|
US5863403A
(en)
*
|
1984-03-29 |
1999-01-26 |
The Board Of Regents Of The University Of Nebraska |
Digital DNA typing
|
|
US6207421B1
(en)
|
1984-03-29 |
2001-03-27 |
Li-Cor, Inc. |
DNA sequencing and DNA terminators
|
|
US5571388A
(en)
*
|
1984-03-29 |
1996-11-05 |
Li-Cor, Inc. |
Sequencing near infrared and infrared fluorescense labeled DNA for detecting using laser diodes and suitable labels thereof
|
|
US5360523A
(en)
*
|
1984-03-29 |
1994-11-01 |
Li-Cor, Inc. |
DNA sequencing
|
|
US6086737A
(en)
*
|
1984-03-29 |
2000-07-11 |
Li-Cor, Inc. |
Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor
|
|
US6004446A
(en)
*
|
1984-03-29 |
1999-12-21 |
Li-Cor, Inc. |
DNA Sequencing
|
|
US4729947A
(en)
*
|
1984-03-29 |
1988-03-08 |
The Board Of Regents Of The University Of Nebraska |
DNA sequencing
|
|
DE3529478A1
(de)
*
|
1985-08-16 |
1987-02-19 |
Boehringer Mannheim Gmbh |
7-desaza-2'desoxyguanosin-nukleotide, verfahren zu deren herstellung und deren verwendung zur nukleinsaeure-sequenzierung
|
|
DE3739366A1
(de)
*
|
1987-04-10 |
1988-10-27 |
Boehringer Mannheim Gmbh |
Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel
|
|
US6211158B1
(en)
*
|
1987-04-10 |
2001-04-03 |
Roche Diagnostics Gmbh |
Desazapurine-nucleotide derivatives, processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof for nucleic acid sequencing and as antiviral agents
|
|
US5459255A
(en)
*
|
1990-01-11 |
1995-10-17 |
Isis Pharmaceuticals, Inc. |
N-2 substituted purines
|
|
US6200747B1
(en)
|
1992-01-28 |
2001-03-13 |
North Shore University Hospital Research Corp. |
Method and kits for detection of fragile X specific, GC-rich DNA sequences
|
|
DE4438918A1
(de)
*
|
1994-11-04 |
1996-05-09 |
Hoechst Ag |
Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung
|
|
US6150510A
(en)
|
1995-11-06 |
2000-11-21 |
Aventis Pharma Deutschland Gmbh |
Modified oligonucleotides, their preparation and their use
|
|
US6054442A
(en)
*
|
1995-07-06 |
2000-04-25 |
Board Of Regents, University Of Texas System |
Methods and compositions for modulation and inhibition of telomerase in vitro
|
|
US6004939A
(en)
*
|
1995-07-06 |
1999-12-21 |
Ctrc Research Foundation Board Of Regents |
Methods for modulation and inhibition of telomerase
|
|
US6291164B1
(en)
*
|
1996-11-22 |
2001-09-18 |
Invitrogen Corporation |
Methods for preventing inhibition of nucleic acid synthesis by pyrophosphate
|
|
US6906185B1
(en)
|
1997-03-20 |
2005-06-14 |
Amersham Biosciences Corp. |
Derivatives of 7-deaza -2′-deoxyguanosine-5'-triphosphate, preparation and use thereof
|
|
GB2323357B
(en)
*
|
1997-03-20 |
1999-09-29 |
Amersham Pharm Biotech Inc |
Derivatives of 7-deaza-2-deoxy-guanosine-5'-triphosphate, preparation and use thereof
|
|
US6660845B1
(en)
*
|
1999-11-23 |
2003-12-09 |
Epoch Biosciences, Inc. |
Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof
|
|
DE60127162T2
(de)
|
2000-10-06 |
2008-04-24 |
The Trustees Of Columbia University In The City Of New York |
Massives Parallelverfahren zur Dekodierung von DNA und RNA
|
|
US9708358B2
(en)
|
2000-10-06 |
2017-07-18 |
The Trustees Of Columbia University In The City Of New York |
Massive parallel method for decoding DNA and RNA
|
|
JP2005516300A
(ja)
|
2002-01-25 |
2005-06-02 |
アプレラ コーポレイション |
製品およびサービスに対する注文を発注し、受理し、および充足する方法
|
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
|
EP1478656B1
(en)
*
|
2002-02-01 |
2009-09-16 |
Life Technologies Corporation |
Oligonucleotide compositions with enhanced efficiency
|
|
WO2003064621A2
(en)
*
|
2002-02-01 |
2003-08-07 |
Ambion, Inc. |
HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
|
|
US20100075423A1
(en)
*
|
2002-06-12 |
2010-03-25 |
Life Technologies Corporation |
Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference
|
|
US20040248094A1
(en)
*
|
2002-06-12 |
2004-12-09 |
Ford Lance P. |
Methods and compositions relating to labeled RNA molecules that reduce gene expression
|
|
US20040029275A1
(en)
*
|
2002-08-10 |
2004-02-12 |
David Brown |
Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
|
|
ES2524048T3
(es)
|
2003-03-31 |
2014-12-03 |
F. Hoffmann-La Roche Ag |
Composiciones y métodos para la detección de ciertos flavivirus, incluidos los miembros del serogrupo del virus de la encefalitis japonesa
|
|
US7572581B2
(en)
|
2003-06-30 |
2009-08-11 |
Roche Molecular Systems, Inc. |
2′-terminator nucleotide-related methods and systems
|
|
US7947817B2
(en)
*
|
2003-06-30 |
2011-05-24 |
Roche Molecular Systems, Inc. |
Synthesis and compositions of 2'-terminator nucleotides
|
|
WO2005044836A2
(de)
|
2003-11-05 |
2005-05-19 |
Genovoxx Gmbh |
Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
|
|
US7158373B2
(en)
*
|
2004-03-08 |
2007-01-02 |
Originatic Llc |
Electronic device having a keyboard rotatable about an axis
|
|
US7939251B2
(en)
|
2004-05-06 |
2011-05-10 |
Roche Molecular Systems, Inc. |
SENP1 as a marker for cancer
|
|
EP2471924A1
(en)
|
2004-05-28 |
2012-07-04 |
Asuragen, INC. |
Methods and compositions involving microRNA
|
|
US7745125B2
(en)
*
|
2004-06-28 |
2010-06-29 |
Roche Molecular Systems, Inc. |
2′-terminator related pyrophosphorolysis activated polymerization
|
|
WO2006016978A1
(en)
*
|
2004-06-30 |
2006-02-16 |
Applera Corporation |
Analog probe complexes
|
|
EP2302053A1
(en)
|
2004-11-12 |
2011-03-30 |
Asuragen, Inc. |
Methods and compositions involving miRNA and miRNA inhibitor molecules
|
|
US20060292586A1
(en)
*
|
2004-12-17 |
2006-12-28 |
Schroth Gary P |
ID-tag complexes, arrays, and methods of use thereof
|
|
US7842794B2
(en)
|
2004-12-17 |
2010-11-30 |
Roche Molecular Systems, Inc. |
Reagents and methods for detecting Neisseria gonorrhoeae
|
|
US20060286590A1
(en)
*
|
2005-06-20 |
2006-12-21 |
Applera Corporation. |
Cis-regulatory modules
|
|
US9169510B2
(en)
|
2005-06-21 |
2015-10-27 |
The Trustees Of Columbia University In The City Of New York |
Pyrosequencing methods and related compositions
|
|
US20070072211A1
(en)
|
2005-06-30 |
2007-03-29 |
Roche Molecular Systems, Inc. |
Asymmetric PCR coupled with post-PCR characterization for the identification of nucleic acids
|
|
GB2446083B
(en)
|
2005-10-31 |
2011-03-02 |
Univ Columbia |
Chemically cleavable 3'-0-allyl-dntp-allyl-fluorophore fluorescent nucleotide analogues and related methods
|
|
WO2007053702A2
(en)
|
2005-10-31 |
2007-05-10 |
The Trustees Of Columbia University In The City Of New York |
Synthesis of four color 3'-o-allyl modified photocleavable fluorescent nucleotides and related methods
|
|
US9677123B2
(en)
|
2006-03-15 |
2017-06-13 |
Siemens Healthcare Diagnostics Inc. |
Degenerate nucleobase analogs
|
|
WO2008036765A2
(en)
|
2006-09-19 |
2008-03-27 |
Asuragen, Inc. |
Micrornas differentially expressed in pancreatic diseases and uses thereof
|
|
JP2010510964A
(ja)
|
2006-09-19 |
2010-04-08 |
アシュラジェン インコーポレイテッド |
治療的介入の標的としての、miR−15、miR−26、miR−31、miR−145、miR−147、miR−188、miR−215、miR−216、miR−331、mmu−miR−292−3pによって調節される遺伝子および経路
|
|
DE112007002932B4
(de)
|
2006-12-01 |
2015-08-06 |
The Trustees Of Columbia University In The City Of New York |
Vierfarben DNA-Sequenzierung mittels Synthese unter Verwendung von abspaltbaren, reversiblen, fluoreszierenden Nucleotidterminatoren
|
|
US7858772B2
(en)
*
|
2006-12-22 |
2010-12-28 |
Roche Molecular Systems, Inc. |
Compounds and methods for synthesis and purification of oligonucleotides
|
|
WO2008083090A2
(en)
|
2006-12-26 |
2008-07-10 |
Siemens Healthcare Diagnostics Inc |
Heteropolynucleotide duplexes with purine-purine base pairing
|
|
DK2725107T3
(da)
*
|
2007-10-19 |
2019-01-02 |
Univ Columbia |
DNA-sekventering med ikke-fluorescerende nukleotidreversible terminatorer og ddNTP'er modificeret med spaltbart mærke og nukleinsyre omfattende inosin med reversible terminatorer
|
|
US10150990B2
(en)
|
2008-04-21 |
2018-12-11 |
Roche Molecular Systems, Inc. |
Ribonucleotide tag nucleic acid detection
|
|
US8258111B2
(en)
|
2008-05-08 |
2012-09-04 |
The Johns Hopkins University |
Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
|
|
CN105200097A
(zh)
*
|
2008-10-20 |
2015-12-30 |
霍夫曼-拉罗奇有限公司 |
改进的等位基因特异性扩增
|
|
US8206929B2
(en)
|
2009-01-07 |
2012-06-26 |
Roche Molecular Systems, Inc. |
Nucleic acid amplification with allele-specific suppression of sequence variants
|
|
US8039215B2
(en)
|
2009-03-10 |
2011-10-18 |
Roche Molecular Systems, Inc. |
Multiplex quantitative nucleic acid amplification and melting assay
|
|
EP2432796B1
(en)
|
2009-05-21 |
2016-08-17 |
Siemens Healthcare Diagnostics Inc. |
Universal tags with non-natural nucleobases
|
|
US8409802B2
(en)
|
2009-08-14 |
2013-04-02 |
Roche Molecular Systems, Inc. |
Format of probes to detect nucleic acid differences
|
|
WO2011050938A1
(de)
|
2009-10-26 |
2011-05-05 |
Genovoxx Gmbh |
Konjugate von nukleotiden und methoden zu deren anwendung
|
|
US8614071B2
(en)
|
2009-12-11 |
2013-12-24 |
Roche Molecular Systems, Inc. |
Preferential amplification of mRNA over DNA using chemically modified primers
|
|
US9238832B2
(en)
|
2009-12-11 |
2016-01-19 |
Roche Molecular Systems, Inc. |
Allele-specific amplification of nucleic acids
|
|
EP2531618B1
(en)
|
2010-02-05 |
2016-01-20 |
Quest Diagnostics Investments Incorporated |
Method to detect repeat sequence motifs in nucleic acid
|
|
ES2631458T3
(es)
|
2010-03-04 |
2017-08-31 |
Interna Technologies B.V. |
Molécula de ARNmi definida por su fuente y sus usos terapéuticos en el cáncer asociado a la EMT
|
|
NZ704322A
(en)
|
2010-07-06 |
2016-07-29 |
Interna Technologies Bv |
Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
|
|
WO2012034007A2
(en)
|
2010-09-10 |
2012-03-15 |
Bio-Rad Laboratories, Inc. |
Size selection of dna for chromatin analysis
|
|
WO2012038049A2
(en)
|
2010-09-22 |
2012-03-29 |
Roche Diagnostics Gmbh |
Amplification of distant nucleic acid targets using engineered primers
|
|
EP2772550B1
(en)
|
2010-11-17 |
2017-03-29 |
Interpace Diagnostics, LLC |
Mirnas as biomarkers for distinguishing benign from malignant thyroid neoplasms
|
|
EP2474617A1
(en)
|
2011-01-11 |
2012-07-11 |
InteRNA Technologies BV |
Mir for treating neo-angiogenesis
|
|
EP2663639B1
(en)
|
2011-01-14 |
2017-09-13 |
Life Technologies Corporation |
Methods for isolation, identification, and quantification of mirnas
|
|
WO2012112606A1
(en)
|
2011-02-15 |
2012-08-23 |
Bio-Rad Laboratories, Inc. |
Detecting methylati0n in a subpopulation of genomic dna
|
|
US9994894B2
(en)
|
2011-04-27 |
2018-06-12 |
Agct Gmbh |
Method and components for detecting nucleic acid chains
|
|
EP2705161A1
(de)
|
2011-05-04 |
2014-03-12 |
Genovoxx GmbH |
Nukleosid-triphosphat-konjugate und methoden zu deren anwendung
|
|
US9624539B2
(en)
|
2011-05-23 |
2017-04-18 |
The Trustees Of Columbia University In The City Of New York |
DNA sequencing by synthesis using Raman and infrared spectroscopy detection
|
|
WO2013019960A1
(en)
|
2011-08-03 |
2013-02-07 |
Bio-Rad Laboratories, Inc. |
Filtering small nucleic acids using permeabilized cells
|
|
US9644241B2
(en)
|
2011-09-13 |
2017-05-09 |
Interpace Diagnostics, Llc |
Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease
|
|
CA2847943C
(en)
|
2011-09-23 |
2017-08-29 |
F.Hoffmann-La Roche Ag |
Use of g-clamp for improved allele-specific pcr
|
|
US20130157884A1
(en)
|
2011-10-26 |
2013-06-20 |
Asuragen, Inc. |
Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
|
|
US9115394B2
(en)
|
2011-12-22 |
2015-08-25 |
Roche Molecular Systems, Inc. |
Methods and reagents for reducing non-specific amplification
|
|
US10174314B2
(en)
|
2011-12-22 |
2019-01-08 |
Interna Technologies B.V. |
MiRNA for treating head and neck cancer
|
|
US9695416B2
(en)
|
2012-07-18 |
2017-07-04 |
Siemens Healthcare Diagnostics Inc. |
Method of normalizing biological samples
|
|
WO2014055117A1
(en)
|
2012-10-04 |
2014-04-10 |
Asuragen, Inc. |
Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
|
|
US10201556B2
(en)
|
2012-11-06 |
2019-02-12 |
Interna Technologies B.V. |
Combination for use in treating diseases or conditions associated with melanoma, or treating diseases or conditions associated with activated B-raf pathway
|
|
EP2971098B1
(en)
|
2013-03-14 |
2018-11-21 |
Translate Bio, Inc. |
Quantitative assessment for cap efficiency of messenger rna
|
|
MX2015011944A
(es)
|
2013-03-14 |
2015-12-01 |
Shire Human Genetic Therapies |
Evaluacion cuantitativa para la eficacia de los casquetes de arn mensajero.
|
|
US9944992B2
(en)
|
2013-03-15 |
2018-04-17 |
The University Of Chicago |
Methods and compositions related to T-cell activity
|
|
US9828629B2
(en)
|
2013-03-15 |
2017-11-28 |
Roche Molecular Systems, Inc. |
Nucleic acid target identification by structure based probe cleavage
|
|
WO2014144883A1
(en)
|
2013-03-15 |
2014-09-18 |
The Trustees Of Columbia University In The City Of New York |
Raman cluster tagged molecules for biological imaging
|
|
JP2016538882A
(ja)
|
2013-10-30 |
2016-12-15 |
グリーン ライフ バイオテック,エルエルシー |
カンキツグリーニング病のための病因定量システム及び治療方法
|
|
US9637791B2
(en)
|
2013-12-20 |
2017-05-02 |
Roche Molecular Systems, Inc. |
Multiplexed nucleic acid target identification by strucutre based probe cleavage
|
|
US9243289B2
(en)
|
2013-12-23 |
2016-01-26 |
Roche Molecular Systems, Inc. |
Method for screening reagents used in PCR assays
|
|
US10087444B2
(en)
|
2014-02-13 |
2018-10-02 |
The Board Of Regents Of The University Of Texas System |
MicroRNA composition for the treatment of neuroblastoma
|
|
US9909169B2
(en)
|
2014-12-17 |
2018-03-06 |
Roche Molecular Systems, Inc. |
Allele-specific amplification of nucleic acids using blocking oligonucleotides for wild type suppression
|
|
CN104845967B
(zh)
|
2015-04-15 |
2020-12-11 |
苏州新海生物科技股份有限公司 |
寡聚核苷酸片段及使用其的选择性扩增目标核酸序列变异体的方法及应用
|
|
ES2929367T3
(es)
|
2016-05-18 |
2022-11-28 |
Hoffmann La Roche |
Amplificación por PCR ultrarrápida cuantitativa usando un dispositivo basado en electrohumectación
|
|
WO2018015365A1
(en)
|
2016-07-18 |
2018-01-25 |
Roche Sequencing Solutions, Inc. |
Asymmetric templates and asymmetric method of nucleic acid sequencing
|
|
AU2018358016A1
(en)
|
2017-11-03 |
2020-05-07 |
Interna Technologies B.V. |
MiRNA molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
|
|
US11691141B2
(en)
|
2017-11-13 |
2023-07-04 |
Roche Sequencing Solutions, Inc. |
Devices for sample analysis using epitachophoresis
|
|
AU2019218557A1
(en)
|
2018-02-12 |
2020-08-20 |
Interna Technologies B.V. |
Anticancer microRNA and lipid formulations thereof
|
|
US12153013B2
(en)
|
2018-10-12 |
2024-11-26 |
Roche Sequencing Solutions, Inc. |
Detection methods for epitachophoresis workflow automation
|
|
US11293061B2
(en)
|
2018-12-26 |
2022-04-05 |
Illumina Cambridge Limited |
Sequencing methods using nucleotides with 3′ AOM blocking group
|
|
CN114269916A
(zh)
|
2019-05-14 |
2022-04-01 |
豪夫迈·罗氏有限公司 |
用于样品分析的装置和方法
|
|
KR20220052938A
(ko)
|
2019-08-01 |
2022-04-28 |
디엔에이 스크립트 |
폴리뉴클레오타이드의 주형-부재 효소적 합성에서의 긴 서열 수율 증가
|
|
EP4168421A1
(en)
|
2020-06-22 |
2023-04-26 |
Illumina Cambridge Limited |
Nucleosides and nucleotides with 3' acetal blocking group
|
|
WO2022020793A1
(en)
|
2020-07-24 |
2022-01-27 |
The Regents Of The University Of California |
Antiviral prodrugs, pharmaceutical formulations, and methods
|
|
EP4347875A1
(en)
|
2021-06-04 |
2024-04-10 |
Translate Bio, Inc. |
Assay for quantitative assessment of mrna capping efficiency
|
|
CA3241326A1
(en)
|
2021-12-03 |
2023-06-08 |
Medicinal Genomics Corporation |
Psilocybe assay
|
|
US20250059600A1
(en)
|
2021-12-09 |
2025-02-20 |
Roche Molecular Systems, Inc. |
Mass based detection of pcr amplicons
|
|
EP4587594A1
(en)
|
2022-09-13 |
2025-07-23 |
Medicinal Genomics Corporation |
<smallcapsilocybe assay
|
|
WO2024104914A1
(en)
|
2022-11-14 |
2024-05-23 |
BioNTech SE |
Rna capping efficiency assay
|
|
IT202200026595A1
(it)
|
2022-12-22 |
2024-06-22 |
Fond Telethon Ets |
Nuovi inibitori di regolatori epigenetici
|
|
WO2024256674A1
(en)
|
2023-06-14 |
2024-12-19 |
Sanofi |
Methods of simultaneously identifying or quantifying capping and tailing modifications of messenger rna
|