KR20050078531A - Composition for inhibiting halitosis - Google Patents

Abstract

The present invention relates to a composition for inhibiting bad breath, 0.01 to 5% by weight based on the total weight of the composition; And 0.0001 to 1% by weight of copper compound. The composition for inhibiting bad breath according to the present invention exhibits a strong bad breath inhibitory effect by implementing an effective bad breath suppression system due to the synergistic interaction of the nasal sol and the copper compound contained in the composition.

Description

Composition for inhibiting bad breath {Composition for inhibiting halitosis}

The present invention relates to a composition for suppressing bad breath.

Bad breath occurs when proteins, food waste, etc. present in saliva are decomposed by microorganisms in the oral cavity, and the resulting amino acids are decomposed again by decalcification enzymes or amino enzymes to produce substances causing odors. The main components that cause bad breath are volatile sulfides (Volatile Sulfide Compounds (VSC)), which include hydrogen sulfide (Hydrogen Sulfide, H ₂ S), methyl mercaptan (CH ₃ SH), dimethyl mercaptan, ( CH ₃ ) ₂ S). In particular, methyl mercaptan is known to be the main component of the disgusting smell during bad breath. In addition to these volatile sulfides, there are volatile amine compounds such as triethylamine, aldehydes, fatty acids, ammonia and the like as bad breath-causing substances.

As a method for suppressing bad breath, a composition for enhancing oral hygiene containing a naxolisol extracted and separated from Curcuma xanthorrhiza is disclosed (Korean Patent Publication No. 2000-0000256, 2000- 0000342, 2000-0006939 and 2000-0073295), the composition for promoting oral hygiene is to take advantage of the antimicrobial properties of oral microorganisms of nagging sol. In addition, PCT / US 92/10662, JP8198709A2, JP7165544A2, WO02 / 41862 and the like disclose a composition for improving oral hygiene using the bad breath-causing substances removal characteristics of copper compounds centered on copper gluconate. However, these oral hygiene-promoting compositions not only focus on the fragmentary bad breath suppression system that removes one-dimensional phosphorus of bad breath occurrence or removes bad breath-causing substances, but also has its limitations.

Accordingly, the technical problem to be achieved by the present invention is to solve the problems of the prior art, to remove the cause of bad breath and the bad breath generating material at the same time, to provide a composition for suppressing bad breath exhibiting a more powerful bad breath control effect.

In order to achieve the above technical problem, the composition for inhibiting bad breath according to the present invention is 0.01 to 5% by weight based on the total weight of the composition; And 0.0001 to 1% by weight of copper compound.

As said copper compound, copper gluconate, copper acetate, copper sulfate, copper chlorophyllin sodium, etc. can be used individually or in mixture of 1 or more types.

Hereinafter, the composition for suppressing bad breath according to the present invention will be described in detail.

Bad breath inhibitor composition according to the present invention is 0.01 to 5% by weight based on the total weight of the composition; And 0.0001 to 1% by weight of copper compound.

Curcuma nagja is a traditional medicinal plant known as turmeric from Java, which is a ginger family, and is known to have various physiological activities such as triglyceride reducing action, anticancer action and serum cholesterol reduction action. The nagging sol contained in the composition for suppressing bad breath of the present invention can be extracted from such curcuma xanthorrhiza (see Korean Patent Publication No. 2000-0073295). Naxolizol has excellent antibacterial activity against oral bacteria such as Streptococcus mutans, Streptococcus sobrinus, and Porphyromonas gingivalis. It is known that it can be effectively used for the prevention and treatment of caries and periodontal disease.

It is also known that copper compounds, in particular copper compounds in the form of salts, trap volatile sulfides produced by bad breath-causing substances to inhibit bad breath. As such a copper compound, copper gluconate, copper acetate, copper sulfate, copper chlorophyllin sodium, or the like may be used alone or in combination of one or more thereof. This is a safe material already secured.

The present inventors have found that the result of the addition of the naxazole sol and the copper compound to the composition for inhibiting bad breath shows a very strong bad breath suppressing effect due to the synergy between these substances and completed the present invention.

In the composition for inhibiting bad breath according to the present invention, the content of naxazole sol is 0.01 to 5% by weight based on the total amount of the composition, the content of the copper compound is 0.0001 to 1% by weight. If the content of naxazole sol and copper compound is less than 0.01 and 0.0001% by weight, respectively, the bad breath inhibitory effect cannot be expected. If the content of naxazole sol and copper compound exceeds 1 and 5% by weight, respectively, the compatibility with the formulation is poor and the product is applied. Difficult in content and not economical in content.

The formulation of the composition for inhibiting bad breath of the present invention specifically includes all of the various formulations of oral hygiene enhancers, such as toothpaste, dentifrice, mouse spray, dietary film, each composition can be prepared by conventional methods.

Hereinafter, a description will be given of the conventional components that can be added to the toothpaste composition of the composition for suppressing bad breath according to the present invention.

The toothpaste composition of the present invention may further contain an abrasive, a humectant, a binder, a foaming agent, a sweetener, a preservative, a pH adjuster, a flavoring agent, etc., in addition to the nagging sol and the copper compound.

Examples of the abrasive include calcium carbonate, calcium hydrogen phosphate, precipitated silica, hydrous alumina, silica gel, insoluble sodium metaphosphate, zirconium silicate, and the like, either alone or in combination of two or more thereof, 20 to 70% by weight, preferably 35 To 55% by weight.

Wetting agents are used 20 to 60% by weight, preferably 20 to 50% by weight of glycerin, sorbitol liquid, polyethylene glycol, etc. alone or in combination of two or more thereof.

As the binder, carrageenan, xanthan gum, carboxymethyl cellulose sodium, carboxyvinyl polymer, sodium alginate and the like are usually suitable. The amount of the binder used is appropriately 0.1 to 3.0% by weight, preferably 0.5 to 2.0% by weight.

Examples of the foaming agent include anionic surfactants such as sodium alkyl sulfate and sodium lauroyl salcosinate, and nonionic surfactants such as sorbitan fatty acid ester, polyoxyethylene hardened castor oil, and polyoxyethylene polyoxypropylene copolymer. As the foaming agent, 0.5 to 5.0% by weight, preferably 0.5 to 2.5% by weight of anionic surfactants and nonionic surfactants are used alone or in combination.

Examples of the sweetening agent include sodium saccharin, aspartame, acesulfame, stevioside, and licorice acid, and these are preferably used in an amount of 0.05 to 0.5% by weight alone or in mixture of two kinds of diacids.

It is preferable to use 0.05-0.25 weight% of preservatives individually or in mixture of 2 types of dioxybenzoic acid ester, benzoic acid, and sodium benzoate.

As the pH adjuster, it is preferable to use 0.02 to 1.5% by weight of phosphoric acid, sodium phosphate, citric acid, sodium citrate, succinic acid, sodium succinate, tartaric acid, sodium stannate alone or two kinds of diacids.

The fragrance substances include aromatic substances used in conventional toothpaste and substances used in food fragrance, such as peppermint oil, menthol, spearmint oil, carbon, anise oil, anitol, eucalyptus oil, and clove oil. Type, eugenol, winter green oil type, methyl salicylate, cinnamon oil type, cinnamic aldehyde and other fragrance components are used, and the material constituting the fragrance is 0.1 to 2.0 weight by mixing one or two or more of the above components %, Preferably 0.5 to 1.5% by weight.

As described above, the composition for inhibiting bad breath according to the present invention can be used by appropriately mixing appropriate amounts within the content range according to the present invention by using an appropriate amount of a component normally used in the product and the main active ingredient.

Hereinafter, the present invention will be described in detail with reference to Examples and Experimental Examples of Toothpaste, Mouthwash, Mouse Spray, and Dietary Film, which are common formulations in a bad breath control composition, but the technical scope of the present invention is limited to these Examples. no.

Preparation of Toothpaste Composition

Toothpaste compositions were prepared according to the ingredients and contents shown in Table 1 below.

The bad breath inhibitory effects on the toothpaste compositions of Examples 1-1 to 1-3 and Comparative Examples 1-1 to 1-3 were measured. Thirty men and women who do not have dental caries were selected to eat the same meal, and after measuring bad breath with Halimeter, the initial degree of bad breath was determined, and each toothpaste was brushed for a certain period of time. Was measured. The usage of Halimeter is as follows. For 2 minutes before the measurement, the mouth was shut and breathed only through the nose. During the measurement, the straw was put into the mouth for about 1.5 seconds and maintained for about 15 seconds. At this time, the straw did not touch the tongue and the lips were kept about 3 ~ 4mm apart. Halimeter measurement value is in ppb, the average of bad breath measurements obtained from each of the test subjects to determine the bad breath inhibition rate of each toothpaste, the results are shown in Table 2 below.

Referring to Table 2, the bad breath produced after eating showed an average inhibition rate of 33% even in Comparative Example 1-1 containing no active ingredient when measured after brushing, but the inhibition rate was not large. In addition, Comparative Examples 1-2 and 1-3 in which naxazole sol and copper gluconate were added, respectively, significantly increased the bad breath inhibition rate compared to Comparative Example 1-1, but Example 1 in which a relatively small amount of naxazole sol and copper gluconate was added The rate of bad breath was smaller than -1. From this, it could be seen that synergistic effect was obtained when naxazole and copper gluconate were used together. Therefore, it can be seen that when the copper compound is mixed together with naxazole sol, which is an oral bad breath causing microbial fungicide, and a bad breath-causing substance remover, the synergistic effects of the respective components can be more effectively suppressed.

Preparation of the fern composition

Tooth liquor compositions were prepared according to the ingredients and contents shown in Table 3 below.

Bad breath inhibitory effects on the dentifrice compositions of Examples 2-1 to 2-3 and Comparative Examples 2-1 to 2-3 were measured. Thirty men and women who do not have dental caries were selected to have the same meal, and the bad breath was measured using a Halimeter to determine the initial degree of bad breath. After each brushing for a certain period of time with each of the fern solution, the bad breath was measured again with a Halimeter 30 minutes later, the use of Halimeter is the same as described above. The bad breath inhibition rate of each drug solution was obtained by averaging the bad breath measurement values obtained from the respective test subjects, and the results are shown in Table 4 below.

Referring to Table 4, the bad breath produced after eating showed an average inhibition rate of 24% even in Comparative Example 2-1 containing no active ingredient when measured after brushing, but the inhibition rate was not large. In addition, Comparative Examples 2-2 and 2-3, in which naxazole sol and copper gluconate were added separately, had significantly increased bad breath inhibition rate compared to Comparative Example 2-1, but Examples in which a relatively small amount of naxazole sol and copper gluconate were added The rate of bad breath was smaller than 2-1. From this, it could be seen that synergistic effect was obtained when naxazole and copper gluconate were used together. Therefore, it can be seen that when the copper compound is mixed together with naxazole sol, which is an oral bad breath causing microbial fungicide, and a bad breath-causing substance remover, the synergistic effects of the respective components can be more effectively suppressed.

Preparation of Mouse Spray Compositions

To prepare a mouse spray composition according to the ingredients and contents shown in Table 5.

The bad breath inhibitory effects on the mouse spray compositions of Examples 3-1 to 3-3 and Comparative Examples 3-1 to 3-3 were measured. Thirty men and women who do not have dental caries were selected to have the same meal, and the bad breath was measured using a Halimeter to determine the initial degree of bad breath. Each mouse spray was sprayed five times evenly in the mouth, and then again bad breath was measured by Halimeter, the use of Halimeter is the same as described above. The bad breath inhibition rate of each mouse spray was obtained by averaging the bad breath measurement values obtained from the respective test subjects, and the results are shown in Table 6 below.

Referring to Table 6, the bad breath produced after eating showed an average inhibition rate of 20% even in Comparative Example 3-1, which contained no active ingredient when measured after brushing, but the inhibition rate was not large. In addition, Comparative Examples 3-2 and 3-3, in which naxazole sol and copper gluconate were added separately, had significantly increased bad breath inhibition rate compared to Comparative Example 3-1. The rate of bad breath was smaller than 3-1. From this, it could be seen that synergistic effect was obtained when naxazole and copper gluconate were used together. Therefore, it can be seen that when the copper compound is mixed together with naxazole sol, which is an oral bad breath causing microbial fungicide, and a bad breath-causing substance remover, the synergistic effects of the respective components can be more effectively suppressed.

Preparation of Dietary Film Compositions

A mouse spray composition was prepared according to the ingredients and contents shown in Table 7 below.

The bad breath inhibitory effects on the dietary film compositions of Examples 4-1 to 4-3 and Comparative Examples 4-1 to 4-3 were measured. Thirty men and women who do not have dental caries were selected to have the same meal, and the bad breath was measured using a Halimeter to determine the initial degree of bad breath. Each dietary film was attached to the tongue, and after the film was completely dissolved in saliva, bad breath was measured again by Halimeter, and the usage of Halimeter was the same as the above-described method. The bad breath inhibition rate of each dietary film was obtained by averaging the bad breath measurement values obtained from the respective test subjects, and the results are shown in Table 8 below.

Referring to Table 8, the bad breath produced after eating showed an average inhibition rate of 15% even in Comparative Example 4-1 containing no active ingredient when measured after brushing, but the inhibition rate was not large. Also, Comparative Examples 4-2 and 4-3, in which naxazole sol and copper gluconate were added separately, had significantly increased bad breath inhibition rate compared to Comparative Example 4-1, but Examples in which a relatively small amount of naxazole sol and copper gluconate were added The rate of bad breath was smaller than 4-1. From this, it could be seen that synergistic effect was obtained when naxazole and copper gluconate were used together. Therefore, it can be seen that when the copper compound is mixed together with naxazole sol, which is an oral bad breath causing microbial fungicide, and a bad breath-causing substance remover, the synergistic effects of the respective components can be more effectively suppressed.

As described above, the bad breath suppressing composition according to the present invention exhibits a strong bad breath suppressing effect by implementing an effective bad breath suppression system due to the synergy of the naxazole sol and the copper compound contained in the composition. The formulation of the composition for inhibiting bad breath is not limited to the toothpaste, dentifrice, mouse spray or dietary film described above, in addition to the gum, mouthwash, ointment and patch formulations and the like can be applied.

Claims (2)

In the bad breath control composition, based on the total weight of the composition 0.01-5% by weight of naxazole; And A composition for inhibiting bad breath, comprising 0.0001 to 1% by weight of a copper compound. The composition of claim 1, wherein the copper compound comprises any one or more selected from the group consisting of copper gluconate, copper acetate, copper sulfate, and copper chlorophyllin sodium.