JP2020143023A - Oral composition - Google Patents

Abstract

To provide an oral composition that is effective in removing colored stains on a tooth, particularly dentinal stains, and has a reduced odor and a good feeling in use, and has user-friendliness with no problem of spinnability.SOLUTION: An oral composition contains (A) polyacrylic acid salt with a weight average molecular weight of 1,000 or more and 20,000 or less and (B) pyrrolidone carboxylic acid or a salt thereof. The oral composition further contains (C) xanthan gum.SELECTED DRAWING: None

Description

The present invention relates to an oral composition having an excellent effect of removing stains on teeth, particularly dentin.

In recent years, there has been an increasing demand for the aesthetics of teeth, and the deterioration of aesthetics due to the coloring and yellowing of the exposed root surface due to the involution of the gums due to aging etc. has become a problem. There is a need for a technique for improving aesthetics by preventing coloring not only on the surface enamel but also on the exposed root surface. However, the exposed dentin on the root surface is yellowish in itself and may be more organic than the constituents of enamel, so the technology for enamel is sufficient to color it. I couldn't prevent it.

By the way, in stain, which is a kind of colored stains on teeth, pellicle containing saliva, food and drink, and luxury items contained in saliva, food and drink, and luxury items causes a coloring reaction, and is laminated and accumulated over time, and the tooth surface. It adhered to the surface and became a strong colored stain. As a means for suppressing stain adhesion, polishing removal by physical action such as an abrasive is generally used, and stain removal using a condensed phosphate such as polyphosphate is also known, but oral mucosal irritation and dentin There was concern about wear and tear, and it was difficult to say that it was suitable for aesthetic dentin.

It has been proposed in Patent Document 1 (Japanese Unexamined Patent Publication No. 2000-247851) that polyacrylic acid having a molecular weight of 20,000 or more can be applied as a color-suppressing coating agent that suppresses coloration of teeth due to accumulation of stains, but mainly enamel. It is a color suppression focusing on quality, and the effect on dentin still has room for improvement. Patent Document 2 (Japanese Patent Publication No. 7-29907) contains about 2.5% of a polyacrylic acid polymer or a polyacrylic acid copolymer having a weight average molecular weight of about 3,500 to 7,500 as an anti-tartar agent. Oral compositions blended in the above amounts have been proposed.

On the other hand, a technique has been proposed in which a lactam compound pyrrolidone carboxylic acid or a salt thereof is applied to remove stains, and Patent Document 3 (International Publication No. 2013/047826) uses the lactam compound pyrrolidone carboxylic acid or a salt thereof as an active ingredient. Although it is disclosed that the effect of suppressing stain formation and the effect of removing stain on enamel (hydroxyapatite) are exhibited by blending the stain removing agent with the above, there is still room for improvement in the effect on dentin. It was something. Further, although it is described as a collagen coloring inhibitor, it suppresses color change due to collagenase, which is different from stain removal of colored stains.
Further, Patent Document 4 (Japanese Patent Laid-Open No. 2016-529300) proposes a tooth whitening method using an oral care composition containing calcium silicate and high refractive index composite particles, but 97% of them are inorganic. It is aimed at the effect of enamel composed of, and it cannot be said that it is an appropriate treatment because there is a problem of oral mucosa and dentin wear at the application site in the ages after 30s when the gums are worrisome. Above, the effect on dentin on the root surface was not sufficient.

Japanese Unexamined Patent Publication No. 2000-247851 Special Fair 7-29907 Gazette International Publication No. 2013/047826 Special Table 2016-529300 Japanese Unexamined Patent Publication No. 2014-40408 Japanese Patent No. 6100755

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an oral composition having an excellent stain removing effect on dental dentin.

As a result of diligent studies to achieve the above object, the present inventors, when (A) polyacrylate having a specific weight average molecular weight and (B) pyrrolidone carboxylic acid or a salt thereof are used in combination, teeth It has an excellent effect of removing stains, which are colored stains attached to dentin, and by blending the components (A) and (B) together in the oral composition, the effect of removing stains on tooth dentin can be obtained. We have found that the invention is excellent, the odor is suppressed, the usability is good, the spinnability is not a problem, and the usability is good.

As mentioned above, compared to the enamel on the tooth surface, dentin itself is yellowish, and the organic substances contained in a large amount of constituents are easily stained with colored stains, and stains of colored stains both quantitatively and qualitatively. Not only is it easy to adhere to, but it is also difficult to remove it. Further, the stain in the oral cavity is formed by forming colored pellicle by saliva component, food and drink, etc. on the tooth surface, and further laminating and depositing it to be firmly constructed. On the other hand, in the present invention, when the components (A) and (B) are used in combination, the stain removing effect of dentin is enhanced by the synergistic action of both, and the component (A) or the component (B) It was possible to impart a particularly remarkable action and effect that cannot be obtained by a single formulation. Therefore, according to the present invention, dentin stain can be removed by an approach different from enamel stain removal, and colored stains on the entire tooth surface can be removed to improve aesthetics.
Polyacrylic acid or a salt thereof known as a binder for an oral composition is generally a crosslinked type having a weight average molecular weight of 100,000 or more, usually about 300,000, and polyacrylic acid or a salt thereof. Is used. However, the action and effect of the present invention is a action and effect peculiar to the combined system of the components (A) and (B), and if the component (A) or the component (B) is absent, the stain removal rate of dentin is low, and When the component (A) is absent, the stain removal rate of dentin is low even if the polyacrylic acid salt contains an inappropriate weight average molecular weight, for example, a crosslinked type having a weight average molecular weight of 300,000. , These were inferior in action and effect (see comparative examples below).
In the present invention, when (C) xanthan gum is further added, the appearance of the preparation can be sufficiently stabilized over time. When the component (B) is mixed with the component (A), liquid separation may occur over time depending on the composition and the appearance of the preparation may be impaired. However, the components (A) and (B) are used in combination. Preferably, by further blending the component (C) in combination, the appearance of the preparation can be sufficiently stabilized even over time without causing liquid separation as described above.

In the examples of Patent Document 3, sodium polyacrylate is blended as a binder together with pyrrolidone carboxylic acid. Patent Document 5 (Japanese Unexamined Patent Publication No. 2014-40408) proposes that a cationic bactericide and a cationic polymer suppress plaque adhesion, and further improve the usability by combining a specific lactam compound, and as a binder. Sodium polyacrylate is described. Patent Document 6 (Patent No. 6100755) describes improvement of the oral moisturizing effect by using pyrrolidonecarboxylic acid or a salt thereof in combination with a specific water-soluble polymer, and polyacrylic acid as the water-soluble polymer. Alternatively, it has also been shown that its salts can be used. However, Patent Documents 3, 5 and 6 do not describe the molecular weight of polyacrylic acid or a salt thereof. On the other hand, the present invention is the removal of dentin stain by the combined system of the components (A) and (B), and even if an inappropriate molecular weight of polyacrylic acid or a salt thereof is blended, (A) It exerts a specific and special action effect that cannot be imparted when a component is lacking.

Therefore, the present invention provides the following oral compositions.
[1]
An oral composition comprising (A) a polyacrylate having a weight average molecular weight of 1,000 or more and 20,000 or less, and (B) pyrrolidone carboxylic acid or a salt thereof.
[2]
The oral composition according to [1], wherein the weight average molecular weight of the polyacrylate component (A) is 2,000 or more and 10,000 or less.
[3]
The oral composition according to [1] or [2], which contains 0.01 to 2% by mass of the component (A) and 0.1 to 10% by mass of the component (B).
[4]
The oral composition according to any one of [1] to [3], wherein (A) / (B) has a mass ratio of 0.003 to 3.
[5]
The oral composition according to any one of [1] to [4], which further contains (C) xanthan gum.
[6]
The oral composition according to [5], which contains 0.1 to 3% by mass of the component (C).
[7]
The oral composition according to any one of [1] to [6] for removing oral stains.
[8]
The oral composition according to any one of [1] to [7], which is a dentifrice composition.

According to the present invention, it is possible to provide an oral composition which is excellent in the stain removing effect of tooth dentin, has a good usability with suppressed odor, and has good usability without any problem in spinnability. Further, it is possible to provide an oral composition having good appearance stability. The oral composition of the present invention can be expected to improve aesthetics by removing dentin stains, which are more difficult to remove than enamel on the tooth surface, without worrying about irritation of the oral mucosa. As a stain remover, it can be applied not only to the prevention or suppression of oral diseases but also to the whitening of teeth, and it can be used even by a person with an exposed root surface.

Hereinafter, the present invention will be described in more detail. The oral composition of the present invention contains (A) a polyacrylate having a weight average molecular weight of 1,000 or more and 20,000 or less, and (B) a pyrrolidone carboxylic acid or a salt thereof.
In the present invention, the component (A) and the component (B) are active ingredients for removing stain of dentin, and a combined system of both components can be blended into an oral composition as an oral stain removing agent.

The polyacrylate of the component (A) has a weight average molecular weight (Mw) of 1,000 or more and 20,000 or less. In this case, from the viewpoint of the stain removing effect of dentin, the weight average molecular weight is 1,000 to 20,000, preferably 2,000 to 10,000, and more preferably 5,000 to 8,000. If the weight average molecular weight is less than 1,000, the stain removing effect of dentin is inferior, and if it exceeds 20,000, the stain removing effect of dentin is lowered, and a sufficient effect cannot be obtained.

The weight average molecular weight was measured by GPC (gel permeation chromatography) under the method and measurement conditions described in Japanese Patent No. 5740859. Specifically, it is shown below.
Method for measuring weight average molecular weight;
The weight average molecular weight is a value measured using a gel permeation chromatograph / multi-angle laser light scattering detector (GPC-MALLS), and the conditions are as follows.
Mobile phase: 0.3M NaClO ₄
NaN ₃ aqueous solution column: TSKgelα-M 2 pre-columns: TSK guardcolumn α
Standard substance: Polyethylene glycol

The polyacrylate of the component (A) is preferably a linear polyacrylate from the viewpoint of stain removing effect.
As the salt, a monovalent salt is preferable, an alkali metal salt or an ammonium salt is more preferable, an alkali metal salt such as a sodium salt or a potassium salt is more preferable, and a sodium salt is particularly preferable.
As such a polyacrylate, a commercially available product sold by Polyscience Co., Ltd. or Toagosei Co., Ltd. can be used.
As a specific commercial product, sodium polyacrylate (Mw: 1,000); linear, manufactured by Polyscience, sodium polyacrylate (Mw: 6,000); linear, manufactured by Toagosei Co., Ltd. , AC-10NP, AC-10NPD, Aron T-50, sodium polyacrylate (Mw: 8,000); linear, manufactured by Polyscience, sodium polyacrylate (Mw: 20,000); linear , Toagosei Co., Ltd., Aron A-20UN, etc. can be used.

The polyacrylic acid salt of the component (A) usually has a lower weight average molecular weight than the polyacrylic acid salt of the binder used in the dentifrice composition, and is different from the polyacrylic acid salt known as a binder. Is different.
When a polyacrylic acid salt other than the component (A) is used instead of the component (A), or when polyacrylic acid in the form of a salt is used, even if the component (B) is used in combination, the dentin Poor stain removal effect.

The blending amount of the component (A) is preferably 0.01 to 2% (mass%, the same applies hereinafter) of the entire composition, more preferably 0.05 to 1%, still more preferably 0.1 to 0.9%. Is. When it is 0.01% or more, the stain removing effect of dentin can be sufficiently obtained. When it is 2% or less, the unpleasant odor derived from the component (A) can be sufficiently suppressed to ensure a good usability.

The component (B) is pyrrolidone carboxylic acid or a salt thereof.
Pyrrolidone carboxylic acid can be obtained by dehydrating glutamic acid extracted from seaweed, wheat, sugar cane and the like. Examples of the salt include an inorganic base salt, an inorganic acid salt, an organic base salt, and an amino acid salt, and the salt is preferably a water-soluble salt, and an inorganic base is particularly preferable. Examples of the inorganic base include alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as calcium salt and magnesium salt, and copper salt, zinc salt, aluminum salt and ammonium salt. Among them, alkali metal salts such as sodium salt and potassium salt, particularly sodium salt is preferable. These may be used alone or in combination of two or more.
As the pyrrolidone carboxylic acid or a salt thereof, a commercially available product can be used. Specific pyrrolidone carboxylic acids include AJIDEW (registered trademark, the same applies hereinafter) A-100 manufactured by Ajinomoto Healthy Supply Co., Ltd., and sodium pyrrolidone carboxylate includes AJIDEW N-50 and PCA manufactured by Ajinomoto Healthy Supply Co., Ltd. Sodium (50% aqueous solution) or the like can be used.

The blending amount of the component (B) is preferably 0.1 to 10%, more preferably 0.5 to 5% of the entire composition. When it is 0.1% or more, the stain removing effect of dentin can be sufficiently obtained. When it is 10% or less, good usability without a problem in spinnability can be sufficiently ensured.

In the present invention, (A) / (B) indicating the quantitative ratio of the component (A) to the component (B) can be 0.001 to 20 as a mass ratio, but the effect of removing stain from dentin can be set. From the point of view, it is preferably 0.003 to 3, more preferably 0.03 to 0.7, and further, from the point of view of odor, 0.03 to 0.6 is particularly preferable. When the mass ratio of (A) / (B) is within the above range, the stain removing effect of dentin is more excellent, and it is possible to sufficiently secure usability with a good odor and no problem in spinnability. ..

The oral composition of the present invention preferably further contains (C) xanthan gum. When the component (C) is blended together with the components (A) and (B), the liquid separation is sufficiently suppressed even with time, and the appearance stability is further improved.
The xanthan gum preferably has a viscosity of 1,000 to 2,000 mPa · s when the viscosity is measured by the method specified in the section of Pharmaceutical Additive Standard 2013 “Xanthan Gum”. Those having such a viscosity are preferable for suppressing liquid separation, and there is no problem in spinnability.
As such xanthan gum, for example, a commercially available product such as Monato Gum DA manufactured by CP Kelco Co., Ltd. can be used.

The blending amount of the component (C) is preferably 0.1 to 3%, more preferably 0.2 to 2.5%, and even more preferably 0.2 to 2% of the entire composition. When the blending amount is within the above range, liquid separation is sufficiently suppressed, high appearance stability can be ensured, and there is no problem in spinnability.

The oral composition of the present invention is particularly suitable as a dentifrice composition, and can be prepared into dentifrice, gel-like toothpaste, liquid dentifrice, etc. in the form of paste, gel, liquid, etc., and is particularly suitable as dentifrice. is there. Further, in the present invention, in addition to the above-mentioned components (A) and (B), and further, a known component according to the dosage form as an optional component other than these, a range that does not interfere with the effect of the present invention. Can be added as needed. Specifically, the dentifrice composition contains an abrasive, a binder, a thickener, a surfactant, a sweetener, a preservative, a colorant, a fragrance, and an active ingredient, and these ingredients and water are mixed. Can be mixed and manufactured.

Examples of the polishing agent include silica-based polishing agents such as silicic anhydride, crystalline silica, amorphous silica, silica gel, and aluminosilicate, zeolite, calcium hydrogen phosphate anhydride, calcium hydrogen phosphate dihydrate, and the like. Examples thereof include calcium pyrophosphate, calcium carbonate, sodium hydrogen carbonate, aluminum hydroxide, alumina, magnesium carbonate, magnesium tertiary phosphate, zirconium silicate, calcium tertiary phosphate, hydroxyapatite, calcium tetraphosphate, and synthetic resin-based abrasives. These can be used alone or in combination of two or more. Among them, silica-based abrasives such as silicic acid anhydride and calcium phosphate-based abrasives such as calcium phosphate, particularly anhydrous, can be used from the viewpoint of oral mucosal irritation and usability. Silica is preferred.
The blending amount of the abrasive is preferably 0 to 20%, and when blended, it is preferably 3 to 20%, particularly 5 to 15%. When 3% or more is blended, the cleaning power against colored substances such as stains is particularly excellent. If too much is added, oral mucosal irritation may occur. The amount of the abrasive in the mouthwash is preferably 0 to 10%, particularly preferably 0 to 5%.
The oral composition of the present invention has an excellent stain removing effect even without an abrasive.

The binder includes gums other than (C) xanthan gum such as tragacanth gum, gellan gum, kalaya gum, and arabic gum, crosslinked polyacrylic acid salt having a weight average molecular weight of more than 20,000, carrageenan, and sodium carboxymethyl cellulose and methyl cellulose. Cellulose derivatives such as hydroxyethyl cellulose and sodium carboxymethyl hydroxyethyl cellulose, organic binders such as polyvinyl alcohol, carboxyvinyl polymer and polyvinylpyrrolidone, and inorganic binders such as silica gel, aluminum silica gel, bee gum and laponite can be blended (the blending amount is: Usually 0.3-10%).

Examples of the viscous agent include sugar alcohols such as sorbitol, maltitol, lactitol, erythritol and xylitol, and polyhydric alcohols such as propylene glycol, and one or more of them can be blended (usually, the blending amount is 5 to 5). 70%).

As the surfactant, an anionic surfactant, a nonionic surfactant, and an amphoteric surfactant may be blended.
Examples of the anionic surfactant include alkyl sulfates having an alkyl group having 12 to 14 carbon atoms, particularly 12 alkyl groups, acyl amino acid salts, acyl taurine salts, α-olefin sulfonates and the like. The acyl groups of the acyl amino acid salt and the acyl taurine salt each have 12 to 14 carbon atoms, particularly preferably 12.
Specific examples of the alkyl sulfate include lauryl sulfate and myristyl sulfate. Examples of the acyl amino acid salt include acylglutamic acid salts such as lauroyl glutamate and myristyl glutamate, and acyl sarcosine salts such as lauroyl sarcosine salt. Examples of the acyl taurine salt include lauroyl methyl taurine salt and the like. As these salts, alkali metal salts such as sodium salt and potassium salt are preferable. As the α-olefin sulfonate, an alkali metal salt such as sodium or potassium of α-olefin sulfonic acid having 14 to 16 carbon atoms can be used, and an α-olefin sulfonate having 14 carbon atoms, particularly sodium, can be used. It is a salt (generic name; sodium tetradecene sulfonate).
Nonionic surfactants include, for example, polyoxyethylene alkyl ether, polyoxyethylene-polyoxypropylene block copolymer, polyoxyethylene hydrogenated castor oil, glycerin ester polyoxyethylene ether, sucrose fatty acid ester, and alcoholamide. , Glycerin fatty acid ester and the like. Of these, polyoxyethylene alkyl ether, polyoxyethylene cured castor oil, alcohololamide, and sorbitan fatty acid ester are preferably used in terms of versatility. The polyoxyethylene alkyl ether preferably has an alkyl chain having 14 to 30 carbon atoms, and preferably has an average added molar number of ethylene oxide (average added EO) of 3 to 30. The polyoxyethylene cured castor oil preferably has an average addition EO of 10 to 100. The alkyl amide preferably has an alkyl chain having 12 to 14 carbon atoms. The sorbitan fatty acid ester preferably has 12 to 18 carbon atoms in the fatty acid. The polyoxyethylene sorbitan fatty acid ester preferably has 16 to 18 carbon atoms in the fatty acid. Further, the polyoxyethylene sorbitan fatty acid ester preferably has an average addition EO of 10 to 40.
Examples of the amphoteric surfactant include acylaminoacetate betaine having an acyl group having 12 to 14 carbon atoms and fatty acid amide propyl betaine. Examples of the acylaminoacetic acid betaine include lauroyldimethylaminoacetic acid betaine, and examples of the fatty acid amide propyl betaine include coconut oil fatty acid amide propyl betaine. Among them, acylaminoacetate betaine, particularly one having a hydrocarbon group (lauryl group) having 12 carbon atoms is preferable, and lauryldimethylaminoacetate betaine is more preferable.
These can be used alone or in combination of two or more.
As the arbitrary surfactant, an anionic surfactant, particularly an α-olefin sulfonate, is preferable in terms of basic performance such as foaming performance and the ability to exhibit this effect, particularly in a dentifrice composition.

The blending amount of the surfactant is preferably 0 to 15%, particularly preferably 0.01 to 10%. When an anionic surfactant is blended, the blending amount is preferably 0.1 to 3%, particularly 0.5 to 2%, and when a nonionic surfactant is blended, the blending amount is 0.01. 10% is good.

In the present invention, when a nonionic surfactant, particularly polyoxyethylene hydrogenated castor oil, is used in combination with the component (A), the odor and taste may be deteriorated and the usability may be deteriorated depending on the amount of the nonionic surfactant added. When a nonionic surfactant is added together with the sex surfactant, such deterioration of odor and taste is prevented, and the stain removing effect of dentin is further improved without deteriorating the usability.

Examples of sweeteners include sodium saccharin, stebioside, dipotassium glycyrrhizinate, perillartine, thaumatin, neoheseridyldihydrochalcone, and asparatylphenylalanine methyl ester. Examples of the preservative include paraoxybenzoic acid ester and sodium benzoate.
Examples of the colorant include Blue No. 1, Yellow No. 4, Titanium Dioxide and the like.

Fragrances are peppermint oil, sparemint oil, anis oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamon oil, coriander oil, mandarin oil, lime. Oil, lavender oil, rosemary oil, laurel oil, camomill oil, caraway oil, majorum oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute peppermint , Absolute rose, orange flower, and other natural fragrances, and fragrances that have been processed (pre-reservoir cut, rear-reservoir cut, distilling, liquid extraction, essence, powder fragrance, etc.), and Mentor, Carvone, Anetol, Methyl salicylate, Synamic aldehyde, 3-l-Mentoxypropane-1,2-diol, Linarol, Linaryl acetate, Limonen, Menton, Menthyl acetate, N-substituted-Paramentan-3-Carboxamide, Pinen, octylaldehyde, citral, pregon, calvier acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexanepropionate, methylanthranilate, ethylmethylphenylglycidate, vanillin, undecalactone, hexanal, isoamyl alcohol , Hexenol, dimethylsulfide, cycloten, furfural, trimethylpyrazine, ethyllactate, ethylthioacetate and other single flavors, as well as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, Known perfume materials used in oral compositions, such as mixed flavors such as fruit mix flavors and tropical fruit flavors, can be used and are not limited to the perfumes of the examples.
Moreover, it is preferable to use 0.000001 to 1% of the above-mentioned fragrance material in the composition. As the perfume for perfume using the above perfume material, it is preferable to use 0.001 to 2.0% in the composition.

Optional active ingredients include nonionic bactericides such as isopropylmethylphenol; cationic bactericides such as cetylpyridinium chloride; lysozyme, amylase, protease, lytic enzyme, SOD (superoxide dismutase) and the like. Enzymes; alkali metal monofluorophosphates such as sodium monofluorophosphate and potassium monofluorophosphate; fluorides such as sodium fluoride and stannous fluoride; tranexamic acid, epsilon aminocaproic acid, allantin, allantinchlorohydroxyaluminum, Anti-inflammatory agents such as dihydrocholesterol, glycyrrhizinic acid, and glycyrrhetinic acid; hypersensitivity improvers such as potassium nitrate and aluminum lactate; zinc compounds such as glycerofluoride, chlorofluoride, sodium chloride, zinc chloride, zinc oxide, zinc citrate; Copper compounds such as copper acid and copper sulfate; vitamins such as vitamin A, vitamin B group, vitamin C and vitamin E; and raw medicines such as lysozyme and cha. One or more of these active ingredients can be used, and an effective amount can be blended as long as the effects of the present invention are not impaired.

Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In the following examples,% indicates mass% unless otherwise specified.
The weight average molecular weight (Mw) was measured by the above method and measurement conditions using a gel permeation chromatograph / multi-angle laser light scattering detector (GPC-MALLS).

[Examples, comparative examples]
Toothpaste compositions (dentifrices) having the compositions shown in Tables 1 to 3 were prepared by a usual method, and these were used as test dentifrice compositions, and the stain removing effect and odor of dentin were evaluated by the following methods. Further, the dentifrice composition in Table 1 was also evaluated for spinnability by the following method, and the dentifrice composition in Table 3 was also evaluated for spinnability and liquid separation by the following method. The results are also shown in Tables 1 to 3.

(1) Evaluation Method of Stain Removal Effect of Dentin The dentin portion of the bovine extracted tooth was mirror-polished with abrasive paper, the polished portion was cut to a length of 5 mm, and the back surface was coated with a transparent manicure. 0.5% aqueous albumin solution, powdered instant green tea (manufactured by Itoen Co., Ltd.) 0.8 g, powdered instant black tea (manufactured by Yanagiya Charaku) 0.8 g and powdered instant coffee (manufactured by Nestlé) 1.4 g The dentin sections were repeatedly immersed in an aqueous solution prepared by adding 100 ml of boiling water and a 0.57% iron (II) citrate ammonium solution for 10 minutes each in turn at 40 ° C. This operation was repeated for about 10 cycles to dry the surface of the dentin section to prepare a dentin model stain of L ^* ≈50 (L50). Incidentally, degree Spectrophotometer adhesion of stains: used (SE7700 manufactured by Nippon Denshoku Industries Co., Ltd.), L ^* value was measured, obtained (Pretreatment of dentin L ^* value: L ₀ ^*) ..
A dentin model stain was placed in a container for a polishing tester using a dental rubber elastic impression material, and immersed in an aqueous solution of a 3-fold diluted test dentifrice composition for 3 minutes. A toothbrush was installed in the polishing tester, and stroke cleaning (stroke speed 120 rpm, stroke width 40 mm, brushing load 200 g) was performed. After stroke cleaning, the dentin model stain was taken out, the color difference was measured (L ₁ ^* ), and the stain removal effect on the dentin was judged by the following evaluation criteria. ○ The above items were accepted.
Stain removal rate (%)
= {(L50-L ₀ ^* )-(L ₁ ^* -L ₀ ^* ) / (L50-L ₀ ^* )} x 100
Evaluation criteria ◎ ◎ ◎: Stain removal rate is 50% or more ◎ ◎: Stain removal rate is 40% or more and less than 50% ◎: Stain removal rate is 30% or more and less than 40% ○: Stain removal rate is 20% or more and less than 30% Δ: Stain removal rate is 10% or more and less than 20% ×: Stain removal rate is less than 10%

(2) Odor evaluation method The test dentifrice composition was filled in a laminated tube container having a diameter of 8 mm, and 10 subject monitors extruded the test dentifrice composition from this tube container and placed about 1 g on the toothbrush and placed the oral cavity. The odor (no unpleasant odor) when the inside was washed was judged by the following four-level scoring criteria. The average value of the scores of 10 people was calculated and judged according to the following evaluation criteria. ○ The above items were accepted.
Rating criteria 4 points: No unpleasant odor in the oral cavity 3 points: Almost no unpleasant odor in the oral cavity 2 points: Slightly unpleasant odor in the oral cavity 1 point: Very unpleasant odor in the oral cavity Evaluation criteria ◎: 3.5 points or more and 4.0 points or less ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and less than 3.0 points ×: less than 2.0 points

(3) Evaluation method of spinnability The test dentifrice composition was filled in a laminated tube container having a diameter of 8 mm, the test dentifrice composition was extruded from this tube container, about 1 g was placed on the toothbrush, and the tube container was placed upward. The state of kneading (spinning property) when the toothbrush was pulled apart was judged by the following evaluation criteria. ○ The above items were accepted.
The spinnability refers to the property that the dentifrice composition stretches like pulling a thread when it is taken out from a tube container, and can be evaluated by measuring the length stretched so as to pull the thread.
Evaluation criteria ◎: Spinning property is less than 0.5 cm and kneading is good ○: Spinning property of 0.5 cm or more and less than 1 cm is observed, but there is no problem in use ×: Spinning property of 1 cm or more Recognized and problematic in use

(4) Evaluation method of liquid separation The test dentifrice composition was filled in a laminated tube container having a diameter of 8 mm, and three of each composition were stored at 50 ° C. for one month, and then the test dentifrice was placed on straw paper from this tube container. The composition was extruded by 10 cm, the length of the liquid exuded on the straw paper was measured, and the degree of liquid separation (no liquid separation) was evaluated from this length according to the following four-step scoring criteria. The average value of the three scores was calculated and judged according to the following evaluation criteria. ○ The above items were considered to be acceptable because the liquid separation of the drug product was suppressed even over time.
Score criteria 4 points: No liquid separation is observed 3 points: There is almost no liquid separation in the mouth part when extruded, and there is no problem in use 2 points: Liquid separation is observed in the mouth part 1 to 3 cm when extruded 1 Point: Evaluation criteria that liquid separation exceeds 3 cm in the mouth when extruded ◎: 3.5 points or more and 4.0 points or less ○: 3.0 points or more and less than 3.5 points △: 2.0 points More than 3.0 points ×: Less than 2.0 points

Details of the raw materials used are shown below.
(A) Sodium polyacrylate (Mw: 1,000)
Linear, Polyscience (A) sodium polyacrylate (Mw: 6,000)
Linear, manufactured by Toagosei Co., Ltd., AC-10NP
(A) Sodium polyacrylate (Mw: 8,000)
Linear, Polyscience (A) sodium polyacrylate (Mw: 20,000)
Linear, manufactured by Toagosei Co., Ltd., Aron A-20UN
Sodium polyacrylate (Mw: 300,000, comparative ingredient)
Cross-linked type, polyacrylic acid manufactured by Polyscience (Mw: 6,000, comparative component)
Linear, manufactured by Toagosei Co., Ltd., Aron A-10SL
(B) Sodium pyrrolidone carboxylate Ajinomoto Healthy Supply Co., Ltd., AJIDEW (registered trademark) N-50
(C) Xanthan gum CP Kelco, Monato gum DA
The numerical value indicating the blending amount of each component in the table is a net conversion value.

Claims (8)

An oral composition comprising (A) a polyacrylate having a weight average molecular weight of 1,000 or more and 20,000 or less, and (B) pyrrolidone carboxylic acid or a salt thereof. The oral composition according to claim 1, wherein the polyacrylate component (A) has a weight average molecular weight of 2,000 or more and 10,000 or less. The oral composition according to claim 1 or 2, which contains 0.01 to 2% by mass of the component (A) and 0.1 to 10% by mass of the component (B). The oral composition according to any one of claims 1 to 3, wherein (A) / (B) is 0.003 to 3 as a mass ratio. The oral composition according to any one of claims 1 to 4, further comprising (C) xanthan gum. The oral composition according to claim 5, which contains 0.1 to 3% by mass of the component (C). The oral composition according to any one of claims 1 to 6, which is for removing oral stains. The oral composition according to any one of claims 1 to 7, which is a dentifrice composition.