JP6307314B2 - Oral stain formation inhibitor and oral composition - Google Patents

Description

  The present invention relates to an oral stain formation inhibitor and an oral composition.

  Stain is a pigment deposit formed on the tooth surface due to tannin pigments, smoking, proteins in the oral cavity, metal ions, etc. contained in coffee, black tea, Japanese tea and the like.

Conventionally, for the purpose of removing stains, oral compositions in which polyethylene glycol or polyvinylpyrrolidone having a stain-dissolving action is blended, and oral compositions in which another component is combined with the component are known. (For example, refer to Patent Document 1).
Moreover, the composition for oral cavity for stain formation inhibition which consists of sulfosuccinic-acid type surfactant which has a specific structure is proposed (for example, refer patent document 2).

JP 2001-131042 A Japanese Patent Laid-Open No. 10-17443

  However, the oral composition as described in Patent Document 1 has a problem that a sufficient stain removal effect cannot be obtained. In addition, the oral composition for inhibiting stain formation described in Patent Document 2 has a problem that the taste and aroma are not good and the feeling of use is bad, such as irritation.

  In addition to this, various components that inhibit the formation of stains have been studied, but none of them satisfy both a sufficient stain formation inhibitory effect and a good feeling of use at the same time, and there is still a need for investigation.

  Therefore, an object of the present invention is to provide an oral stain formation inhibitor having a sufficient stain formation inhibitory effect and a good feeling of use, and an oral composition containing the oral stain formation inhibitor.

As a result of intensive studies, the present inventors have found that a specific component can achieve both a sufficient stain formation inhibitory effect and a good feeling of use, and have completed the present invention.
That is, the present invention is as follows.
(1) An oral stain formation inhibitor comprising sodium tetradecenesulfonate.
(2) An oral composition comprising the oral stain formation inhibitor according to (1).

  The oral stain formation inhibitor of the present invention is composed of sodium tetradecene sulfonate, has a sufficient stain formation inhibitory effect, does not affect the taste and aroma, does not feel unpleasant stimulation, and has a good feeling of use Have. Therefore, the oral stain formation inhibitor of the present invention can be suitably used for an oral composition intended to inhibit the formation of stain.

Hereinafter, the present invention will be described in more detail.
The oral stain formation inhibitor of the present invention comprises sodium tetradecene sulfonate (also referred to as olefin (C14-16) sodium sulfonate). And this invention is made | formed based on the new knowledge that sodium tetradecene sulfonate has the outstanding stain formation inhibitory effect.

  By applying the oral stain formation inhibitor of the present invention to the oral cavity, sodium tetradecenesulfonate suppresses the accumulation of coloring substances that cause stain formation, and prevents the stain from adhering to the tooth surface. Can be considered.

The oral stain formation inhibitor of the present invention is applied to various oral compositions such as mouthwashes, liquid toothpastes, mouth fresheners, mouthwashes (gargles), liquid toothpastes and toothpastes, troches, chewing gums and the like. It can mix | blend and use.
Among these, from the viewpoint that the effects of the present invention are satisfactorily achieved, it is preferably used as a form of a liquid preparation such as a mouthwash, liquid toothpaste, or mouth freshener. These can be made into preparations by known means.

  When the oral stain formation inhibitor of the present invention is used in the oral composition, the blending amount may be appropriately adjusted according to the form of the oral composition. By setting the content to 005% by mass or more, preferably 0.01% by mass or more, a sufficient stain formation inhibitory effect can be obtained. Moreover, in order to suppress foaming and improve usability, the composition for oral cavity is 2% by mass or less, preferably 1% by mass or less. More preferably, it is good to set it as 0.03-0.5 mass%.

Moreover, when setting it as the said composition for oral cavity, various well-known additives can be mix | blended as needed.
For example, fluorides such as sodium fluoride and sodium monofluorophosphate; azulene, azulene sulfonate, β-glycyrrhetinic acid, glycyrrhizic acid and salts, dihydrocholesterol, epidihydrocholesterin, buckwheat extract, sugar beet extract, dl-acetate Anti-inflammatory agents such as α-tocopherol, ε-aminocaproic acid, tranexamic acid; bactericides such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, chlorhexidine salt, triclosan, isopropylmethylphenol, alkyldiaminoethylglycine hydrochloride; gantrezic acid, chloride Anticalculus agents such as zinc and organic acid zinc; astringents such as hinokitiol, allantoin, allantochlorohydroxyaluminum, allantoindihydroxyaluminum, sodium chloride Wetting agents such as glycerin, sorbitol, polyethylene glycol; foaming agents such as sodium lauryl sulfate; fragrances such as pinene, peppermint oil, cinnamon oil, glove oil, eugenol, lemon oil, vanillin, cineol, eucalyptus oil; saccharin, sodium saccharin, xylitol Sweeteners such as erythritol, sorbitol, stevia; colorants such as blue No. 1, yellow No. 5, yellow No. 4, yellow 202 (1), green No. 3, green No. 201, red No. 102; parabens, Preservatives such as sodium benzoate and butyl paraoxybenzoate; pH adjusters such as monosodium phosphate and disodium phosphate; POE hydrogenated castor oil, POE / POP block polymer, POE / POP alkyl ether, POE alkyl ether, POE Alkylfe Nonionic surfactants such as ether, POE fatty acid ester, POE higher alcohol ether, POE / POP fatty acid ester, POE sorbitan fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester; lauryl sulfate Sodium, myristyl sulfate, POE alkyl ether sulfate, lauroyl sarcosine sodium, myristoyl sarcosine sodium, alkyl ether carboxylate, alkyl phosphate, POE alkyl ether phosphate, N-acyl taurate, POE alkyl ether phosphate・ Anionic surfactants such as phosphates and sulfonates; alkyltrimethylammonium chloride, dialkyldimethylammonium chloride, Cetylpyridinium, benzethonium chloride, benzalkonium chloride, cationic surfactants such as POE alkylamine, fatty acid amides.

For example, in order to make a mouthwash, water and ethanol may be used as a solvent and prepared by a conventional method using the desired additives as described above. For example, the mouthwash can be prepared by sequentially mixing the components under stirring.
Moreover, when the pH is adjusted to 5 to 10 using a pH adjuster, the usability in the oral cavity is further improved. Furthermore, it is preferable that the amount of ethanol used is 25% by mass or less, preferably 10% or less, based on the total amount of the mouthwash, since irritation in the oral cavity can be suppressed.

  EXAMPLES Hereinafter, although an Example and a comparative example demonstrate this invention further, this invention is not restrict | limited to the following example at all.

<Test Example 1: Stain formation inhibition confirmation test>
(Preparation of base)
Each component described in the following Table 1 was mixed and dissolved under stirring at room temperature (about 25 ° C.) to prepare a base.

(Sample preparation)
Samples 1 to 4 were prepared by mixing 99.5 w / v% of the base obtained above and 0.5 w / v% of the components shown in Table 2 below.

The following stain formation inhibition confirmation test was performed on the obtained samples 1 to 4 and the sample 5 including the base.
(Create test plate)
A test plate was prepared by sequentially performing the following steps (1) to (2).
(1) One side of a hydroxyapatite plate (HAP) 10 mm × 10 mm was polished with water-resistant abrasive paper (# 1000).
(2) The polished HAP was immersed in 0.12% hydrochloric acid for 30 seconds, then in a supersaturated aqueous sodium carbonate solution for 30 seconds, and finally neutralized with distilled water to prepare a test plate.

(Examination procedure)
The following steps (i) to (vi) were sequentially performed, and this was repeated 10 times to prepare a sample.
(I) Immerse the test plate in 3 mL of human saliva for 1 hour.
(Ii) The test plate is further immersed in 3 mL of a 1% aqueous solution of chlorhexidine gluconate for 1 minute.
(Iii) Immerse the test plate in 3 mL of specimen and gently shake for 30 seconds.
(Iv) The test plate is immersed in 3 mL of 0.57% aqueous solution of ammonium iron (III) citrate for 30 seconds.
(V) Immerse the test plate in 3 mL of concentrated black tea extract for 20 minutes.
(Vi) Wash the test plate with water for 30 seconds while gently shaking in water.

(Calculation of stain formation inhibition rate)
The HAP polished surface before the test and the polished HAP polished surface after the test were each measured with a color difference meter (“CR-321” manufactured by Konica Minolta Co., Ltd.), and the L value (lightness) was calculated. The formation inhibition rate was calculated. In addition, calculation of L value was repeated 3 times and the average value was calculated | required. The results are shown in Table 3.
Stain formation inhibition rate (%) = (L2 / L1) × 100
(In the formula, L1 is the L value of the polished surface of the HAP before the test, and L2 is the L value of the polished surface of the HAP after the test.)

  From the results of Table 3, the oral stain formation inhibitor comprising sodium tetradecenesulfonate of the present invention has an excellent stain formation inhibitory effect compared to other components that are considered to have a stain formation inhibitory effect. I understood. Moreover, since a high stain formation inhibition rate was obtained only by immersing and lightly shaking, it was found that it is suitable to apply to a liquid preparation such as a mouthwash used by rinsing the oral cavity.

<Test Example 2: Sensory evaluation>
(Preparation of base)
A base was prepared in the same manner as in Test Example 1.

(Sample preparation)
The obtained base 99.5 w / v% was mixed with components 0.5 w / v% shown in Table 4 below to prepare various specimens 6-12. A sample consisting only of the base was designated as Sample 13.

Sensory evaluation was performed on each of the obtained specimens 6 to 13.
The sensory evaluation is performed by 6 panelists to determine the aroma, taste, and irritation based on the following evaluation criteria, with an average score of 4 or higher: “◎”, 3 or higher but less than 4: “○”, 2 points Above 3 points were set as “Δ”, and above 1 point and below 2 points were set as “X”. The results are shown in Table 5.
〔Evaluation criteria〕
5 points: very good 4 points: good 3 points: normal 2 points: bad 1 point: very bad

  From the results shown in Table 5, it was shown that the specimen 6 using the oral stain formation inhibitor composed of sodium tetradecenesulfonate of the present invention was very good in all of the aroma, taste and irritation. In addition, it was found that the specimen 6 has a good fragrance and taste, and a moderate irritation feeling as compared with the specimens 7 to 12 using other components, and an excellent usability can be obtained.

<Reference test example: Stain formation inhibition confirmation test>
(Sample preparation)
Samples 14 and 15 were prepared by mixing and dissolving the components described in Table 6 below at room temperature (about 25 ° C.) with stirring.

The obtained specimens 14 and 15 were subjected to the following stain formation inhibition confirmation test.
(Create test plate)
A test plate was prepared by sequentially performing the following steps (1) to (2).
(1) One side of a hydroxyapatite plate (HAP) 10 mm × 10 mm was polished with water-resistant abrasive paper (# 1000).
(2) The polished HAP was immersed in 0.12% hydrochloric acid for 30 seconds and then in a supersaturated aqueous sodium carbonate solution for 30 seconds, and then neutralized with distilled water to prepare a test plate.
(Examination procedure)
The following steps (i) to (vi) were sequentially performed, and this was repeated 10 times to prepare a sample.
(I) Immerse the test plate in 3 mL of human saliva for 1 hour.
(Ii) The test plate is further immersed in 3 mL of a 1% aqueous solution of chlorhexidine gluconate for 1 minute.
(Iii) Immerse the test plate in 3 mL of specimen and gently shake for 30 seconds.
(Iv) The test plate is immersed in 3 mL of 0.57% aqueous solution of ammonium iron (III) citrate for 30 seconds.
(V) Immerse the test plate in 3 mL of concentrated black tea extract for 20 minutes.
(Vi) Wash the test plate with water for 30 seconds while gently shaking in water.

(Calculation of stain formation inhibition rate)
In the same manner as in Test Example 1, the stain formation inhibition rate was calculated.
The results are shown in Table 7.

  From the results shown in Table 7, the stain formation inhibitor composed of conventionally known polyethylene glycol and / or polyvinyl pyrrolidone was insufficient in the stain formation inhibitory effect, despite being incorporated in a larger amount than the specimen 1. .

Claims (2)

  An oral stain formation inhibitor comprising sodium tetradecenesulfonate. The composition for oral cavity for stain formation inhibition which mix | blended the stain formation inhibitor for oral cavity of Claim 1.