JPWO2019053887A1 - 超臨界流体装置 - Google Patents
超臨界流体装置 Download PDFInfo
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- JPWO2019053887A1 JPWO2019053887A1 JP2019541603A JP2019541603A JPWO2019053887A1 JP WO2019053887 A1 JPWO2019053887 A1 JP WO2019053887A1 JP 2019541603 A JP2019541603 A JP 2019541603A JP 2019541603 A JP2019541603 A JP 2019541603A JP WO2019053887 A1 JPWO2019053887 A1 JP WO2019053887A1
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- diameter pipe
- small
- heating unit
- flow rate
- supercritical fluid
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/40—Selective adsorption, e.g. chromatography characterised by the separation mechanism using supercritical fluid as mobile phase or eluent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
- B01D15/161—Temperature conditioning
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/326—Control of physical parameters of the fluid carrier of pressure or speed pumps
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/328—Control of physical parameters of the fluid carrier of pressure or speed valves, e.g. check valves of pumps
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6004—Construction of the column end pieces
- G01N2030/6013—Construction of the column end pieces interfaces to detectors
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- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Health & Medical Sciences (AREA)
- Details Of Valves (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Description
4a,4b 送液ポンプ
6 二酸化炭素ボンベ
8 モディファイア容器
10 ミキサ
12 試料注入部
14 分析カラム
16 検出器
18 背圧制御弁
20 小径流路
22 カップリング
24 大径流路
26 小径配管加熱部
28 大径配管加熱部
30 制御部
32 温度センサ
Claims (7)
- 移動相が流れる分析流路と、
前記分析流路の下流端に設けられ、前記分析流路内の圧力を所定の圧力に調節する背圧制御弁と、
前記背圧制御弁の出口に接続され、内部の圧力が大気圧よりも高い圧力に維持される内径を有する小径配管と、
前記小径配管の下流端に接続され、前記小径配管よりも大きい内径をもつ大径配管と、
前記大径配管を加熱するための大径配管加熱部と、を備えた超臨界流体装置。 - 前記大径配管加熱部よりも小さい加熱量で前記小径配管を加熱するように構成された小径配管加熱部をさらに備えている、請求項1に記載の超臨界流体装置。
- 前記大径配管加熱部と前記小径配管加熱部のそれぞれの加熱量を制御するように構成された制御部をさらに備え、
前記制御部は、前記分析流路を流れる移動相の流量が所定流量以下であるときは前記小径配管を前記小径配管加熱部によって加熱し、前記分析流路を流れる移動相の流量が前記所定流量を超えているときは前記大径配管のみを前記大径配管加熱部によって加熱するように構成されている、請求項2に記載の超臨界流体装置。 - 前記大径配管加熱部の温度を検出する温度センサと、
前記大径配管加熱部と前記小径配管加熱部のそれぞれの加熱量を制御するように構成された制御部と、さらに備え、
前記制御部は、前記温度センサにより検出される前記大径配管の温度が所定温度以上であるときは前記小径配管加熱部のみを駆動し、前記温度センサにより検出される前記大径配管の温度が所定温度未満であるときは前記大径配管加熱部を駆動するように構成されている、請求項2に記載の超臨界流体装置。 - 前記大径配管加熱部は、前記大径配管に電流を流して前記大径配管を発熱させるように構成された電気回路を含む、請求項1から4のいずれか一項に記載の超臨界流体装置。
- 前記小径配管の内径は前記背圧制御弁内に設けられた出口流路の内径と略同一である、請求項1から5のいずれか一項に記載の超臨界流体装置。
- 前記大径配管の内径は前記小径配管の内径の2倍以上である、請求項1から6のいずれか一項に記載の超臨界流体装置。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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PCT/JP2017/033496 WO2019053887A1 (ja) | 2017-09-15 | 2017-09-15 | 超臨界流体装置 |
Publications (2)
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JPWO2019053887A1 true JPWO2019053887A1 (ja) | 2020-05-28 |
JP6852796B2 JP6852796B2 (ja) | 2021-03-31 |
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JP2019541603A Active JP6852796B2 (ja) | 2017-09-15 | 2017-09-15 | 超臨界流体装置 |
Country Status (4)
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US (1) | US11435324B2 (ja) |
JP (1) | JP6852796B2 (ja) |
CN (1) | CN110914684B (ja) |
WO (1) | WO2019053887A1 (ja) |
Citations (9)
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US5866004A (en) * | 1992-10-16 | 1999-02-02 | Suprex Corporation | Automated supercritical fluid extraction method and apparatus |
JP2004510126A (ja) * | 2000-05-11 | 2004-04-02 | オンタジェン コーポレイション | 多チャンネル高処理量精製装置及びその方法 |
JP2011118880A (ja) * | 2009-10-28 | 2011-06-16 | Jasco Corp | 超臨界流体用圧力制御装置 |
JP2013016797A (ja) * | 2011-06-30 | 2013-01-24 | Semes Co Ltd | 基板処理装置及び超臨界流体排出方法 |
WO2014083639A1 (ja) * | 2012-11-28 | 2014-06-05 | 株式会社島津製作所 | 超臨界流体処理装置 |
WO2016088252A1 (ja) * | 2014-12-05 | 2016-06-09 | 株式会社島津製作所 | 試料回収機構及びその試料回収機構を備えた超臨界流体装置 |
WO2016147379A1 (ja) * | 2015-03-19 | 2016-09-22 | 株式会社島津製作所 | 超臨界流体装置 |
JP3209072U (ja) * | 2016-12-13 | 2017-03-02 | 株式会社島津製作所 | 超臨界流体装置 |
JP3211870U (ja) * | 2017-05-22 | 2017-08-10 | 株式会社島津製作所 | 超臨界流体装置 |
Family Cites Families (6)
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EP0427671B1 (de) * | 1989-11-08 | 1994-07-27 | Ciba-Geigy Ag | Ventil |
FR2712762B1 (fr) * | 1993-11-19 | 1996-02-02 | Electricite De France | Dispositif et procédé de chauffage par effet Joule d'un fluide dans un tube formant résistance électrique. |
US7964029B2 (en) * | 2006-07-17 | 2011-06-21 | Thar Instrument, Inc. | Process flowstream collection system |
CN101396646A (zh) * | 2007-09-28 | 2009-04-01 | 天津市职业大学 | 超临界流体处理装置 |
DE202009003807U1 (de) * | 2009-03-20 | 2010-08-12 | Voss Automotive Gmbh | Elektrisches Heizsystem für ein Fluid-Leitungssystem |
WO2012174437A1 (en) | 2011-06-17 | 2012-12-20 | Waters Technologies Corporation | Methods and devices for open-bed atmospheric collection for supercritical fluid chromatography |
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2017
- 2017-09-15 WO PCT/JP2017/033496 patent/WO2019053887A1/ja active Application Filing
- 2017-09-15 US US16/643,795 patent/US11435324B2/en active Active
- 2017-09-15 CN CN201780092957.5A patent/CN110914684B/zh active Active
- 2017-09-15 JP JP2019541603A patent/JP6852796B2/ja active Active
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5866004A (en) * | 1992-10-16 | 1999-02-02 | Suprex Corporation | Automated supercritical fluid extraction method and apparatus |
JP2004510126A (ja) * | 2000-05-11 | 2004-04-02 | オンタジェン コーポレイション | 多チャンネル高処理量精製装置及びその方法 |
JP2011118880A (ja) * | 2009-10-28 | 2011-06-16 | Jasco Corp | 超臨界流体用圧力制御装置 |
JP2013016797A (ja) * | 2011-06-30 | 2013-01-24 | Semes Co Ltd | 基板処理装置及び超臨界流体排出方法 |
WO2014083639A1 (ja) * | 2012-11-28 | 2014-06-05 | 株式会社島津製作所 | 超臨界流体処理装置 |
WO2016088252A1 (ja) * | 2014-12-05 | 2016-06-09 | 株式会社島津製作所 | 試料回収機構及びその試料回収機構を備えた超臨界流体装置 |
WO2016147379A1 (ja) * | 2015-03-19 | 2016-09-22 | 株式会社島津製作所 | 超臨界流体装置 |
JP3209072U (ja) * | 2016-12-13 | 2017-03-02 | 株式会社島津製作所 | 超臨界流体装置 |
JP3211870U (ja) * | 2017-05-22 | 2017-08-10 | 株式会社島津製作所 | 超臨界流体装置 |
Also Published As
Publication number | Publication date |
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US11435324B2 (en) | 2022-09-06 |
CN110914684B (zh) | 2022-11-08 |
JP6852796B2 (ja) | 2021-03-31 |
WO2019053887A1 (ja) | 2019-03-21 |
US20200209199A1 (en) | 2020-07-02 |
CN110914684A (zh) | 2020-03-24 |
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