JPWO2019039292A1 - 微小カプセル又はビーズの製造方法 - Google Patents
微小カプセル又はビーズの製造方法 Download PDFInfo
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- JPWO2019039292A1 JPWO2019039292A1 JP2019538065A JP2019538065A JPWO2019039292A1 JP WO2019039292 A1 JPWO2019039292 A1 JP WO2019039292A1 JP 2019538065 A JP2019538065 A JP 2019538065A JP 2019538065 A JP2019538065 A JP 2019538065A JP WO2019039292 A1 JPWO2019039292 A1 JP WO2019039292A1
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Abstract
Description
すなわち、本発明の要旨は以下の通りである。
(1)表面を複数の固体微粒子で被覆した、内包物質を含むモノマー液滴又はポリマー液滴を平面上に配置する工程と、平面上に配置した前記モノマー液滴又は前記ポリマー液滴を気相中で固化することによりカプセル又はビーズの外殻部を形成するとともに、前記外殻部によって囲まれる領域を形成する工程とを含み、前記領域には前記内包物質が内包されることを特徴とする、微小カプセル又はビーズの製造方法。
(2)前記外殻部によって囲まれる前記領域は複数あり、それぞれの前記領域に前記内包物質が内包されることを特徴とする、前記(1)に記載の微小カプセル又はビーズの製造方法。
(3)前記微小カプセル又は前記ビーズから固体微粒子を除去する工程をさらに含む、前記(1)又は(2)に記載の微小カプセル又はビーズの製造方法。
(4)平面上に配置した前記モノマー液滴を気相中で固化する工程が、前記モノマー液滴を平面上で重合することを含み、平面上に配置した前記ポリマー液滴を気相中で固化する工程が、前記ポリマー液滴中の溶媒を除去することを含む、前記(1)〜(3)のいずれかに記載の微小カプセル又はビーズの製造方法。
(5)前記モノマーが(メタ)アクリレート、スチレン系モノマー及びジビニルベンゼンから選ばれる少なくとも1種である、前記(4)に記載の微小カプセル又はビーズの製造方法。
(6)ポリマーからなる外殻部と、前記外殻部によって囲まれた領域に内包される内包物質とからなる微小カプセル又はビーズ。
(7)前記外殻部によって囲まれる前記領域は複数あり、それぞれの前記領域に前記内包物質が内包されることを特徴とする、前記(6)に記載の微小カプセル又はビーズ。
(8)前記外殻部の厚みが略均一であることを特徴とする、前記(6)に記載の微小カプセル又はビーズ。
(9)前記ポリマーが、(メタ)アクリレート、スチレン系モノマー及びジビニルベンゼンから選ばれる少なくとも1種のモノマーから形成されたポリマーである、前記(6)に記載の微小カプセル又はビーズ。
(10)前記外殻部の表面には微粒子が付着していないことを特徴とする、前記(6)〜(9)のいずれかに記載の微小カプセル又はビーズ。
(11)前記外殻部の表面には微粒子を除去した痕跡が残存していることを特徴とする、前記(6)〜(9)のいずれかに記載の微小カプセル又はビーズ。
固体微粒子として、早瀬らの報告(Angew Chem Int Ed Engl.2013, 52 (41), 10788-10791)にしたがい、撥水撥油性を示す柔軟多孔性材料であるマシュマロゲルを作製した。
内包物質としてテトラデカンを用い、壁材モノマーとしてトリメチロールプロパントリメタクリレートを用いた。トリメチロールプロパントリメタクリレートに、光重合開始剤としてカンファーキノン(1mol%)及び重合促進剤として4−(ジメチルアミノ)安息香酸エチル(1mol%)を溶解した。続いて、得られた溶液に、トリメチロールプロパントリメタクリレート:テトラデカンの重量比が4:6となるようにテトラデカンを加えた。得られた溶液の5μLの液滴をマシュマロゲル微粒子粉末上に滴下し、粉末上で転がして、マシュマロゲル微粒子粉末を液滴にまぶして、表面全体がマシュマロゲル微粒子で被覆されたモノマー液滴(リキッドマーブル)を作製した。リキッドマーブルをガラスシャーレ上に配置した。リキッドマーブルは安定であり、濡れ広がることなく、また、平面上に複数個配置しても合一することなく高密度で配置できた。リキッドマーブルの1つに対し、20℃にて、波長430〜485nm及び強度1200mW/cm2以上の可視光を2分間照射することでモノマーの光重合を行い、モノマー液滴を固化して、テトラデカンをトリメチロールプロパントリメタクリレートから形成されたポリマー内に内包する球状の固体ビーズを得た。ビーズ表面のマシュマロゲル微粒子をキムワイプ(日本製紙クレシア製)で拭き取ることにより除去した。得られたビーズのテトラデカンの内包効率(=カプセル内に内包された量/仕込み量×100)は100±3%であり、高効率で内包できることが示された。ビーズの粒径は2mmであった。
内包物質のテトラデカンをα−トコフェロールに代え、トリメチロールプロパントリメタクリレート:α−トコフェロールの重量比を9:1とし、可視光の照射時間を4分間に変えた以外は実施例1と同様にしてα−トコフェロールが内包された球状の固体ビーズを得た。実施例2で得られたビーズの顕微鏡写真を図3に示す。得られたビーズのα−トコフェロールの内包効率は103±3%であり、粒径は2mmであった。
内包物質として蒸留水を用い、壁材ポリマーとしてポリスチレンを用いた。トルエンにポリスチレン(7.5重量%)を溶解した。得られたポリスチレン溶液7mLに蒸留水3mLを加え、撹拌することでポリスチレン溶液中に蒸留水を分散させた。その溶液10mLをマシュマロゲル微粒子粉末上に滴下し、マシュマロゲル微粒子粉末を液滴にまぶして、表面全体がマシュマロゲル微粒子で被覆されたポリマー液滴(リキッドマーブル)を作製した。リキッドマーブルを底面直径30mmのビーカーに入れ、25℃で1時間、200rpmにて旋回震盪することでリキッドマーブルからトルエンを蒸発させて、ポリマー液滴を固化して、蒸留水をポリスチレン中に内包する球状の固体カプセルを得た。実施例3で得られたカプセルの顕微鏡写真を図4に示す。得られたカプセルの蒸留水の内包効率は91±5%であり、粒径は2mmであった。
単核型(中空)の球状カプセルを調製した。具体的には、トリメチロールプロパントリメタクリレートに、カンファーキノン(1mol%)及び4−(ジメチルアミノ)安息香酸エチル(1mol%)を溶解した。得られた溶液の8μLの液滴をマシュマロゲル微粒子粉末上に滴下し、粉末上で転がして、マシュマロゲル微粒子粉末を液滴にまぶして、表面全体がマシュマロゲル微粒子で被覆されたモノマー液滴(リキッドマーブル)を作製した。続いて、蒸留水2μLをリキッドマーブル中にリキッドマーブルの形を壊さないようにして注射針を用いて注入し、この液滴を底面直径30mmのビーカーに入れ、ビーカーを所定の振盪速度にて旋回震盪した。旋回震盪開始から所定時間経過後に、光束24WのLEDライトを1.5分間照射することによりモノマーを光重合させて液滴を固化させた。旋回震盪速度(0〜190rpm)及び旋回震盪開始から光照射までの旋回震盪時間(0〜30秒)を変化させ、球状且つ壁厚みが均一な単核型カプセルを調製できる条件を選定した。カプセルが球状かどうかは、以下のようにして求めたカプセルの真球度合いにより評価した。
2 固体微粒子
3 微小カプセル又はビーズ
Claims (11)
- 表面を複数の固体微粒子で被覆した、内包物質を含むモノマー液滴又はポリマー液滴を平面上に配置する工程と、平面上に配置した前記モノマー液滴又は前記ポリマー液滴を気相中で固化することによりカプセル又はビーズの外殻部を形成するとともに、前記外殻部によって囲まれる領域を形成する工程とを含み、前記領域には前記内包物質が内包されることを特徴とする、微小カプセル又はビーズの製造方法。
- 前記外殻部によって囲まれる前記領域は複数あり、それぞれの前記領域に前記内包物質が内包されることを特徴とする、請求項1に記載の微小カプセル又はビーズの製造方法。
- 前記微小カプセル又は前記ビーズから固体微粒子を除去する工程をさらに含む、請求項1又は2に記載の微小カプセル又はビーズの製造方法。
- 平面上に配置した前記モノマー液滴を気相中で固化する工程が、前記モノマー液滴を平面上で重合することを含み、平面上に配置した前記ポリマー液滴を気相中で固化する工程が、前記ポリマー液滴中の溶媒を除去することを含む、請求項1〜3のいずれか1項に記載の微小カプセル又はビーズの製造方法。
- 前記モノマーが(メタ)アクリレート、スチレン系モノマー及びジビニルベンゼンから選ばれる少なくとも1種である、請求項4に記載の微小カプセル又はビーズの製造方法。
- ポリマーからなる外殻部と、前記外殻部によって囲まれた領域に内包される内包物質とからなる微小カプセル又はビーズ。
- 前記外殻部によって囲まれる前記領域は複数あり、それぞれの前記領域に前記内包物質が内包されることを特徴とする、請求項6に記載の微小カプセル又はビーズ。
- 前記外殻部の厚みが略均一であることを特徴とする、請求項6に記載の微小カプセル又はビーズ。
- 前記ポリマーが、(メタ)アクリレート、スチレン系モノマー及びジビニルベンゼンから選ばれる少なくとも1種のモノマーから形成されたポリマーである、請求項6に記載の微小カプセル又はビーズ。
- 前記外殻部の表面には微粒子が付着していないことを特徴とする、請求項6〜9のいずれか1項に記載の微小カプセル又はビーズ。
- 前記外殻部の表面には微粒子を除去した痕跡が残存していることを特徴とする、請求項6〜9のいずれか1項に記載の微小カプセル又はビーズ。
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