JP2008201704A - Tooth whitening composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a tooth whitening composition effectively peeling and removing the pellicle. <P>SOLUTION: The tooth whitening composition contains (A) one or more kinds of straight-chain or cyclic water-soluble polyphosphates expressed by general formula (1) or (2): M<SB>n+2</SB>P<SB>n</SB>O<SB>3n+1</SB>(1), (MPO<SB>3</SB>)<SB>m</SB>(2) (in the formulas, M is Na or K; n is an integer of ≥2; and m is an integer of ≥3) and (B) a polymer compound composed of a monomer expressed by general formula (3) and/or (4) or a polymer compound composed of a monomer mixture containing a dimethyldiallyl ammonium salt. In the general formulas (3) and (4), R<SP>1</SP>is a hydrogen atom or a methyl group; Y is an oxygen atom or an NH group; R<SP>2</SP>is a 1-8C straight or branched-chain alkylene group which may be substituted with a hydroxyl group; R<SP>3</SP>groups are each independently a 1-12C straight or branched-chain alkyl group; and X is a halogen atom. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a tooth whitening composition capable of effectively removing a pellicle.

  In stains such as stains and tooth surface stains such as plaque, proteins in saliva are adsorbed on the tooth surface to form a film called a pellicle, and the colored components adhere to the pellicle as a scaffold. Furthermore, it is considered that stains that are difficult to remove by brushing are formed by laminating and calcifying the colored stains.

  Conventionally, in order to remove colored stains, the following mechanical action method or chemical action removal method has been used. For example, an oral composition containing a specific organic peroxide (Patent Document 1: US Pat. No. 3,988,433), an oral composition using a cationic active agent and malic acid in combination (Patent Document 2: US Pat. No. 4,183,916), oral composition containing an ester having an aromatic ring (Patent Document 3: Japanese Patent Publication No. 48-43869), chelating agent having a stability coefficient of Fe> Ca Composition for oral cavity (Patent Document 4: Japanese Patent Application Laid-Open No. 51-108029), oral composition containing polyphosphate and polyvalent metal cation (Patent Document 5: Japanese Patent Application Laid-Open No. 52-108029) No.), a composition for oral cavity using phytic acid and an organic acid in combination (Patent Document 6: JP 56-18911 A), tartronic acid, glyceric acid, hydroxy-n-butyric acid, dihydroxymalonic acid. Combined oral composition (Patent Document 7: Japanese Patent Application Laid-Open No. 60-41117), oral composition using a combination of carvone, anethole or 3-octanol and a solvent extract of the genus plant (Patent Document 8: Special No. 61-286315), an oral composition containing 2-octanol (Patent Document 9: JP-A-62-151498), an oral composition containing a specific monoterpene (Patent Document 10: JP-A-62-181212), an oral composition containing an aliphatic ester having 7 to 11 carbon atoms (Patent Document 11: JP-A-62-189233), citric acid, polyphosphate and non- Composition for oral cavity containing ionic surfactant (Patent Document 12: JP-A-7-126131), composition for oral cavity containing polyphosphoric acid, orthophosphate and anionic surfactant Patent Document 13: Japanese Patent Laid-Open No. 09-012437), oral composition containing polyphosphoric acid, orthophosphate, and amphoteric surfactant (Patent Document 14: Japanese Patent Laid-Open No. 09-012438), sulfosuccinic acid-based active agent Oral composition (Patent Document 15: Japanese Patent Laid-Open No. 10-17444) containing an amino acid, and an oral composition containing an amino acid surfactant (Patent Document 16: Japanese Patent Laid-Open No. 10-17444).

  However, most of the above effects depend on mechanical action, and the effects are not always sufficient. From the above, there has been a demand for a composition for whitening teeth that can effectively remove stains such as stains and plaques by chemical action by effectively removing the pellicle.

U.S. Pat. No. 3,988,433 U.S. Pat.No. 4,183,916 Japanese Patent Publication No. 48-43869 JP 51-108029 A JP-A-52-108029 JP 56-18911 A Japanese Patent Laid-Open No. 60-41117 JP-A-61-286315 JP 62-151498 A JP-A-62-181212 Japanese Patent Laid-Open No. 62-189233 JP-A-7-126131 JP 09-012437 A JP 09-012438 A Japanese Patent Laid-Open No. 10-17444 Japanese Patent Laid-Open No. 10-17444 JP 2001-342123 A JP 2002-187829 A JP 2005-179230 A JP 58-196300 A JP-A-6-65189

  This invention is made | formed in view of the said situation, and it aims at providing the composition for tooth whitening which peels and removes a pellicle effectively.

  As a result of intensive studies to achieve the above object, the present inventor has (A) one or more of linear or cyclic polyphosphates represented by the following general formula (1) or (2): B) a polymer compound obtained by polymerizing a monomer represented by the following general formula (3) and / or (4), or a polymer compound obtained by polymerizing a monomer mixture containing a dimethyldiallylammonium salt; In combination, the pellicle can be effectively peeled and removed by chemical action to effectively remove stains such as stains and plaques and obtain a whitening effect on the teeth. The present invention has been made.

（式中、Ｒ¹は水素原子又はメチル基、Ｙは酸素原子又はＮＨを示し、Ｒ²は水酸基で置換されていてもよい炭素数１〜８の直鎖状又は分岐状のアルキレン基、Ｒ³はそれぞれ独立に炭素数１〜１２の直鎖又は分岐鎖のアルキル基、Ｘはハロゲン原子を示す。）
［２］．（Ｂ）成分が、一般式（３）及び（４）中のＹが酸素原子であり、一般式（３）及び／又は（４）で表される単量体を重合してなる高分子化合物である［１］記載の歯牙美白用組成物、
［３］．（Ｂ）成分が、ヒドロキシエチルセルロース・ジメチルジアリルアンモニウム塩、ポリジメチルジアリルアンモニウム塩、又はジメチルジアリルアンモニウム塩とアクリル系ビニルモノマーとの共重合体である［１］記載の歯牙美白用組成物を提供する。 Therefore, the present invention
[1]. A composition for tooth whitening comprising the following (A) and (B):
(A) The following general formula (1) or (2)
M _{n + 2} P _n O _{3n + 1} (1)
(MPO ₃ ) _m (2)
(In the formula, M represents Na or K, n is 2 or more, and m is an integer of 3 or more.)
One or more of linear or cyclic water-soluble polyphosphates represented by:
(B) A polymer obtained by polymerizing a monomer represented by the following general formula (3) and / or (4), or a polymer obtained by copolymerizing a monomer mixture containing dimethyldiallylammonium salt. Compound

(Wherein R ¹ represents a hydrogen atom or a methyl group, Y represents an oxygen atom or NH, R ² represents a linear or branched alkylene group having 1 to 8 carbon atoms which may be substituted with a hydroxyl group, R ³ independently represents a linear or branched alkyl group having 1 to 12 carbon atoms, and X represents a halogen atom.)
[2]. The component (B) is a polymer compound obtained by polymerizing the monomer represented by the general formula (3) and / or (4), wherein Y in the general formulas (3) and (4) is an oxygen atom. [1] The composition for tooth whitening according to
[3]. (B) The tooth whitening composition according to [1], wherein the component (B) is a hydroxyethylcellulose / dimethyldiallylammonium salt, polydimethyldiallylammonium salt, or a copolymer of dimethyldiallylammonium salt and an acrylic vinyl monomer. .

  ADVANTAGE OF THE INVENTION According to this invention, the composition for tooth whitening which peels and removes a pellicle effectively can be provided.

The composition for tooth whitening of this invention contains the following (A) and (B).
(A) component is the following general formula (1) or (2)
M _{n + 2} P _n O _{3n + 1} (1)
(MPO ₃ ) _m (2)
(In the formula, M represents Na or K, n is 2 or more, and m is an integer of 3 or more.)
One or two or more of linear or cyclic polyphosphates represented by the formula (1) or water-soluble ones are preferably used.

  Examples of the polyphosphate represented by the general formula (1) include sodium pyrophosphate and potassium pyrophosphate having a polymerization degree n = 2, sodium tripolyphosphate and potassium tripolyphosphate having n = 3, sodium tetrapolyphosphate having n = 4, Examples thereof include potassium tetrapolyphosphate and linear polyphosphates such as sodium metaphosphate having high polymerization degree and potassium metaphosphate.

  Examples of the polyphosphate represented by the general formula (2) include sodium trimetaphosphate and potassium trimetaphosphate having a polymerization degree m = 3, sodium tetrametaphosphate and potassium tetrametaphosphate having m = 4, and sodium hexametaphosphate having m = 6. And cyclic polyphosphates such as potassium hexametaphosphate.

  The polyphosphate represented by the general formula (1) or (2) is used singly or in combination of two or more, and among these, the straight chain represented by the general formula (1) Polyphosphoric acid is preferred, and sodium pyrophosphate and potassium pyrophosphate are particularly preferred.

  The blending amount of the component (A) is preferably 0.1 to 10% (mass percentage, the same applies hereinafter), more preferably 1 to 7%, based on the entire composition for tooth whitening. If the blending amount is less than 0.1%, the effect may be inferior, and if it exceeds 10%, the taste may be deteriorated.

（式中、Ｒ¹は水素原子又はメチル基、Ｙは酸素原子又はＮＨを示し、Ｒ²は水酸基で置換されていてもよい炭素数１〜８の直鎖状又は分岐状のアルキレン基、Ｒ³はそれぞれ独立に炭素数１〜１２の直鎖又は分岐鎖のアルキル基、Ｘはハロゲン原子を示す。） Component (B) is (i) a polymer compound obtained by polymerizing a monomer represented by the following general formula (3) and / or (4), or (ii) a monomer containing a dimethyldiallylammonium salt. A polymer compound obtained by polymerizing a mixture, which can be used alone or in combination of two or more. By using these cationic polymer compounds in combination with the component (A), the pellicle can be effectively removed by a chemical action, and a tooth whitening effect can be obtained.

(Wherein R ¹ represents a hydrogen atom or a methyl group, Y represents an oxygen atom or NH, R ² represents a linear or branched alkylene group having 1 to 8 carbon atoms which may be substituted with a hydroxyl group, R ³ independently represents a linear or branched alkyl group having 1 to 12 carbon atoms, and X represents a halogen atom.)

  Examples of the monomer represented by the general formula (3) include dialkylaminoalkyl methacrylates such as dimethylaminoethyl methacrylate, dimethylaminoethyl acrylate, diethylaminoethyl methacrylate, diethylaminoethyl acrylate, dipropylaminoethyl methacrylate, and dipropylaminoethyl acrylate. And a compound or a dialkylaminoalkyl acrylate compound. The monomer represented by the general formula (4) includes dimethylaminoethyl methacrylate methyl chloride salt, dimethylaminoethyl acrylate methyl chloride salt, diethylaminoethyl methacrylate methyl chloride salt, diethylaminoethyl acrylate methyl chloride salt, dipropylaminoethyl methacrylate. Examples thereof include dialkylaminoalkyl methacrylate methyl chloride salt compounds such as methyl chloride salts and dipropylaminoethyl acrylate methyl chloride salts, and dialkylaminoalkyl acrylate methyl chloride salt compounds. As the polymer compound, a homopolymer obtained by polymerizing a monomer represented by the general formula (3) or (4), and a monomer represented by the general formula (3) or (4) are copolymerized. And a copolymer (copolymer). Among these, Y in the general formulas (3) and (4) is an oxygen atom, and a polymer compound obtained by polymerizing the monomer represented by the general formula (3) and / or (4) is preferable. Polydimethylaminoethyl methacrylate, which is a homopolymer of dimethylaminoethyl methacrylate, and polydimethylaminoethyl methacrylate methyl chloride, which is a homopolymer of dimethylaminoethyl methacrylate methyl chloride, are preferred.

  Polymer compounds obtained by polymerizing a monomer mixture containing dimethyldiallylammonium salt include hydroxyethylcellulose / dimethyldiallylammonium salt, polydimethyldiallylammonium salt which is a homopolymer of dimethyldiallylammonium salt, dimethyldiallylammonium salt and acrylic polymer. A polymer compound obtained by copolymerizing a monomer mixture composed of a vinyl monomer is preferred. Examples of the acrylic vinyl monomer include acrylic acid, methacrylic acid, and acrylamide. Examples of counter ions that form salts include halogen ions such as chlorine ions and methosulphate ions.

  Hydroxyethylcellulose / dimethyldiallylammonium salt is a cationic polymer obtained by graft polymerization of dimethyldiallylammonium salt to hydroxyethylcellulose. As nitrogen content, it is 0.1 to 3%, More preferably, it is 0.5 to 2.5%. Examples of such hydroxyethylcellulose / dimethyldiallylammonium salt include Cellcoat L-200 and Cellcoat H-100, which are commercially available from Nippon SC Co., Ltd. These counter ions are chloride ions.

  The polydimethyldiallylammonium salt is a homopolymer obtained by polymerizing dimethyldiallylammonium salt, and examples thereof include Marcoat 100 manufactured by Nalco Japan. As a polymer compound obtained by copolymerizing a monomer mixture composed of dimethyldiallylammonium salt and acrylic vinyl monomer, Marcoat 280, which is a copolymer (copolymer) of dimethyldiallylammonium salt and acrylic acid, dimethyldiallyl And Marcoat 550 which is a copolymer (copolymer) of an ammonium salt and acrylamide.

  The average molecular weight of the polymer compound (B) is not particularly limited, but is preferably 1,000 to 1,000,000. The measurement method is gel permeation chromatography (hereinafter abbreviated as GPC), dimethylformamide (hereinafter abbreviated as DMF) mixed with 10 mmol / L of lithium bromide as a mobile phase, and polystyrene as a standard. Is a method of converting the molecular weight.

  (B) As for the compounding quantity of a component, 0.001-2% is preferable with respect to the whole composition for tooth whitening, More preferably, it is 0.005-1%, More preferably, it is 0.01-0.5%. . If the blending amount is less than 0.001%, the effect may be inferior.

  The composition for tooth whitening of the present invention can be applied as a toothpaste such as toothpaste and liquid toothpaste, dental cream, dental whitening pack, mouthwash, dental whitening liquid, chewing gum and the like. Can be prepared on the basis of a conventional method, using an arbitrary component according to the type within a range not impairing the effects of the present invention. Examples of optional components include abrasives, binders, wetting agents, surfactants, and perfume ingredients.

  As abrasives, silica-based abrasives such as silica gel, precipitated silica, aluminosilicate, dicalcium phosphate dihydrate and anhydrous, tricalcium phosphate, calcium carbonate, aluminum hydroxide, magnesium carbonate, tricalcium phosphate, 1 type (s) or 2 or more types, such as a calcium phosphate and other synthetic resins, may be mix | blended.

  As binders, cellulose derivatives such as carrageenan, sodium carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, alginic acid derivatives such as sodium alginate, propylene glycol alginate, gums such as xanthan gum, julan gum, tragacanth gum, karaya gum, polyvinyl alcohol, polyacrylic Synthetic binders such as sodium silicate and carboxyvinyl polymer, silica gel, magnesium aluminum silicate (Bee gum; manufactured by Sanyo Chemical Industries), synthetic sodium silicate / magnesium (trade name Laponite; manufactured by Tosoh Silica) One kind or two or more kinds such as an inorganic binder may be blended.

  As a wetting agent, 1 type (s) or 2 or more types of polyhydric alcohols, such as glycerin, sorbit, propylene glycol, xylit, maltite, and lactit, can be mix | blended.

  As the surfactant, an anionic surfactant, a cationic surfactant, a nonionic surfactant and the like can be blended. Specifically, sodium lauryl sulfate, sodium α-olefin sulfonate, N-acyl sal Cosinate, N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, N-acyl taurate, sucrose fatty acid ester, alkylol amide, polyoxyethylene sorbitan monostearate, polyoxy Examples include ethylene hydrogenated castor oil, propylene oxide-ethylene oxide block polymer (trade name Pluronic; manufactured by BASF).

  As fragrance ingredients, menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, cineol, linalool, ethyl linalool, vanillin, thymol, peppermint oil, spearmint oil, winter green oil, cassia oil, Perfumes such as clove oil, clove oil, and eucalyptus oil can be blended alone or in combination, and sweeteners such as saccharin sodium, stevioside, glycyrrhizin, perilartin, and thaumatin can be blended.

In the present invention, cationic fungicides such as chlorhexidine benzethonium chloride, benzalkonium chloride, cetylpyridinium chloride, decanium chloride, phenolic compounds such as triclosan, hinokitiol, isopropylmethylphenol, dextranase, mutanase, lysozyme, amylase, protease, lytic enzymes, enzymes such as superoxide dismutase, vitamin E, vitamins such as vitamin B _6, sodium monofluorophosphate, alkali metal monofluorophosphate salts such as potassium monofluorophosphate, fluoride Sodium, fluoride such as stannous fluoride, tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxallantoin, dihydrocholestanol, glycyl Chin acids, glycyrrhetinic acid, bisabolol, glycerophosphate, chlorophyll, sodium chloride, a known active ingredient, such as water-soluble inorganic phosphoric acid compounds may be formulated alone or in combination.

  Although it will not specifically limit if pH (25 degreeC) of the composition for tooth whitening of this invention is a range which is safe in the oral cavity and a human body, pH 5-9 is preferable, More preferably, pH 6- 8. As a preferred pH adjuster, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, sodium hydroxide, potassium hydroxide, sodium carbonate, sodium citrate, sodium hydrogen citrate, sodium phosphate, sodium hydrogen phosphate, etc. are blended. obtain.

  The tooth whitening composition of the present invention has an excellent pellicle removal effect and is suitable as a pellicle removal composition. Further, due to this effect, stains such as stains and plaques can be effectively removed not by mechanical means but by chemical action, and parts that cannot be reached by the brush can be cleaned. Therefore, an excellent tooth whitening effect can be exhibited, and the chemical cleaning effect in the oral cavity can be remarkably improved.

  EXAMPLES Hereinafter, although a preparation example, a test example, an Example, and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, unless otherwise specified, “%” in the composition represents mass%.

[Preparation Example 1: Synthetic polymer 1]
Preparation of polydimethylaminoethyl methacrylate (hereinafter abbreviated as pDM) Into a 1000 mL separable flask equipped with a stirrer, reflux condenser, thermometer, monomer dropping port, initiator dropping port, and nitrogen introducing tube, ethanol 160 g Then, heating was started in a 85 ° C. hot water bath, and introduction of nitrogen was started from the nitrogen introduction tube.
Meanwhile, 80 g of dimethylaminoethyl methacrylate and 96 g of ethanol were weighed into a 300 mL beaker and stirred to prepare a uniform monomer solution.
In addition, 0.978 g of 2,2′-azobis-2-methylbutyronitrile was weighed in a 100 mL beaker and dissolved by adding 64 g of ethanol to prepare an initiator solution.
Next, when the internal temperature of the separable flask reaches 78 ° C., using a dropping pump,
An initiator solution and a monomer solution were added over 2 hours, and stirring was further continued for 5 hours to complete the polymerization.
After cooling, the reaction solvent was removed and dried to obtain a polymer (polymer). When the molecular weight was converted with GPC using dimethylformamide (hereinafter abbreviated as DMF for short) mixed with 10 mmol / L of lithium bromide and polystyrene as a standard, the weight average molecular weight was 70,000. The monomer structural unit is shown in the following formula (5).

[Preparation Example 2: Synthetic polymer 2]
Preparation of polydimethylaminoethyl methacrylate methyl chloride salt (hereinafter abbreviated as pDMC) In a 1000 mL separable flask equipped with a stirrer, reflux condenser, thermometer, monomer dropping port, initiator dropping port, and nitrogen introducing tube Then, 160 g of ethanol was added, and heating was started in a 85 ° C. hot water bath, and introduction of nitrogen was started from a nitrogen introduction tube.
Meanwhile, in a 300 mL beaker, 80 g of dimethylaminoethyl methacrylate methyl chloride salt and 96 g of ethanol were weighed and mixed to prepare a uniform monomer solution.
In addition, 0.741 g of 2,2′-azobis-2-methylbutyronitrile was weighed in a 100 mL beaker and dissolved by adding 64 g of ethanol to prepare an initiator solution.
Next, when the internal temperature of the separable flask reaches 78 ° C., using a dropping pump,
An initiator solution and a monomer solution were added over 2 hours, and stirring was further continued for 5 hours to complete the polymerization.
After cooling, the reaction solvent was removed and dried to obtain a polymer (polymer). When the molecular weight was converted with GPC using dimethylformamide (hereinafter abbreviated as DMF for short) mixed with 10 mmol / L of lithium bromide and polystyrene as a standard, the weight average molecular weight was 70,000. The monomer structural unit is shown in the following formula (6).

[Other polymer examples]
Marcote 100 (Nalco Japan Co., Ltd.): Dimethyldiallylammonium homopolymer Marcote 280 (Nalco Japan Co., Ltd.): Copolymer (copolymer) of dimethyldiallylammonium salt and acrylic acid
Marcote 550 (Nalco Japan Co., Ltd.): Copolymer (copolymer) of dimethyl diallylammonium salt and acrylamide
Cell coat L-200, H-100 (manufactured by Nippon SC): Hydroxyethyl cellulose / dimethyl diallylammonium chloride salt Leogard XE (manufactured by Lion): α = 0.2, α = 0.6 (cationization) cellulose)

[Test Example 1]
Solution adjustment Potassium pyrophosphate (3.0 g) was placed in a sample bottle, and water was added thereto to make a total amount of 100 g to prepare a 3.0% potassium pyrophosphate solution. Furthermore, 0.01 g of each cationic polymer compound shown in Table 1 was taken in a sample bottle, and 9.99 g of water or 3.0% potassium pyrophosphate solution was added and dissolved therein, and each component shown in Table 1 was listed in the table. The aqueous solution mix | blended with the density | concentration shown in was adjusted. The pellicle peelability of this sample was evaluated. In addition, as each cationic high molecular compound, the synthetic polymers 1 and 2 obtained by the said preparation example, and the commercially available polymer were used.

Evaluation of pellicle peelability on the surface of a model tooth 5 mL of human discharge saliva was added to a conical tube in which 0.1 g of hydroxyapatite powder (HAP powder) (Taihei Chemical Co., Ltd .: specific surface area 6.4 g / m ² ) was weighed. The treatment was carried out at a temperature of 30 ° C. for 1 hour. After the treatment, the supernatant saliva was removed by centrifugation (1000 G, 3 minutes), and 5 g of ion-exchanged water was added and mixed. Further, the supernatant solution was removed by centrifugation (1000 G, 3 minutes), and washing was performed to prepare pellicle-formed HAP.
To the obtained pellicle-formed HAP, 5 g of the sample shown in Table 1 was added and rotated for 2 hours (30 rpm). After the treatment, the mixture was centrifuged (1000 G · 3 minutes), and the supernatant was collected.
The total carbon concentration (TOC) of the collected supernatant was measured using (TOC-V _{CSH / CSN} (manufactured by Shimadzu Corporation)), and the amount of peeled pellicle was calculated based on the following formula.
Pellicle peel amount = processed supernatant solution TOC concentration−initial sample TOC concentration From the pellicle peel amount, pellicle peelability is shown based on the following evaluation criteria.
<Evaluation criteria for pellicle peelability>
X: Ta-Ts is less than 0 ppm
Δ: Ta-Ts is 0 ppm or more and less than 50 ppm ○: Ta-Ts is 50 ppm or more and less than 100 ppm A: Ta-Ts is 100 ppm or more Initial sample (sample having the composition shown in Table 1) TOC concentration: Ts
After treatment, supernatant solution TOC concentration: Ta

Evaluation of Tea Colored Stain Detergent Detergency The surface of a hydroxyapatite plate (HAP plate) (φ7 mm × 3.5 mm, manufactured by Pentax) was polished with a polishing machine (ECOMET3, manufactured by BUEHILER) and water-resistant polishing paper # 240. After this rough-cut HAP plate was treated with human discharge saliva for 30 minutes, it was shaken in black tea-iron aqueous solution (containing 0.05% iron chloride in black tea) for 30 seconds, and the same operation was repeated twice. Then, it wash | cleaned and dried with 300 mL of ion-exchange water, and produced the colored stain HAP board. The initial color difference of the colored soiled HAP plate and the colored soiled HAP plate were brushed 30 times in the sample of Table 1 and taken out to measure the color difference. In the evaluation judgment, the color difference meter ΔE value was measured with a color difference meter (color / color difference meter CR-300 manufactured by Minolta).
The coloring stain washing rate (%) was calculated based on the following formula.
Color stain cleaning rate (%) = (initial color difference ΔE value−color difference ΔE value after brushing) / initial color difference ΔE value × 100
From the obtained colored stain cleaning rate (%), the color stain cleanability is shown based on the following evaluation criteria.
<Evaluation criteria for coloring stain cleanability>
X: Colored stain cleaning rate is less than 10%
Δ: Colored stain cleaning rate of 10% or more and less than 30% ○: Colored stain cleaning rate of 30% or more and less than 50% A: Colored stain cleaning rate of 50% or more

[Examples 8 to 16]
A tooth whitening composition having the following composition was prepared.

[Example 8]
Dentifrice composition%
Polyoxyethylene (average number of moles added 30) hydrogenated castor oil 1.0
(NIKKOL (registered trademark) HCO-30, manufactured by Nikko Chemicals Co., Ltd.)
Silicic anhydride 15.0
Sodium polyacrylate (Leogic 250H, manufactured by Nippon Pure Chemical Co., Ltd.) 0.8
Sodium carboxymethylcellulose 0.8
(CMC Daicel (registered trademark) 1350, manufactured by Daicel Chemical Industries, Ltd.)
Sodium alginate (IL-6G, manufactured by Kimika Co., Ltd.) 0.3
pDMC (Preparation Example 2) 0.3
Titanium oxide 0.5
Aluminum oxide 1.0
70% sorbite solution 30.0
Xylitol 5.0
Propylene glycol 3.0
Sodium lauryl sulfate 0.2
Sodium fluoride 0.21
Potassium pyrophosphate 3.0
Fragrance 1.0
Purified water balance
Total 100.0

[Example 9]
Dentifrice composition%
Polyoxyethylene (average number of moles added 30) hydrogenated castor oil 1.5
(EMALEX (registered trademark) HC-30, manufactured by Nippon Emulsion Co., Ltd.)
Silicic anhydride 18.0
Polyvinylpyrrolidone (K-30, manufactured by BASF Japan) 0.2
Sodium carboxymethylcellulose 1.5
(CMC Daicel (registered trademark) 1260, manufactured by Daicel Chemical Industries, Ltd.)
Hydroxypropylcellulose (HPC-L, manufactured by Nippon Soda Co., Ltd.) 0.5
Marcote 100 0.3
Titanium oxide 0.5
70% sorbite solution 22.0
Xylitol 10.0
Propylene glycol 3.0
Sodium lauryl sulfate 0.3
Sodium fluoride 0.21
Potassium pyrophosphate 3.0
Fragrance 1.1
Purified water balance
Total 100.0%

[Example 10]
Mouthwash composition%
Polyoxyethylene (average number of moles added 40) hydrogenated castor oil 1.0
(EMALEX HC-40, manufactured by Nippon Emulsion Co., Ltd.)
pDMC (Preparation Example 2) 0.3
Citric acid 0.01
Trisodium citrate 0.3
Benzalkonium chloride 0.01
Saccharin sodium 0.1
Xylitol 5.0
Potassium pyrophosphate 3.0
0.1% green No.3 0.8
Fragrance 0.3
Purified water balance
Total 100.0%

[Example 11]
Mouthwash composition%
Polyoxyethylene (average number of moles added 80) hydrogenated castor oil 1.5
(NIKKOL (registered trademark) HCO-80, manufactured by Nikko Chemicals Corporation)
Marcote 100 0.3
Citric acid 0.01
Trisodium citrate 0.3
Benzalkonium chloride 0.01
Saccharin sodium 0.1
Xylitol 5.0
Potassium pyrophosphate 3.0
0.1% green No.3 0.8
Fragrance 0.3
Purified water balance
Total 100.0%

[Example 12]
Mouthwash composition%
Polyoxyethylene (average number of moles added 60) hydrogenated castor oil 2.0
(NIKKOL (registered trademark) HCO-60, manufactured by Nikko Chemicals Co., Ltd.)
Marcote 100 0.3
Sodium fluoride 0.05
Isopropyl methylphenol 0.05
Ethanol 3.0
Citric acid 0.01
Trisodium citrate 0.3
Saccharin sodium 0.1
Potassium pyrophosphate 3.0
0.1% green No.3 0.8
Fragrance 0.3
Purified water balance
Total 100.0%

[Example 13]
Mouthwash composition%
Polyoxyethylene (average number of moles added 50) hydrogenated castor oil 1.3
(EMALEX HC-50, manufactured by Nippon Emulsion Co., Ltd.)
pDMC (Preparation Example 2) 0.3
Sodium fluoride 0.05
Triclosan 0.05
Ethanol 3.0
Citric acid 0.01
Trisodium citrate 0.3
Saccharin sodium 0.1
0.1% green No.3 0.8
Sodium pyrophosphate 2.0
Fragrance 0.3
Purified water balance
Total 100.0%

[Example 14]
Chewing gum composition%
Polyoxyethylene (average number of moles added 40) hydrogenated castor oil 0.2
(EMALEX HC-40, manufactured by Nippon Emulsion Co., Ltd.)
Polyoxyethylene (average number of moles added 50) hydrogenated castor oil 0.3
(EMALEX HC-50, manufactured by Nippon Emulsion Co., Ltd.)
pDMC (Preparation Example 2) 0.3
Gum base material 25.0
Sorbit powder 34.6
Mannitol powder 15.0
Maltitol powder 10.0
Sodium pyrophosphate 2.0
Fragrance 1.5
Glycerin 3.5
Saccharin 0.1
Purified water balance
Total 100.0%

[Example 15]
Chewing gum composition%
Polyoxyethylene (average number of moles added 60) hydrogenated castor oil 1.5
(NIKKOL (registered trademark) HCO-60, manufactured by Nikko Chemicals Co., Ltd.)
Marcote 100 0.3
Gum base material 25.0
Sorbit powder 30.0
Mannitol powder 15.0
Maltitol powder 10.0
Sodium pyrophosphate 3.0
Fragrance 1.5
Glycerin 3.5
Saccharin 0.1
Purified water balance
Total 100.0%

[Example 16]
Chewing gum composition%
Polyoxyethylene (average number of moles added 50) hydrogenated castor oil 1.8
(EMALEX HC-50, manufactured by Nippon Emulsion Co., Ltd.)
Marcote 100 0.3
Gum base 30.0
Sorbit powder 54.6
Mannitol powder 15.0
Maltitol powder 10.0
Sodium pyrophosphate 3.0
Fragrance 1.3
Glycerin 6.0
Aspartame 0.05
Purified water remaining
Total 100.0%

Claims (3)

A tooth whitening composition comprising the following (A) and (B):
(A) The following general formula (1) or (2)
M _{n + 2} P _n O _{3n + 1} (1)
(MPO ₃ ) _m (2)
(In the formula, M represents Na or K, n is 2 or more, and m is an integer of 3 or more.)
One or more of linear or cyclic water-soluble polyphosphates represented by:
(B) A polymer compound obtained by polymerizing a monomer represented by the following general formula (3) and / or (4), or a polymer compound obtained by polymerizing a monomer mixture containing a dimethyldiallylammonium salt. .

(Wherein R ¹ represents a hydrogen atom or a methyl group, Y represents an oxygen atom or NH, R ² represents a linear or branched alkylene group having 1 to 8 carbon atoms which may be substituted with a hydroxyl group, R ³ independently represents a linear or branched alkyl group having 1 to 12 carbon atoms, and X represents a halogen atom.)   The component (B) is a polymer compound obtained by polymerizing the monomer represented by the general formula (3) and / or (4), wherein Y in the general formulas (3) and (4) is an oxygen atom. The composition for tooth whitening according to claim 1.   2. The tooth whitening composition according to claim 1, wherein the component (B) is a hydroxyethylcellulose / dimethyldiallylammonium salt, polydimethyldiallylammonium salt, or a copolymer of a dimethyldiallylammonium salt and an acrylic vinyl monomer.