling of effect (the feeling of effect that the tooth surface became smooth) was judged according to the following criteria. In the case of ○ or ◎, the tooth surface was continuously felt to be smooth, and it was judged that the effect was good.
Evaluation criteria for actual feeling of effect 4 points: Very felt 3 points: Slightly felt 2 points: Not felt so much 1 point: Not felt Smooth feeling continues Judgment criteria ◎: Average score 3.5 points or more ○: Average score 3 .0 points or more and less than 3.5 points Δ: Average points 2.0 points or more and less than 3.0 points ×: Average points less than 2.0 points

Details of the raw materials used are shown below.
The component (a) used, sodium polyacrylate (comparative product) and polyacrylic acid (comparative product) are the same as above.
(C) Sodium alginate manufactured by Kimika Co., Ltd., Kimika Algin (c) Propylene glycol alginate manufactured by Kimika Co., Ltd., Kimiroid BF

The dentifrices of Examples II 12 to 19 in Table 7 had an excellent effect of suppressing stain formation, and the effect was also high. In addition, there was no discomfort derived from the component (a) and there was no spinnability, and the feeling of use was good.

As a result of evaluating the stain formation inhibitory effect on the dentifrice compositions (2-1) to (2-13) of Example I in Table 4 by the same method as in (3) above, all of them were obtained. It was "◎◎".

Claims (21)

(A) An oral stain remover containing a polyacrylate having a weight average molecular weight of 1,000 or more and 20,000 or less. (A) Polyacrylic acid salt having a weight average molecular weight of 1,000 or more and 20,000 or less, and (b) condensed phosphoric acid, phytic acid, and malic acid having a pH of 1 to 11 at 25 ° C. of a 1 mass% aqueous solution. An oral stain remover containing one or more chelating agents selected from citric acid, malic acid, succinic acid, dicarboxylic acid and salts thereof. The oral stain remover according to claim 2, wherein (a) / (b) has a mass ratio of 0.01 to 50. (A) The oral stain remover according to any one of claims 1 to 3, wherein the component polyacrylic acid salt has a weight average molecular weight of 1,000 or more and 10,000 or less. (A) Polyacrylic acid salt having a weight average molecular weight of 1,000 or more and 20,000 or less, and (b) condensed phosphoric acid, phytic acid, and malic acid having a pH of 1 to 11 at 25 ° C. of a 1 mass% aqueous solution. An oral composition containing one or more chelating agents selected from citric acid, malic acid, succinic acid, dicarboxylic acid and salts thereof. (A) The oral composition according to claim 5, wherein the polyacrylate component has a weight average molecular weight of 1,000 or more and 10,000 or less. The oral composition according to claim 5 or 6, wherein (a) / (b) is 0.01 to 50 as a mass ratio. The oral composition according to any one of claims 5 to 7, which contains 0.01 to 2% by mass of the component (a) and 0.03 to 3% by mass of the component (b). The oral composition according to any one of claims 5 to 8, further comprising (c) 0.05 to 2% by mass of one or more alginic acid derivatives selected from alginate and alginic acid ester. The oral composition according to any one of claims 5 to 9, which is for removing stains. The oral composition according to any one of claims 5 to 10, which is a dentifrice composition. (A) An oral stain formation inhibitor containing a polyacrylate having a weight average molecular weight of 1,000 or more and 20,000 or less. An oral stain formation inhibitor containing (a) a polyacrylate having a weight average molecular weight of 1,000 or more and 20,000 or less, and (c) one or more alginic acid derivatives selected from alginate and alginate ester. The oral stain formation inhibitor according to claim 13, wherein (a) / (c) is 0.05 to 5 as a mass ratio. The oral stain formation inhibitor according to any one of claims 12 to 14, wherein the weight average molecular weight of the polyacrylate is 1,000 or more and 10,000 or less. An oral composition containing (a) a polyacrylate having a weight average molecular weight of 1,000 or more and 20,000 or less, and (c) one or more alginic acid derivatives selected from alginate and alginate ester. The oral composition according to claim 16, wherein the polyacrylate has a weight average molecular weight of 1,000 or more and 10,000 or less. The oral composition according to claim 16 or 17, wherein (a) / (c) is 0.05 to 5 as a mass ratio. The oral composition according to any one of claims 16 to 18, which contains 0.01 to 2% by mass of the component (a) and 0.05 to 2% by mass of the component (c). The oral composition according to any one of claims 16 to 19, which is for suppressing stain formation. The oral composition according to any one of claims 16 to 20, which is a dentifrice composition.