|
US4729947A
(en)
*
|
1984-03-29 |
1988-03-08 |
The Board Of Regents Of The University Of Nebraska |
DNA sequencing
|
|
US5571388A
(en)
*
|
1984-03-29 |
1996-11-05 |
Li-Cor, Inc. |
Sequencing near infrared and infrared fluorescense labeled DNA for detecting using laser diodes and suitable labels thereof
|
|
US5863403A
(en)
*
|
1984-03-29 |
1999-01-26 |
The Board Of Regents Of The University Of Nebraska |
Digital DNA typing
|
|
US6086737A
(en)
*
|
1984-03-29 |
2000-07-11 |
Li-Cor, Inc. |
Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor
|
|
US5360523A
(en)
*
|
1984-03-29 |
1994-11-01 |
Li-Cor, Inc. |
DNA sequencing
|
|
US6207421B1
(en)
|
1984-03-29 |
2001-03-27 |
Li-Cor, Inc. |
DNA sequencing and DNA terminators
|
|
US6004446A
(en)
*
|
1984-03-29 |
1999-12-21 |
Li-Cor, Inc. |
DNA Sequencing
|
|
DE3529478A1
(de)
*
|
1985-08-16 |
1987-02-19 |
Boehringer Mannheim Gmbh |
7-desaza-2'desoxyguanosin-nukleotide, verfahren zu deren herstellung und deren verwendung zur nukleinsaeure-sequenzierung
|
|
DE3739366A1
(de)
*
|
1987-04-10 |
1988-10-27 |
Boehringer Mannheim Gmbh |
Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel
|
|
US6211158B1
(en)
*
|
1987-04-10 |
2001-04-03 |
Roche Diagnostics Gmbh |
Desazapurine-nucleotide derivatives, processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof for nucleic acid sequencing and as antiviral agents
|
|
US5459255A
(en)
*
|
1990-01-11 |
1995-10-17 |
Isis Pharmaceuticals, Inc. |
N-2 substituted purines
|
|
US6200747B1
(en)
|
1992-01-28 |
2001-03-13 |
North Shore University Hospital Research Corp. |
Method and kits for detection of fragile X specific, GC-rich DNA sequences
|
|
DE4438918A1
(de)
*
|
1994-11-04 |
1996-05-09 |
Hoechst Ag |
Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung
|
|
US6150510A
(en)
*
|
1995-11-06 |
2000-11-21 |
Aventis Pharma Deutschland Gmbh |
Modified oligonucleotides, their preparation and their use
|
|
US6004939A
(en)
*
|
1995-07-06 |
1999-12-21 |
Ctrc Research Foundation Board Of Regents |
Methods for modulation and inhibition of telomerase
|
|
WO1997002279A1
(en)
*
|
1995-07-06 |
1997-01-23 |
Ctrc Research Foundation |
Methods and compositions for modulation and inhibition of telomerase
|
|
US6291164B1
(en)
|
1996-11-22 |
2001-09-18 |
Invitrogen Corporation |
Methods for preventing inhibition of nucleic acid synthesis by pyrophosphate
|
|
GB2323357B
(en)
*
|
1997-03-20 |
1999-09-29 |
Amersham Pharm Biotech Inc |
Derivatives of 7-deaza-2-deoxy-guanosine-5'-triphosphate, preparation and use thereof
|
|
US6906185B1
(en)
|
1997-03-20 |
2005-06-14 |
Amersham Biosciences Corp. |
Derivatives of 7-deaza -2′-deoxyguanosine-5'-triphosphate, preparation and use thereof
|
|
US6660845B1
(en)
*
|
1999-11-23 |
2003-12-09 |
Epoch Biosciences, Inc. |
Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof
|
|
US9708358B2
(en)
|
2000-10-06 |
2017-07-18 |
The Trustees Of Columbia University In The City Of New York |
Massive parallel method for decoding DNA and RNA
|
|
WO2002029003A2
(en)
|
2000-10-06 |
2002-04-11 |
The Trustees Of Columbia University In The City Of New York |
Massive parallel method for decoding dna and rna
|
|
WO2003065146A2
(en)
|
2002-01-25 |
2003-08-07 |
Applera Corporation |
Methods for placing, accepting, and filling orders for products and services
|
|
WO2003064621A2
(en)
*
|
2002-02-01 |
2003-08-07 |
Ambion, Inc. |
HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
|
|
ATE529512T1
(de)
|
2002-02-01 |
2011-11-15 |
Life Technologies Corp |
Doppelsträngige oligonukleotide
|
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
|
US20040248094A1
(en)
*
|
2002-06-12 |
2004-12-09 |
Ford Lance P. |
Methods and compositions relating to labeled RNA molecules that reduce gene expression
|
|
US20100075423A1
(en)
*
|
2002-06-12 |
2010-03-25 |
Life Technologies Corporation |
Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference
|
|
US20040029275A1
(en)
*
|
2002-08-10 |
2004-02-12 |
David Brown |
Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
|
|
CA2520538C
(en)
|
2003-03-31 |
2014-04-29 |
F. Hoffmann-La Roche Ag |
Compositions and methods for detecting certain flaviviruses, including members of the japanese encephalitis virus serogroup
|
|
US7572581B2
(en)
*
|
2003-06-30 |
2009-08-11 |
Roche Molecular Systems, Inc. |
2′-terminator nucleotide-related methods and systems
|
|
US7947817B2
(en)
*
|
2003-06-30 |
2011-05-24 |
Roche Molecular Systems, Inc. |
Synthesis and compositions of 2'-terminator nucleotides
|
|
EP1725572B1
(de)
|
2003-11-05 |
2017-05-31 |
AGCT GmbH |
Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
|
|
US7158373B2
(en)
*
|
2004-03-08 |
2007-01-02 |
Originatic Llc |
Electronic device having a keyboard rotatable about an axis
|
|
US7939251B2
(en)
|
2004-05-06 |
2011-05-10 |
Roche Molecular Systems, Inc. |
SENP1 as a marker for cancer
|
|
EP2290068A3
(en)
|
2004-05-28 |
2012-01-04 |
Asuragen, Inc. |
Methods and compositions involving microRNA
|
|
US7745125B2
(en)
*
|
2004-06-28 |
2010-06-29 |
Roche Molecular Systems, Inc. |
2′-terminator related pyrophosphorolysis activated polymerization
|
|
WO2006016978A1
(en)
*
|
2004-06-30 |
2006-02-16 |
Applera Corporation |
Analog probe complexes
|
|
ES2503765T3
(es)
|
2004-11-12 |
2014-10-07 |
Asuragen, Inc. |
Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN
|
|
US7842794B2
(en)
|
2004-12-17 |
2010-11-30 |
Roche Molecular Systems, Inc. |
Reagents and methods for detecting Neisseria gonorrhoeae
|
|
US20060292586A1
(en)
*
|
2004-12-17 |
2006-12-28 |
Schroth Gary P |
ID-tag complexes, arrays, and methods of use thereof
|
|
US20060286590A1
(en)
*
|
2005-06-20 |
2006-12-21 |
Applera Corporation. |
Cis-regulatory modules
|
|
WO2007002204A2
(en)
|
2005-06-21 |
2007-01-04 |
The Trustees Of Columbia University In The City Of New York |
Pyrosequencing methods and related compostions
|
|
US7465561B2
(en)
|
2005-06-30 |
2008-12-16 |
Roche Molecular Systems, Inc. |
Probes and methods for hepatitis C virus typing using single probe analysis
|
|
WO2007053719A2
(en)
|
2005-10-31 |
2007-05-10 |
The Trustees Of Columbia University In The City Of New York |
Chemically cleavable 3'-o-allyl-dntp-allyl-fluorophore fluorescent nucleotide analogues and related methods
|
|
GB2446084B
(en)
|
2005-10-31 |
2011-03-02 |
Univ Columbia |
Synthesis of four color 3-o-allyl modified photocleavable fluorescent nucleotides and related methods
|
|
EP1994182B1
(en)
|
2006-03-15 |
2019-05-29 |
Siemens Healthcare Diagnostics Inc. |
Degenerate nucleobase analogs
|
|
AU2007299748A1
(en)
|
2006-09-19 |
2008-03-27 |
Asuragen, Inc. |
miR-15, miR-26, miR -31,miR -145, miR-147, miR-188, miR-215, miR-216 miR-331, mmu-miR-292-3p regulated genes and pathways as targets for therapeutic intervention
|
|
WO2008036765A2
(en)
|
2006-09-19 |
2008-03-27 |
Asuragen, Inc. |
Micrornas differentially expressed in pancreatic diseases and uses thereof
|
|
GB2457402B
(en)
|
2006-12-01 |
2011-10-19 |
Univ Columbia |
Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
|
|
US7858772B2
(en)
*
|
2006-12-22 |
2010-12-28 |
Roche Molecular Systems, Inc. |
Compounds and methods for synthesis and purification of oligonucleotides
|
|
US8399194B2
(en)
|
2006-12-26 |
2013-03-19 |
Siemens Healthcare Diagnostics Inc. |
Heteropolynucleotide duplexes with purine—purine base pairing
|
|
EP2725107B1
(en)
|
2007-10-19 |
2018-08-29 |
The Trustees of Columbia University in the City of New York |
DNA sequencing with non-fluorescent nucleotide reversible terminators and cleavable label modified ddNTPs and nucleic acid comprising inosine with reversible terminators
|
|
US10150990B2
(en)
|
2008-04-21 |
2018-12-11 |
Roche Molecular Systems, Inc. |
Ribonucleotide tag nucleic acid detection
|
|
WO2009137807A2
(en)
|
2008-05-08 |
2009-11-12 |
Asuragen, Inc. |
Compositions and methods related to mirna modulation of neovascularization or angiogenesis
|
|
JP5624044B2
(ja)
*
|
2008-10-20 |
2014-11-12 |
エフ.ホフマン−ラ ロシュアーゲーF.Hoffmann−La Roche Aktiengesellschaft |
改善されたアレル−特異的増幅
|
|
US8206929B2
(en)
|
2009-01-07 |
2012-06-26 |
Roche Molecular Systems, Inc. |
Nucleic acid amplification with allele-specific suppression of sequence variants
|
|
US8039215B2
(en)
|
2009-03-10 |
2011-10-18 |
Roche Molecular Systems, Inc. |
Multiplex quantitative nucleic acid amplification and melting assay
|
|
EP2432796B1
(en)
|
2009-05-21 |
2016-08-17 |
Siemens Healthcare Diagnostics Inc. |
Universal tags with non-natural nucleobases
|
|
US8409802B2
(en)
|
2009-08-14 |
2013-04-02 |
Roche Molecular Systems, Inc. |
Format of probes to detect nucleic acid differences
|
|
WO2011050938A1
(de)
|
2009-10-26 |
2011-05-05 |
Genovoxx Gmbh |
Konjugate von nukleotiden und methoden zu deren anwendung
|
|
US8614071B2
(en)
|
2009-12-11 |
2013-12-24 |
Roche Molecular Systems, Inc. |
Preferential amplification of mRNA over DNA using chemically modified primers
|
|
US9238832B2
(en)
|
2009-12-11 |
2016-01-19 |
Roche Molecular Systems, Inc. |
Allele-specific amplification of nucleic acids
|
|
EP3460074B1
(en)
|
2010-02-05 |
2020-10-07 |
Quest Diagnostics Investments Incorporated |
Method to detect repeat sequence motifs in nucleic acid
|
|
EP2542678B1
(en)
|
2010-03-04 |
2017-04-12 |
InteRNA Technologies B.V. |
A MiRNA MOLECULE DEFINED BY ITS SOURCE AND ITS THERAPEUTIC USES IN CANCER ASSOCIATED WITH EMT
|
|
AU2011274619B2
(en)
|
2010-07-06 |
2016-11-10 |
Interna Technologies Bv |
miRNA and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated BRAF pathway
|
|
CA2810520C
(en)
|
2010-09-10 |
2019-03-12 |
Bio-Rad Laboratories, Inc. |
Size selection of dna for chromatin analysis
|
|
WO2012038049A2
(en)
|
2010-09-22 |
2012-03-29 |
Roche Diagnostics Gmbh |
Amplification of distant nucleic acid targets using engineered primers
|
|
EP2640851A2
(en)
|
2010-11-17 |
2013-09-25 |
Asuragen, Inc. |
Mirnas as biomarkers for distinguishing benign from malignant thyroid neoplasms
|
|
EP2474617A1
(en)
|
2011-01-11 |
2012-07-11 |
InteRNA Technologies BV |
Mir for treating neo-angiogenesis
|
|
EP2663639B1
(en)
|
2011-01-14 |
2017-09-13 |
Life Technologies Corporation |
Methods for isolation, identification, and quantification of mirnas
|
|
US20120208193A1
(en)
|
2011-02-15 |
2012-08-16 |
Bio-Rad Laboratories, Inc. |
Detecting methylation in a subpopulation of genomic dna
|
|
WO2012146377A1
(de)
|
2011-04-27 |
2012-11-01 |
Dmitry Cherkasov |
Methoden und komponenten zur detektion von nukleinsäureketten
|
|
EP2705161A1
(de)
|
2011-05-04 |
2014-03-12 |
Genovoxx GmbH |
Nukleosid-triphosphat-konjugate und methoden zu deren anwendung
|
|
WO2012162429A2
(en)
|
2011-05-23 |
2012-11-29 |
The Trustees Of Columbia University In The City Of New York |
Dna sequencing by synthesis using raman and infrared spectroscopy detection
|
|
CN103732761A
(zh)
|
2011-08-03 |
2014-04-16 |
伯乐实验室公司 |
使用透化处理的细胞过滤小核酸
|
|
WO2013040251A2
(en)
|
2011-09-13 |
2013-03-21 |
Asurgen, Inc. |
Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
|
|
JP6050820B2
(ja)
|
2011-09-23 |
2016-12-21 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
改良された対立遺伝子特異的pcrのためのg−クランプの使用
|
|
US20130157884A1
(en)
|
2011-10-26 |
2013-06-20 |
Asuragen, Inc. |
Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
|
|
EP3369818B1
(en)
|
2011-12-22 |
2021-06-09 |
InteRNA Technologies B.V. |
Mirna for treating head and neck cancer
|
|
US9115394B2
(en)
|
2011-12-22 |
2015-08-25 |
Roche Molecular Systems, Inc. |
Methods and reagents for reducing non-specific amplification
|
|
WO2014015098A1
(en)
|
2012-07-18 |
2014-01-23 |
Siemens Healthcare Diagnostics Inc. |
A method of normalizing biological samples
|
|
WO2014055117A1
(en)
|
2012-10-04 |
2014-04-10 |
Asuragen, Inc. |
Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
|
|
EP2917348A1
(en)
|
2012-11-06 |
2015-09-16 |
InteRNA Technologies B.V. |
Combination for use in treating diseases or conditions associated with melanoma, or treating diseases or conditions associated with activated b-raf pathway
|
|
EA201591283A1
(ru)
|
2013-03-14 |
2016-02-29 |
Шир Хьюман Дженетик Терапис, Инк. |
Количественная оценка эффективности кэп матричной рнк
|
|
ES2708562T3
(es)
|
2013-03-14 |
2019-04-10 |
Translate Bio Inc |
Evaluación cuantitativa de la eficacidad de tapa de ARN mensajero
|
|
US10648026B2
(en)
|
2013-03-15 |
2020-05-12 |
The Trustees Of Columbia University In The City Of New York |
Raman cluster tagged molecules for biological imaging
|
|
EP2970909A4
(en)
|
2013-03-15 |
2017-02-15 |
The University of Chicago |
Methods and compositions related to t-cell activity
|
|
US9828629B2
(en)
|
2013-03-15 |
2017-11-28 |
Roche Molecular Systems, Inc. |
Nucleic acid target identification by structure based probe cleavage
|
|
WO2015066341A2
(en)
|
2013-10-30 |
2015-05-07 |
Green Life Biotech, Llc |
Pathogenesis quantification systems and treatment methods for citrus greening blight
|
|
US9637791B2
(en)
|
2013-12-20 |
2017-05-02 |
Roche Molecular Systems, Inc. |
Multiplexed nucleic acid target identification by strucutre based probe cleavage
|
|
US9243289B2
(en)
|
2013-12-23 |
2016-01-26 |
Roche Molecular Systems, Inc. |
Method for screening reagents used in PCR assays
|
|
US10087444B2
(en)
|
2014-02-13 |
2018-10-02 |
The Board Of Regents Of The University Of Texas System |
MicroRNA composition for the treatment of neuroblastoma
|
|
US9909169B2
(en)
|
2014-12-17 |
2018-03-06 |
Roche Molecular Systems, Inc. |
Allele-specific amplification of nucleic acids using blocking oligonucleotides for wild type suppression
|
|
CN104845967B
(zh)
|
2015-04-15 |
2020-12-11 |
苏州新海生物科技股份有限公司 |
寡聚核苷酸片段及使用其的选择性扩增目标核酸序列变异体的方法及应用
|
|
EP3458597B1
(en)
|
2016-05-18 |
2022-09-07 |
Roche Diagnostics GmbH |
Quantitative real time pcr amplification using an electrowetting-based device
|
|
ES2910080T3
(es)
|
2016-07-18 |
2022-05-11 |
Hoffmann La Roche |
Moldes asimétricos y procedimiento asimétrico de secuenciación de ácido nucleico
|
|
AU2018358016A1
(en)
|
2017-11-03 |
2020-05-07 |
Interna Technologies B.V. |
MiRNA molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
|
|
CN111656179B
(zh)
|
2017-11-13 |
2023-11-03 |
豪夫迈·罗氏有限公司 |
用于使用表位电泳进行样品分析的装置
|
|
AU2019218557A1
(en)
|
2018-02-12 |
2020-08-20 |
Interna Technologies B.V. |
Anticancer microRNA and lipid formulations thereof
|
|
US12153013B2
(en)
|
2018-10-12 |
2024-11-26 |
Roche Sequencing Solutions, Inc. |
Detection methods for epitachophoresis workflow automation
|
|
US11293061B2
(en)
|
2018-12-26 |
2022-04-05 |
Illumina Cambridge Limited |
Sequencing methods using nucleotides with 3′ AOM blocking group
|
|
WO2020229437A1
(en)
|
2019-05-14 |
2020-11-19 |
F. Hoffmann-La Roche Ag |
Devices and methods for sample analysis
|
|
US20220403435A1
(en)
|
2019-08-01 |
2022-12-22 |
Dna Script Sas |
Increasing Long-Sequence Yields In Template-Free Enzymatic Synthesis of Polynucleotides
|
|
CA3177293A1
(en)
|
2020-06-22 |
2021-12-30 |
Illumina Cambridge Limited |
Nucleosides and nucleotides with 3' acetal blocking group
|
|
WO2022020793A1
(en)
|
2020-07-24 |
2022-01-27 |
The Regents Of The University Of California |
Antiviral prodrugs, pharmaceutical formulations, and methods
|
|
CA3221100A1
(en)
|
2021-06-04 |
2022-12-08 |
Frank Derosa |
Assay for quantitative assessment of mrna capping efficiency
|
|
US20250034662A1
(en)
|
2021-12-03 |
2025-01-30 |
Medicinal Genomics Corporation |
Psilocybe assay
|
|
EP4444904A1
(en)
|
2021-12-09 |
2024-10-16 |
F. Hoffmann-La Roche AG |
Mass based detection of pcr amplicons
|
|
EP4587594A1
(en)
|
2022-09-13 |
2025-07-23 |
Medicinal Genomics Corporation |
<smallcapsilocybe assay
|
|
JP2025539043A
(ja)
|
2022-11-14 |
2025-12-03 |
バイオンテック・エスイー |
Rnaキャッピング効率アッセイ
|
|
IT202200026595A1
(it)
|
2022-12-22 |
2024-06-22 |
Fond Telethon Ets |
Nuovi inibitori di regolatori epigenetici
|
|
WO2024256674A1
(en)
|
2023-06-14 |
2024-12-19 |
Sanofi |
Methods of simultaneously identifying or quantifying capping and tailing modifications of messenger rna
|