JP2011201861A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition for oral cavity improving adsorption effect of cetylpyridinium chloride, having microbicidal activity to oral microbes, onto surfaces of teeth, and further suppressing adhesion of stain.SOLUTION: The composition for oral cavity contains cetylpyridinium chloride and one or more kinds of OH-containing compounds selected from the group consisting of thymol, isopropylmethylphenol, terpineol, eugenol, linalool, geraniol and citronellol and, in addition, one or more kinds of diol compounds selected from the group consisting of hexane diol and octane diol, wherein the content of the OH-containing compound is 0.001-0.3 mass% and the content of cetyl pyridinium chloride is 0.01-0.3 mass%.

Description

  The present invention relates to an oral composition that promotes the adsorption effect of cetylpyridinium chloride on the tooth surface and suppresses the adhesion of stain. More specifically, a composition for oral cavity containing 0.01 to 0.5% by mass of cetylpyridinium chloride and 0.001 to 0.3% by mass of a compound having a specific hydroxyl group, and in addition to the above, hexanediol And an oral composition containing one or more diol compounds selected from the group consisting of octanediol.

  Cetylpyridinium chloride not only has high bactericidal activity against oral bacteria, but also adsorbs to the oral mucosa and tooth surface, inhibits the adsorption of oral bacteria to the surface of the tooth and oral mucosa, improves oral hygiene, It is known to suppress plaque formation. Therefore, cetylpyridinium chloride is blended in many oral compositions for the purpose of preventing and improving periodontal diseases and bad breath.

  Various methods have been disclosed for further enhancing the bactericidal activity of the cationic bactericides such as cetylpyridinium chloride against oral bacteria. Patent Document 1 discloses that the combination of cetylpyridinium chloride with a lower alkyl ester of an N-long chain acyl basic amino acid or a salt thereof promotes the adsorption of cetylpyridinium chloride to teeth. The effect of promoting the adsorption of a cationic fungicide to a tooth by a lower alkyl ester of a long-chain acyl basic amino acid or a salt thereof is most enhanced in a pH range of 5.5 to 6.5. Incorporation of a specific compound into a composition for oral cavity in which an agent and a nonionic surfactant are used in combination effectively prevents inactivation of the bactericidal agent, and Patent Document 4 describes cetylpyridinium chloride. The combination of specific polyoxyethylene hydrogenated castor oil does not inhibit the adsorption of cetylpyridinium chloride to teeth compared to other surfactants, patent text 5, the cationic microbicide is mixed with a cationic polymer and an organic acid or a salt thereof to increase the retention of the cationic fungicide in the oral cavity, and can effectively prevent plaque formation; Patent Document 6 discloses that polyvinyl alcohol is used to enhance the adsorptivity of cetylpyridinium chloride to teeth. However, not only a sufficient adsorption amount of cetylpyridinium chloride could not be obtained, but also the adhesion of stain to the tooth surface due to the blending of cetylpyridinium chloride could not be suppressed.

JP-A-4-36231 JP-A-9-286712 JP 60-255717 A JP-A-4-173728 JP 2000-34213 A Japanese Patent Laid-Open No. 2003-113059

  This invention makes it a subject to provide the composition for oral cavity which suppressed the adhesion | attachment of a stain while improving the adsorption effect to the tooth surface of the cetyl pyridinium chloride which has bactericidal activity with respect to an oral cavity bacteria.

  As a result of intensive studies in view of such circumstances, the present inventors have formulated 0.01 to 0.5% by mass of a compound having a specific hydroxyl group with 0.01 to 0.5% by mass of cetylpyridinium chloride, It is found that the adsorption effect of cetylpyridinium chloride on the tooth surface is increased, and further, when a specific diol compound is blended, the adsorption effect of cetylpyridinium chloride on the tooth surface is enhanced and the adhesion of stain is suppressed. It came to complete.

That is, this invention provides the composition for oral cavity of the following items 1-5 especially.
Item 1.
0.001 to 0.3% by mass of a compound having one or more hydroxyl groups selected from the group consisting of thymol, isopropylmethylphenol, terpineol, eugenol, linalool, geraniol and citronellol, and 0.01 to 0.3% of cetylpyridinium chloride. An oral composition containing 5% by mass.
Item 2.
Item 2. The oral composition according to Item 1, wherein the compound having a hydroxyl group is thymol, isopropylmethylphenol, terpineol, or geraniol.
Item 3.
Item 3. The oral composition according to any one of Items 1 and 2, wherein the compounding amount of the compound having a hydroxyl group is 0.01 to 0.1% by mass.
Item 4.
Item 4. The oral composition according to any one of Items 1 to 3, further comprising one or more diol compounds selected from the group consisting of hexanediol and octanediol.
Item 5.
Item 5. The oral composition according to Item 4, wherein the diol compound is at least one selected from the group consisting of 2-methyl-2,4-pentanediol and 2-ethyl-1,3-hexanediol. .
Item 6.
Item 6. The oral composition according to any one of Items 1 to 5, wherein the oral composition is a liquid or liquid oral composition.
Item 7.
A compound having one or more hydroxyl groups selected from the group consisting of thymol, isopropylmethylphenol, terpineol, eugenol, linalool, geraniol, citronellol, one or more diol compounds selected from the group consisting of hexanediol and octanediol, and A composition containing cetylpyridinium chloride, wherein the content of the compound having a hydroxyl group is 0.001 to 0.3% by mass and the content of cetylpyridinium chloride is 0.01 to 0.5% by mass A method of promoting adsorption of cetylpyridinium chloride and suppressing adhesion of stain on a tooth surface by a composition.

  The composition for oral cavity of the present invention inhibits adhesion of oral bacteria causing dental caries or periodontal disease to the tooth surface by further enhancing the activity of cetylpyridinium chloride and promoting the adsorption effect on the tooth surface. Thus, it is possible to effectively suppress the formation of plaque and suppress the adhesion of stain to the tooth surface.

  The composition for oral cavity according to the present invention contains a compound having one or more hydroxyl groups selected from the group consisting of thymol, isopropylmethylphenol, terpineol, eugenol, linalool, geraniol, citronellol, and cetylpyridinium chloride, and further hexanediol. And a composition containing one or more diol compounds selected from the group consisting of octanediol, wherein the content of the compound having a hydroxyl group is 0.001 to 0.3% by mass and the content of cetylpyridinium chloride is 0. 0.01 to 0.3% by mass.

  Examples of the compound having a hydroxyl group used in the present invention include thymol (2-isopropyl-5-methylphenol), isopropylmethylphenol (4-isopropyl-3-methylphenol), terpineol, eugenol, linalool, geraniol, and citronellol. Of these, thymol, isopropylmethylphenol, terpineol, eugenol and geraniol are preferred, thymol, isopropylmethylphenol, terpineol and geraniol are more preferred, and thymol, isopropylmethylphenol and terpineol are most preferred. These can be used alone or in combination of two or more. As a compounding quantity, it is 0.001-0.3 mass%, 0.005-0.1 mass% is preferable, 0.01-0.1 is further more preferable, 0.01-0.05 mass% is Most preferred. If the amount exceeds 0.3% by mass, the flavor of the oral composition may be deteriorated or the desired effect may not be expected. If the amount is less than 0.001% by mass, the desired effect is obtained. This is not preferable because it may not be obtained.

  Cetylpyridinium chloride used in the present invention is a cationic bactericidal agent contained in a quaternary ammonium compound and is widely used in the field of oral compositions. Such cetylpyridinium chloride can be blended in an amount of 0.01 to 0.5% by weight, preferably 0.05 to 0.3% by weight, most preferably, based on the total amount of the liquid oral composition of the present invention. 0.05 mass% can be mix | blended. If the amount is less than 0.01% by mass, the effect of adsorbing cetylpyridinium chloride on the tooth surface is lowered. On the other hand, if the amount exceeds 0.5% by mass, problems such as bitterness during use are not preferable.

  Examples of the diol compound used in the present invention include hexanediol and octanediol. More specifically, as hexanediol, 1,2-hexanediol, 1,5-hexanediol, 1,6-hexanediol, 2,3-hexanediol, 2,5-hexanediol, 2-methyl- 2,4-pentanediol is exemplified, and as octanediol, 1,2-octanediol, 1,8-octanediol, 2,3-octanediol, 2,4-octanediol, 1,2-octanediol, 2-ethyl-1,3-hexanediol is exemplified. These can be blended alone or in combination of two or more. Of these, 1,2-hexanediol, 1,5-hexanediol, 1,6-hexanediol, 2,3-hexanediol, 2,5-hexanediol, 2-methyl-2,4-pentanediol, 2 -Ethyl-1,3-hexanediol is preferable, 2-methyl-2,4-pentanediol and 2-ethyl-1,3-hexanediol are more preferable, and 2-methyl-2,4-pentanediol is most preferable. . These can be used alone or in combination of two or more. Although it does not specifically limit as a compounding quantity, Usually, it is 0.1-10 mass%, Preferably it is 0.5-8 mass%, Most preferably, it is 1-5 mass%.

  The oral composition of the present invention is not particularly limited, but is a toothpaste, a liquid dentifrice, a mouthwash, a liquid, a gel, a pasta, a spray, a gum, a soft paste (cream-form preparation) ), Ointment-like preparations, and the like (dosage forms). Among these, a soft paste (cream-form preparation) gel, liquid or liquid form is preferable, and a liquid or liquid form such as a mouthwash, liquid dentifrice, spray, or liquid is more preferable, and a mouthwash is Most preferred.

  The composition for oral cavity of the present invention is thymol, isopropylmethylphenol, terpineol, eugenol, linalool, geraniol, citronellol, hexanediol, octanediol and cetylpyridinium chloride, as long as the effects of the present invention are not impaired. You may mix | blend the component which can be normally mix | blended with the composition for oral cavity.

  As the surfactant, a nonionic surfactant, an anionic surfactant or an amphoteric surfactant can be blended. Specifically, nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters, maltose fatty acid esters, and lactose fatty acid esters, fatty acid alkanolamides, sorbitan fatty acid esters, fatty acid monoglycerides, and polyoxyethylene addition coefficients of 4 to 15. A polyoxyethylene alkyl ether type having an alkyl group having 10 to 18 carbon atoms or a polyoxyethylene alkyl phenyl ether having a polyoxyethylene addition coefficient of 10 to 18 and an alkyl group having 9 carbon atoms, diethyl sebacate, poly Oxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyethylene glycol fatty acid ester, polyester Renranorin, polyethylene sterols, polyethylene lanolin alcohols, alkyl glucosides, polyoxyethylene polyoxypropylene block copolymers, and the like. Anionic surfactants include sulfate esters such as sodium lauryl sulfate and polyoxyethylene lauryl ether sulfate, sodium lauryl sulfosuccinate, sulfosuccinates such as sodium polyoxyethylene lauryl ether sulfosuccinate, cocoyl sarcosine sodium, lauroylmethylalanine Examples include acyl amino acid salts such as sodium, cocoyl methyl taurine sodium and the like. Zwitterionic surfactants include betaine acetate type activators such as lauryl dimethylaminoacetic acid betaine, coconut oil fatty acid amidopropyldimethylaminoacetic acid betaine, and imidazoline type such as N-cocoyl-N-carboxymethyl-N-hydroxyethylethylenediamine sodium. Examples include activators and amino acid type activators such as N-lauryldiaminoethylglycine. These surfactants can be blended alone or in combination of two or more.

  As a flavoring agent, for example, menthol, carvone, methyl salicylate, vanillin, benzyl succinate, methyl eugenol, anethole, limonene, ocimene, n-decyl alcohol, methyl acetate, citronenyl acetate, cineol, ethyl linalool, vanillin, thyme , Nutmeg, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, perilla oil, winter green oil, clove oil, eucalyptus oil, pimento oil, tea tree oil, tabana oil, star Examples include anise oil, fennel oil, diatom oil, and basil oil. These fragrance | flavors can be used individually or in combination of 2 or more types.

  Examples of the abrasive include abrasive silica such as abrasive precipitated silica and abrasive gel silica, calcium hydrogenphosphate dihydrate and anhydride, calcium phosphate, tertiary calcium phosphate, tertiary magnesium phosphate, calcium pyrophosphate, hydroxyapatite Insoluble sodium metaphosphate, aluminum silicate, zirconium silicate, calcium silicate, calcium carbonate, magnesium carbonate, alumina, aluminum hydroxide, calcium sulfate, polymethyl methacrylate, pumice, bentonite, synthetic resin, etc. It is done. These binders can be used alone or in combination of two or more.

  Examples of binders include cellulose derivatives such as sodium carboxymethylcellulose, carboxymethylethylcellulose salt, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, microbially produced polymers such as xanthan gum, gellan gum, tragacanth gum, karaya gum, arabiya gum, carrageenan, dextrin. Natural polymers such as natural rubbers, synthetic polymers such as polyvinyl alcohol and polyvinyl pyrrolidone, thickening silica, inorganic binders such as bee gum, O- [2-hydroxy-3- (trimethylammonio) propyl] chloride Cationic binders such as hydroxyethyl cellulose can be mentioned. These binders can be used alone or in combination of two or more.

  Sweetening agents include, for example, saccharin, saccharin sodium, acesulfame potassium, stevia extract, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perilartin, saumatine, aspartylphenylalanine methyl ester, methoxycinnamic aldehyde, palatinose, palatinit, erythritol, multi Tall, xylitol, lactitol and the like. These sweeteners can be used alone or in combination of two or more.

  As the wetting agent, for example, glycerin, ethylene glycol, propylene glycol, sorbit, polyethylene glycol, polypropylene glycol and the like can be used alone or in combination of two or more.

  Examples of the preservative include parabens such as methylparaben and propylparaben, and benzoates such as sodium benzoate. These preservatives can be used alone or in combination of two or more.

  Examples of pH adjusters include citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, aspartic acid, succinic acid, glucuronic acid, fumaric acid, glutamic acid, adipic acid, and salts thereof, hydrochloric acid, sodium hydroxide , Potassium hydroxide, sodium silicate and the like. These components can be contained in the oral composition of the present invention alone or in combination of two or more. In addition, as long as the composition for oral cavity of this invention is a range which can be used in an oral cavity, the pH will not be restrict | limited, However, Usually, pH is 3.0-10.5, Preferably it is pH 5.5-8.0.

  As a medicinal component, in addition to cetylpyridinium chloride as a bactericidal agent, for example, cationic bactericides such as chlorhexidine hydrochloride, chlorhexidine gluconate, benzethonium chloride, benzalkonium chloride; amphoteric bactericides such as dodecyldiaminoethylglycine; isopropylmethylphenol, Nonionic fungicides such as triclosan; Enzymes such as dextranase, amylase, protease, mutanase, lysozyme, lytic enzyme (lytechenzyme); Glycyrrhizic acid salts such as glycyrrhetinic acid and dipotassium glycyrrhizinate as anti-inflammatory agents; Nicotinic acid or tocopherol acetate, etc .; Tranexamic acid, epsilon aminocaproic acid, etc. as antiplasmin agent; Ascorbic acid, etc. as bleeding remedy; Fluorine compounds such as sodium fluoride as remineralization agents; plant extracts extracted with water-soluble solvents, chlorophyll, sodium chloride, caropeptides, zinc chloride, hinokitiol, etc. It can mix | blend combining a seed | species or more.

  In addition, the liquid oral composition of the present invention may contain an N-long chain acyl basic amino acid lower alkyl ester or a salt thereof. In particular, the basic amino acid moiety may be ornithine, lysine or arginine, which may be either optically active or racemic. The acyl group is a saturated or unsaturated fatty acid residue having 8 to 22 carbon atoms, and examples thereof include single fatty acid residues such as lauroyl group, myristyl group, palmitoyl group, stearoyl group, and coconut oil. Natural mixed fatty acid residues such as fatty acid residues and beef oil fatty acid residues may also be used. Examples of lower alkyl esters include methyl esters, ethyl esters, and propyl esters. As salts of these N-long chain acyl basic amino acid lower alkyl esters, inorganic acid salts such as hydrochloride and sulfate; glutamate, pyroglutamate, acetate, tartrate, citrate, fatty acid salt, Organic acid salts such as acidic amino acid salts are listed. In particular, glutamate, pyroglutamate, acetate, and citrate are preferable. Specific examples of N-long chain acyl basic amino acid lower alkyl esters or salts thereof include N-cocoyl-L-arginine ethyl ester / pyrrolidone carboxylate (CAE), N-lauryl-L-arginine ethyl ester, Examples include pyrrolidone carboxylate.

  Hereinafter, the present invention will be specifically described, but the present invention is not limited to the following examples. In the following, “%” means “mass%” unless otherwise specified.

Method for evaluating adsorption of cetylpyridinium chloride on tooth surface As a model of tooth enamel, 50 mg of hydroxyapatite powder (BIO-RAD Lab. Hydroxyapatite Bio-Gel HTP Gel) (hereinafter abbreviated as “HA”) was sterilized by ultraviolet light. The artificial pellicle was formed on the apatite surface by immersing in 2 ml of human saliva at 37 ° C. for 15 hours, and then centrifuged (3000 rpm, 10 minutes) to remove the supernatant. Next, the hydroxyapatite was immersed in 2 ml of each solution sample at 37 ° C. for 15 minutes, centrifuged (3000 rpm, 10 minutes), and then the supernatant was removed. Furthermore, after adding 2 ml of distilled water and stirring, an operation of performing centrifugation (3000 rpm, 10 minutes) and removing the supernatant was performed twice. Next, CPC adsorbed to hydroxyapatite was extracted using an extract (10 mM sodium lauryl sulfate, 40 mM citrate buffer pH 3.0 / acetonitrile = 25/75), and CPC retained in 50 mg of hydroxyapatite was quantified by HPLC. The amount was determined. The unit of adsorption amount of cetylpyridinium chloride is μg.

Judgment criteria ◎: Adsorption amount of cetylpyridinium chloride is 790 or more ○: Adsorption amount of cetylpyridinium chloride is 690 or more and less than 790 ×: Adsorption amount of cetylpyridinium chloride is less than 690

Stain adhesion amount evaluation method An acrylic plate (10 mm × 30 mm × 5 mm) was immersed in 0.3% bovine serum albumin for 2 minutes, distilled water for 30 seconds, test sample for 2 minutes, and distilled water for 30 seconds in this order. . Next, 10 g of black tea leaf was added to 1000 ml of boiling water, and immersed in a black tea extract extracted for 2 minutes for 60 minutes. The treated acrylic plate was immersed in distilled water for 30 seconds and then naturally dried, and the color tone of the acrylic plate surface was measured by measuring the absorbance at 395 nm. Furthermore, the operation of dipping the black tea extract and measuring the absorbance of the acrylic plate was repeated 10 times.

Criteria 4: The measured value of absorbance is less than 0.60 3: The measured value of absorbance is 0.60 or more and less than 0.64 2: The measured value of absorbance is 0.64 or more and less than 0.67 1: The measured value of absorbance is 0.67 or more

Comprehensive evaluation Comprehensive evaluation was performed according to the following criteria.

Judgment criteria ◎: Adsorption amount evaluation of cetylpyridinium chloride is ◎ and adhesion amount evaluation of stain is 4
○: Adsorption amount evaluation of cetylpyridinium chloride is ◎ or ○, and adhesion amount evaluation of stain is 3 or 2.
X: Adsorption amount evaluation of cetylpyridinium chloride is x or Adhesion amount evaluation of stain is 1

  As shown in Table 1 or 2, an oral composition containing 0.001 to 0.3% by mass of thymol, isopropylmethylphenol, terpineol, eugenol, linalool, geraniol, and citronellol and cetylpyridinium chloride is cetylpyridinium chloride. It is apparent that the composition for oral cavity containing hexanediol or octanediol suppresses the adhesion of stains by promoting the adsorption to the surface of hydroxyapatite. In particular, an oral composition in which 0.01 to 0.3% by mass of thymol, terpineol and isopropylmethylphenol was mixed with 0.05% by mass of cetylpyridinium chloride had a remarkable effect of adsorbing cetylpyridinium chloride on the hydroxyapatite surface. .

  Hereinafter, although the prescription of the Example of the composition for oral cavity which concerns on this invention is given, this invention is not limited to the following prescription.

Formulation Example 1 Mouthwash

Ingredients Amount
Cetylpyridinium chloride 0.05
Eugenol 0.02
Glycerin 10.0
Propylene glycol 3.0
Polyoxyethylene (40) hydrogenated castor oil 0.4
Fragrance 0.1
Methyl paraoxybenzoate 0.1
N-cocoyl-L-arginine ethyl ester
・ Pyrrolidone carboxylate 0.05
Saccharin sodium 0.01
β-glycyrrhetinic acid 0.01
pH adjusting agent
Purified water balance
Total 100.0

Formulation Example 2 Mouthwash

Ingredients Amount
Cetylpyridinium chloride 0.05
2-Methyl-2,4-pentanediol 3.0
Turpineol 0.05
Decaglyceryl monolaurate 0.3
Glycerin 9.0
Propylene glycol 3.0
Fragrance 0.1
Saccharin sodium 0.01
pH adjuster
Purified water balance
Total 100.0

Formulation Example 3 Liquid Dentifrice

Ingredients Amount
Cetylpyridinium chloride 0.05
2-Ethyl-1,3-hexanediol 1.0
Timor 0.02
Monostearic acid polyoxyethylene (20) sorbitan 0.2
Glycerin 10.0
Ethanol 3.0
Fragrance 0.1
Saccharin sodium 0.01
pH adjuster
Purified water balance
Total 100.0

Formulation Example 4 Liquid Dentifrice

Ingredients Amount
Cetylpyridinium chloride 0.2
Geraniol 0.01
Glycerin 11.0
Propylene glycol 3.0
Polyoxyethylene (60) hydrogenated castor oil 0.4
Fragrance 0.1
Tocopherol acetate 0.05
N-cocoyl-L-arginine ethyl ester
・ Pyrrolidone carboxylate 0.05
Saccharin sodium 0.01
pH adjusting agent
Purified water balance
Total 100.0

Formulation Example 5 Liquid dentifrice

Ingredients Amount
Cetylpyridinium chloride 0.05
Citronellol 0.2
2-Methyl-2,4-pentanediol 2.0
Sorbitol 30.0
Propylene glycol 3.0
Sodium carboxymethylcellulose 3.0
Fragrance 1.0
Polyoxyethylene (60) hydrogenated castor oil 0.5
Sodium fluoride 0.2
Methyl paraoxybenzoate 0.1
pH adjusting agent
Purified water balance
Total 100.0

Formulation Example 6 Dentifrice

Ingredients Amount
Cetylpyridinium chloride 0.05
Turpineol 0.2
Calcium carbonate 30.0
Sorbitol 25.0
Glycerin 10.0
Thickening silica 3.0
Propylene glycol 2.0
Sodium carboxymethylcellulose 1.0
Fragrance 1.0
Polyoxyethylene (60) hydrogenated castor oil 0.5
Saccharin sodium 0.2
Titanium oxide 0.3
Sodium fluoride 0.2
Dipotassium glycyrrhizinate 0.1
Methyl paraoxybenzoate 0.1
pH adjusting agent
Purified water balance
Total 100.0

Formulation Example 7 Dentifrice

Ingredients Amount
Cetylpyridinium chloride 0.05
Eugenol 0.2
Isopropyl methylphenol 0.05
2-Methyl-2,4-pentanediol 3.0
Sorbitol 45.0
Abrasive silica 18.0
Thickening silica 3.0
Polyethylene glycol 400 3.0
Fragrance 1.0
Polyoxyethylene (40) hydrogenated castor oil 0.5
Sodium carboxymethylcellulose 0.4
Saccharin sodium 0.2
Sodium fluoride 0.2
pH adjusting agent
Purified water balance
Total 100.0

Formulation Example 8 Mouse Spray

Ingredients Amount
Cetylpyridinium chloride 0.05
2-Ethyl-1,3-hexanediol 3.0
Linalool 0.1
Ethanol 30.0
Glycerin 10.0
Polyoxyethylene (60) hydrogenated castor oil 1.0
Fragrance 1.0
l-Menthol 0.5
Saccharin sodium 0.1
pH adjusting agent
Purified water balance
Total 100.0

Claims (7)

  0.001 to 0.3% by mass of a compound having one or more hydroxyl groups selected from the group consisting of thymol, isopropylmethylphenol, terpineol, eugenol, linalool, geraniol and citronellol, and 0.01 to 0.3% of cetylpyridinium chloride. An oral composition containing 5% by mass.   The composition for oral cavity according to claim 1, wherein the compound having a hydroxyl group is thymol, isopropylmethylphenol, terpineol, or geraniol.   The composition for oral cavity according to claim 1, wherein the compounding amount of the compound having a hydroxyl group is 0.01 to 0.1% by mass.   Furthermore, 1 or more types of diol compounds chosen from the group which consists of hexanediol and octanediol are contained, The composition for oral cavity in any one of Claims 1-3 characterized by the above-mentioned.   The oral composition according to claim 4, wherein the diol compound is at least one selected from the group consisting of 2-methyl-2,4-pentanediol and 2-ethyl-1,3-hexanediol. object.   The oral composition according to any one of claims 1 to 5, wherein the oral composition is a liquid or liquid oral composition.   A compound having one or more hydroxyl groups selected from the group consisting of thymol, isopropylmethylphenol, terpineol, eugenol, linalool, geraniol, citronellol, one or more diol compounds selected from the group consisting of hexanediol and octanediol, and A composition containing cetylpyridinium chloride, wherein the content of the compound having a hydroxyl group is 0.001 to 0.3% by mass and the content of cetylpyridinium chloride is 0.01 to 0.5% by mass A method of promoting adsorption of cetylpyridinium chloride and suppressing adhesion of stain on a tooth surface by a composition.