JPWO2018003762A1 - 賦形剤及び錠剤 - Google Patents
賦形剤及び錠剤 Download PDFInfo
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- JPWO2018003762A1 JPWO2018003762A1 JP2018525160A JP2018525160A JPWO2018003762A1 JP WO2018003762 A1 JPWO2018003762 A1 JP WO2018003762A1 JP 2018525160 A JP2018525160 A JP 2018525160A JP 2018525160 A JP2018525160 A JP 2018525160A JP WO2018003762 A1 JPWO2018003762 A1 JP WO2018003762A1
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- Prior art keywords
- excipient
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- crystalline cellulose
- starch
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- 229920002472 Starch Polymers 0.000 claims abstract description 26
- 235000019698 starch Nutrition 0.000 claims abstract description 26
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- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 claims abstract description 9
- 239000000905 isomalt Substances 0.000 claims abstract description 9
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- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 8
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- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims abstract description 8
- 239000008101 lactose Substances 0.000 claims abstract description 8
- 239000000845 maltitol Substances 0.000 claims abstract description 8
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims abstract description 8
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- 238000002156 mixing Methods 0.000 description 5
- 239000006185 dispersion Substances 0.000 description 4
- 230000007062 hydrolysis Effects 0.000 description 4
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
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- 241000251555 Tunicata Species 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
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- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
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- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- AQEDFGUKQJUMBV-UHFFFAOYSA-N copper;ethane-1,2-diamine Chemical compound [Cu].NCCN AQEDFGUKQJUMBV-UHFFFAOYSA-N 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
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- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 229960003943 hypromellose Drugs 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
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- 235000019359 magnesium stearate Nutrition 0.000 description 1
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- 239000000203 mixture Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229940114930 potassium stearate Drugs 0.000 description 1
- ANBFRLKBEIFNQU-UHFFFAOYSA-M potassium;octadecanoate Chemical compound [K+].CCCCCCCCCCCCCCCCCC([O-])=O ANBFRLKBEIFNQU-UHFFFAOYSA-M 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000005979 thermal decomposition reaction Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
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- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
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- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
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- C08K5/04—Oxygen-containing compounds
- C08K5/15—Heterocyclic compounds having oxygen in the ring
- C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
- C08K5/1535—Five-membered rings
- C08K5/1539—Cyclic anhydrides
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/02—Cellulose; Modified cellulose
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/0047—Detergents in the form of bars or tablets
- C11D17/0065—Solid detergents containing builders
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/04—Detergent materials or soaps characterised by their shape or physical properties combined with or containing other objects
- C11D17/041—Compositions releasably affixed on a substrate or incorporated into a dispensing means
- C11D17/042—Water soluble or water disintegrable containers or substrates containing cleaning compositions or additives for cleaning compositions
- C11D17/044—Solid compositions
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- A23P10/00—Shaping or working of foodstuffs characterised by the products
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- Food Science & Technology (AREA)
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- Medicinal Preparation (AREA)
- Detergent Compositions (AREA)
- General Preparation And Processing Of Foods (AREA)
Abstract
Description
マルチトール、イソマルト、マルトース及びラクトースからなる群から選ばれた一種以上の硬化剤と、
でんぷんと、
結晶セルロースとを含有することを特徴とする。
でんぷんとして、タピオカでんぷん、とうもろこしでんぷん、じゃがいもでんぷん及び米でんぷんと、結晶セルロースとして、結晶セルロース1(旭化成ケミカルズ社製 商品名「セオラス」)、結晶セルロース2(栄研商事社製 商品名「ヘヴァテン101」)及び結晶セルロース3(栄研商事社製 商品名「ヘヴァテン102」)と、硬化剤として、イソマルト、マルチトール、マルトース及びラクトースとを表1及び表2に示した所定量ずつを攪拌機に供給し、均一に混合して賦形剤を製造した。
得られた錠剤を24.9℃の水1リットル中に投入した。錠剤を静止状態の水中に投入し、錠剤がその体積の2/3崩壊した時点から60rpmの回転数で水を攪拌し、錠剤が完全に崩壊するまで攪拌した。錠剤を静止状態の水中に投入してから錠剤が完全に崩壊するまでの時間を測定した。錠剤を静止状態の水中に投入してから300秒経過しても崩壊しなかった場合は「Bad」とした。
得られた錠剤の硬度を硬度計(藤原製作所社製 商品名「木屋式硬度計」)を用いて測定した。
本出願は、2016年6月28日に出願された日本国特許出願第2016−128150号に基づく優先権を主張し、この出願の開示はこれらの全体を参照することにより本明細書に組み込まれる。
Claims (6)
- マルチトール、イソマルト、マルトース及びラクトースからなる群から選ばれた一種以上の硬化剤と、でんぷんと、結晶セルロースとを含有することを特徴とする賦形剤。
- でんぷん100質量部、結晶セルロース5〜20質量部及び硬化剤0.2〜10質量部を含有していることを特徴とする請求項1に記載の賦形剤。
- でんぷんがタピオカでんぷんであることを特徴とする請求項1又は請求項2に記載の賦形剤。
- 粉末の錠剤化に用いられることを特徴とする請求項1又は請求項2に記載の賦形剤。
- 請求項1に記載の賦形剤と、原料となる粉末とを含有していることを特徴とする錠剤。
- 粉末の含有量と賦形剤の含有量との比(粉末の含有量/賦形剤の含有量)が6.4以下であることを特徴とする請求項5に記載の錠剤。
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CN113388341A (zh) * | 2021-06-17 | 2021-09-14 | 安徽精公检测检验中心有限公司 | 一种固体粘结剂及其制备方法和应用 |
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US20230025286A1 (en) * | 2019-12-06 | 2023-01-26 | Synthon B.V. | Pharmaceutical composition comprising eltrombopag bis(monoethanolamine) |
CN111035620B (zh) * | 2019-12-25 | 2021-08-27 | 广州莱可福生物科技有限公司 | 一种辅料组合物、植物甾醇复合营养素咀嚼片及其制备方法 |
BR112023000655A2 (pt) * | 2020-07-14 | 2023-01-31 | Johnson & Johnson Consumer Inc | Composição de limpeza sólida apresentando desintegração controlada |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004064810A1 (ja) * | 2003-01-21 | 2004-08-05 | Nippon Shinyaku Co., Ltd. | 口腔内速崩性錠剤 |
WO2007114376A1 (ja) * | 2006-03-30 | 2007-10-11 | Nippon Zoki Pharmaceutical Co., Ltd. | 固形医薬製剤 |
WO2008018371A1 (fr) * | 2006-08-08 | 2008-02-14 | Kissei Pharmaceutical Co., Ltd. | Comprimé à désagrégation orale ayant un goût amer masqué et son procédé de production |
WO2010092828A1 (ja) * | 2009-02-12 | 2010-08-19 | 富士化学工業株式会社 | 崩壊性粒子組成物及びそれを用いた速崩壊性圧縮成型物 |
WO2012001977A1 (ja) * | 2010-06-29 | 2012-01-05 | 富士化学工業株式会社 | 崩壊性組成物及び易崩壊性圧縮成型物 |
WO2013054872A1 (ja) * | 2011-10-14 | 2013-04-18 | 大塚製薬株式会社 | 7-[4-(4-ベンゾ[b]チオフェン-4-イル-ピペラジン-1-イル)ブトキシ]-1H-キノリン-2-オン又はその塩を含む錠剤 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IES990573A2 (en) | 1998-07-17 | 2000-03-08 | Procter & Gamble | Detergent tablet |
CN1768741A (zh) * | 1999-05-21 | 2006-05-10 | 橘生药品工业株式会社 | 即释型口服用药物组合物 |
JP4588818B2 (ja) * | 1999-09-16 | 2010-12-01 | 日本化学機械製造株式会社 | 錠剤用賦形剤及び錠剤 |
JP5110757B2 (ja) * | 2000-07-05 | 2012-12-26 | 旭化成ケミカルズ株式会社 | セルロース粉末 |
EP1886678B1 (en) * | 2005-05-18 | 2017-04-19 | Sumitomo Dainippon Pharma Co., Ltd. | Stable tablet containing droxidopa |
JP2008037853A (ja) * | 2006-08-01 | 2008-02-21 | Higuchi Shokai:Kk | イソマルトを含有する速崩壊性医薬品固形製剤 |
EP2062599A4 (en) * | 2006-09-14 | 2013-03-27 | Astellas Pharma Inc | ORAL DISSOLVING TABLET AND METHOD FOR THE PRODUCTION THEREOF |
WO2009104739A1 (ja) * | 2008-02-21 | 2009-08-27 | 田辺三菱製薬株式会社 | 経口投与用固形製剤 |
CA2735037C (en) * | 2008-09-04 | 2016-07-12 | Cargill Incorporated | Tabletting of erythritol |
CN109069653A (zh) * | 2016-02-16 | 2018-12-21 | 特华制药株式会社 | 口腔内速崩性片剂用造粒物 |
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Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004064810A1 (ja) * | 2003-01-21 | 2004-08-05 | Nippon Shinyaku Co., Ltd. | 口腔内速崩性錠剤 |
WO2007114376A1 (ja) * | 2006-03-30 | 2007-10-11 | Nippon Zoki Pharmaceutical Co., Ltd. | 固形医薬製剤 |
WO2008018371A1 (fr) * | 2006-08-08 | 2008-02-14 | Kissei Pharmaceutical Co., Ltd. | Comprimé à désagrégation orale ayant un goût amer masqué et son procédé de production |
WO2010092828A1 (ja) * | 2009-02-12 | 2010-08-19 | 富士化学工業株式会社 | 崩壊性粒子組成物及びそれを用いた速崩壊性圧縮成型物 |
WO2012001977A1 (ja) * | 2010-06-29 | 2012-01-05 | 富士化学工業株式会社 | 崩壊性組成物及び易崩壊性圧縮成型物 |
WO2013054872A1 (ja) * | 2011-10-14 | 2013-04-18 | 大塚製薬株式会社 | 7-[4-(4-ベンゾ[b]チオフェン-4-イル-ピペラジン-1-イル)ブトキシ]-1H-キノリン-2-オン又はその塩を含む錠剤 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113388341A (zh) * | 2021-06-17 | 2021-09-14 | 安徽精公检测检验中心有限公司 | 一种固体粘结剂及其制备方法和应用 |
CN113388341B (zh) * | 2021-06-17 | 2023-09-15 | 安徽精公检测检验中心有限公司 | 一种固体粘结剂及其制备方法和应用 |
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KR20190022709A (ko) | 2019-03-06 |
US20190201345A1 (en) | 2019-07-04 |
JP2022051776A (ja) | 2022-04-01 |
JP7239119B2 (ja) | 2023-03-14 |
JP7020688B2 (ja) | 2022-02-16 |
CN109414051A (zh) | 2019-03-01 |
WO2018003762A1 (ja) | 2018-01-04 |
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